HealthMap: A cluster randomised trial of interactive health plans and self-management support to prevent coronary heart disease in people with HIV

Background The leading causes of morbidity and mortality for people in high-income countries living with HIV are now non-AIDS malignancies, cardiovascular disease and other non-communicable diseases associated with ageing. This protocol describes the trial of HealthMap, a model of care for people with HIV (PWHIV) that includes use of an interactive shared health record and self-management support. The aims of the HealthMap trial are to evaluate engagement of PWHIV and healthcare providers with the model, and its effectiveness for reducing coronary heart disease risk, enhancing self-management, and improving mental health and quality of life of PWHIV. Methods/Design The study is a two-arm cluster randomised trial involving HIV clinical sites in several states in Australia. Doctors will be randomised to the HealthMap model (immediate arm) or to proceed with usual care (deferred arm). People with HIV whose doctors are randomised to the immediate arm receive 1) new opportunities to discuss their health status and goals with their HIV doctor using a HealthMap shared health record; 2) access to their own health record from home; 3) access to health coaching delivered by telephone and online; and 4) access to a peer moderated online group chat programme. Data will be collected from participating PWHIV (n = 710) at baseline, 6 months, and 12 months and from participating doctors (n = 60) at baseline and 12 months. The control arm will be offered the HealthMap intervention at the end of the trial. The primary study outcomes, measured at 12 months, are 1) 10-year risk of non-fatal acute myocardial infarction or coronary heart disease death as estimated by a Framingham Heart Study risk equation; and 2) Positive and Active Engagement in Life Scale from the Health Education Impact Questionnaire (heiQ). Discussion The study will determine the viability and utility of a novel technology-supported model of care for maintaining the health and wellbeing of people with HIV. If shown to be effective, the HealthMap model may provide a generalisable, scalable and sustainable system for supporting the care needs of people with HIV, addressing issues of equity of access. Trial registration Universal Trial Number (UTN) U111111506489; ClinicalTrial.gov Id NCT02178930 submitted 29 June 2014

Crystal structure of an intermolecular 2:1 complex between adenine and thymine.Evidence for both Hoogsteen and `quasi-Watson-Crick' interactions

The titled complex, obtained by co-crystallization (EtOH/25 degrees C),is apparently the only known complex of the free bases. Its crystal structure, as determined by X-ray diffraction at both 90 K and 313 K, showed that one A-T pair involves a Hoogsteen interaction, and the other a Watson-Crick interaction but only with respect to the adenine unit. The absence of a clear-cut Watson-Crick base pair raises intriguing questions about the basis of the DNA double helix. (C) 2010 Elsevier Ltd. All rights reserved.

El clero argentino durante la Revolución (1810- 1816) según las oraciones patrióticas : análisis de los casos de: Diego Zabaleta, Gregorio Funes, Francisco de Paula Castañeda y Pedro de Castro Barros

Resumen: El presente trabajo es un análisis individual de cada Oración Patriótica enunciada en el título. En cada una de ellas se destaca, como eje de estudio, el lenguaje utilizado y el orden dialéctico que cada personaje propone. El tiempo histórico en que cada uno de los discursos fue pronunciado es también analizado como relación directa a la naturaleza del mensaje. Se busca remarcar además la preeminencia que tuvo el clero criollo como uno de los actores sociales fundamentales del proceso revolucionario.

La Iglesia y el movimiento independentista rioplatense: incertidumbres, aceptación y acompañamiento (1810-1816)

En torno al sexenio comprendido entre las dos fechas distintivas del Bicentenario argentino, 1810 y 1816, el autor se propone una lectura histórica sobre los hombres y las ideas que rodearon a la Primera Junta de gobierno, la función propagandista del clero, el cuestionamiento por parte de dos obispos de la legitimidad de la revolución y el apoyo de un obispo patriota, el período de “interregno episcopal” y la continuidad religiosa, la obra cultural de la Junta y la celebración del Congreso de la Independencia en Tucumán. Se afirma, a partir de las fuentes, el lugar de aceptación que tuvo la IglesiaCatólica en esta época.

