Las élites vascas en el gobierno de la monarquía borbónica : redes sociales, carreras y hegemonía en el siglo XVIII (1700-1746)

815 p. : il., graf.

Documentación geométrica del patrimonio: propuesta conceptual y metodológica

Tesis Doctoral desarrollada en el programa de Doctorado "Diseño e Ingeniería del Producto y de Procesos Industriales" del Departamento de Ingeniería Mecánica de la Universidad de La Rioja.-- Fecha de lectura: septiembre de 2007.-- 322 pp.

Berriz Aizkibelen Euskera eskuizkribuaz : Edizio eta iturriak

[EN] In this paper I offer a new edition of the Euskera manuscript, written by the bascologist J.F. Aizkibel in 1856. The preliminary study focuses on a survey of the sources extensively used by Aizkibel, which are mainly two: Schleicher's Die Sprachen Europas (1850 [1852]) and Champollion-Figeac's Égypte ancienne (1840). Moreover, the comparison with the sources reveals us that Aizkibel intended to adapt Schleicher’s and Champollion-Figeac's analyses to attest that Basque was originally a very ancient monosyllabic language, and that it was spoken by cultured people. Some other linguistic ideas of Aizkibel are also discussed.

Combined Fluorescent-Chromogenic In Situ Hybridization for Identification and Laser Microdissection of Interphase Chromosomes

Chromosome territories constitute the most conspicuous feature of nuclear architecture, and they exhibit non-random distribution patterns in the interphase nucleus. We observed that in cell nuclei from humans with Down Syndrome two chromosomes 21 frequently localize proximal to one another and distant from the third chromosome. To systematically investigate whether the proximally positioned chromosomes were always the same in all cells, we developed an approach consisting of sequential FISH and CISH combined with laser-microdissection of chromosomes from the interphase nucleus and followed by subsequent chromosome identification by microsatellite allele genotyping. This approach identified proximally positioned chromosomes from cultured cells, and the analysis showed that the identity of the chromosomes proximally positioned varies. However, the data suggest that there may be a tendency of the same chromosomes to be positioned close to each other in the interphase nucleus of trisomic cells. The protocol described here represents a powerful new method for genome analysis

Collision tumour involving a rectal gastrointestinal stromal tumour with invasion of the prostate and a prostatic adenocarcinoma

Background: Gastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies in adults (<2%). GISTs can be located at any level of the gastrointestinal tract; the stomach is the most common location (60-70%), in contrast to the rectum, which is most rare (4%). When a GIST invades into the adjacent prostate tissue, it can simulate prostate cancer. In this study, we report on a case comprising the unexpected collision between a rectal GIST tumour and a prostatic adenocarcinoma. Findings: We describe the complexity of the clinical, endoscopic and radiological diagnosis, of the differential diagnosis based on tumour biopsy, and of the role of neoadjuvant therapy using imatinib prior to surgical treatment. Conclusions: Although isolated cases of coexisting GISTs and prostatic adenocarcinomas have reviously been described, this is the first reported case in the medical literature of a collision tumour involving a rectal GIST and prostatic adenocarcinoma components.

Enfermedad de Parkinson por mutación vasca de la dardarina (LRRK2): estudio epidemiológico, clínico y genético

149 p.

A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold

Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous proteins, sequence alignment methods often fail to identify relationships arising from convergent evolution, exon shuffling, and modular reuse of catalytic units. We have previously established a computational method to detect functions in proteins based on the spatial and electrostatic properties of the catalytic residues (CLASP). CLASP identified a promiscuous serine protease scaffold in alkaline phosphatases (AP) and a scaffold recognizing a beta-lactam (imipenem) in a cold-active Vibrio AP. Subsequently, we defined a methodology to quantify promiscuous activities in a wide range of proteins. Here, we assemble a module which encapsulates the multifarious motifs used by protease families listed in the MEROPS database. Since APs and proteases are an integral component of outer membrane vesicles (OMV), we sought to query other OMV proteins, like phospholipase C (PLC), using this search module. Our analysis indicated that phosphoinositide-specific PLC from Bacillus cereus is a serine protease. This was validated by protease assays, mass spectrometry and by inhibition of the native phospholipase activity of PI-PLC by the well-known serine protease inhibitor AEBSF (IC50 = 0.018 mM). Edman degradation analysis linked the specificity of the protease activity to a proline in the amino terminal, suggesting that the PI-PLC is a prolyl peptidase. Thus, we propose a computational method of extending protein families based on the spatial and electrostatic congruence of active site residues.

