Evaluation of sediment production and siltation in a small earth dam in Fernandópolis, SP

The siltation is a natural process, but can be accelerated by human actions and results in major problems for the reservoirs, reducing its useful volume for irrigation. An example of this problem was the reduction of the area of mirror water of Fernandópolis municipal dam in 48.3% during 20 years. Therefore, this study aimed to evaluate the production of sediments and siltation of Fernandópolis municipal dam from a methodology that can be applied to small earth dams for agricultural purposes. For this, it was monitored, monthly throughout the year, the volume of sediment deposited in the reservoir. The percentage of retention sediment in Fernandópolis municipal dam ranged from 53.9 to 94.5%, that associated with a high specific sediment yield, will cause its full silting in at most 57 years. It is recommended to minimize this process the restoration of permanent preservation areas and the removal of 17,500 m³ of sediment from the riverbed of the dam.

AGRICULTURAL MACHINERY AND IMPLEMENTS DESIGN PROCESS: GUIDELINES FOR SMALL AND MID-SIZED BUSINESSES

ABSTRACT This study aims at presenting the process of machine design and agricultural implements by means of a reference model, formulated with the purpose of explaining the development activities of new products, serving as a guideline to coach human resources and to assist in formalizing the process in small and medium-sized businesses (SMB), i.e. up to 500 employees. The methodology used included the process modeling, carried out from case studies in the SMB, and the study of reference models in literature. The modeling formalism used was based on the IDEF0 standard, which identifies the dimensions required for the model detailing: input information; activities; tasks; knowledge domains; mechanisms; controls and information produced. These dimensions were organized in spreadsheets and graphs. As a result, a reference model with 27 activities and 71 tasks was obtained, distributed over four phases of the design process. The evaluation of the model was carried out by the companies participating in the case studies and by experts, who concluded that the model explains the actions needed to develop new products in SMB.

Performance of small wind turbines: simulation of electricity supply to loads connected to the public or isolated grid

ABSTRACT The successful in the implementation of wind turbines depends on several factors, including: the wind resource at the installation site, the equipment used, project acquisition and operational costs. In this paper, the production of electricity from two small wind turbines was compared through simulation using the computer software HOMER - a national model of 6kW and an imported one of 5kW. The wind resources in three different cities were considered: Campinas (SP/BR), Cubatão (São Paulo/BR) and Roscoe (Texas/ USA). A wind power system connected to the grid and a wind isolated system - batteries were evaluated. The results showed that the energy cost ($/kWh) is strongly dependent on the windmill characteristics and local wind resource. Regarding the isolated wind system – batteries, the full supply guarantee to the simulated electrical load is only achieved with a battery bank with many units and high number of wind turbines, due to the intermittency of wind power.

Small potatoes - palasia naisten työnteon historiasta

Kirjallisuusarvostelu

Small animal endoscopy

Kirjallisuusarvostelu

Ylioptimismin Vaikutus Listautumisantien Alihinnoitteluun Suomen Markkinoilla

Osakeyhtiöiden pörssiin listautumisia tutkittaessa on yleisesti huomattu, että ensimmäisen listautumispäivän aikana kyseisten yhtiöiden osakkeiden tarjoamat tuotot ovat poikkeuksellisen suuria. Kyseinen ilmiö tunnetaan yleisesti listautumisannin alihinnoittelun anomaliana. Listautumisista keskusteltaessa teorioita on luotu kolmesta eri anomaliasta; (i) uusien osakkeiden alihinnoittelu, (ii) alihinnoittelun syklisyys (Ritter, 1984) ja (iii) alihinnoitellun listautumisannin pitkän aikavälin huono menestyminen (Ritter, 1991). Useat tutkimukset (mm. Beatty ja Ritter, 1986) osoittavat, että ainoastaan maltillinen alihinnoittelu on edukasta listautuvalle yritykselle, mutta ennen kaikkea annin järjestäjälle. Lisäksi mm. Shillerin (1990) tekemä kyselytutkimus, jonka mukaan suurin osa sijoittajista ei perusta listautuvaan yritykseen kohdistuvia sijoituksiaan fundamentteihin, osoittaa, että tuotot eivät ole puhtaasti seurausta ainoastaan alihinnoittelusta. Tämä tutkimus pyrkii määrittelemään aiemmin vähäisesti tutkittua markkinoiden ylioptimismin vaikutusta listautumisannin jälkeisiin ensimmäisen päivän tuottoihin (alihinnoitteluun), käyttämällä aiempien tutkimusten tuloksia ja perusteltuja päätelmiä teoriapohjan luonnissa. Luotua teoriaa testataan empiirisesti käyttäen hyödyksi Helsingin pörssiin (OMXH) listautuneista yrityksistä vuodesta 1998 vuoden 2007 loppuun kerättyä dataa. Aineiston tuottamat tulokset tukivat aiempaa kirjallisuutta. Lisäksi tutkimuksista kyettiin toteamaan, että ylioptimismilla on vaikutusta listautumisantien jälkeisissä lyhyen aikavälin tuotoissa. Tuloksiin on kuitenkin suhtauduttava kriittisesti pienen aineistokoon takia.

