Predictive score for mortality in patients with COPD exacerbations attending hospital emergency departments

Background: Limited information is available about predictors of short-term outcomes in patients with exacerbation of chronic obstructive pulmonary disease (eCOPD) attending an emergency department (ED). Such information could help stratify these patients and guide medical decision-making. The aim of this study was to develop a clinical prediction rule for short-term mortality during hospital admission or within a week after the index ED visit. Methods: This was a prospective cohort study of patients with eCOPD attending the EDs of 16 participating hospitals. Recruitment started in June 2008 and ended in September 2010. Information on possible predictor variables was recorded during the time the patient was evaluated in the ED, at the time a decision was made to admit the patient to the hospital or discharge home, and during follow-up. Main short-term outcomes were death during hospital admission or within 1 week of discharge to home from the ED, as well as at death within 1 month of the index ED visit. Multivariate logistic regression models were developed in a derivation sample and validated in a validation sample. The score was compared with other published prediction rules for patients with stable COPD. Results: In total, 2,487 patients were included in the study. Predictors of death during hospital admission, or within 1 week of discharge to home from the ED were patient age, baseline dyspnea, previous need for long-term home oxygen therapy or non-invasive mechanical ventilation, altered mental status, and use of inspiratory accessory muscles or paradoxical breathing upon ED arrival (area under the curve (AUC) = 0.85). Addition of arterial blood gas parameters (oxygen and carbon dioxide partial pressures (PO2 and PCO2)) and pH) did not improve the model. The same variables were predictors of death at 1 month (AUC = 0.85). Compared with other commonly used tools for predicting the severity of COPD in stable patients, our rule was significantly better. Conclusions: Five clinical predictors easily available in the ED, and also in the primary care setting, can be used to create a simple and easily obtained score that allows clinicians to stratify patients with eCOPD upon ED arrival and guide the medical decision-making process.

Determination of drugs used in combined cardiovascular therapy

Cardiovascular diseases are nowadays the first cause of mortality worldwide, causing around the 30% of global deaths each year. The risk of suffering from cardiovascular illnesses is strongly related to some factors such as hypertension, high cholesterol levels, diabetes, obesity The combination of these different risk factors is known as metabolic syndrome and it is considered a pandemic due to the high prevalence worldwide. The pathology of the disorders implies a combined cardiovascular therapy with drugs which have different targets and mechanisms of action, to regulate each factor separately. The simultaneous analysis of these drugs turns interesting but it is a complex task since the determination of multiple substances with different physicochemical properties and physiological behavior is always a challenge for the analytical chemist. The complexity of the biological matrices and the difference in the expected concentrations of some analytes require the development of extremely sensitive and selective determination methods. The aim of this work is to fill the gap existing in this field of the drug analysis, developing analytical methods capable of quantifying the different drugs prescribed in combined cardiovascular therapy simultaneously. Liquid chromatography andem mass spectrometry (LCMS/MS) has been the technique of choice throughout the main part of this work, due to the high sensitivity and selectivity requirements.

Home-Automation System

Nuestro proyecto trata de obtener un sistema centralizado para el manejo y monitorización de un conjunto de aparatos eléctricos del hogar, tales como luces, cámaras, sensores, y otros aparatos mediante una aplicación para dispositivos móviles Android. También se facilita una herramienta web para administrar dichos aparatos. Nuestro sistema da soporte al manejo individual y manual de estos aparatos, por ejemplo encender una lámpara, así como la posibilidad de incluir programas que se ejecuten a una determinada hora, y con una determinada recurrencia. Por ejemplo, se puede programar el encendido de una luz todos los días a las 20:00. Además, también se pueden crear reglas que, dado una determinada situación, realicen una serie de acciones. Por ejemplo, si se detecta que la luminosidad baja de cierto valor (detectado mediante un sensor de luz), se encienda una lámpara. Para conseguir esto se ha realizado una aplicación centralizada, a modo de servidor, que se comunica con los aparatos eléctricos mediante diferentes protocolos de comunicación, así como con el dispositivo móvil Android, y una aplicación web administrativa, a través de un portal de servicios web.

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy

12 p.

