342 resultados para Wistert, Alvin


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Entrar al análisis de los factores de liderazgo de las zonas francas de Colombia, República Dominicana y Taiwán, resulta básico abordar el tema del liderazgo empresarial, como la estructura principal del éxito en las organizaciones del mundo

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La historia como factor destinado a brindar una orientación acerca de la presencia y transformación de la figura desde el siglo XVI. La descripción de hechos pasados es utilizada como método para explicar cambios que se han presentado en la materia

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A pesar que la valoración de marcas es una disciplina relativamente reciente, el valor que una marca le representa a su dueño ha estado incubado desde la creación misma de las primeras marcas comerciales

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El interés de esta investigación es analizar las implicaciones de la formalización de las Madres Comunitarias en el desarrollo e implementación del programa de Hogares Comunitarios de Bienestar del ICBF. Se analiza y se explica cómo La formalización de las Madres Comunitarias hace que el programa de Hogares Comunitarios de Bienestar sufra un proceso de burocratización en dos vías donde se privilegian por un lado la tecnificación y profesionalización de las madres comunitarias y por otro el manejo del trabajo social por organizaciones y asociaciones, el cual comienza a desplazar el plano comunitario voluntario (familias y vecinos) a un plano institucional de carácter obligatorio, lo que tiende a cambiar la esencia del programa. Para desarrollar esta investigación se tomara como referente teórico el concepto de burocratización de Max Weber desde las tendencias de la racionalización y la societarización

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Este artículo explora un tema central en la filosofía de la religión actual: la relación entre la razón y la fe, a partir de la controversia que genera la defensa de Norman Malcolm del argumento ontológico de San Anselmo. Dado que Malcolm es conocido por su postura fideísta, surge la cuestión de cómo es posible que defienda al mismo tiempo dos posiciones que parecen contrarias: por un lado, que las demostraciones racionales son irrelevantes para producir la fe y, por el otro, que haya un argumento a favor de la existencia de Dios que pueda ser considerado válido. Esta posición se puede entender a partir de la tesis propuesta en este trabajo que consiste en sostener que si bien la fe religiosa no se obtiene por argumentos, la argumentación racional tiene un lugar dentro de la fe, el cual consiste en ayudar a comprender por la razón aquello que se cree. Este trabajo intenta mostrar que la postura de Malcolm no es contradictoria en tanto que implica la diferencia entre la creencia "que Dios existe", la cual sería el objeto de los argumentos racionales y no supone ninguna práctica o devoción religiosa, y la creencia "en Dios", la cual a la vez que presupone que Dios existe, constituye el tipo de creencia propiamente religiosa que se entiende en términos de confianza, fe y devoción.

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Parte de la relación del hombre con la tecnología, según la han estudiado Aldous Huxley, Isaac Asimov, Ray Bradbury y Alvin Toffler. Seguidamente, se adentra en la relación entre Tecnología y Educación, donde examina la interacción usuario-computadora. También aborda la Realidad Virtual y el Espacio Cibernético. Realiza un estudio de Internet: su historia, sus elementos y conceptos más importantes, los usos de la Realidad Virtual y el camino hacia la Universidad Virtual, con las experiencias mexicanas en este campo. La segunda parte está dedicada a comparar dos instituciones mexicanas de Educación Superior en el área de la Comunicación y Periodismo en el uso, reflexión y conocimiento de las nuevas tecnologías: El Proyecto Universidad Virtual del sistema del Instituto Superior y de Educación Superior de Monterrey (ITESM) y la Escuela de Periodismo 'Carlos Septién García'.

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This paper will present a conceptual framework for the examination of land redevelopment based on a complex systems/networks approach. As Alvin Toffler insightfully noted, modern scientific enquiry has become exceptionally good at splitting problems into pieces but has forgotten how to put the pieces back together. Twenty-five years after his remarks, governments and corporations faced with the requirements of sustainability are struggling to promote an ‘integrated’ or ‘holistic’ approach to tackling problems. Despite the talk, both practice and research provide few platforms that allow for ‘joined up’ thinking and action. With socio-economic phenomena, such as land redevelopment, promising prospects open up when we assume that their constituents can make up complex systems whose emergent properties are more than the sum of the parts and whose behaviour is inherently difficult to predict. A review of previous research shows that it has mainly focused on idealised, ‘mechanical’ views of property development processes that fail to recognise in full the relationships between actors, the structures created and their emergent qualities. When reality failed to live up to the expectations of these theoretical constructs then somebody had to be blamed for it: planners, developers, politicians. However, from a ‘synthetic’ point of view the agents and networks involved in property development can be seen as constituents of structures that perform complex processes. These structures interact, forming new more complex structures and networks. Redevelopment then can be conceptualised as a process of transformation: a complex system, a ‘dissipative’ structure involving developers, planners, landowners, state agencies etc., unlocks the potential of previously used sites, transforms space towards a higher order of complexity and ‘consumes’ but also ‘creates’ different forms of capital in the process. Analysis of network relations point toward the ‘dualism’ of structure and agency in these processes of system transformation and change. Insights from actor network theory can be conjoined with notions of complexity and chaos to build an understanding of the ways in which actors actively seek to shape these structures and systems, whilst at the same time are recursively shaped by them in their strategies and actions. This approach transcends the blame game and allows for inter-disciplinary inputs to be placed within a broader explanatory framework that does away with many past dichotomies. Better understanding of the interactions between actors and the emergent qualities of the networks they form can improve our comprehension of the complex socio-spatial phenomena that redevelopment comprises. The insights that this framework provides when applied in UK institutional investment into redevelopment are considered to be significant.

