Stability of the factorial structure of metabolic syndrome from childhood to adolescence : a 6-year follow-up study

Background: Metabolic syndrome (MS) is a clustering of cardiometabolic risk factors that is considered a predictor of cardiovascular disease, type 2 diabetes and mortality. There is no consistent evidence on whether the MS construct works in the same way in different populations and at different stages in life. Methods: We used confirmatory factor analysis to examine if a single-factor-model including waist circumference, triglycerides/HDL-c, insulin and mean arterial pressure underlies metabolic syndrome from the childhood to adolescence in a 6-years follow-up study in 174 Swedish and 460 Estonian children aged 9 years at baseline. Indeed, we analyze the tracking of a previously validated MS index over this 6-years period. Results: The estimates of goodness-of-fit for the single-factor-model underlying MS were acceptable both in children and adolescents. The construct stability of a new model including the differences from baseline to the end of the follow-up in the components of the proposed model displayed good fit indexes for the change, supporting the hypothesis of a single factor underlying MS component trends. Conclusions: A single-factor-model underlying MS is stable across the puberty in both Estonian and Swedish young people. The MS index tracks acceptably from childhood to adolescence.

Pravastatin inhibits cell proliferation and increased MAT1A expression in hepatocarcinoma cells and in vivo models

Background: Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeutic effect in vitro and in vivo models. Method: We design in vitro and in vivo model. In vitro we used PLC and determine cell proliferation. In vivo, we used and animal model to determined, PCNA and MAT1A expression and transaminases levels. Results: We found that pravastatin decreases cell proliferation in vitro (cell proliferation in pravastatin group was 82%, in sorafenib group 51% and in combined group 40%) and in vivo (in pravastatin group 80%, in sorafenib group 76.4% and in combined group 72.72%). The MAT1A levels, was significantly higher in Pravastatin group (D 62%, P 94%, S 71%, P + S 91%). The transaminases levels, decreased significantly in Pravastatin group (GOT and GPT levels D 619.5 U/L; 271 U/L) (P 117.5 U/L; 43.5 U/L) (S 147 U/L; 59 U/L) (P + S 142 U/L; 59 U/L). Conclusion: The combination of pravastatin + sorafenib were more effective than Sorafenib alone.

Un impuesto singular: el diezmo-señor y la sal en Añana, siglos XVI-XIX

[ES]Cuando a partir de 1564 las salinas de Añana comenzaron a producir para la Corona, sus propietarios se vieron obligados a pagar al rey un tributo anual por el uso de las mueras, admitidas como un ius regalia de la monarquía: el diezmoseñor. Desde entonces, todo el entramado de la fabricación y venta de la sal se organizó en torno a él. En este artículo se analizan algunas de las características de este canon tan singular que se mantuvo en vigor hasta el siglo XX.

Astarloaren ekarpena euskal gramatikaren ikerketetan

Pablo Pedro Astarloaren jaiotzako 250. urteurrena dela eta, Durangon, 2002-VI-29an Euskaltzaindiaren bilera irekian irakurritako txostena

Hacia una edición crítica del manuscrito Lazarraga

Presentado en las Jornadas Euskal testuen edizioa: gaurko ikuspegiak eta etorkizuneko ikuspegiak = Edición de textos vascos: perspectivas actuales, perspectivas futuras (Bilbo, 2008.11.11-12)

Amatasunaren gaineko diskurtsoak euskal eleberrigintza garaikidean

[EUS] Artikulu honetan, bi alde aski diferenteak aztertu nahiko genituzke amatasunaren inguruko diskurtsoetan. Batetik, lehen partean, datu soziologikoak eskuan, aztertu nahi ditugu, 1979-2009 bitartean, amatasunak izan dituen gorabeherak. Beraz, datu soziologikoak buruan, literatur testuak aztertu ditugu bigarren atalean. Artikulu hau garatzeko orduan, protagonista ugalkortasun garaian dauden emakumeak dituzten literatur lanen hautua eginda batik bat.

