New scientific paradigms for probiotics and prebiotics

The inaugural meeting of the International Scientific Association for Probiotics and Prebiotics (ISAPP) was held May 3 to May 5 2002 in London, Ontario, Canada. A group of 63 academic and industrial scientists from around the world convened to discuss current issues in the science of probiotics and prebiotics. ISAPP is a non-profit organization comprised of international scientists whose intent is to strongly support and improve the levels of scientific integrity and due diligence associated with the study, use, and application of probiotics and prebiotics. In addition, ISAPP values its role in facilitating communication with the public and healthcare providers and among scientists in related fields on all topics pertinent to probiotics and prebiotics. It is anticipated that such efforts will lead to development of approaches and products that are optimally designed for the improvement of human and animal health and well being. This article is a summary of the discussions, conclusions, and recommendations made by 8 working groups convened during the first ISAPP workshop focusing on the topics of: definitions, intestinal flora, extra-intestinal sites, immune function, intestinal disease, cancer, genetics and genomics, and second generation prebiotics. Humans have evolved in symbiosis with an estimated 1014 resident microorganisms. However, as medicine has widely defined and explored the perpetrators of disease, including those of microbial origin, it has paid relatively little attention to the microbial cells that constitute the most abundant life forms associated with our body. Microbial metabolism in humans and animals constitutes an intense biochemical activity in the body, with profound repercussions for health and disease. As understanding of the human genome constantly expands, an important opportunity will arise to better determine the relationship between microbial populations within the body and host factors (including gender, genetic background, and nutrition) and the concomitant implications for health and improved quality of life. Combined human and microbial genetic studies will determine how such interactions can affect human health and longevity, which communication systems are used, and how they can be influenced to benefit the host. Probiotics are defined as live microorganisms which, when administered in adequate amounts confer a health benefit on the host.1 The probiotic concept dates back over 100 years, but only in recent times have the scientific knowledge and tools become available to properly evaluate their effects on normal health and well being, and their potential in preventing and treating disease. A similar situation exists for prebiotics, defined by this group as non-digestible substances that provide a beneficial physiological effect on the host by selectively stimulating the favorable growth or activity of a limited number of indigenous bacteria. Prebiotics function complementary to, and possibly synergistically with, probiotics. Numerous studies are providing insights into the growth and metabolic influence of these microbial nutrients on health. Today, the science behind the function of probiotics and prebiotics still requires more stringent deciphering both scientifically and mechanistically. The explosion of publications and interest in probiotics and prebiotics has resulted in a body of collective research that points toward great promise. However, this research is spread among such a diversity of organisms, delivery vehicles (foods, pills, and supplements), and potential health targets such that general conclusions cannot easily be made. Nevertheless, this situation is rapidly changing on a number of important fronts. With progress over the past decade on the genetics of lactic acid bacteria and the recent, 2,3 and pending, 4 release of complete genome sequences for major probiotic species, the field is now armed with detailed information and sophisticated microbiological and bioinformatic tools. Similarly, advances in biotechnology could yield new probiotics and prebiotics designed for enhanced or expanded functionality. The incorporation of genetic tools within a multidisciplinary scientific platform is expected to reveal the contributions of commensals, probiotics, and prebiotics to general health and well being and explicitly identify the mechanisms and corresponding host responses that provide the basis for their positive roles and associated claims. In terms of human suffering, the need for effective new approaches to prevent and treat disease is paramount. The need exists not only to alleviate the significant mortality and morbidity caused by intestinal diseases worldwide (especially diarrheal diseases in children), but also for infections at non-intestinal sites. This is especially worthy of pursuit in developing nations where mortality is too often the outcome of food and water borne infection. Inasmuch as probiotics and prebiotics are able to influence the populations or activities of commensal microflora, there is evidence that they can also play a role in mitigating some diseases. 5,6 Preliminary support that probiotics and prebiotics may be useful as intervention in conditions including inflammatory bowel disease, irritable bowel syndrome, allergy, cancer (especially colorectal cancer of which 75% are associated with diet), vaginal and urinary tract infections in women, kidney stone disease, mineral absorption, and infections caused by Helicobacter pylori is emerging. Some metabolites of microbes in the gut may also impact systemic conditions ranging from coronary heart disease to cognitive function, suggesting the possibility that exogenously applied microbes in the form of probiotics, or alteration of gut microecology with prebiotics, may be useful interventions even in these apparently disparate conditions. Beyond these direct intervention targets, probiotic cultures can also serve in expanded roles as live vehicles to deliver biologic agents (vaccines, enzymes, and proteins) to targeted locations within the body. The economic impact of these disease conditions in terms of diagnosis, treatment, doctor and hospital visits, and time off work exceeds several hundred billion dollars. The quality of life impact is also of major concern. Probiotics and prebiotics offer plausible opportunities to reduce the morbidity associated with these conditions. The following addresses issues that emerged from 8 workshops (Definitions, Intestinal Flora, Extra-Intestinal Sites, Immune Function, Intestinal Disease, Cancer, Genomics, and Second Generation Prebiotics), reflecting the current scientific state of probiotics and prebiotics. This is not a comprehensive review, however the study emphasizes pivotal knowledge gaps, and recommendations are made as to the underlying scientific and multidisciplinary studies that will be required to advance our understanding of the roles and impact of prebiotics, probiotics, and the commensal microflora upon health and disease management.