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Facioscapulohumeral muscular dystrophy (FSHD) is a progressive muscle disorder that has been associated with a contraction of 3.3-kb repeats on chromosome 4q35. FSHD is characterized by a wide clinical inter- and intrafamilial variability, ranging from wheelchair-bound patients to asymptomatic carriers. Our study is unique in comparing the gene expression profiles from related affected, asymptomatic carrier, and control individuals. Our results suggest that the expression of genes on chromosome 4q is altered in affected and asymptomatic individuals. Remarkably, the changes seen in asymptomatic samples are largely in products of genes encoding several chemokines, whereas the changes seen in affected samples are largely in genes governing the synthesis of GPI-linked proteins and histone acetylation. Besides this, the affected patient and related asymptomatic carrier share the 4qA161 haplotype. Thus, these polymorphisms by themselves do not explain the pathogenicity of the contracted allele. Interestingly, our results also suggest that the miRNAs might mediate the regulatory network in FSHD. Together, our results support the previous evidence that FSHD may be caused by transcriptional dysregulation of multiple genes, in cis and in trans, and suggest some factors potentially important for FSHD pathogenesis. The study of the gene expression profiles from asymptomatic carriers and related affected patients is a unique approach to try to enhance our understanding of the missing link between the contraction in D4Z4 repeats and muscle disease, while minimizing the effects of differences resulting from genetic background.

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This study aimed to evaluate the potential of soybean-promoted acidic nitrite reduction and to correlate this activity with the content of phenolics and with the bactericidal activity against Escherichia coli O157:H7. Extracts of embrionary axes and cotyledons enriched in phenolics increased (center dot)NO formation at acidic pH at values that were 7.1 and 4.5 times higher, respectively, when compared to the reduction of the nonenriched extracts. Among the various phenolics accumulated in the soybean extracts, five stimulated nitrite reduction in the following decreasing order of potency: epicatechin gallate, chlorogenic acid, caffeic acid, galic acid and p-coumaric acid. Extracts of embrionary axes presented higher contents of epicatechin gallate and caffeic acid, compared to that of cotyledons, indicating a positive correlation between activity of the extracts and content of phenolics with regard to nitrite reducing activity. Soybean extracts enriched in phenolics interacted synergistically with acidified nitrite to prevent E. coli O157:H7 growth. The results suggest that soybean phenolics may interfere with the metabolism of (center dot)NO in an acidic environment by accelerating the reduction of nitrite, with a potential antimicrobial effect in the stomach.

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Vários autores defendem a evolução dos sistemas de produção atuais para o que seria um modelo pós-industrial ou informacional, revendo alguns conceitos fundamentais no campo da administração, como a padronização da produção, as economias de escala, os fatores de motivação do grupos organizacionais e a estrutura organizacional. Autores como Alvin Tofler e Daniel Bell falaram em industrialismo e informacionalismo (ou pós-industrialismo). (Tofler, 1970, 1980; Bell, 1970). Estes conceitos estão sendo retomados por outros autores, atualmente, para descrever a evolução da sociedade ocidental e das organizações. (Castells, 1999) (De Masi, 2000). O surgimento do conceito de aprendizagem organizacional a partir de um certo momento, entrou na moda e passou a fazer parte do discurso empresarial padrão, estando associado ao modelo Pós-Industrial. Pretende-se, neste projeto, fazer uma análise crítica da evolução do conceito de aprendizagem nas organizações, definindo-se e analisando-se as diversas teorias que tratam deste tema.

