Contributions to unsupervised and supervised learning with applications in digital image processing

311 p. : il.

Biocompatible Bacterial Cellulose-Poly(2-hydroxyethyl methacrylate) Nanocomposite Films

A series of bacterial cellulose-poly(2-hydroxyethyl methacrylate) nanocomposite films was prepared by in situ radical polymerization of 2-hydroxyethyl methacrylate (HEMA), using variable amounts of poly(ethylene glycol) diacrylate (PEGDA) as crosslinker. Thin films were obtained, and their physical, chemical, thermal, and mechanical properties were evaluated. The films showed improved translucency compared to BC and enhanced thermal stability and mechanical performance when compared to poly(2-hydroxyethyl methacrylate) (PHEMA). Finally, BC/PHEMA nanocomposites proved to be nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus are pointed as potential dry dressings for biomedical applications.

Global pressures, specific responses: effects of nutrient enrichment in streams from different biomes

13 p. + 2 p. (Erratum)

Evidence for classification of c.1852_1853AA > GC in MLH1 as a neutral variant for Lynch syndrome

Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. Reports on the pathogenicity of the c.1852_1853AA>GC (p.Lys618Ala) variant of the MLH1 gene are conflicting. In this study, we provide new evidence indicating that this variant has no significant implications for LS. Methods: The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls). Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers. Results: Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%), seven were suspected of having hereditary CRC (2.8%) and 11 were controls (2.68%). There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both families. Only two positive cases of microsatellite instability (2/17, 11.8%) were detected in tumours from p.Lys618Ala carriers, indicating that this variant does not play a role in functional inactivation of MLH1 in CRC patients. Conclusions: The p.Lys618Ala variant should be considered a neutral variant for LS. These findings have implications for the clinical management of CRC probands and their relatives.

La seguridad social del empleo doméstico : evolución y perspectivas

482 p.

Identificación y caracterización de centros de unión para purinas de membrana plasmática de células aisladas de glándulas gástricas

149 p. : il.

Design and synthesis of biofunctional magnetic/fluorescent glyco-nanoparticles and quantum dots and their application as specific molecular imaging probes

206 p.

Influencia del metabolismo del glutatión y de la actividad gamma-glutamiltranspeptidasa en la respuesta antitumoral del ácido retinoico en líneas tumorales de rabdomiosarcoma con diferente grado de diferenciación

228 p. : il. Nota: Otro título en Teseo: "la modulación selectiva de los niveles de glutatión con l-2-oxo-4-tiazolidina carboxilato aumenta la eficacia de la interleucina-2 e incrementa el beneficio terapéutico de la bioquimioterapia del melanoma metastático"

Materiales Condensados y con Estructura Abierta basados en Fosfitos de Metales 3d

438 p.

Mecanismos fisiológicos de respuesta de la cebada al impacto de la sequía y el elevado CO2 : adaptación al cambio climático

251 p. : il., col.

¿Quiénes son los padres del niño abandonado?

Capítulo 9 del libro: Guisasola, Jenaro ; Garmendia, Mikel (eds.) "Aprendizaje basado en problemas, proyectos y casos: diseño e implementación de experiencias en la universidad" (ISBN: 978-84-9860-959-2)

La modulación selectiva de los niveles de glutatión con l-2-oxo-4-tiazolidina carboxilato aumenta la eficacia de la interleucina-2 e incrementa el beneficio terapéutico de la bioquimioterapia del melanoma metastático

268 p. : il.

Impacto psicológico de la mastectomía en la mujer: el rol de la enfermera

La mastectomía, ya sea debida a un cáncer de mama o realizada profilácticamente, es considerada por muchas mujeres como un ataque a su feminidad e identidad, causando en ellas un gran impacto psicosocial que comprometerá su calidad de vida. Por un lado, la mastectomía afecta negativamente a algunos aspectos de su autopercepción como son su imagen corporal o su sexualidad. Por otro lado, sus relaciones sociales pueden verse perjudicadas, pudiendo resultar en una ruptura con sus parejas o en el cese de sus relaciones sexuales incluso tras la reconstrucción. Ante estos problemas, la enfermera debe ayudar a la mujer a adaptarse a esta nueva situación a través de unos cuidados individualizados que favorezcan su auto-aceptación y promuevan la reestructuración social. Sin embargo, muchas enfermeras reconocen una falta de conocimiento y dificultades comunicativas a la hora de abordar estos temas, así como una escasez de medios para poder realizarlo. Por todo ello, parece evidente la necesidad de una formación específica al respecto.

Influencia de las células madre mesenquimales en la recuperación de oligodendrocitos sometidos a estrés oxidativo

179 p.

El ácido all trans retinoico reduce in vitro el efecto protumoral de los factores de crecimiento e incrementa la eficacia de la quimioterapia en el rabdomiosarcoma S4MH

257 p.