Finnish Institutional Innovation Support Policies from Russian Entrepreneurs' Perspective: Establishing Cross-Border Technology Oriented Start-Up Firm

The purpose of this thesis is to study how Russian entrepreneurs perceive Finnish institutional environment and innovation support policies provided in the country, as well as to present a practical example in form of a case study of one technology oriented start-up firm which was established in Finland by Russian entrepreneurs. The empirical research of the thesis is conducted qualitatively in two parts. First part is conducted through online questionnaire with open questions in order to review the perceptions of Russian entrepreneurs in general. Second part is based on personal interviews with case company’s founders with the focus on the process of establishing the company in Finland. In the first part of the empirical research, five Russian start-up firms were contacted, and four responses were received. All of these responses were qualified for further analysis. The findings of the first part of the research reveal that Russian entrepreneurs have rather positive attitudes towards Finnish institutional innovation support policies. However, most of the entrepreneurs stated that they are unlikely to create their presence in Finland. As an outcome of the second part of the research, the process of establishing a case company in Finland is illustrated. In order to be able to establish companies in Finland, Russian entrepreneurs who have a permanent residence outside European Economic Area (EEA) are required to apply for a permission to perform business operations in the country. In addition, the established company must engage in improving the economical stand of the country by creating new work places, raising tax revenues, develop technologies and generate innovations in the country.

Empiirinen analyysi tilitoimiston liikeriskeistä ja niiden hallinnasta

Tämän tutkimuksen aiheena ovat tilitoimiston liikeriskit ja niiden hallinta. Tilitoimistot ovat merkittävässä asemassa tuottaessaan asiakasyrityksistään taloudellista tietoa paitsi yritykselle itselleen myös sen sidosryhmille sekä yhteiskunnalle. Tilitoimiston toimintaa ja samalla riskienhallintaa ohjaa erityisesti hyvä tilitoimistotapa, jonka noudattaminen auttaa ylläpitämään ammatillista arvostusta. Tilitoimiston liikeriskit voidaan jakaa henkilöstöriskeiksi, sopimus- ja vastuuriskeiksi sekä tietoriskeiksi, joihin kuuluvat myös väärinkäytösriskit. Sopimus- ja vastuuriskejä hallitaan kirjallisin toimeksiantosopimuksin vakiosopimusehtoja käyttämällä sekä vastuuvakuutuksin. Tietoriskien hallinnassa apuna ovat salas-sapitosopimukset, tietoturvatoimet ja ohjeet. Väärinkäytösriskejä hallitaan parhaiten ennaltaehkäisemällä. Henkilöstö on tilitoimistojen suurin resurssi, mutta samalla myös suurin riskitekijä. Henkilöstö on myös avainasemassa tilitoimistojen riskienhallinnan toteuttamisessa. Suurimpia henkilöstöön kohdistuvia riskejä ovat avainhenkilöihin, työhyvinvointiin, jaksamiseen, motivaatioon sekä työvoiman saatavuuteen kohdistuvat riskit. Näitä kaikkia pystytään hallitsemaan toimivalla henkilöstöhallinnolla ja varahenkilöjärjestelmillä. Tutkimuksen empiirinen osio toteutettiin satunnaisesti valittuihin eteläsuomalaisiin tilitoimistoihin suunnatulla kyselytutkimuksella. Tutkimustuloksista käy ilmi, että tilitoimistojen tieto-, sopimus- ja vastuuriskien hallinta on hyvällä tasolla, mutta että henkilöstöriskien hallinnassa on jonkin verran parantamisen varaa. Tutkimus vahvistaa myös, että pk-sektorilla toimivien tilitoimistojen kannattaa käyttää kokonaisvaltaista riskienhallintaa liikeriskiensä hallitsemiseen ja toiminnan laadun turvaamiseen.