Proektirovanie perevodčeskih slovarej special'noj leksiki

The methodology of designing normative terminological products has been described in several guides and international standards. However, this methodology is not always applicable to designing translation-oriented terminological products which differ greatly from normative ones in terms of volume, function, and primary target group. This dissertation has three main goals. The first is to revise and enrich the stock of concepts and terms required in the process of designing an LSP dictionary for translators. The second is to detect, classify, and describe the factors which determine the characteristics of an LSP dictionary for translators and affect the process of its compilation. The third goal is to provide recommendations on different aspects of dictionary design. The study is based on an analysis of dictionaries, dictionary reviews, literature on translation-oriented lexicography, material from several dictionary projects, and the results of questionnaires. Thorough analysis of the concept of a dictionary helped us to compile a list of designable characteristics of a dictionary. These characteristics include target group, function, links to other resources, data carrier, list of lemmata, information about the lemmata, composition of other parts of the dictionary, compression of the data, structure of the data, and access structure. The factors which determine the characteristics of a dictionary have been divided into those derived from the needs of the intended users and those reflecting the restrictions of the real world (e.g. characteristics of the data carrier and organizational factors) and attitudes (e.g. traditions and scientific paradigms). The designer of a dictionary is recommended to take the intended users' needs as the starting point and aim at finding the best compromise between the conflicting factors. When designing an LSP dictionary, much depends on the level of knowledge of the intended users about the domain in question as well as their general linguistic competence, LSP competence, and lexicographic competence. This dissertation discusses the needs of LSP translators and the role of the dictionary in the process of translation of an LSP text. It also emphasizes the importance of planning lexicographic products and activities, and addresses many practical aspects of dictionary design.

Mamès, profèsorn oun kindèr likht. Éducation en petite enfance en CPE. Le cas des femmes hassidiques Belz en services de garde en milieu familial accrédités.

La présente thèse est construite en trois parties. La première partie est précédée du chapitre 1 qui présente les premières données du travail de terrain sur les femmes hassidiques Belz, l’éducation des jeunes enfants et l’histoire de la communauté. La première partie est composée de trois chapitres qui analysent les notions relatives à la petite enfance, notamment sa définition et sa conception à travers l’histoire humaine récente et selon différentes cultures. Le chapitre 2 examine la question de la petite enfance en soi et des conditions qui la définissent. Le chapitre 3 analyse l’institutionnalisation de la petite enfance dans le monde moderne contemporain. Le chapitre 4 analyse l’avènement de la norme scientifique et son impact sur la petite enfance en ce qui a trait à l’éducation et au développement. Ces chapitres analysent notamment l’éducation en petite enfance en CPE (Centres de la petite enfance) au Québec. La deuxième partie de la thèse, composée aussi de trois chapitres, présente les paradigmes scientifiques et les cadres conceptuels dominants en petite enfance. Le chapitre 5 explique l’impact du « néolibéralisme » ou de la modernité avancée en petite enfance. Le chapitre 6 présente le nouveau paradigme du « postfondamentalisme » en petite enfance et le chapitre 7, celui de l’éco-éducation ainsi que la posture de « l’écosophie » en petite enfance. Ce dernier propose une application pédagogique de l’éco-éducation et de l’écosophie en petite enfance. La troisième partie fait état du travail de terrain en anthropologie au sein de la communauté féminine des Hassidim Belz de Montréal, notamment au sein des services de garde en milieux familial accrédités par le ministère de la Famille du Québec. Elle se divise en deux chapitres. Le chapitre 8 analyse l’incident de la Directive contre l’enseignement religieux en services de garde subventionnés. Le chapitre 9 propose les résultats du travail de terrain sur la philosophie de vie et la spiritualité des femmes hassidiques Belz de Montréal. La conclusion générale intègre le paradigme de l’éco-éducation et la posture de « l’écosophie » en petite enfance à la philosophie de vie et la spiritualité des femmes hassidiques Belz de Montréal. Elle propose un « réenchantement » du développement et de l’éducation en petite enfance.