Design,optimization and in vivo evaluation of non-viral vectors for gene therapy. Applications in ocular disorders

227 págs.

Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia

17 p.

Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent

Background: Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are used as markers in some cancers. In the present study, the activity and protein and mRNA expression of these glycoproteins were analysed in a subset of clear-cell (CCRCC) and chromophobe (ChRCC) renal cell carcinomas, and in renal oncocytomas (RO). Methods: Peptidase activities were measured by conventional enzymatic assays with fluorogen-derived substrates. Gene expression was quantitatively determined by qRT-PCR and membrane-bound protein expression and distribution analysis was performed by specific immunostaining. Results: The activity of both glycoproteins was sharply decreased in the three histological types of renal tumors. Protein and mRNA expression was strongly downregulated in tumors from distal nephron (ChRCC and RO). Moreover, soluble DPP IV activity positively correlated with the aggressiveness of CCRCCs (higher activities in high grade tumors). Conclusions: These results support the pivotal role for DPP IV and NEP in the malignant transformation pathways and point to these peptidases as potential diagnostic markers.

Ekonomian lizentziaturako matematika IV. Azterketak

Ekonomian Lizentziaturako Matematika IV irakasgaia gainditu behar duten ikasleentzat, eta baita ere, gai batzuetan, gradu berriko Matematika I eta Matematika II irakasgaiko ikasleentzat.Ekonomian Lizentziaturako Matematika IV irakasgaiko azken hamar urteetan jarri diren azterketak eta haien erantzunak aurkituko dituzue. Lehenengo zatian, egin gabeko azterketak daude, ordena kronologikoan, zaharrenetik berrienera, eta bigarren zatian, erantzunak daude, ordena kronologikoan ere baina gaika ere. Horrela, programaren gai bakoitzaren ariketa guztiak elkarrekin aurkituko dituzue, gaiz gai ikasi nahi izanez gero.

[Reseña] F. Petrarca, De viris illustribus, I, II, IV (eds. S. Ferrone, C. Malta, P. de Capua), Firenze, Le Lettere, 2006-2007

[ES] Un real decreto de 1904, emitido con motivo de la celebración del VI Centenario del nacimiento de Petrarca (1304-1374), creó la Commissione per l’Edizione Nazionale delle Opere di Francesco Petrarca. Después de un siglo en el que los estudios petrarquescos han experimentado un florecimiento espectacular, con varias revistas y colecciones dedicadas exclusivamente a Petrarca y con una deslumbrante nómina de especialistas, han visto la luz siete de los veinte volúmenes previstos inicialmente.

Exámenes resueltos de matemáticas para economistas IV

Matemáticas para Economistas IV es una asignatura cuatrimestral dedicada fundamentalmente a la optimización con convexidad que se ha impartido en los últimos años en el segundo curso de la licenciatura de Economía en la Facultad de Ciencias Económicas y Empresariales de la Universidad del País Vasco. Esta publicación recoge problemas planteados en los exámenes de esta asignatura desde el año 2000 al 2009, en las convocatorias de junio y septiembre.

Ugarteburu terminologia jardunaldiak (2010). Euskararen garapena esparru akademikoetan. Espezialitate hizkerak eta terminologia IV

