Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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01/05/2013
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| Resumo |
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups. |
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| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Berndt , S I , Gustafsson , S , Mägi , R , Ganna , A , Wheeler , E , Feitosa , M F , Justice , A E , Monda , K L , Croteau-Chonka , D C , Day , F R , Esko , T , Fall , T , Ferreira , T , Gentilini , D , Jackson , A U , Luan , J , Randall , J C , Vedantam , S , Willer , C J , Winkler , T W , Wood , A R , Workalemahu , T , Hu , Y-J , Lee , S H , Liang , L , Lin , D-Y , Min , J L , Neale , B M , Thorleifsson , G , Yang , J , Albrecht , E , Amin , N , Bragg-Gresham , J L , Cadby , G , den Heijer , M , Eklund , N , Fischer , K , Goel , A , Hottenga , J-J , Huffman , J E , Jarick , I , Johansson , Å , Johnson , T , Kanoni , S , Kleber , M E , König , I R , Kristiansson , K , Kutalik , Z , Lamina , C , Lecoeur , C , Li , G , Mangino , M , McArdle , W L , Medina-Gomez , C , Müller-Nurasyid , M , Ngwa , J S , Nolte , I M , Paternoster , L , Pechlivanis , S , Perola , M , Peters , M J , Preuss , M , Rose , L M , Shi , J , Shungin , D , Smith , A V , Strawbridge , R J , Surakka , I , Teumer , A , Trip , M D , Tyrer , J , Van Vliet-Ostaptchouk , J V , Vandenput , L , Waite , L L , Zhao , J H , Absher , D , Asselbergs , F W , Atalay , M , Attwood , A P , Balmforth , A J , Basart , H , Beilby , J , Bonnycastle , L L , Brambilla , P , Bruinenberg , M , Campbell , H , Chasman , D I , Chines , P S , Collins , F S , Connell , J M , Cookson , W O , de Faire , U , de Vegt , F , Dei , M , Dimitriou , M , Edkins , S , Estrada , K , Evans , D M , Farrall , M , Ferrario , M M , Ferrières , J , Franke , L , Frau , F , Gejman , P V , Grallert , H , Grönberg , H , Gudnason , V , Hall , A S , Hall , P , Hartikainen , A-L , Hayward , C , Heard-Costa , N L , Heath , A C , Hebebrand , J , Homuth , G , Hu , F B , Hunt , S E , Hyppönen , E , Iribarren , C , Jacobs , K B , Jansson , J-O , Jula , A , Kähönen , M , Kathiresan , S , Kee , F , Khaw , K-T , Kivimäki , M , Koenig , W , Kraja , A T , Kumari , M , Kuulasmaa , K , Kuusisto , J , Laitinen , J H , Lakka , T A , Langenberg , C , Launer , L J , Lind , L , Lindström , J , Liu , J , Liuzzi , A , Lokki , M-L , Lorentzon , M , Madden , P A , Magnusson , P K , Manunta , P , Marek , D , März , W , Mateo Leach , I , McKnight , B , Medland , S E , Mihailov , E , Milani , L , Montgomery , G W , Mooser , V , Mühleisen , T W , Munroe , P B , Musk , A W , Narisu , N , Navis , G , Nicholson , G , Nohr , E A , Ong , K K , Oostra , B A , Palmer , C N A , Palotie , A , Peden , J F , Pedersen , N , Peters , A , Polasek , O , Pouta , A , Pramstaller , P P , Prokopenko , I , Pütter , C , Radhakrishnan , A , Raitakari , O , Rendon , A , Rivadeneira , F , Rudan , I , Saaristo , T E , Sambrook , J G , Sanders , A R , Sanna , S , Saramies , J , Schipf , S , Schreiber , S , Schunkert , H , Shin , S-Y , Signorini , S , Sinisalo , J , Skrobek , B , Soranzo , N , Stančáková , A , Stark , K , Stephens , J C , Stirrups , K , Stolk , R P , Stumvoll , M , Swift , A J , Theodoraki , E V , Thorand , B , Tregouet , D-A , Tremoli , E , Van der Klauw , M M , van Meurs , J B J , Vermeulen , S H , Viikari , J , Virtamo , J , Vitart , V , Waeber , G , Wang , Z , Widén , E , Wild , S H , Willemsen , G , Winkelmann , B R , Witteman , J C M , Wolffenbuttel , B H R , Wong , A , Wright , A F , Zillikens , M C , Amouyel , P , Boehm , B O , Boerwinkle , E , Boomsma , D I , Caulfield , M J , Chanock , S J , Cupples , L A , Cusi , D , Dedoussis , G V , Erdmann , J , Eriksson , J G , Franks , P W , Froguel , P , Gieger , C , Gyllensten , U , Hamsten , A , Harris , T B , Hengstenberg , C , Hicks , A A , Hingorani , A , Hinney , A , Hofman , A , Hovingh , K G , Hveem , K , Illig , T , Jarvelin , M-R , Jöckel , K-H , Keinanen-Kiukaanniemi , S M , Kiemeney , L A , Kuh , D , Laakso , M , Lehtimäki , T , Levinson , D F , Martin , N G , Metspalu , A , Morris , A D , Nieminen , M S , Njølstad , I , Ohlsson , C , Oldehinkel , A J , Ouwehand , W H , Palmer , L J , Penninx , B , Power , C , Province , M A , Psaty , B M , Qi , L , Rauramaa , R , Ridker , P M , Ripatti , S , Salomaa , V , Samani , N J , Snieder , H , Sørensen , T I A , Spector , T D , Stefansson , K , Tönjes , A , Tuomilehto , J , Uitterlinden , A G , Uusitupa , M , van der Harst , P , Vollenweider , P , Wallaschofski , H , Wareham , N J , Watkins , H , Wichmann , H-E , Wilson , J F , Abecasis , G R , Assimes , T L , Barroso , I , Boehnke , M , Borecki , I B , Deloukas , P , Fox , C S , Frayling , T , Groop , L C , Haritunian , T , Heid , I M , Hunter , D , Kaplan , R C , Karpe , F , Moffatt , M F , Mohlke , K L , O'Connell , J R , Pawitan , Y , Schadt , E E , Schlessinger , D , Steinthorsdottir , V , Strachan , D P , Thorsteinsdottir , U , van Duijn , C M , Visscher , P M , Di Blasio , A M , Hirschhorn , J N , Lindgren , C M , Morris , A P , Meyre , D , Scherag , A , McCarthy , M I , Speliotes , E K , North , K E , Loos , R J F & Ingelsson , E 2013 , ' Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture ' Nature genetics , vol 45 , no. 5 , pp. 501-12 . DOI: 10.1038/ng.2606 |
| Palavras-Chave | #Anthropometry #Body Height #Body Mass Index #Case-Control Studies #European Continental Ancestry Group #Genetic Predisposition to Disease #Genome-Wide Association Study #Genotype #Humans #Meta-Analysis as Topic #Obesity #Phenotype #Polymorphism, Single Nucleotide #Quantitative Trait Loci #Waist-Hip Ratio |
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article |
