TNF-alpha and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
---|---|
Data(s) |
30/09/2013
20/05/2014
30/09/2013
20/05/2014
01/01/2008
|
Resumo |
Leptospirosis is a public health problem worldwide and its etiology remains unclear. Its pathogenesis involves a complex interaction between host and infecting microorganism. The inflammatory reaction that controls the infection process also underscores many pathophysiological events occurring in leptospirosis. We investigated the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in renal tissues by immunohistochemical and histopathological examination in animals experimentally inoculated with Leptospira serovar Canicola. All the tests were carried out 2, 7, 14, 21 or 28 days after inoculation. Although TNF-alpha and IL-6 had been detected in tissues throughout the observation period, these cytokines appeared more intensely during the initial phase of infection. Therefore, both TNF-alpha and IL-6 were associated with the immunopathogenesis of leptospirosis. This profile suggests a high immunocellular response throughout the early infection stages followed by subsequent humoral response. |
Formato |
533-540 |
Identificador |
http://dx.doi.org/10.1590/S1678-91992008000300012 Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 3, p. 533-540, 2008. 1678-9199 http://hdl.handle.net/11449/132302 10.1590/S1678-91992008000300012 S1678-91992008000300012 WOS:000259279500012 2-s2.0-52249107118 S1678-91992008000300012-en.pdf |
Idioma(s) |
eng |
Publicador |
Universidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) |
Relação |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
Direitos |
openAccess |
Palavras-Chave | #IL-6 #Immunohistochemistry #Leptospirosis #Mice #TNF-α #Animalia #Leptospira #Leptospira interrogans #Leptospira interrogans serovar Canicola #Mus #Rattus |
Tipo |
info:eu-repo/semantics/article |