Investimentos, fontes de financiamento e evolução do setor de infra-estrutura no Brasil: 1950-1996

O presente trabalho apresenta uma análise do setor de infra-estrutura brasileiro durante o período 1950-1996. Para isto foram levantadas séries de investimentos e medidas físicas para os setores elétrico, de telecomunicações, rodoviário, ferroviário, portuário e aeroportuário que até hoje estavam indisponíveis. Mostramos que no período 1950-79 observa-se um crescimento acelerado dos investimentos no setor, principalmente em energia elétrica e transportes. Na década de 80, com a deterioração financeira do Estado, um endividamento crescente e um processo de aceleração inflacionária, os investimentos das estatais foram drasticamente reduzidos. Para isto também contribuiu os desvinculamentos de impostos aprovados na constituição de 1988. Em alguns casos os investimentos caem para menos que um quinto da média dos anos setenta, o que acabou provocando aumento dos custos e deterioração da qualidade dos serviços

Series macroeconómicas del Istmo Centroamericano, 1950-1996

Incluye Bibliografía

Aquella utopía del cambio social : Bertolt Brecht en el teatro latinoamericano, porteño y mendocino (1950-1996)

El presente trabajo da cuenta de algunas proyecciones de Bertolt Brecht en el teatro europeo, latinoamericano, porteño y mendocino. Se indagan las relaciones con el sistema europeo para ver de qué modo las apropiaciones responden a adecuaciones de lo extranjero a nuestras necesidades, en un proceso de resemantización en que dicha poética se integra al sistema teatral latinoamericano y argentino. En esta evolución de las formas o historia interna, los cambios se explican en relación con el campo cultural, el contexto histórico y social y la captación de nuevos públicos. Se sintetizan los aportes bibliográficos más significativos así como la repercusión en la crítica periodística y los testimonios de los directores teatrales más importantes. Las diferentes épocas, delimitadas por etapas, están comprendidas entre 1960 y 2000.

Indiana, the sesquicentennial of the establishment of the Territorial Government; an exhibit in the Library of Congress, Washington, D.C., November 30, 1950, to April 30, 1951.

Includes index.

Sistemática, filogenia e distribuição geográfica das espécies sul-americanas de Centris (Paracentris) Cameron, 1903 e de Centris (Penthemisia) Moure, 1950, incluindo uma análise filogenética do "grupo Centris" sensu Ayala, 1998 (Hymenoptera, Apoidea, Centridini)

Systematics, phylogeny and geographical distribution of the South American species of Centris (Paracentris) Cameron, 1903, and Centris (Penthemisia) Moure, 1950, including a phylogenetic analysis of the "Centris group" sensu Ayala, 1998 (Hymenoptera, Apoidea, Centridini). A cladistic analysis with the objective of testing the hypothesis of monophily of Centris (Paracentris) Cameron, 1903, and of studying its phylogenetic relationships with the other subgenera that belong to the Centris group, sensu Ayala, 1998, and the relationships among the species that occur in South America, is presented. Centris (Paracentris) is a group of New World bees of amphitropical distribution, especially diversified in the Andes and in the xeric areas of South and North America. Thirty-one species were included in the analysis, four considered as outgroup, and 49 characters, all from external morphology and genitalia of adult specimens. Parsimony analyses with equal weights for the characters and successive weighting were performed with the programs NONA and PAUP, and analyses of implied weighting with the program PeeWee. The strict consensus among the trees obtained in all the analyses indicates that C. (Paracentris), as previously recognized, is a paraphyletic group. In order to eliminate that condition, the subgenera C. (Acritocentris), C. (Exallocentris) and C. (Xerocentris), all described by SNELLING (1974) are synonymized under C. (Paracentris). The subgenus C. (Penthemisia) Moure, 1950, previously considered a synonym of C. (Paracentris), is reinstated, but in a more restricted sense than originally proposed and with the following species: Centris brethesi Schrottky, 1902; C. buchholzi Herbst, 1918; C. chilensis (Spinola, 1851), C. mixta mixta Friese, 1904, and C. mixta tamarugalis Toro & Chiappa, 1989. Centris mixta, previously recognized as the only South American species of the subgenus C. (Xerocentris), a group supposedly amphitropical, came out as the sister-species of C. buchholzi. The following South American species were recognized under Centris (Paracentris): Centris burgdorfi Friese, 1901; C. caelebs Friese, 1900; C. cordillerana Roig-Alsina, 2000; C. euphenax Cockerell, 1913; C. flavohirta Friese, 1900; C. garleppi (Schrottky, 1913); C. klugii Friese, 1900; C. lyngbyei Jensen-Haarup, 1908; C. mourei Roig-Alsina, 2000; C. neffi Moure, 2000; C. nigerrima (Spinola, 1851); C. toroi sp. nov.; C. tricolor Friese, 1900; C. unifasciata (Schrottky, 1913), and C. vogeli Roig-Alsina, 2000. The relationships among the subgenera of the "Centris group" were: (Xanthemisia (Penthemisia (Centris s. str. - Paracentris))). Centris xanthomelaena Moure & Castro 2001, an endemic species of the Caatinga and previously considered a C. (Paracentris), came out as the sister group of C. (Centris) s. str. A new species of C. (Paracentris) from Chile is described: Centris toroi sp. nov. Lectotypus designations and redescriptions are presented for Centris burgdorfi, C. caelebs, C. lyngbyei, C. tricolor, C. autrani Vachal, 1904 and C. smithii Friese, 1900. New synonyms proposed: C. buchholzi Herbst, 1918 = Centris wilmattae Cockerell, 1926 syn. nov.; C. caelebs Friese, 1900 = Paracentris fulvohirta Cameron, 1903. The female of C. vogeli Roig-Alsina, 2000 and the male of C. xanthomelaena are described.