El paradigma del Desarrollo Urbano Sostenible -DUS- como referente del proceso de toma de decisiones legislativas en Colombia. Análisis de la agenda legislativa del Congreso de la República entre 1991 y 2006

Este trabajo contribuye al análisis de la incidencia del paradigma del Desarrollo Urbano Sostenible en el proceso de toma de decisiones legislativas en Colombia, concentrándose en la discusión y definición de la agenda legislativa sobre asuntos urbanos, durante el periodo 1991-2006.

A produção de conhecimento e verdade no contemporâneo

O presente artigo procura refletir sobre a produção de conhecimento e verdade no contemporâneo articuladas com o conceito de biopoder e a imersão do sujeito na construção desse conhecimento. Mediante tais reflexões, chega-se à conclusão que as ciências humanas precisam rever o lugar cômodo do cientificismo acadêmico para repensar e relativizar a verdade visando a transformação das práticas sociais objetivantes e historicamente construídas para uma outra forma de conhecimento capaz de questionar as instâncias instituídas nos campos do saber e do poder a fim de propor novos paradigmas científicos e uma subjetividade mais autêntica e com novas significações

A psicologia na educação: dos paradigmas científicos às finalidades educacionais

Este artigo analisa algumas teorias psicológicas e suas contribuições para a educação. Discute estas teorias sob a concepção de paradigma, originária de Thomas Kuhn, e propõe que o único critério para aceitá-las ou recusá-las no campo educacional é o estabelecimento de finalidades educacionais.

Os Paradigmas da imprensa na cobertura das políticas ambientais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Preservação e patrimônio no instituto histórico e geográfico de São Paulo (1894-1937)

O Instituto Histórico e Geográfico de São Paulo, inaugurado no ano de 1894, foi um dos mais importantes espaços de formulação ideológica das elites intelectuais paulistas, na virada do século XIX. Ao longo da primeira república, esses associados produziram um vasto e eclético conjunto de artigos, unindo, de forma bastante singular, beletrismo e erudição com os paradigmas científicos próprios de sua época. Além disso, os sócios do IHGSP, localizados em um período anterior à consolidação dos espaços acadêmicos, também discutiram aspectos da preservação do patrimônio local e regional, inserindo-os em uma lógica própria de valorização da história e da civilização bandeirante, como um modelo de ação e atuação a ser admirado e seguido por todo o país.

La goutte et la feuille. Transfigurations de la beauté naturelle dans la littérature européenne: Chateaubriand, Hölderlin et Leopardi.

La goutte et la feuille . Transfigurations de la beauté naturelle dans la littérature européenne : Chateaubriand , Hölderlin et Leopardi . La thèse se présente comme une étude morphologique de l'esthétique de la nature à la fin de 18 ans. Siècle. Le dénominateur commun est une étude comparative des paradigmes scientifiques et des images symboliques utilisés dans la littérature européenne . Sous ce point de vue la thèse identifie les formes originaires de la goutte et de la feuille comme un point de contact entre des moments culturels distincts, même si entrelacés. Un passage particulièrement important du travail est l'analyse structurelle du paysage . Le paysage est le point culminant d'accès aux secrets de l'écriture romantique. Le paysage commence avec la représentation classique du jardin édénique et se termine avec la forêt exotique américaine. Celle-ci est décrite par Chateaubriand, en tant qu’objet d’une KOINONIE stylistique à l’immensité sublime du désert et l'océan . Hölderlin place avec la beauté naturelle devient une harmonie secrète et sombre dans l'inconscient symbolique de l'âme humaine . Leopardi est l'auteur du désenchantement , et pourtant il est encore capable de pressentir empathiquement la mesure de l’imagination envers la beauté naturelle. Avec Léopards , cependant, s’accomplit la séparation finale entre l’EPOS de la beauté naturelle et l’ETHOS de la nature . Cette dernière est une grandeur morale, et au fait elle représente le moment de la dissolution nihiliste, notamment magnitude de l’esthétique typiquement romantique . Après Chateaubriand , Leopardi , et Hölderlin beauté naturelle ne seront plus transfigurant .

