Sistema Essix MTM: uma alternativa estética para a movimentação

The increased interest in orthodontics by adults has led companies to develop new treatment alternatives that use less visible and more aesthetic orthodontic appliances. The aesthetic aligners stand out among the treatment options that attend these expectations. This paper presented some relevant aspects of these devices, as well as two cases treated with Essix MTM (Dentsply) system, in which all aesthetic and functional objectives proposed treatment have been achieved. The results of this study support the idea that, when properly indicated, aesthetic aligners are a viable treatment option within the clinical routine of the orthodontist.

Tentativa católica de modernidade: o conceito de pessoa humana e sua realização histórica (1960-1980)

Pós-graduação em História - FCHS

Alterações celulares induzidas pelo estresse térmico em embriões bovinos

Fundação de Apoio à Pesquisa do Estado de São Paulo (FAPESP)

Roland Barthes e o combate do bem e do mal

O presente artigo parte da releitura de Barthes de Guerra e paz, de Tolstoi, para entender alguns movimentos de escritura presentes nos manuscritos de seu romance "Vita Nova". Para isso, procuramos encontrar um elemento no livro de Tolstoi que ele pretendia desenvolver em seu romance: o combate do Bem e do Mal, questão desenvolvida no último texto escrito por Barthes antes de morrer.

Analysis of the influence of epitope flanking regions on MHC class I restricted antigen presentation

Peptides presented by MHC class I molecules for CTL recognition are derived mainly from cytosolic proteins. For antigen presentation on the cell surface, epitopes require correct processing by cytosolic and ER proteases, efficient TAP transport and MHC class I binding affinity. The efficiency of epitope generation depends not only on the epitope itself, but also on its flanking regions. In this project, the influence of the C-terminal region of the model epitope SIINFEKL (S8L) from chicken ovalbumin (aa 257-264) on antigen processing has been investigated. S8L is a well characterized epitope presented on the murine MHC class I molecule, H-2Kb. The Flp-In 293Kb cell line was transfected with different constructs each enabling the expression of the S8L sequence with different defined C-terminal flanking regions. The constructs differed at the two first C-terminal positions after the S8L epitope, so called P1’ and P2’. At these sites, all 20 amino acids were exchanged consecutively and tested for their influence on H-2Kb/S8L presentation on the cell surface of the Flp-In 293Kb cells. The detection of this complex was performed by immunostaining and flow cytometry. The prevailing assumption is that proteasomal cleavages are exclusively responsible for the generation of the final C-termini of CTL epitopes. Nevertheless, recent publications showed that TPPII (tripeptidyl peptidase II) is required for the generation of the correct C-terminus of the HLA-A3-restricted HIV epitope Nef(73-82). With this background, the dependence of the S8L generation on proteasomal cleavage of the designed constructs was characterized using proteasomal inhibitors. The results obtained indicate that it is crucial for proteasomal cleavage, which amino acid is flanking the C-terminus of an epitope. Furthermore, partially proteasome independent S8L generation from specific S8L-precursor peptides was observed. Hence, the possibility of other existing endo- or carboxy-peptidases in the cytosol that could be involved in the correct trimming of the C-terminus of antigenic peptides for MHC class I presentation was investigated, performing specific knockdowns and using inhibitors against the target peptidases. In parallel, a purification strategy to identify the novel peptidase was established. The purified peaks showing an endopeptidase activity were further analyzed by mass spectrometry and some potential peptidases (like e.g. Lon) were identified, which have to be further characterized.

Le proverbe: une approche contrastive franco-italienne la notion de temps proverbial

Dans un contexte de communication, des bonnes compétences linguistiques ne suffisent pas puisque la connaissance approfondie de la culture cible s’avère également une question fondamentale. Il est donc nécessaire d’adopter une attitude communicative adéquate pour que le message puisse être reçu correctement. Parmi les aspects culturels auxquels le parlant doit accorder une grande importance figurent les proverbes. Les proverbes sont des énoncés d’origine populaire qui recèlent un contenu moral et éthique dont la visée est apprendre aux hommes à bien vivre en société. Les messages véhiculés par les proverbes sont l’héritage de l’expérience des ancêtres dont il faut faire trésor pour comprendre les mœurs, le mode de vie et la pensée d’une communauté donnée : voilà donc pourquoi les proverbes ont été dénommés «sagesse des nations». Depuis la nuit de temps, les proverbes sont transmis de père en fils par voie orale : l’usage quotidien et l’apprentissage par cœur en ont fait des formules fixées dont la structure binaire rimique et rythmique facilite la mémorisation. Par ailleurs, les proverbes sont souvent à interpréter en clé métaphorique, le figement étant l’un des traits définitoires de ce genre du discours. Si les proverbes, énoncés de sagesse populaire, étaient autrefois des sources d’autorité morale, aujourd’hui, au contraire, ils ont perdu leur valeur éthique et sont en train de tomber en désuétude en tant que forme de littérature de deuxième rang, véhiculant des contenus stéréotypés. Néanmoins, les proverbes représentent toujours une clé de lecture pour étudier les sociétés dont ils constituent une partie très importante du patrimoine linguistique et culturel, ce que l’on nomme « patrimoine immatériel ». Le travail que nous allons proposer se penche sur le rôle et l’importance des proverbes, en présentant une approche à l’analyse contrastive des proverbes concernant la notion de temps en langue italienne et française.