Collecção das Leis do Brazil de 1816

Parte 1 - Cartas de Lei, Alvarás, Decretos e Cartas Régias

Der Sängerkrieg auf der Wartburg. El tema de la lid de los poetas y su recepción literaria en Novalis, E. T. A. Hoffmann, Friedrich de la Motte Fouqué y Richard Wagner

282 págs.Correo electrónico: bea.muro@gmail.com

Memoria politica sobre a capitania de Santa Catharina, escripta no Rio de Janeiro em o anno de 1816

Tabella das produções dos tres Reinos da Natureza, que ha na capitania de Santa Catharina, escriptas por ordem alphabetica : reino vegetal, reino animal. Mappa das producções, consumo, e exportação da Capitania de Santa Catharina, no anno de 1810. Calculo aproximado das despezas da companhia, durante a primeira epocha, em conformidade do disposto nos artigos 2, 3., 4., 6., do appendice.

Voyage au Brésil, dans les années 1815, 1816 et 1817

Ouvrage enrichi d'un superbe atlas, compose de 41 planches gravées en taille-douce, et de trois carte.

Beyond Watson and Crick : programming the self-assembly and reconfiguration of DNA nanostructures based on stacking interactions

Life is the result of the execution of molecular programs: like how an embryo is fated to become a human or a whale, or how a person’s appearance is inherited from their parents, many biological phenomena are governed by genetic programs written in DNA molecules. At the core of such programs is the highly reliable base pairing interaction between nucleic acids. DNA nanotechnology exploits the programming power of DNA to build artificial nanostructures, molecular computers, and nanomachines. In particular, DNA origami—which is a simple yet versatile technique that allows one to create various nanoscale shapes and patterns—is at the heart of the technology. In this thesis, I describe the development of programmable self-assembly and reconfiguration of DNA origami nanostructures based on a unique strategy: rather than relying on Watson-Crick base pairing, we developed programmable bonds via the geometric arrangement of stacking interactions, which we termed stacking bonds. We further demonstrated that such bonds can be dynamically reconfigurable.

The first part of this thesis describes the design and implementation of stacking bonds. Our work addresses the fundamental question of whether one can create diverse bond types out of a single kind of attractive interaction—a question first posed implicitly by Francis Crick while seeking a deeper understanding of the origin of life and primitive genetic code. For the creation of multiple specific bonds, we used two different approaches: binary coding and shape coding of geometric arrangement of stacking interaction units, which are called blunt ends. To construct a bond space for each approach, we performed a systematic search using a computer algorithm. We used orthogonal bonds to experimentally implement the connection of five distinct DNA origami nanostructures. We also programmed the bonds to control cis/trans configuration between asymmetric nanostructures.

The second part of this thesis describes the large-scale self-assembly of DNA origami into two-dimensional checkerboard-pattern crystals via surface diffusion. We developed a protocol where the diffusion of DNA origami occurs on a substrate and is dynamically controlled by changing the cationic condition of the system. We used stacking interactions to mediate connections between the origami, because of their potential for reconfiguring during the assembly process. Assembling DNA nanostructures directly on substrate surfaces can benefit nano/microfabrication processes by eliminating a pattern transfer step. At the same time, the use of DNA origami allows high complexity and unique addressability with six-nanometer resolution within each structural unit.

The third part of this thesis describes the use of stacking bonds as dynamically breakable bonds. To break the bonds, we used biological machinery called the ParMRC system extracted from bacteria. The system ensures that, when a cell divides, each daughter cell gets one copy of the cell’s DNA by actively pushing each copy to the opposite poles of the cell. We demonstrate dynamically expandable nanostructures, which makes stacking bonds a promising candidate for reconfigurable connectors for nanoscale machine parts.

Occurrence of the Macrocyclops distinctus (Richard) (Copepoda, cyclopoidida) in Rybinsk reservoir. [Translation of: Materialy po biologii i gidrologii Volzhskikh Vodokhranilishch. Moscow, Leningrad 1963, pp. 13-16]

This brief chapter describes the occurrence Macrocyclops distinctus in the littoral zone of the Rybinsk Reservoir. Sampling was undertaken in summer and autumn 1961. In order to facilitate distinction of M. distinctus and Macrocyclops fuscus the author presents drawings of the whole species and certain characteristic parts of the body, and also gives a description of M. distinctus, comparing it with M. fuscus.

Del boceto al objeto a través del BIT en la obra "La materia del tiempo", de Richard Serra

423 p.

