Mary Jean Collins-Robeson at NOW conference, Philadelphia

General note: Title and date provided by Bettye Lane.

Mary Jean Collins-Robson at NOW conference, Houston

General note: Title and date provided by Bettye Lane.

School of Nursing Class of 1999

Top Row: Felicia Allen, Michael Anderson, Lisa Armstead, Shannon Arterburn, April Ballard, Stacey Bancroft, Veronica Barcelona, Mary Barringer, Jaralee Basso, Courtney Beck, Karina Bouffard, Becky Bradford, Dawn Burdette, Biance Cerroni

Row 2: Surlin Chadha, James Chambers, Matt Brady, Trish Donovan, Patricia Letowrneau, Amy Prouty, Mary Hawk, Kim Yaekle, Joy Caraan, Jill Awai, Kerry Szymke, Lawra Knapp, Trish Therrian, Kelly Collardey, Julie Collins

Row 3: Kimberly Collins, Jill Collison, Michelle Colvia, Erika Cross, Erin Dassance, Amanda DeFever

Row 4: Janis Dinnel, Corey Eisenberg, Lisa Falzetta, Amy Farley, Jennifer Fulcher, Lori George, Pamela George, Royace A. Gibson

Row 5: Pamela Giles, Nicole Grecu, Janet Green, Jessica Grose, Jill Hall, Jill Hiler, Shamika Hinson, Melissa Hitchcock

Row 6: Rebekah Hopper, Steven Thrke, Kevri Johnson, Rebecca Johnson, Shannon Johnson, Jan Lee, Beverly Jones, Ada Sue Hinshaw, Susan Boehm, Nola Pender, Patricia Coleman Burn, Jody Joslyn, Jennifer Kerr, Erin Kingsley, Heather Knudsen, Kristie Krzyzanski

Row 7: Sarah Kyle, Michelle Laughlis, Julie Leibowitz, Erin Maki, Rachel Malone, Amanda Manoni, Kara marsh, Carrie McClung, Kristi Miller, Kristine Moe, Kimberly Morton, Thecla Moschouris, Meg Mountainbear, Michelle Newberg, Aarti parekh, Heather Pawlak

Row 8: Diana Piergentili, Alison Pinta, Gail Prahaska, Jennifer Pruchnik, Kimberly Rendz, Sarah Repp, Eunice Rhiew, Kyle Rinehart, Roni robarge, Audrey Salazar, Dana Schaffner, Sally Scott, Nicole Sell, Mary Jean Siasoco, Deborah Slizewski, Rebecca Snyder

Row 9: Carmen Taylor, Chereena Tennis, Monigue Tett, Lindsay Thibert, Cindy Thompson, Alpa Tolia, Jessie Ulmer, Shannon Waigle, Jennifer Walsh, MacKenzie Waters, Christie Wiseley, Mari Yelorda

Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease.

OBJECTIVE: Strict lifelong compliance to a gluten-free diet (GFD) minimizes the long-term risk of mortality, especially from lymphoma, in adult celiac disease (CD). Although serum IgA antitransglutaminase (IgA-tTG-ab), like antiendomysium (IgA-EMA) antibodies, are sensitive and specific screening tests for untreated CD, their reliability as predictors of strict compliance to and dietary transgressions from a GFD is not precisely known. We aimed to address this question in consecutively treated adult celiacs. METHODS: In a cross-sectional study, 95 non-IgA deficient adult (median age: 41 yr) celiacs on a GFD for at least 1 yr (median: 6 yr) were subjected to 1) a dietician-administered inquiry to pinpoint and quantify the number and levels of transgressions (classified as moderate or large, using as a cutoff value the median gluten amount ingested in the overall noncompliant patients of the series) over the previous 2 months, 2) a search for IgA-tTG-ab and -EMA, and 3) perendoscopic duodenal biopsies. The ability of both antibodies to discriminate celiacs with and without detected transgressions was described using receiver operating characteristic curves and quantified as to sensitivity and specificity, according to the level of transgressions. RESULTS: Forty (42%) patients strictly adhered to a GFD, 55 (58%) had committed transgressions, classified as moderate (< or = 18 g of gluten/2 months; median number 6) in 27 and large (>18 g; median number 69) in 28. IgA-tTG-ab and -EMA specificity (proportion of correct recognition of strictly compliant celiacs) was 0.97 and 0.98, respectively, and sensitivity (proportion of correct recognition of overall, moderate, and large levels of transgressions) was 0.52, 0.31, and 0.77, and 0.62, 0.37, and 0.86, respectively. IgA-tTG-ab and -EMA titers were correlated (p < 0.001) to transgression levels (r = 0.560 and R = 0.631, respectively) and one to another (p < 0.001) in the whole patient population (r = 0.834, N = 84) as in the noncompliant (r = 0.915, N = 48) group. Specificity and sensitivity of IgA-tTG-ab and IgA-EMA for recognition of total villous atrophy in patients under a GFD were 0.90 and 0.91, and 0.60 and 0.73, respectively. CONCLUSIONS: In adult CD patients on a GFD, IgA-tTG-ab are poor predictors of dietary transgressions. Their negativity is a falsely secure marker of strict diet compliance.