Para una relectura del compromiso en los años sesenta: paradoja, escritura transparente, retracción de Antonio Gamoneda

[ES] En este artículo se trata de analizar el planteamiento del compromiso poético a la altura del comienzo de la década de los años sesenta, a partir del análisis de esa modalidad de escritura en Blues castellano de Antonio Gamoneda, libro cuyos poemas datan de 1961–1966, aunque permaneció inédito hasta 1982. Leído en el contexto de su producción, Blues castellano muestra una solidaridad absoluta con algunos de los modelos poéticos comprometidos de la época (Nazim Hikmet, Bertolt Brecht, los espirituales negros, etc.), así como una vinculación hacia un tipo de compromiso poético que va a hacer recaer su dimensión crítica en el lenguaje poético, no sólo en el referente externo. En Blues castellano se consolidan ya algunos de los conceptos centrales de la poesía gamonediana posterior: retracción, búsqueda de una escritura transparente, desaparición del sujeto en la escritura, etc.

Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk

Background: Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucose metabolism occurs through the modulation of cytokines and related molecules. The purpose of the study was to assess the associations between dietary intake of vitamin K and peripheral adipokines and other metabolic risk markers related to insulin resistance and type 2 diabetes mellitus. Methods: Cross-sectional and longitudinal assessments of these associations in 510 elderly participants recruited in the PREDIMED centers of Reus and Barcelona (Spain). We determined 1-year changes in dietary phylloquinone intake estimated by food frequency questionnaires, serum inflammatory cytokines and other metabolic risk markers. Results: In the cross-sectional analysis at baseline no significant associations were found between dietary phylloquinone intake and the rest of metabolic risk markers evaluated, with exception of a negative association with plasminogen activator inhibitor-1. After 1-year of follow-up, subjects in the upper tertile of changes in dietary phylloquinone intake showed a greater reduction in ghrelin (-15.0%), glucose-dependent insulinotropic peptide (-12.9%), glucagon-like peptide-1 (-17.6%), IL-6 (-27.9%), leptin (-10.3%), TNF (-26.9%) and visfatin (-24.9%) plasma concentrations than those in the lowest tertile (all p<0.05). Conclusion: These results show that dietary phylloquinone intake is associated with an improvement of cytokines and other markers related to insulin resistance and diabetes, thus extending the potential protection by dietary phylloquinone on chronic inflammatory diseases.

Arantxa Urretabizkaiaren narrazio lanetako amatasunak: genero arteko harreman berrien paradigma

[EUS] Artikulu honen bidez, Arantxa Urretabizkaiak amatasuna bere narratiban nola jorratu duen agerian jarri nahi da. Horrela, Zergatik panpox (1979), Koaderno gorria (1998) eta Hiru Mariak (2010) eleberrietako, eta Aspaldian espero zaitudalako ez nago sekula bakarrik (1983) ipuin bildumako amak aztertu dira artikulu honetan. Lehenik, amatasunaren inguruan esparru teorikoa eraiki da. Hortaz, egun teoria feministak amatasunaren inguruan zedarriturikoa eta esanikoa aurkeztu da. Ondoren, kritika feminista metodologia gisa harturik, aipaturiko narrazioetako literatur protagonistak aztertu dira. Ondorio nagusi gisa esan daiteke aztertutako amatasunaren irudikapenak ez direla hegemonikoak, alternatiboak edota emergenteak baizik. Ama bakarrak, helduak, lan munduan nahiz politikan dihardutenak aurkitu ditugu literatur testu hauetan, hitz batean, harreman berriak sorrarazi dituzten literatur pertsonaiak. Harreman berri horiek, hain justu ere, genero arteko harreman berrien paradigma lirateke.