Arquifanía: la arquitectura como manifestación

Arquifanía: arquitectura y epifanía. La revelación que se da en el proyectar, en el construir y en el habitar. Desentrañar los protagonistas y el escenario de ese encuentro es el objetivo de esta tesis. Nace de una doble inquietud: la relación entre literatura y arquitectura y la constatación de algo inconmensurable en la arquitectura. A lo largo de los siglos la teoría de la arquitectura ha hecho un gran esfuerzo por racionalizar todos los aspectos de la disciplina. La sistematización del orden y jerarquía de los espacios, el uso de parámetros más rigurosos en los cálculos estructurales, el desarrollo de la técnica y el estudio de los esquemas funcionales han supuesto una fuente inagotable de manifestaciones arquitectónicas. Los paradigmas científicos, incluso, han resultado fundamentales en la creación de nuevos lenguajes. Sin embargo, en este camino de racionalización se han orillado aspectos de difícil cuantificación. Pese a que en la experiencia diaria del arquitecto se constata la presencia de parámetros inconmensurables, la teoría de la arquitectura no ha integrado de forma sistemática este conocimiento. De aquí nace la presente tesis doctoral. En ella se estudia, por analogía con el resto de artes, el concepto de manifestación. Se analiza de qué manera la obra arquitectónica se manifiesta, haciendo uso de su autonomía, y se convierte en la que dirige al arquitecto en todos los tiempos de la existencia de la obra: desde su génesis en el tiempo del proyecto hasta la experiencia de la obra terminada en el tiempo de la historia. Se considera que reflexionar en el concepto de manifestación puede aportar luces sobre la disciplina arquitectónica en un doble momento. Se estudia por una parte la actitud y el proceder del arquitecto ante la génesis del proyecto y por otra su posicionamiento ante la obra ya existente, sometida a su análisis (para la posterior síntesis) generando una espiral de conocimiento siempre abierta y en continuo enriquecimiento. Se analiza la obra de María Zambrano, filósofa, y José Ángel Valente, poeta, en busca de la definición del concepto de manifestación. El momento creativo, la naturaleza de la palabra poética, la actitud del poeta ante su obra, el conocimiento y la revelación de la belleza son temas recurrentes en sus obras y crean un corpus teórico que permite elaborar una teoría poética sólida y abierta, llena de sugerencias que se dirige con precisión al momento de la generación de la forma: su epifanía. A continuación se repasa el concepto de manifestación en la actividad de algunos artistas de la modernidad que, de manera implícita o explícita, han hablado del concepto de epifanía. A menudo de forma intuitiva, los artistas han detectado en su actividad la condición de ser depositarios de un don que se renueva en cada obra ejecutada. Entrelazado con su trabajo y con la disciplina diaria los artistas experimentan un diálogo con la obra, que se revela libre y con voluntad de manifestarse. Enunciado el problema y hecho el repaso por el mundo de la creación artística, nos enfrentamos con el núcleo de la tesis: ¿hasta qué punto y de qué manera el concepto de manifestación es válido en arquitectura? El discurso busca en la actividad de múltiples arquitectos la validez del concepto de manifestación. Se rastrean testimonios, textos, obras y análisis de obras. De esta investigación surge una topografía, un atlas de revelaciones de manifestaciones arquitectónicas: constataciones explícitas, testimonios implícitos o intuiciones. A través de este periplo entre el concepto de manifestación que la razón poética ofrece y la experiencia de muchos arquitectos se intenta responder, aunque sea parcialmente, a las preguntas que surgen al llevar a las últimas consecuencias la arquifanía: ¿En qué momento existe una voluntad de forma? ¿De qué manera encuentra el arquitecto la forma? ¿Cómo se le presenta? ¿Es el arquitecto el verdadero artífice de la obra? ¿O es en cambio un ser a la espera de la aparición? ABSTRACT Archiphany: architecture and epiphany. The revelation taking place in designing, building and living. The objective of the present dissertation is to unravel the protagonists and the scenario of this encounter. It stems from a double interest: the relationship between literature and architecture and the discovery of something incommensurable in architecture. Over the centuries, architectural theory has made a great effort in order to rationalise all aspects of this discipline. Thus, the systematization of the order and hierarchy of space, the use of more rigorous parameters on the structural analysis, the development of technical capacities and the study of functional schemes have been an inexhaustible source of architectural manifestations. Even scientific paradigms have been essential in the creation of new languages. However, aspects of difficult quantification have been relegated in this path of rationalisation. Whereas the presence of immeasurable parameters are encountered in the daily experience of the architect, architectural theory has failed to systematically integrate this knowledge. This is the driving force of this thesis. It explores, by analogy with the other arts, the concept of manifestation. It discusses how the architectural work manifests itself, making use of its autonomy, becoming the one leading the architect during the whole existence of the work: from its genesis in the designing time until the experience of the completed work in the historical time. In the present dissertation, it is assumed that reflecting on the concept of manifestation might shed light on two different moments on the way to project architecture. The architect approach to the project genesis is studied on the one hand, while in the other hand it is considered his positioning in front of the existing work, as well as his analysis (for a following synthesis) that generates an ever-open and ever-enriching spiral of knowledge. In the search for a definition of the concept of manifestation, the work of the philosopher María Zambrano and the poet José Ángel Valente are analysed. The creative moment, the nature of the poetic word, the attitude of the poet in front of his work, the knowledge and the revelation of beauty are persistent issues in their works. They create a theoretical corpus allowing to develop a sound and open poetical theory full of suggestions, accurately directed to the time of the form generation: its epiphany. The concept of manifestation is then reviewed in the activity of some modern artists that talked about the concept of epiphany –either implicitly or explicitly. Often in an intuitive way, artists have come to realize in their activity to be the depositories of a gift that is renewed in each work. Intertwined with their work and with their daily discipline, artists experience a dialogue with the work, which proves to be free and willing to manifest itself. Having stated the problem and having reviewed the world of artistic creation, we are confronted with the core of the thesis: Up to which extent and in which way is the concept of manifestation valid for architecture? Validity and evidence of this concept is sought in the activity of multiple architects. Texts, works, analysis, reviews and testimonies are investigated. From this research, a topography, an atlas of revelations of architectural manifestations arises: explicit findings, implicit witnesses or intuitions. By means of this journey going from the concept of manifestation hinted by the poetic reason to the experience of many architects, the ultimate questions risen by archiphany are meant to be answered (though partially): When does a will of form emerge? How does the architect find the form? How does it appear? Is the architect the true creator of the work? Or is he instead a being waiting for the vision?