Linking Family Engagement with a Rights Perspective: Macro Factors Influencing Practice

While child welfare practitioners in many countries are struggling to develop methods of effective family engagement, they operate within different national and cultural contexts which influence, both positively and negatively, the ability to engage with families. Increasingly, international comparisons are necessary to further understanding of the development of social work practice. This is particularly necessary because most countries utilize international frameworks (such as the United National Convention on the Rights of the Child) to provide guidance in the development of policies, programs, and interventions. Each country (and locality) struggles to advance practice to be more effective and humane. Our paper offers a comparative analysis focused on family-oriented and rights-based frameworks of different countries. Based on a review of current national policies and a review of the literature regarding family based practices, we examine similarities and differences among four countries: the United Kingdom, Sweden, the United States, and South Korea. These countries were selected because they have some similarities (advanced industrialized democracies, professional social work, formal child protection systems) but have some differences in their social welfare systems (policies, specific practices, socio-cultural context). These differences can be utilized to advance understanding regarding the promise and potential for family engagement strategies. We then discuss the utility of this comparison for theory-building in the arena of child care practice and conclude by identifying the challenges and limitations of this work.

Does systematic instruction in rhythmic movement influence the speech of the deaf

This paper discusses the influence of rhythm in teaching of hearing impaired children.

National Household Education Survey of 1995 : adult education data file user's manual /

Mode of access: Internet.

Fieldbook of Illinois land snails,

Mode of access: Internet.

La finalité morale chez les théologiens de saint Augustin à Duns Scot,

"Auteurs consultés": p. [311]-312.

Will small business become the nation's leading employer of graduates with bachelor's degrees in science and engineering? /

Mode of access: Internet.

A empresa produtiva e a racionalidade substantiva : a teoria da ação comunicativa de Jürgen Habermas no ambiente organizacional interativo : de Mary Parker Follett a Collins e Porras

Este estudo trata da possibilidade de as empresas produtivas possuírem elementos característicos das organizações substantivas, tendo como perspectiva geral a construção de um ambiente organizacional integrativo, com base na teoria da ação comunicativa, de Jürgen Habermas e na noção de racionalidade substantiva, de Guerreiro Ramos. Apresenta, a partir dos trabalhos de Mary Parker Follett e de Araujo Santos, o conceito de ambiente organizacional integrativo, que sustenta a identidade de interesses entre trabalhadores e empresa e valoriza aspectos como a auto-realização, o autodesenvolvimento e a satisfação do ser humano, confrontando-o com a realidade do ambiente cultural brasileiro e sua influência nas práticas administrativas. Tendo como ponto de partida a pesquisa empreendida por Maurício Serva sobre o fenômeno das organizações substantivas, empreende, através de estudo de caso, um exame no cotidiano organizacional de uma empresa produtiva brasileira do ramo industrial, de modo a investigar a existência da ação racional substantiva nas suas diversas dinâmicas, processos e práticas administrativas, submetendo-a a uma avaliação com base em uma escala de intensidade da racionalidade substantiva e da racionalidade instrumental. Investiga ainda a possibilidade da existência de integração de interesses entre trabalhadores e empresa, caracterizando assim o ambiente organizacional integrativo.

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

FTO genotype is associated with phenotypic variability of body mass index

There is evidence across several species for genetic control of phenotypic variation of complex traits1, 2, 3, 4, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ~170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype)5, 6, 7, is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of ~0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation9, 10. Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000.

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.