Changes in social inequalities in disability-free life expectancy in Southern Europe: the case of the Basque Country

Background: Health expectancy is a useful tool to monitor health inequalities. The evidence about the recent changes in social inequalities in healthy expectancy is relatively scarce and inconclusive, and most studies have focused on Anglo-Saxon and central or northern European countries. The objective of this study was to analyse the changes in socioeconomic inequalities in disability-free life expectancy in a Southern European population, the Basque Country, during the first decade of the 21st century. Methods: This was an ecological cross-sectional study of temporal trends on the Basque population in 1999-2003 and 2004-2008. All-cause mortality rate, life expectancy, prevalence of disability and disability free-life expectancy were calculated for each period according to the deprivation level of the area of residence. The slope index of inequality and the relative index of inequality were calculated to summarize and compare the inequalities in the two periods. Results: Disability free-life expectancy decreased as area deprivation increased both in men and in women. The difference between the most extreme groups in 2004-2008 was 6.7 years in men and 3.7 in women. Between 1999-2003 and 2004-2008, socioeconomic inequalities in life expectancy decreased, and inequalities in disability-free expectancy increased in men and decreased in women. Conclusions: This study found important socioeconomic inequalities in health expectancy in the Basque Country. These inequalities increased in men and decreased in women in the first decade of the 21st century, during which the Basque Country saw considerable economic growth.

The impact of economic crises on social inequalities in health: what do we know so far?

Since 2008, Western countries are going through a deep economic crisis whose health impacts seem to be fundamentally counter-cyclical: when economic conditions worsen, so does health, and mortality tends to rise. While a growing number of studies have presented evidence on the effect of crises on the average population health, a largely neglected aspect of research is the impact of crises and the related political responses on social inequalities in health, even if the negative consequences of the crises are primarily borne by the most disadvantaged populations. This commentary will reflect on the results of the studies that have analyzed the effect of economic crises on social inequalities in health up to 2013. With some exceptions, the studies show an increase in health inequalities during crises, especially during the Southeast Asian and Japanese crises and the Soviet Union crisis, although it is not always evident for both sexes or all health or socioeconomic variables. In the Nordic countries during the nineties, a clear worsening of health equity did not occur. Results about the impacts of the current economic recession on health equity are still inconsistent. Some of the factors that could explain this variability in results are the role of welfare state policies, the diversity of time periods used in the analyses, the heterogeneity of socioeconomic and health variables considered, the changes in the socioeconomic profile of the groups under comparison in times of crises, and the type of measures used to analyze the magnitude of social inequalities in health. Social epidemiology should further collaborate with other disciplines to help produce more accurate and useful evidence about the relationship between crises and health equity.

Dietary animal and plant protein intakes and their associations with obesity and cardio-metabolic indicators in European adolescents: the HELENA cross-sectional study

Background: Previous studies suggest that dietary protein might play a beneficial role in combating obesity and its related chronic diseases. Total, animal and plant protein intakes and their associations with anthropometry and serum biomarkers in European adolescents using one standardised methodology across European countries are not well documented. Objectives: To evaluate total, animal and plant protein intakes in European adolescents stratified by gender and age, and to investigate their associations with cardio-metabolic indicators (anthropometry and biomarkers). Methods: The current analysis included 1804 randomly selected adolescents participating in the HELENA study (conducted in 2006-2007) aged 12.5-17.5 y (47% males) who completed two non-consecutive computerised 24-h dietary recalls. Associations between animal and plant protein intakes, and anthropometry and serum biomarkers were examined with General linear Model multivariate analysis. Results: Average total protein intake exceeded the recommendations of World Health Organization and European Food Safety Authority. Mean total protein intake was 96 g/d (59% derived from animal protein). Total, animal and plant protein intakes (g/d) were significantly lower in females than in males and total and plant protein intakes were lower in younger participants (12.5-14.9 y). Protein intake was significantly lower in underweight subjects and higher in obese ones; the direction of the relationship was reversed after adjustments for body weight (g/(kg.d)). The inverse association of plant protein intakes was stronger with BMI z-score and body fat percentage (BF%) compared to animal protein intakes. Additionally, BMI and BF% were positively associated with energy percentage of animal protein. Conclusions: This sample of European adolescents appeared to have adequate total protein intake. Our findings suggest that plant protein intakes may play a role in preventing obesity among European adolescents. Further longitudinal studies are needed to investigate the potential beneficial effects observed in this study in the prevention of obesity and related chronic diseases.