Gestor de radio FM y sistema RDS - FM radio RDS

En este documento se recoge toda la documentación asociada al desarrollo de la aplicación para dispositivos móviles Firefox OS, FM Radio RDS. La experiencia ha sido muy satisfactoria, a pesar de las frustraciones pasadas. Se han conseguido cumplir todos los objetivos establecidos inicialmente, obteniendo como resultado una aplicación muy cercana a la ideada. Se puede considerar una herramienta útil y novedosa para la reproducción de la radio FM en función de la posición en los dispositivos con el sistema operativo móvil Firefox OS. Se tiene previsto añadir futuras mejoras, como darle un enfoque más social. Personalmente, se han logrado alcanzar habilidades en el desarrollo de aplicaciones web que me permitirán realizar otros proyectos futuros. A pesar de no haber cumplido con los plazos establecidos en la planificación principal, la sensación personal es positiva al haber conseguido realizar un trabajo de tal magnitud por cuenta propia.

偏振差分反射谱(RDS)测试系统

利用RDS测试系统，可以在近垂直入射条件下，测量出样品的反射系数在样品平面内两个互相垂直的方向上的细微差异，即所谓平面内光学各向异性。它对研究半导体材料及其量子阱超晶格等低维结构中的平面内光学各向同性、半导体表面重构和对外延生长过程中的实时监控都具有重要作用。该系统已为研究工作提供了大量数据。

Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene

We introduced a targeted single base deletion at codon 307 of the rds-peripherin gene in mice, similar mutations being known to cause autosomal dominant retinitis pigmentosa (RP) in man. Histopathological and electroretinographic analysis indicate that the retinopathy in mice homozygous for the codon 307 mutation appears more rapid than that in the naturally occurring null mutant, the rds(-/-) mouse, suggesting that the rds-307 mutation displays a dominant negative phenotype in combination with that due to haplosufficiency. RP is the most prevalent cause of registered visual handicap in those of working age in developed countries, the 50 or so mutations so far identified within the RDS-peripherin gene accounting for up to 10% of dominant cases of the disease. Given the sequence homologies that exist between the murine rds-peripherin and the human RDS-peripherin gene, this disease model, the first to be generated for peripherin-based RP using gene targeting techniques, should in principle be of value in the work-up in mice of therapeutics capable of targeting transcripts derived from the human gene.

Whither RDS? An investigation of respondent driven sampling as a method of recruiting mainstream marijuana users.

Background: An important challenge in conducting social research of specific relevance to harm reduction programs is locating hidden populations of consumers of substances like cannabis who typically report few adverse or unwanted consequences of their use. Much of the deviant, pathologized perception of drug users is historically derived from, and empirically supported, by a research emphasis on gaining ready access to users in drug treatment or in prison populations with higher incidence of problems of dependence and misuse. Because they are less visible, responsible recreational users of illicit drugs have been more difficult to study. Methods: This article investigates Respondent Driven Sampling (RDS) as a method of recruiting experienced marijuana users representative of users in the general population. Based on sampling conducted in a multi-city study (Halifax, Montreal, Toronto, and Vancouver), and compared to samples gathered using other research methods, we assess the strengths and weaknesses of RDS recruitment as a means of gaining access to illicit substance users who experience few harmful consequences of their use. Demographic characteristics of the sample in Toronto are compared with those of users in a recent household survey and a pilot study of Toronto where the latter utilized nonrandom self-selection of respondents. Results: A modified approach to RDS was necessary to attain the target sample size in all four cities (i.e., 40 'users' from each site). The final sample in Toronto was largely similar, however, to marijuana users in a random household survey that was carried out in the same city. Whereas well-educated, married, whites and females in the survey were all somewhat overrepresented, the two samples, overall, were more alike than different with respect to economic status and employment. Furthermore, comparison with a self-selected sample suggests that (even modified) RDS recruitment is a cost-effective way of gathering respondents who are more representative of users in the general population than nonrandom methods of recruitment ordinarily produce. Conclusions: Research on marijuana use, and other forms of drug use hidden in the general population of adults, is important for informing and extending harm reduction beyond its current emphasis on 'at-risk' populations. Expanding harm reduction in a normalizing context, through innovative research on users often overlooked, further challenges assumptions about reducing harm through prohibition of drug use and urges consideration of alternative policies such as decriminalization and legal regulation.

