894 resultados para Normative validation


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D'après des études récentes, le lien qui unit les propriétés objectives de la peine (c.-à-d. la sévérité, la certitude et la célérité de la peine) et les propriétés telles que perçues par les délinquants potentiels serait faible, voire inexistant. Par conséquent, les politiques publiques s'appuyant sur le paradigme dissuasif seraient inefficaces pour réduire la criminalité. Toutefois, ces études s'appuient sur un modèle conceptuel limité qui sous-entend que la peine produirait uniquement de la dissuasion. Cette étude vise donc à tester un modèle élargi de prévention générale qui intègre à la fois les notions de dissuasion et de validation normative. D'après ce modèle, l'effet préventif de la peine pourrait s'effectuer à travers les valeurs et les croyances des délinquants potentiels, et ce sans nécessairement modifier leurs perceptions de la peine. Afin de vérifier l'utilité d'un tel modèle, des données ont été colligées à l'aide d'un sondage sur les habitudes de conduite de 448 jeunes conducteurs québécois. Les résultats indiquent que les mécanismes dissuasifs, tels que la certitude perçue d'arrestation et la sévérité perçue des peines, n'ont pas d'effet significatif sur l'intention délictuelle des automobilistes. Toutefois, les valeurs et les croyances de l'automobiliste jouent un rôle essentiel dans la décision d'adopter un comportement routier respectueux des lois. Les automobilistes percevant les problématiques de sécurité routière (c.-à-d. alcool au volant ou vitesse) comme graves auraient moins d'intentions délinquantes. Ces valeurs et ces croyances seraient modulées à la fois par les expériences d'impunité et par le niveau d'exposition aux différentes activités policières sur les routes. Ces résultats suggèrent que l'application des lois peut produire un effet préventif sans nécessairement que des mécanismes dissuasifs en soient responsables.

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Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood. Instruments for diagnosing ADHD in childhood are well validated and reliable, but diagnosis of ADHD in adults remains problematic. Attempts have been made to develop criteria specific for adult ADHD, resulting in the development of self-report and observer-rated questionnaires. To date, the Conners Adult ADHD Rating Scales (CAARS) are the international standard for questionnaire assessment of ADHD. The current study evaluates a German version of the CAARS self-report (CAARS-S).

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Anomie theorists have been reporting the suppression of shared welfare orientations by the overwhelming dominance of economic values within capitalist societies since before the outset of neoliberalism debate. Obligations concerning common welfare are more and more often subordinated to the overarching aim of realizing economic success goals. This should be especially valid with for social life in contemporary market societies. This empirical investigation examines the extent to which market imperatives and values of the societal community are anchored within the normative orientations of market actors. Special attention is paid to whether the shape of these normative orientations varies with respect to the degree of market inclusion. Empirical analyses, based on the data of a standardized written survey within the German working population carried out in 2002, show that different types of normative orientation can be distinguished among market actors. These types are quite similar to the well-known types of anomic adaptation developed by Robert K. Merton in “Social Structure and Anomie” and are externally valid with respect to the prediction of different forms of economic crime. Further analyses show that the type of normative orientation actors adopt within everyday life depends on the degree of market inclusion. Confirming anomie theory, it is shown that the individual willingness to subordinate matters of common welfare to the aim of economic success—radical market activism—gets stronger the more actors are included in the market sphere. Finally, the relevance of reported findings for the explanation of violent behavior, especially with view to varieties of corporate violence, is discussed.

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This report presents a new extraction method of the dinophysistoxins (DTXs), confirmed by quantification using high-performance liquid chromatography coupled to mass spectrometry with an ion trap and electro spray interface (HPLC/ESI/MS2). The method originality consists on the adaptation of DTXs basic extraction procedure (liquid/ liquid) to a solid phase extraction (SPE) via a robotic station: ASPEC XLi The parameters of the automatization procedure were optimized to obtain the best DTXs recovery rate. These improvements were loaded with digestive gland mussel homogenat realized on a silica cartridge SPE, activated in hexane/chloroform (50:50), washed with hexane/chloroform (50:50) and extracted by an elution gradient (chloroform methanol (65:35) and methanol (100%)). This method was validated according to two normative referentials (linearity, detection quantification limits and accuracy…) : - The Guide of the Pharmacy industry: Analytical Validation, report of the commission SFSTP 1992 (French Corporation of the Sciences and Technical Pharmaceutical), - - The Procedure of validation of an alternative method in compare to a reference method. (AFNOR, 1998. NF V 03-110). Comparison with the classical liquid/liquid extraction and the automated method present clear advantages. In an analytical method the extraction is generally considered to be the most labor-intensive and error-prone step. This new procedure allowed us to increase throughput, to improve the reproducibility and to reduce the error risks due to the individual manual treatments.

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Our aim was to determine the normative reference values of cardiorespiratory fitness (CRF) and to establish the proportion of subjects with low CRF suggestive of future cardio-metabolic risk.