I. Hitzaldia: - Andrés Alberdi (EIMA): EIMA eta ikasmaterialaren kalitatea. - Araceli Diaz de Lezana: Euskarazko terminologiaren normalizazioa: terminología batzordea. - Juan Garzia (EHU, Euskara Zerbitzua): EHUko Euskara Zerbitzua: ereduak ontzeko bideak lantzen. - Antton Gurrutxaga et alii (Elhuyar): Internet, corpusak eta terminología: Internetetik espezialitate-corpusak erauzteko teknikak eta horien ebaluazioa. - Josu Landa: Corpusen iraultza: maiztasunen korapiloa. - UZEI: Euskara juridikoa eta abokatuen hizkuntza-baliabideak. II. Komunikazioak: - Xabier Alberdi (EHU): Kalkoen eragina euskara akademikoaren garapen lexikoan: Lan Zuzenbideko terminología. - Kepa Altonaga (EHU): Arnaut Abadia (1843-1916), gure zientzia-prosaren aurrendari ahaztu bat. - Xabier Arregi, Ana Arruarte, Xabier Artola, Mikel Lersundi, Gotzon Santander eta Joseba Umbellina (IXA): TZOS: Terminologia Zerbitzurako On-line Sistema. - José Ramón Etxebarria (EHU): Matematika eta fisikako zenbait esamolde estandaritzateko proposamena. - Joseba Ezeiza (EHU): DB (Dokumentu Biltegia): corpus akademikoak sortzeko eta kudeatzeko azpiegitura teknologikoa. - Julio García García de los Salmones (EHU): Kalkoaren kontzeptua eta haren terminologia ikasliburuetan eta gramatiketan. - Jacinto Iturbe (EHU): Elementu kimikoen izenen formak hainbat hiztegitan eta gaur eguneko forma kanonikoak. - Itziar San Martín, Igone Zabala eta Joseba Ezeiza (EHU): Aditzetiko izenak erregistro-bereizle gisa: corpus espezializatu baten azterketa morfopragmatikoa. - Igone Zabala eta Agurtzane Elordui (EHU): Nominalizazioa estrategia diskurtsibo gisa: corpus akademikoaren azterketaren beharra.

Zientzia eta Teknologia Fakultateko IV. Ikerkuntza Jardunaldiak

[EU]I. Abstracts. Ahozko komunikazioak 1. Biozientziak: Alderdi Molekularrak 2. Biozientziak: Ingurune Alderdiak. 3. Fisika eta Ingenieritza Elektronika 4. Geología 5. Matematika 6. Kimika 7. Ingenieritza Kimikoa eta Kimika II. Abstracts. Idatzizko Komunikazioak (Posterrak) 1. Biozientziak 2. Fisika eta Ingenieritza Elektronika 3. Geologia 4. Matematika 5. Kimika 6. Ingenieritza Kimikoa

Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy

Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be elevated in severe autism, leading to the 'anabolic hypothesis' of its etiology. Here we performed a focused microarray analysis of genes belonging to NOTCH and WNT signaling cascades, as well as genes related to AD and apoptosis pathways in cerebellar samples from autistic individuals, to provide further evidence for pathological relevance of these cascades for autism. By using the limma package from R and false discovery rate, we demonstrated that 31% (116 out of 374) of the genes belonging to these pathways displayed significant changes in expression (corrected P-values <0.05), with mitochondria- related genes being the most downregulated. We also found upregulation of GRIN1, the channel-forming subunit of NMDA glutamate receptors, and MAP3K1, known activator of the JNK and ERK pathways with anti-apoptotic effect. Expression of PSEN2 (presinilin 2) and APBB1 (or F65) were significantly lower when compared with control samples. Based on these results, we propose a model of NMDA glutamate receptor-mediated ERK activation of alpha-secretase activity and mitochondrial adaptation to apoptosis that may explain the early brain overgrowth and disruption of synaptic plasticity and connectome in autism. Finally, systems pharmacology analyses of the model that integrates all these genes together (NOWADA) highlighted magnesium (Mg2+) and rapamycin as most efficient drugs to target this network model in silico. Their potential therapeutic application, in the context of autism, is therefore discussed.

Paleoambiente y antropización en los Pirineos de Navarra durante el Holoceno medio (VI-IV PDF milenios cal. BC): Una perspectiva palinológica

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas

Aristóteles, «Poética» 1454a 24, y la tragedia del siglo IV

[ES] La cualidad de "semejantes", el requisito que Aristóteles señala han de poseer los personajes de la tragedia en «Poét.» 1454a 24, ha recibido fundamentalmente dos interpretaciones distintas. Una, la que supone que tal semejanza lo es con el hombre ordinario, está bien asentada dentro de la argumentación general de la «Poética»; la otra, que relaciona el concepto con el prototipo mítico, requiere más aclaraciones que la anterior si se pretende que pueda ser aristotélica. De ello nos ocupamos en el presente artículo, poniendo en relación la práctica contemporánea, la tragedia del siglo IV, con las opiniones de Aristóteles en la «Poética».