Análise de dados coletados por respondent-driven sampling(RDS): um estudo da prevalência de HIV e fatores associados entre mulheres trabalhadoras do sexo em 10 cidades brasileiras

O grupo das mulheres trabalhadoras do sexo (MTS) é reconhecido como uma populaçãode maior risco à infecção pelo HIV, tanto pela prevalência elevada, como por suavulnerabilidade social como pelos fatores relacionados à própria atividade profissional. Porém, arealização de estudos nos subgrupos de maior risco ao HIV mediante estratégias convencionaisde amostragem é, em geral, problemática por essas populações possuírem pequena magnitudeem termos populacionais e por estarem vinculados a comportamentos estigmatizados ouatividades ilegais. Em 1997, foi proposto um método de amostragem probabilística parapopulações de difícil acesso denominado Respondent-Driven Sampling (RDS). O método éconsiderado como uma variante da amostragem em cadeia e possibilita a estimação estatísticados parâmetros de interesse. Na literatura internacional, para análise de dados coletados porRDS, muitos autores têm utilizado técnicas estatísticas multivariadas tradicionais, sem levar emconta a estrutura de dependência das observações, presente nos dados coletados por RDS.A presente tese tem por objetivo contribuir para suprir informações sobre as práticas derisco relacionadas ao HIV entre as mulheres trabalhadoras do sexo (MTS) com odesenvolvimento de método estatístico para análise de dados coletados com o método deamostragem RDS. Com tal finalidade, foram utilizadas as informações coletadas na PesquisaCorrente da Saúde realizada em dez cidades brasileiras, com 2.523 MTS recrutadas por RDS,entre os anos de 2008 e 2009. O questionário foi autopreenchido e incluiu módulos sobrecaracterísticas da atividade profissional, práticas sexuais, uso de drogas, testes periódicos deHIV, e acesso aos serviços de saúde.Primeiramente, foram descritos alguns pressupostos do RDS e todas as etapas deimplantação da pesquisa. Em seguida, foram propostos métodos de análise multivariada, considerando o RDS como um desenho complexo de amostragem.

Direito e etnoconservação: estudo da participação na gestão ambiental da RDS Estadual Ponta do Tubarão - RN

Given the prediction of the Federal Constitution of 1988 about the need to establish some areas to be especially protected, it was published the Law No. 9.985/00, which established the National System of Conservation Units. Several aspects make these units differ from one another, one of them being the possibility of presence of even traditional human populations inside the area to be protected. In case of allowing these people to continue in the area, it still must be provided their participation in the management of the new space. Management councils show up, then, as a specific way of social and political participation. This way, from an overview of legal norms and the doctrine that are relevant to the topic, It is aimed to make a legal and theoretical survey about the process of traditional populations permanence inside Conservation Units, with aspects linked to ethnoconservation and, therefore, to participation in environmental management of these specially protected spaces

Entendendo as interações entre povos pesqueiros, manguezal e área protegida: RDS estadual Ponta do Tubarão (RN, Brasil)

The mangrove ecosystem has a great importance to maintaining marine biodiversity, and to the livelihoods of communities living around it. Despite its importance, many mangrove areas have been extensively cleared and converted to other uses. There are few places where communities can retain their traditional uses of mangrove. A good example of conservation of traditional costumes are the fishing communities of the Sustainable Development Reserve (Reserva de Desenvolvimento Sustentável RDS) Ponta do Tubarão. The creation of the reserve came from the own population, and the devastation of a mangrove area, which would be destined for activity shrimp, was one of the reasons that led the population to ask authorities the establishment of a legally protected area. Thus, this study aimed to investigate the environmental perception of the fishing communities of RDS Ponta do Tubarão with respect to the mangroves in a biological, ecological and social perspective as well as evaluate the influence of the reserve in the mangrove conservation and quality of life. To meet objectives of this study was required the appropriation of some method and approaches of ethnosciences and environmental perception. Data were collected through direct observation, and semi-structured interviews. Through content analysis found that the population has a strong dependence on the mangrove ecosystem, as well as provides a good ecological knowledge of ecosystem functions. It was also found that the reservation has a good performance in the conservation of the mangroves; however, need to outline strategies to conciliate both the biological and cultural conservation.

ENTENDENDO AS INTERAÇÕES ENTRE POVOS PESQUEIROS, MANGUEZAL E ÁREA PROTEGIDA: RDS ESTADUAL PONTA DO TUBARÃO (RN, BRASIL)

The mangrove ecosystem has a great importance to maintaining marine biodiversity, and to the livelihoods of communities living around it. Despite its importance, many mangrove areas have been extensively cleared and converted to other uses. There are few places where communities can retain their traditional uses of mangrove. A good example of conservation of traditional costumes are the fishing communities of the Sustainable Development Reserve (Reserva de Desenvolvimento Sustentável RDS) Ponta do Tubarão. The creation of the reserve came from the own population, and the devastation of a mangrove area, which would be destined for activity shrimp, was one of the reasons that led the population to ask authorities the establishment of a legally protected area. Thus, this study aimed to investigate the environmental perception of the fishing communities of RDS Ponta do Tubarão with respect to the mangroves in a biological, ecological and social perspective as well as evaluate the influence of the reserve in the mangrove conservation and quality of life. To meet objectives of this study was required the appropriation of some method and approaches of ethnosciences and environmental perception. Data were collected through direct observation, and semi-structured interviews. Through content analysis found that the population has a strong dependence on the mangrove ecosystem, as well as provides a good ecological knowledge of ecosystem functions. It was also found that the reservation has a good performance in the conservation of the mangroves; however, need to outline strategies to conciliate both the biological and cultural conservation.