Excipients in medicines for children:scientific and regulatory paradigms

There is an ongoing debate over the use of pharmaceutical excipients in medicines for children, triggered by the increased number of formulations suitable for this target patient population. Pharmaceutical excipients can be regarded as essential / necessary enablers in formulation development. These are materials other than the 'active pharmaceutical ingredient' which are added to the formulation to achieve a specific function1. This may include aiding in the processing or manufacture of the drug delivery system such as lubricants or flow aids, controlling the release of the active ingredient to achieve modified release, enhance patient acceptability by improving taste of medicines or to develop easily swallowed dosage forms.

Changing Paradigms in Biblical Criticism : 2 Kings 22:1 23:30 in the Flux of Discourses

The subject and methodology of biblical scholarship has expanded immense-ly during the last few decades. The traditional text-, literary-, source- and form-critical approaches, labeled historical-critical scholarship , have faced the challenge of social sciences. Various new literary, synchronic readings, sometimes characterized with the vague term postmodernism, have in turn challenged historicalcritical, and social-scientific approaches. Widened limits and diverging methodologies have caused a sense of crisis in biblical criticism. This metatheoretical thesis attempts to bridge the gap between philosophical discussion about the basis of biblical criticism and practical academic biblical scholarship. The study attempts to trace those epistemological changes that have produced the wealth of methods and results within biblical criticism. The account of the cult reform of King Josiah of Judah as reported in 2 Kings 22:1 23:30 serves as the case study because of its importance for critical study of the Hebrew Bible. Various scholarly approaches embracing 2 Kings 22:1 23:30 are experimentally arranged around four methodological positions: text, author, reader, and context. The heuristic model is a tentative application of Oliver Jahraus s model of four paradigms in literary theory. The study argues for six theses: 1) Our knowledge of the world is con-structed, fallible and theory-laden. 2) Methodological plurality is the neces-sary result of changes in epistemology and culture in general. 3) Oliver Jahraus s four methodological positions in regard to literature are also an applicable model within biblical criticism to comprehend the methodological plurality embracing the study of the Hebrew Bible. 4) Underlying the methodological discourse embracing biblical criticism is the epistemological ten-sion between the natural sciences and the humanities. 5) Biblical scholars should reconsider and analyze in detail concepts such as author and editor to overcome the dichotomy between the Göttingen and Cross schools. 6) To say something about the historicity of 2 Kings 22:1 23:30 one must bring together disparate elements from various disciplines and, finally, admit that though it may be possible to draw some permanent results, our conclusions often remain provisional.

