Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits.

Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically acquired metabolic phenotypes by using the EUMODIC EMPReSS protocols across a large panel of isogenic but diverse strains of mice (BXD type) to study the genetic control of metabolism. We generated and analyzed 140 classical phenotypes and deposited these in an open-access web service for systems genetics (www.genenetwork.org). Heritability, influence of sex, and genetic modifiers of traits were examined singly and jointly by using quantitative-trait locus (QTL) and expression QTL-mapping methods. Traits and networks were linked to loci encompassing both known variants and novel candidate genes, including alkaline phosphatase (ALPL), here linked to hypophosphatasia. The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders.

Improving the use of the nursing process: the impact of charting methodology developed from King's conceptual framework on the use of the nursing process

The purpose of this study was to assess the effects of changing a nursing documentation system, developed from King's Conceptual Framework, on the use of the nursing process. The null hypothesis was that there would be no significant increase in the reflection of the use of the nursing process on the nursing care plan or nurses' notes, as a result of using a nursing documentation system developed using King's Conceptual Framework (1981). The design involved the development of a questionnaire that was used to review health records pre and post implementation of a documentation system developed based on King's Conceptual Framework and Theory of Goal Attainment (1981). A Record Completeness Score was obtained from some of the questions. The null hypothesis was rejected. The results of the study have implications for nursing administration and the evaluation of nursing practice. If the use of a documentation system developed from a conceptual framework increases the reflection of the nursing process on the patient's health record, nursing will have the means to measure patient outcomes/goal attainment. All health care organizations and levels of government are focusing on methods to monitor and control the health-care dollar. In order for nursing to clearly determine the costs associated with nursing care, measurement of patient outcomes/goal attainment will need to be possible. In order to measure patient outcomes/goals attainment nurses will need to be able to collect data on their practice. It will be critical that nursing have a documentation system in place which facilitates the reflection of the nursing process within a theoretical framework.

Investing Online: Concerns about the Evolving Use of the Internet as an Investment Tool in the Secondary Market Context

La croissance dramatique du commerce électronique des titres cache un grand potentiel pour les investisseurs, de même que pour l’industrie des valeurs mobilières en général. Prenant en considération ses risques particuliers, les autorités réglementaires vivent un défi important face à l’Internet en tant que nouveau moyen d’investir. Néanmoins, malgré l’évolution technologique, les objectifs fondamentaux et l’approche des autorités réglementaires restent similaires à ce qui se produit présentement. Cet article analyse l’impact de l’Internet sur le commerce des valeurs mobilières en se concentrant sur les problèmes soulevés par l’utilisation de ce nouveau moyen de communication dans le contexte du marché secondaire. Par conséquent, son objectif est de dresser le portrait des plaintes typiques des investisseurs, de même que celui des activités frauduleuses en valeurs mobilières propres au cyberespace. L’auteur fait une synthèse des développements récents en analysant l’approche des autorités réglementaires, les études doctrinales, la jurisprudence et les cas administratifs. L'auteure désire remercier la professeure Raymonde Crête pour ses précieux commentaires et conseils.

The use of the video camera in the English class. 'La utilización de la cámara de vídeo en la clase de inglés'.

Seminario realizado por cuatro profesoras de distintos centros educativos de Vizcaya para la elaboración de cinco 'projects', cada uno con ejercicios para diferentes niveles, que tienen como objetivo inmediato la práctica de estructuras del lenguaje en un marco comunicativo y como objetivo global la realización de una filmación sobre el tema básico del project. Los temas tratados son: el uso de la cámara de vídeo, las noticias, los anuncios (publicidad), video clips, cuentos y narraciones. Los resultados se valoran como muy positivos debido a la motivación de filmar el producto final.

The Use of the Common European Framework of Reference for Languages to Evaluate Compositions in the English Exam Section of the University Admission Examination. 'El uso del Marco Com??n Europeo de Referencia para las Lenguas para evaluar las redacciones en la secci??n de ingl??s de la Prueba de Acceso a la Universidad'

Monogr??fico con el t??tulo: 'Nuevas perspectivas en la secci??n de idiomas de la Prueba de Acceso a la Universidad'. Resumen basado en el de la publicaci??n

The use of the bi-factor model to test the uni-dimensionality of a battery of reasoning tests

Resumen tomado de la publicación

Use of the storage oscilloscope to train deaf children to convey meaning in sentences through intonation control

This paper is a review of a study to determine if profoundly deaf adolescents could be trained in intonation control in using a two-channel storage oscilloscope.

The effect and the use of the typewriter upon the reading and language of deaf children

This paper discusses a study to determine if the use of a typewriter had an effect on the reading ability of hearing impaired children.

Use of the storage oscilloscope to train deaf children to convey meaning in sentences through intonation control

This paper is a review of a study to determine if profoundly deaf adolescents could be trained in intonation control in using a two-channel storage oscilloscope.