Una proposta de treball educatiu en centres oberts des de l'aproximació al disseny curricular en educació social

El Centre obert apareix com una resposta idònia per a l'atenció social a la població infantil compresa entre els 3/4 i 16/18 anys. Parlar de Centre Obert és fer referencia a l'exercici d'una important responsabilitat pública, a saber: aportar nous models i oportunitats de socialització a subjectes amb certes dificultats de normalització. Les dites dificultats corresponen a diferents reptes que avui planteja el social.

Ahorro para el retiro en Colombia: patrones y determinantes

La decisión de los individuos acerca del ahorro para el retiro ha sido abordada teóricamente bajo la hipótesis de que el sistema de seguridad social se comporta como un sustituto de otros mecanismos de ahorro. Este documento presenta evidencia de los patrones y determinantes del ahorro para el retiro en Colombia a partir de la Gran Encuesta Integrada de Hogares de 2007. Los resultados muestran que el 63% de los ocupados declaran no ahorrar para su vejez. A partir de modelos de selección discreta se encuentra que individuos jóvenes, de sexo masculino, con menor nivel educativo, residentes en zonas rurales, y trabajadores cuenta propia, presentan menores probabilidades de ah orrar para el retiro; además las características socioeconómicas resultan significativas en la determinación del mecanismo de ahorro utilizado.

The N-terminal domain of a K+ channel β subunit increases the rate of C-type inactivation from the cytoplasmic side of the channel

Voltage-gated K+ channels are complexes of membrane-bound, ion-conducting α and cytoplasmic ancillary (β) subunits. The primary physiologic effect of coexpression of α and β subunits is to increase the intrinsic rate of inactivation of the α subunit. For one β subunit, Kvβ1.1, inactivation is enhanced through an N-type mechanism. A second β subunit, Kvβ1.2, has been shown to increase inactivation, but through a distinct mechanism. Here we show that the degree of enhancement of Kvβ1.2 inactivation is dependent on the amino acid composition in the pore mouth of the α subunit and the concentration of extracellular K+. Experimental conditions that promote C-type inactivation also enhance the stimulation of inactivation by Kvβ1.2, showing that this β subunit directly stimulates C-type inactivation. Chimeric constructs containing just the nonconserved N-terminal region of Kvβ1.2 fused with an α subunit behave in a similar fashion to coexpressed Kvβ1.2 and α subunit. This shows that it is the N-terminal domain of Kvβ1.2 that mediates the increase in C-type inactivation from the cytoplasmic side of the pore. We propose a model whereby the N terminus of Kvβ1.2 acts as a weakly binding “ball” domain that associates with the intracellular vestibule of the α subunit to effect a conformational change leading to enhancement of C-type inactivation.