Alegia klasikoak euskaraz: Isopeteko, La Fontaineren eta Samaniegoren alegien berridazketen azterketa

521 p.

Hizkuntza-eraldaketa organizazioetan : esperientzia eta modelizazioa. dinamizazio soziolinguistikoa gizarte pedagogiaren baitan

649 p.

Enpresen hazkunde bide ezberdinak

Enpresen hazkunde bide ezberdinak aztertzeko helburuarekin, 1821. urtean sortu zen Bureau Veritas konpainia aukeratu dut, gaur egun mundu mailan liderra den enpresa multinazionala. Lehenik eta behin, 180 urtetan zehar Bureau Veritas-ek izan duen ibilbidea aztertuko dugu enpresa hobeto ezagutzeko eta sortu zenetik lider izatera eraman dituen ekintzak edo aldagaiak zeintzuk izan diren ikusteko. Ondoren, Bureau Veritas-en azkenengo plan estrategikoak ikusiko ditugu. Alde batetik 2007-2011 urte bitartekoa eta bestetik, 2012-2015 urtetarako enpresak planteatutakoa. Azken hau, aurrekoan lortutako emaitzetan oinarritzen da eta geroago ikusiko dugun bezala, nahiz eta ingurune makroekonomikoak laguntzen ez duen, 2015 urterako plan estrategikoa proiektu garrantzitsua da konpainiarentzat eta irabazlearen estrategia bezala aurkezten dute. Hau guztia aztertu eta gero, dauden hazkunde bide ezberdinak eta kasu bakoitzean zein izango litzateke egokiena aztertuko dugu. Bureau Veritas-en kasuan, hauen artean, absortzio bidezko fusioa da nagusi eta horregatik, Bureau Veritas-ek 2007. urtean burutu zuen ECA (Entidad Colaboradora de la Administración) enpresa katalanaren eskuraketa aztertuko dugu, hau da, eskuraketa honekin Bureau Veritas-ek zituen helburuak, eskuraketa prozesua nolakoa izan zen, ECA-ren integrazioa prozesua, ondorioak…

Cuerno electroacústico: restauración de patrimonio en la UPV/EHU

Dirigido por JON BARREDO en colaboración de MAITE INSAUSTI. Diseño gráfico y tratamiento de la imágen HAYDÉ NEGRO .-- 54 p.

Papel de la N-nervonil esfingomielina en la organización lateral y la estabilidad nanomecánica de bicapas lipídicas

Los lípidos de las membranas biológicas no son perfectamente miscibles entre sí, con frecuencia dan origen a “dominios” bidimensionales separados lateralmente cuando se resuspenden en agua. Las mezclas esfingomielina/dioleilfosfatidilcolina/colesterol dan origen con frecuencia a dominios, pero esto no ocurre cuando la esfingomielina es insaturada (p. ej. N-nervonil esfingomielina). En este trabajo se han aplicado técnicas calorimétricas y estructurales para estudiar el comportamiento de mezclas N-nervonil esfingomielina/dioleilfosfatidilcolina/colesterol/ceramida. En presencia de ceramida y de N-nervonil esfingomielina se observa formación de dominios laterales, al contrario de lo que ocurría en ausencia de ceramida.

Early Medial Temporal Atrophy Scale (EMTA)

186 p.

Spin orbitronics in metals

158 p.

Physico-chemical interactions between compartment-forming lipids and other prebiotically relevant biomolecules

Lipids are essential constituents of contemporary living cells, serving as structural molecules that are necessary to form membranous compartments. Amphiphilic lipid-like molecules may also have contributed to prebiotic chemical evolution by promoting the synthesis, aggregation and cooperative encapsulation of other biomolecules. The resulting compartments would allow systems of molecules to be maintained that represent microscopic experiments in a natural version of combinatorial chemistry. Here we address these possibilities and describe recent results related to interactions between amphiphiles and other biomolecules during early evolution toward the first living cells.