Manejo florestal comunitário em unidades de conservação na Amazônia: uma avaliação de impactos na Resex Verde para Sempre - PA e na RDS Rio Negro - AM

Os planos de manejo florestal comunitário são importantes instrumentos de geração de renda e preservação ambiental para as populações tradicionais que vivem nas Unidades de Conservação da região amazônica. No entanto, poucas são as evidências de que esta atividade tenha trazido benefícios sociais a estas comunidades. Neste contexto, a presente pesquisa teve como principal objetivo identificar os impactos econômicos e sociais a partir da introdução do Projeto de Apoio ao Manejo Florestal Sustentável na Amazônia (ProManejo) na Reserva Extrativista (Resex) Verde para Sempre (Porto de Moz – PA) e do Programa Bolsa Floresta (PBF) na Reserva de Desenvolvimento Sustentável (RDS) Rio Negro (Novo Airão – AM). Para tanto, foi realizada uma pesquisa do tipo avaliação de efetividade, contemplando três dimensões: (i) objetiva, que exprime a alteração na renda e em sua composição entre os períodos ex-ante e ex-post à iniciativa; (ii) substantiva, que visa auferir as variações nas condições sociais, tais como, habitação, infraestrutura e acesso a bens de consumo, e; (iii) subjetiva, que busca descrever a percepção de melhoria das variáveis econômicas (renda e benefícios), sociais (atendimento dos serviços públicos) e ambientais (redução do desmatamento). O estudo também pode ser classificado como um quase experimento, o qual utilizou três tipos de estratégias de pesquisa: bibliográfica, documental e de campo. Este último contemplou a aplicação de um questionário estruturado por meio de entrevistas domiciliares com os/as chefes de família, e possibilitou conhecer 53% das famílias beneficiárias do projeto na Resex e 63% na RDS. As evidências apontam que ambas as iniciativas surtiram impactos positivos, principalmente, no incremento da renda das famílias e na redução do desmatamento. Em relação às condições de vida e à gestão do plano de manejo florestal, os resultados indicam uma situação mais favorável na RDS, devido à metodologia participativa e ao prazo indeterminado de término do Programa Bolsa Floresta (PBF).

Análise socioeconômica e ambiental das populações tradicionais da Reserva de Desenvolvimento Sustentável (RDS) dos Quilombos de Barra do Turvo e Área de Proteção Ambiental (APA) do Planalto do Turvo, Mosaico de Jacupiranga/SP

As Unidades de Conservação são sub-divididas em duas categorias: Proteção Integral, com objetivos de manutenção do ecossistema livre da interferência humana na qual é permitido apenas o uso indireto; e de Desenvolvimento Sustentável, que tem por objetivo equilibrar a conservação da natureza com o uso sustentável dos recursos naturais. O Parque de Jacupiranga era localizado na região sul do estado de São Paulo, denominada Vale do Ribeira, sendo criado em 1961 com aproximadamente 141 mil ha e cerca de 8 mil moradores presentes no seu interior, incluindo comunidades tradicionais, quilombolas, e agricultores migrantes de outros estados. O mosaico de Jacupiranga foi criado em 2008, com o objetivo de atender reivindicações dos moradores que sofriam restrições de suas atividades por estar dentro de uma unidade de conservação de proteção integral, com isso, o antigo PEJ sofreu a recategorização, e foram criadas 3 unidades de proteção integral e 7 de uso sustentável na antiga área do parque. O objetivo foi analisar as mudanças socioeconômicas e ambientais das famílias que sofreram com a recategorização do antigo Parque Estadual do Jacupiranga para a Reserva de Desenvolvimento Sustentável (RDS) dos Quilombos de Barra do Turvo e a Área de Proteção Ambiental (APA) do Planalto do Turvo, Mosaico de Jacupiranga/SP, onde a legislação ambiental permite a presença de moradores bem como suas atividades de subsistência. A coleta de dados foi feita pelo processo de entrevistas estruturadas realizadas com 12 moradores escolhidos por indicação dos próprios moradores das áreas tanto da APA quando da RDS. Com isso, pode-se observar uma maior liberdade nas atividades de uso da terra praticadas pelos moradores, contudo, mesmo com a recategorização, os investimentos públicos locais não são suficientes para propiciar uma boa qualidade de vida para as famílias das áreas analisadas

RASAGILINE INTERFERES WITH NEURODEGENERATION IN THE PRPH2/RDS MOUSE

Rasagiline (N-propargyl-1(R)-aminoindan) is a second-generation propargylamine with neuroprotective effects. We used the Prph2/rds mouse to assess the effect of rasagiline on photoreceptor cell death and to examine the possible modulation of different pathways of programmed cell death.