Presságios literários e herança plástica: Emerson e Thoreau; Richard Serra, Waltercio Caldas e outros

O presente estudo ambiciona examinar as escritas literárias de Ralph Waldo Emerson (1803-1882) e Henry David Thoreau (1817-1862) considerando-as como uma forma de presságio de arte na América, ou seja, como uma escrita literária que parece ter sido herdada no ambiente artístico das obras plásticas contemporâneas de Richard Serra (1939-) e Waltercio Caldas (1946-), entre outras. Tal herança endossa a noção de linguagem ordinária, compreendida como o ponto de acolhimento, ou de uma inquietação, que se faz presente nas circunstâncias da contemporaneidade. Por sua vez, o gesto de endereçamento que envolve estas escrituras expressa a marca de uma indecibilidade acerca da continuidade ou descontinuidade da existência de categorias como literatura, filosofia e artes. Assim, a problematização dessas remissões ganha vulto no presente estudo, por meio de uma abordagem em perspectiva comparada entre Thoreau, Emerson, Waltercio, Serra e outros. E deste modo, a questão que se estabelece nesse panorama diz respeito aos problemas do pensamento, que em âmbito plástico parecem se estender para uma tradição crítica no Novo Mundo

O pragmatismo antiteórico de Richard A. Posner e as respostas da teoria moral para a decisão judicial

Este trabalho apresenta uma análise crítica à forma de se abordar casos jurídicos e proferir decisões judiciais denominada abordagem judicial pragmática, disseminada pelo magistrado e professor norte-americano Richard A. Posner. O objetivo é explicitar suas principais características e contornos, bem como sua repulsa pela teorização abstrata e pelos debates e argumentos morais na decisão judicial. A partir disso, pretende-se refutar parte dessa abordagem pragmática, por meio de argumentos levantados por filósofos morais e profissionais do direito a saber: Ronald Dworkin, Charles Fried, Anthony Kronman, John T. Noonan Jr e Martha C. Nussbaum - em defesa de uma abordagem que prega a inevitável utilização do raciocínio teórico, assim como a argumentação e reflexão moral na resolução de casos difíceis relacionados ao direito. Também será destacado como a repulsa pragmática pela teoria moral e abstrata é incompatível com a conjuntura justeórica contemporânea e como a análise de alguns casos difíceis expõe a falibilidade, ainda que parcial, desse estilo de abordagem pregado por Posner.

Horizontal and vertical movements of juvenile bluefin tuna (Thunnus thynnus) in relation to oceanographic conditions of the western North Atlantic, determined with ultrasonic telemetry

We employed ultrasonic transmitters to follow (for up to 48 h) the horizontal and vertical movements of five juvenile (6.8–18.7 kg estimated body mass) bluefin tuna (Thunnus thynnus) in the western North Atlantic (off the eastern shore of Virginia). Our objective was to document the fishes’ behavior and distribution in relation to oceanographic conditions and thus begin to address issues that currently limit population assessments based on aerial surveys. Estimation of the trends in adult and juvenile Atlantic bluefin tuna abundance by aerial surveys, and other fishery-independent measures, is considered a priority. Juvenile bluefin tuna spent the majority of their time over the continental shelf in relatively shallow water (generally less then 40 m deep). Fish used the entire water column in spite of relatively steep vertical thermal gradients (≈24°C at the surface and ≈12°C at 40 m depth), but spent the majority of their time (≈90%) above 15 m and in water warmer then 20°C. Mean swimming speeds ranged from 2.8 to 3.3 knots, and total distance covered from 152 to 289 km (82–156 nmi). Because fish generally remained within relatively con-fined areas, net displacement was only 7.7–52.7 km (4.1–28.4 nmi). Horizontal movements were not correlated with sea surface temperature. We propose that it is unlikely that juvenile bluefin tuna in this area can detect minor horizontal temperature gradients (generally less then 0.5°C/km) because of the steep vertical temperature gradients (up to ≈0.6°C/m) they experience during their regular vertical movements. In contrast, water clarity did appear to influence behavior because the fish remained in the intermediate water mass between the turbid and phytoplankton-rich plume exiting Chesapeake Bay (and similar coastal waters) and the clear oligotrophic water east of the continental shelf.