Code Generation Paradigms On Optical Orthogonal And Other Codes In a Fiber Optic CDMA Lan

Code Division Multiple Access (CDMA) techniques, by far, had been applied to LAN problems by many investigators, An analytical study of well known algorithms for generation of Orthogonal codes used in FO-CDMA systems like those for prime, quasi-Prime, Optical Orthogonal and Matrix codes has been presented, Algorithms for OOCs like Greedy/Modified Greedy/Accelerated Greedy algorithms are implemented. Many speed-up enhancements. for these algorithms are suggested. A novel Synthetic Algorithm based on Difference Sets (SADS) is also proposed. Investigations are made to vectorise/parallelise SADS to implement the source code on parallel machines. A new matrix for code families of OOCs with different seed code-words but having the same (n,w,lambda) set is formulated.

Localized data gathering paradigms for small and marginal farm lands in Semi-Arid region – Issues and Concerns

In this work we explore the application of wireless sensor technologies for the benefit of small and marginal farmers in semi-arid regions. The focus in this paper is to discuss the merits and demerits of data gathering & relay paradigms that collect localized data over a wide area. The data gathered includes soil moisture, temperature, pressure, rain data and humidity. The challenge to technology intervention comes mainly due to two reasons: (a) Farmers in general are interested in crop yield specific to their piece of land. This is because soil texture can vary rapidly over small regions. (b) Due to a high run-off, the soil moisture retention can vary from region to region depending on the topology of the farm. Both these reasons alter the needs drastically. Additionally, small and marginal farms can be sandwiched between rich farm lands. The village has very little access to grid power. Power cuts can extend up to 12 hours in a day and upto 3 or 4 days during some months in the year. In this paper, we discuss 3 technology paradigms for data relaying. These include Wi-Fi (Wireless Fidelity), GPRS (General Packet Radio Service) and DTN (Delay and Disruption Tolerant Network) technologies. We detail the merits and demerits of each of these solutions and provide our final recommendations. The project site is a village called Chennakesavapura in the state of Karnataka, India.

Three parallel programming paradigms: Comparisons on an archetypal PDE computation

Three paradigms for distributed-memory parallel computation that free the application programmer from the details of message passing are compared for an archetypal structured scientific computation -- a nonlinear, structured-grid partial differential equation boundary value problem -- using the same algorithm on the same hardware. All of the paradigms -- parallel languages represented by the Portland Group's HPF, (semi-)automated serial-to-parallel source-to-source translation represented by CAP-Tools from the University of Greenwich, and parallel libraries represented by Argonne's PETSc -- are found to be easy to use for this problem class, and all are reasonably effective in exploiting concurrency after a short learning curve. The level of involvement required by the application programmer under any paradigm includes specification of the data partitioning, corresponding to a geometrically simple decomposition of the domain of the PDE. Programming in SPMD style for the PETSc library requires writing only the routines that discretize the PDE and its Jacobian, managing subdomain-to-processor mappings (affine global-to-local index mappings), and interfacing to library solver routines. Programming for HPF requires a complete sequential implementation of the same algorithm as a starting point, introduction of concurrency through subdomain blocking (a task similar to the index mapping), and modest experimentation with rewriting loops to elucidate to the compiler the latent concurrency. Programming with CAPTools involves feeding the same sequential implementation to the CAPTools interactive parallelization system, and guiding the source-to-source code transformation by responding to various queries about quantities knowable only at runtime. Results representative of "the state of the practice" for a scaled sequence of structured grid problems are given on three of the most important contemporary high-performance platforms: the IBM SP, the SGI Origin 2000, and the CRAYY T3E.