Vapaaehtoinen tilintarkastus pienissä yrityksissä - empiirinen tutkimus

Tutkimuksen tavoitteena oli löytää ne tekijät, jotka vaikuttavat vapaaehtoisen tilintarkastuksen valintaan pienissä yrityksissä. Pienen yrityksen rajat määriteltiin noudattaen tilintarkastuslaissa säädettyjä rajoja tilintarkastusvelvollisuudesta. Empiirinen osuus suoritettiin kvalitatiivisena usean tapauksen tutkimuksena haastattelemalla kuutta eri pienyrityksen johtoon tai omistukseen kuuluvaa henkilöä. Aineisto kerättiin puolistrukturoidun ja teemahaastattelun välimaastoon sijoittuvilla haastatteluilla. Tulokset analysoitiin kokoamalla litteroiduista haastatteluista kokonaisuudet teemoittain. Tutkimuksessa haastateltiin myös tilintarkastajaa sekä pankin edustajaa puolistrukturoidulla haastattelulla lisäämään tulosten luotettavuutta. Tutkimuksen tulosten perusteella tilintarkastuksen valintaan vaikuttavia tekijöitä löytyi useita, sekä negatiivisia että positiivisia. Aikaisemmista tutkimuksista tuttujen ulkoisen rahoituksen, verottajan, ulkoistetun taloushallinnon sekä omistusrakenteen lisäksi uudeksi tilintarkastuksen valintaan vaikuttavaksi tekijäksi löydettiin toimiala. Yritysten välisen kaupankäynnin toimialoilla näyttäisi tutkimuksen perusteella olevan vaikutus tilintarkastukseen, mutta tutkimuksessa käytetyn pienen yritysjoukon takia tarvitaan lisätutkimuksia tekijän vaikutuksesta.

Leiomioma perfurado do intestino delgado

A perforated jejunal leiomyoma is a rare condition; only seven cases have been described in the literature. We report a case of a 45 years old man with a perforate acute abdomen. At laparotomy, a 12 cm multilobulated firm mass, located 20 cm distal from Treitz ligament, was removed. Histological sections disclosed a jejunal leiomyoma. The benign pattern of the lesion was confirmed with no mitosis and no atypical cellurarity. Five years later, the patient is free of the disease.

SOCIAL MEDIA IN INTERNATIONAL BRAND COMMUNICATION OF SMES - A multiple case study of small Finnish design-intensive companies

Social media is a rather new phenomenon which has revolutionised the world of online communication. However, academic research on how companies can benefit from social media is lacking. The research objective of this thesis was to examine the use of social media in international brand communication of small Finnish design-intensive companies. Therefore, this research contributes also to the research gap in SME branding. The focus was on communication targeted at consumers. The research was carried out as a mixed methods research employing the questionnaire and multiple case study methods. The questionnaire was used to gather preliminary information on Finnish design-intensive companies and to provide an eligible list of companies for deeper examination. Then, four case companies were studied in more depth. The empirical evidence of the case companies was mainly gathered through theme interviews. The results of the questionnaire shed light on the internationalisation of small Finnish designintensive companies. On average, the companies had internationalised rather quickly after they had been founded. However, the share of exports was rather low in most of the companies. The results revealed also that social media was already used widely in the exporting companies and the use can be expected to grow in future. The findings of the multiple case study suggest that branding activities in small Finnish designintensive companies are constrained by limited resources and skills. In addition, the branding activities are strongly guided by the vision and values of the entrepreneur(s) rather than extensive marketing research. The brand structure was simple in all case companies and they aimed at having a standardised brand image across markets. However, all case companies had faced a need for some adaptation of their international brand communication. Internationally important brand communication channels were international fairs, the internet, word-of-mouth and social media. Social media offered a cost-effective brand communication channel for the case companies. It was used for various purposes, such as creating brand awareness and affecting how the brand is perceived. The entrepreneurs found the use of social media to be rather easy and the case companies had not faced any major challenges. However, the companies had recognised that communication in social media requires consistency and planning. The planning was rather informal and stayed on a general level. Overall, the utilisation of social media in the case companies was limited by a lack of resources. It seemed to affect especially the follow-up of brand communication in social media which stayed rather superficial.

