Crystal structure of an intermolecular 2:1 complex between adenine and thymine.Evidence for both Hoogsteen and `quasi-Watson-Crick' interactions
| Data(s) |
15/06/2010
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| Resumo |
The titled complex, obtained by co-crystallization (EtOH/25 degrees C),is apparently the only known complex of the free bases. Its crystal structure, as determined by X-ray diffraction at both 90 K and 313 K, showed that one A-T pair involves a Hoogsteen interaction, and the other a Watson-Crick interaction but only with respect to the adenine unit. The absence of a clear-cut Watson-Crick base pair raises intriguing questions about the basis of the DNA double helix. (C) 2010 Elsevier Ltd. All rights reserved. |
| Formato |
application/pdf |
| Identificador |
http://eprints.iisc.ernet.in/28562/1/letters.pdf Chandrasekhar, Sosale and Naik, TangaliRavikumar R and Nayak, Susanta K and Row, TayurGuru N (2010) Crystal structure of an intermolecular 2:1 complex between adenine and thymine.Evidence for both Hoogsteen and `quasi-Watson-Crick' interactions. In: Bioorganic & Medicinal Chemistry Letters, 20 (12). pp. 3530-3533. |
| Publicador |
Elsevier Science |
| Relação |
http://dx.doi.org/10.1016/j.bmcl.2010.04.131 http://eprints.iisc.ernet.in/28562/ |
| Palavras-Chave | #Solid State & Structural Chemistry Unit #Organic Chemistry |
| Tipo |
Journal Article PeerReviewed |