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O presente estudo propõe-se a investigar as práticas pedagógicas desenvolvidas na Escola Municipal de Frevo do Recife, visando a identificar Inovação Pedagógica neste contexto escolar. O objetivo é compreender como a corporeidade se constitui enquanto processo que possibilita o desenvolvimento de ações pedagógicas inovadoras. Visando tal objeto a pesquisa fundamenta-se em estudos que abordam a relação educação e corporeidade. O estudo dividese em duas partes, uma epistemológica e a outra metodológica. A primeira parte fornece os fundamentos teóricos que sustentam o estudo, contextualizando a corporeidade enquanto elemento da linguagem educacional. Identifica o que os saberes científicos têm apontado sobre o corpo e sua relação com a área educacional, segundo os autores: Merleau-Ponty (1994), Alvin Toffler (1980), Seymour Papert (1994), Gimeno Sacristán (2002), Carlos Fino (2008), Jesus Maria Sousa (2005). A segunda parte contempla a abordagem etnográfica discutida por Georges Lapassade (2005), Roberto Macedo (2010), Laurence Bardin (1997). Participaram da pesquisa os professores e os estudantes adolescentes e jovens que frequentam a Escola de Frevo perquirida. Com base nas falas dos sujeitos investigados, obteve-se, como resultado, algumas categorias, as quais se podem destacar: A arte dançante enquanto espaço para a formação; valorização do frevo; a dança como expressão da emoção; a construção da identidade pernambucana a partir do frevo. Nesse sentido, os dados apontaram que a Escola de Frevo pesquisada apresenta práticas pedagógicas que possibilitam o desenvolvimento de aprendizagem significativa. Desse modo, pode-se inferir que as práticas pedagógicas propostas na Escola de Frevo, em estudo, possibilitaram práticas pedagógicas que incentivam e desenvolvem a formação humana, pois se observa, nos depoimentos dos estudantes investigados, a valorização e o reconhecimento social. Como fator inovador, constatou-se maior liberdade para se expressar, criar, ousar, num imbrincamento entre a tradição e a inovação. Com relação às práticas pedagógicas dançantes, destacou-se a compreensão numa visão de educação integral onde inventividade, ludicidade, sensualidade e energia pulsante, construíram aprendizagens próprias, mediante uma prática pedagógica singular que justifica esta ação investigadora contextualizada na Escola de Frevo investigada. Esta pesquisa possibilitou perceber que a intencionalidad pedagógica centrada no lúdico, na corporeidade, nas interações e nas inúmeras apresentações que reforçam as ações e podem levar à Inovação Pedagógica.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Many cell types have no known functional attributes. In the bladder and prostate, basal epithelial and stromal cells appear similar in cytomorphology and share several cell surface markers. Their total gene expression (transcriptome) should provide a clear measure of the extent to which they are alike functionally. Since urologic stromal cells are known to mediate organ-specific tissue formation, these cells in cancers might exhibit aberrant gene expression affecting their function. For transcriptomes, cluster designation (CD) antigens have been identified for cell sorting. The sorted cell populations can be analyzed by DNA microarrays. Various bladder cell types have unique complements of CD molecules. CD9(+) urothelial, CD104(+) basal and CD13(+) stromal cells of the lamina propria were therefore analyzed, as were CD9(+) cancer and CD13(+) cancer-associated stromal cells. The transcriptome datasets were compared by principal components analysis for relatedness between cell types; those with similarity in gene expression indicated similar function. Although bladder and prostate basal cells shared CD markers such as CD104, CD44 and CD49f, they differed in overall gene expression. Basal cells also lacked stem cell gene expression. The bladder luminal and stromal transcriptomes were distinct from their prostate counterparts. In bladder cancer, not only the urothelial but also the stromal cells showed gene expression alteration. The cancer process in both might thus involve defective stromal signaling. These cell-type transcriptomes provide a means to monitor in vitro models in which various CD-isolated cell types can be combined to study bladder differentiation and bladder tumor development based on cell-cell interaction.

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BACKGROUND CD90+ prostate cancer-associated (CP) stromal cells represent a diseased cell type found only in tumor tissue. They differ from their normal counterpart in gene expression and inductive signaling. Genetic reprogramming by induced pluripotent stem (iPS) cell technology can effectively change adult cells into stem-like cells through wholesale alteration of the gene expression program. This technology might be used to erase the abnormal gene expression of diseased cells. The resultant iPS cells would no longer express the disease phenotype, and behave like stem cells. METHODS CP stromal cells, isolated from tumor tissue of a surgically resected prostate by anti-CD90-mediated sorting and cultured in vitro, were transfected with in vitro packaged lentiviral expression vectors containing stem cell transcription factor genes POU5F1, LIN28, NANOG, and SOX2. RESULTS Alkaline phosphatase-positive iPS cells were obtained in about 3 weeks post-transfection at a frequency of 10-4. Their colony morphology was indistinguishable from that of human embryonic stem (ES) cells. Transcriptome analysis showed a virtually complete match in gene expression between the iPS and ES cells. CONCLUSIONS Genes of CP stromal cells could be fully inactivated by genetic reprogramming. As a consequence, the disease phenotype was cured. Prostate 72:14531463, 2012. (c) 2012 Wiley Periodicals, Inc.