The spindle assembly checkpoint as a drug target - Novel small-molecule inhibitors of Aurora kinases

Cell division (mitosis) is a fundamental process in the life cycle of a cell. Equal distribution of chromosomes between the daughter cells is essential for the viability and well-being of an organism: loss of fidelity of cell division is a contributing factor in human cancer and also gives rise to miscarriages and genetic birth defects. For maintaining the proper chromosome number, a cell must carefully monitor cell division in order to detect and correct mistakes before they are translated into chromosomal imbalance. For this purpose an evolutionarily conserved mechanism termed the spindle assembly checkpoint (SAC) has evolved. The SAC comprises a complex network of proteins that relay and amplify mitosis-regulating signals created by assemblages called kinetochores (KTs). Importantly, minor defects in SAC signaling can cause loss or gain of individual chromosomes (aneuploidy) which promotes tumorigenesis while complete failure of SAC results in cell death. The latter event has raised interest in discovery of low molecular weight (LMW) compounds targeting the SAC that could be developed into new anti-cancer therapeutics. In this study, we performed a cell-based, phenotypic high-throughput screen (HTS) to identify novel LMW compounds that inhibit SAC function and result in loss of cancer cell viability. Altogether, we screened 65 000 compounds and identified eight that forced the cells prematurely out of mitosis. The flavonoids fisetin and eupatorin, as well as the synthetic compounds termed SACi2 and SACi4, were characterized in more detail utilizing versatile cell-based and biochemical assays. To identify the molecular targets of these SAC-suppressing compounds, we investigated the conditions in which SAC activity became abrogated. Eupatorin, SACi2 and SACi4 preferentially abolished the tensionsensitive arm of the SAC, whereas fisetin lowered also the SAC activity evoked by lack of attachments between microtubules (MTs) and KTs. Consistent with the abrogation of SAC in response to low tension, our data indicate that all four compounds inhibited the activity of Aurora B kinase. This essential mitotic protein is required for correction of erratic MT-KT attachments, normal SAC signaling and execution of cytokinesis. Furthermore, eupatorin, SACi2 and SACi4 also inhibited Aurora A kinase that controls the centrosome maturation and separation and formation of the mitotic spindle apparatus. In line with the established profound mitotic roles of Aurora kinases, these small compounds perturbed SAC function, caused spindle abnormalities, such as multi- and monopolarity and fragmentation of centrosomes, and resulted in polyploidy due to defects in cytokinesis. Moreover, the compounds dramatically reduced viability of cancer cells. Taken together, using a cell-based HTS we were able to identify new LMW compounds targeting the SAC. We demonstrated for the first time a novel function for flavonoids as cellular inhibitors of Aurora kinases. Collectively, our data support the concept that loss of mitotic fidelity due to a non-functional SAC can reduce the viability of cancer cells, a phenomenon that may possess therapeutic value and fuel development of new anti-cancer drugs.

Application of social media and ICT-tools in new and small business ventures.

The current research emphasizes on various questions raised and deliberated upon by different entrepreneurs. It provides a valuable contribution to comprehend the importance of social media and ICT-applications. Furthermore, it demonstrates how to support and implement the management consulting and business coaching start-ups with the help of social media and ICT-tools. The thesis presents a literary review from different information systems science, SME and e-business journals, web articles, as well as, survey analysis reports on social media applications. The methodology incorporated into a qualitative research method in which social anthropological approaches were used to oversee the case study activities in order to collect data. The collaborative social research approach was used to shelter the action research method. The research discovered that new business start-ups, as well as small businesses do not use social media and ICT-tools, unlike most of the large corporations use. At present, the current open-source ICT-technologies and social media applications are equally available for new and small businesses as they are available for larger companies. Successful implementation of social media and ICT-applications can easily enhance start-up performance and overcome business hassles. The thesis sheds some light on effective and innovative implementation of social media and ICT-applications for new business risk takers and small business birds. Key words