The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

c-Abl is a nonreceptor tyrosine kinase that is activated by certain DNA-damaging agents. The present studies demonstrate that nuclear c-Abl binds constitutively to the protein tyrosine phosphatase SHPTP1. Treatment with ionizing radiation is associated with c-Abl-dependent tyrosine phosphorylation of SHPTP1. The results demonstrate that the SH3 domain of c-Abl interacts with a WPDHGVPSEP motif (residues 417-426) in the catalytic domain of SHPTP1 and that c-Abl phosphorylates C terminal Y536 and Y564 sites. The functional significance of the c-Abl-SHPTP1 interaction is supported by the demonstration that, like c-Abl, SHPTP1 regulates the induction of Jun kinase activity following DNA damage. These findings indicate that SHPTP1 is involved in the response to genotoxic stress through a c-Abl-dependent mechanism.

N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons.

Ca2+ influx controls multiple neuronal functions including neurotransmitter release, protein phosphorylation, gene expression, and synaptic plasticity. Brain L-type Ca2+ channels, which contain either alpha 1C or alpha 1D as their pore-forming subunits, are an important source of calcium entry into neurons. Alpha 1C exists in long and short forms, which are differentially phosphorylated, and C-terminal truncation of alpha 1C increases its activity approximately 4-fold in heterologous expression systems. Although most L-type calcium channels in brain are localized in the cell body and proximal dendrites, alpha 1C subunits in the hippocampus are also present in clusters along the dendrites of neurons. Examination by electron microscopy shows that these clusters of alpha 1C are localized in the postsynaptic membrane of excitatory synapses, which are known to contain glutamate receptors. Activation of N-methyl-D-aspartate (NMDA)-specific glutamate receptors induced the conversion of the long form of alpha 1C into the short form by proteolytic removal of the C terminus. Other classes of Ca2+ channel alpha1 subunits were unaffected. This proteolytic processing reaction required extracellular calcium and was blocked by inhibitors of the calcium-activated protease calpain, indicating that calcium entry through NMDA receptors activated proteolysis of alpha1C by calpain. Purified calpain catalyzed conversion of the long form of immunopurified alpha 1C to the short form in vitro, consistent with the hypothesis that calpain is responsible for processing of alpha 1C in hippocampal neurons. Our results suggest that NMDA receptor-induced processing of the postsynaptic class C L-type Ca2+ channel may persistently increase Ca2+ influx following intense synaptic activity and may influence Ca2+-dependent processes such as protein phosphorylation, synaptic plasticity, and gene expression.

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

The specific signal transduction function of the gamma c subunit in the interleukin (IL) 2, IL-4, IL-7, IL-9, and IL-15 receptor complexes remains undefined. The present structure-function analyses demonstrated that the entire cytoplasmic tail of gamma c could be functionally replaced in the IL-2 receptor (IL-2R) signaling complex by a severely truncated erythropoietin receptor cytoplasmic domain lacking tyrosine residues. Heterodimerization of IL-2R beta with either gamma c or the truncated erythropoietin receptor chain led to an array of specific signals normally derived from the native IL-2R despite the substitution of Janus kinase JAK2 for JAK3 in the receptor complex. These findings thus suggest a model in which the gamma c subunit serves as a common and generic "trigger" chain by providing a nonspecific Janus kinase for signaling program initiation, while signal specificity is determined by the unique "driver" subunit in each of the gamma c- containing receptor complexes. Furthermore, these results may have important functional implications for the asymmetric design of many cytokine receptor complexes and the evolutionary design of receptor subfamilies that share common trigger or driver subunits.

Avaliação da prevalência de cárie dentária em escolares de localidade urbana da região Sudeste do Brasil

Realizou-se no ano de 1994, na cidade de Paulínia, Estado de São Paulo (Brasil), um levantamento epidemiológico de cárie dentária com o intuito de comparar a atual prevalência com os dados de um estudo prévio de 1980. Foram examinados 1.416 escolares de 7 a14 anos de idade, de ambos os sexos, por 10 dentistas previamente calibrados, utilizando-se os índices CPO.D e CPO.S. Verificou-se que houve uma queda da prevalência de cárie em 67,8% em relação aos dados de 1980. Observou-se uma inversão dos componentes do índice CPO.D: em 1980 prevalecia o componente cariado (69,5%), enquanto que o componente obturado prevaleceu em 1994 (79,0%). Os componentes extraídos e a extração indicada praticamente desapareceram no ano de 1994.