Strengthening the Reporting of Observational Studies in Epidemiology for respondent-driven sampling studies: "STROBE-RDS" statement.

OBJECTIVES Respondent-driven sampling (RDS) is a new data collection methodology used to estimate characteristics of hard-to-reach groups, such as the HIV prevalence in drug users. Many national public health systems and international organizations rely on RDS data. However, RDS reporting quality and available reporting guidelines are inadequate. We carried out a systematic review of RDS studies and present Strengthening the Reporting of Observational Studies in Epidemiology for RDS Studies (STROBE-RDS), a checklist of essential items to present in RDS publications, justified by an explanation and elaboration document. STUDY DESIGN AND SETTING We searched the MEDLINE (1970-2013), EMBASE (1974-2013), and Global Health (1910-2013) databases to assess the number and geographical distribution of published RDS studies. STROBE-RDS was developed based on STROBE guidelines, following Guidance for Developers of Health Research Reporting Guidelines. RESULTS RDS has been used in over 460 studies from 69 countries, including the USA (151 studies), China (70), and India (32). STROBE-RDS includes modifications to 12 of the 22 items on the STROBE checklist. The two key areas that required modification concerned the selection of participants and statistical analysis of the sample. CONCLUSION STROBE-RDS seeks to enhance the transparency and utility of research using RDS. If widely adopted, STROBE-RDS should improve global infectious diseases public health decision making.

Deficiency of rds/peripherin causes photoreceptor death in mouse models of digenic and dominant retinitis pigmentosa

Retinitis pigmentosa (RP) is a group of inherited blinding diseases caused by mutations in multiple genes including RDS. RDS encodes rds/peripherin (rds), a 36-kDa glycoprotein in the rims of rod and cone outer-segment (OS) discs. Rom1 is related to rds with similar membrane topology and the identical distribution in OS. In contrast to RDS, no mutations in ROM1 alone have been associated with retinal disease. However, an unusual digenic form of RP has been described. Affected individuals in several families were doubly heterozygous for a mutation in RDS causing a leucine 185 to proline substitution in rds (L185P) and a null mutation in ROM1. Neither mutation alone caused clinical abnormalities. Here, we generated transgenic/knockout mice that duplicate the amino acid substitutions and predicted levels of rds and rom1 in patients with RDS-mediated digenic and dominant RP. Photoreceptor degeneration in the mouse model of digenic RP was faster than in the wild-type and monogenic controls by histological, electroretinographic, and biochemical analysis. We observed a positive correlation between the rate of photoreceptor loss and the extent of OS disorganization in mice of several genotypes. Photoreceptor degeneration in RDS-mediated RP appears to be caused by a simple deficiency of rds and rom1. The critical threshold for the combined abundance of rds and rom1 is ≈60% of wild type. Below this value, the extent of OS disorganization results in clinically significant photoreceptor degeneration.

Comparison of Complications and Efficacy of NIPPV and Nasal CPAP in Preterm Infants With RDS

Background: Respiratory distress syndrome (RDS) is one of the most common diseases in neonates admitted to NICU. For this important cause of morbidity and mortality in preterm neonates, several treatment methods have been used. To date, non-invasive methods are preferred due to fewer complications. Objectives: Herein, two non-invasive methods of ventilation support are compared: NCPAP vs. NIPPV. Patients and Methods: This is a randomized clinical trial. Premature neonates with less than 34 weeks gestation, suffering from RDS entered the study, including 151 newborns admitted to Vali-Asr NICU during 2012-2013. Most of these patients received surfactant as early rescue via INSURE method and then randomly divided into two NCPAP (73 neonates) and NIPPV (78 neonates) groups. Both early and late complications are compared including extubation failure, hospital length of stay, GI perforation, apnea, intraventricular hemorrhage (IVH) and mortality rate. Results: The need for re-intubation was 6% in NIPPV vs. 17.6% in NCPAP group, which was statistically significant (P = 0.031). The length of hospital stay was 23.92 ± 13.5 vs. 32.61 ± 21.07 days in NIPPV and NCPAP groups, respectively (P = 0.002). Chronic lung disease (CLD) was reported to be 4% in NCPAP and 0% in NIPPV groups (P = 0.035). The most common complication occurred in both groups was traumatization of nasal skin and mucosa, all of which fully recovered. Gastrointestinal perforation was not reported in either group. Conclusions: This study reveals the hospital length of stay, re-intubation and BPD rates are significantly declined in neonates receiving NIPPV as the treatment for RDS.