Interazione terreno-montante nelle barriere di sicurezza

La tesi inizia indagando il trend degli incidenti con fuoriuscita stradale avvenuti negli ultimi dieci anni andando in seguito a verificare uno dei molteplici aspetti che caratterizzano le barriere di sicurezza, dispositivi installati al fine di ridurre gli effetti delle fuoriuscite. In particolare ci si e concentrati sulla variazione della lunghezza di infissione del montante delle barriere che in terreni differenti da quelli in cui si eseguono i crash-test possono dare risultati risultati differenti in termini di deformazioni della barriera in caso di urto.

Beyond Belief: Japanese Approaches to the Meaning of Religion

For several centuries, Japanese scholars have argued that their nation’s culture—including its language, religion and ways of thinking—is somehow unique. The darker side of this rhetoric, sometimes known by the English term “Japanism” (nihon-jinron), played no small role in the nationalist fervor of the late-nineteenth and early twentieth centuries. While much of the so-called “ideology of Japanese uniqueness” can be dismissed, in terms of the Japanese approach to “religion,” there may be something to it. This paper highlights some distinctive—if not entirely unique—features of the way religion has been categorized and understood in Japanese tradition, contrasting these with Western (i.e., Abrahamic), and to a lesser extent Indian and Chinese understandings. Particular attention is given to the priority of praxis over belief in the Japanese religious context. Des siècles durant, des chercheurs japonais ont soutenu que leur culture – soit leur langue, leur religion et leurs façons de penser – était en quelque sorte unique. Or, sous son jour le plus sombre, cette rhétorique, parfois désignée du terme de « japonisme » (nihon-jinron), ne fut pas sans jouer un rôle déterminant dans la montée de la ferveur nationaliste à la fin du XIXe siècle, ainsi qu’au début du XXe siècle. Bien que l’on puisse discréditer pour l’essentiel cette soi-disant « idéologie de l’unicité japonaise », la conception nippone de la « religion » constitue, quant à elle, un objet d’analyse des plus utiles et pertinents. Cet article met en évidence quelques caractéristiques, sinon uniques du moins distinctives, de la manière dont la religion a été élaborée et comprise au sein de la tradition japonaise, pour ensuite les constrater avec les conceptions occidentale (abrahamique) et, dans une moindre mesure, indienne et chinoise. Une attention toute particulière est ici accordée à la praxis plutôt qu’à la croyance dans le contexte religieux japonais.

Adaptive Cube Tessellation for Topologically Correct Isosurfaces

Three dimensional datasets representing scalar fields are frequently rendered using isosurfaces. For datasets arranged as a cubic lattice, the marching cubes algorithm is the most used isosurface extraction method. However, the marching cubes algorithm produces some ambiguities which have been solved using different approaches that normally imply a more complex process. One of them is to tessellate the cubes into tetrahedra, and by using a similar method (marching tetrahedra), to build the isosurface. The main drawback of other tessellations is that they do not produce the same isosurface topologies as those generated by improved marching cubes algorithms. We propose an adaptive tessellation that, being independent of the isovalue, preserves the topology. Moreover the tessellationallows the isosurface to evolve continuously when the isovalue is changed continuously.

Ephemere Architektur in Sevilla im „Siglo de Oro“ Die Feierlichkeiten zu Ehren Ferdinands III. 1671

Die Einwohner Sevillas wurden im 17. Jahrhundert Zeugen eines besonderen Ereignisses, der Seligsprechung Ferdinands III. von Kastilien und León. Zu seinen Ehren wurde ein Fest veranstaltet, das mit der phantasievollen und reichen Gestaltung seiner ephemeren Architekturen einen Sonderplatz in der Geschichte der andalusischen Stadt einnimmt. Diese Monumente wurden in einer Festpublikation, der für eine größtmögliche Anschaulichkeit Kupferstiche beigefügt wurden, ausführlich geschildert, was eine Rekonstruktion des Aussehens der vergänglichen Architekturen, ihrer vielschichtigen dekorativen Programme und nicht zuletzt der Intentionen hinter den Dekorationen möglich macht.

Beyond the Margins: Analyzing Social Exclusion with a Homeless Client Dataset

A great share of literature on social exclusion has been based mainly on the analysis of official survey data. Whereas these efforts have provided insights into the characteristics and conditions of those people living at the margins of mainstream social relations, they have however failed to encompass those who live beyond these very margins. Meanwhile, research on these hidden subpopulations, such as homeless and other vulnerable groups, remains generally less abundant and is significantly detached from the theoretical core of the debate on social exclusion. The concern about these shortcomings lies at the heart of our research. We seek to bring some light to the area by using data made available by an organization that provides services to people experiencing homelessness in Barcelona (Spain). The data sample contains clients in early stages of exclusion and others in chronic situations. Thus, we attempt to identify some of the variables that operate in preventing the "chronification" of those individuals in situation of social exclusion. Our findings suggest that certain variables such as educational level, income and housing type, which are considered to be central predictors in the analysis of poverty, behave differently when analyzing differences between stages of social exclusion. Although these results cannot be extrapolated to the whole Spanish or European reality, they could provide useful insight for future investigations on this topic.

On genitive linking in Songhay

Die Songhaysprachen verwenden unterschiedliche Konstruktionen, um Genitivbeziehungen auszudrücken. In den hier 'Mainstream' genannten Songhaysprachen findet sich vornehmlich eine Konstruktion ohne weitere Verbindungselemente mit dem Possessor an erster Stellung. In den so genannten nördlichen Songhaysprachen findet sich die gleiche Reihenfolge von Possessor und Possessum, dort werden sie jedoch durch eine Adposition n getrennt. Die Forschung hat bisher meistens die Ansicht vertreten, dieses n sei aus dem Tuareg entlehnt worden, wo man ja eine Genitivpräposition n hat. Diese Ableitung ist jedoch problematisch, da im Tuareg der Possessor dem Possessum folgt, also eine umgekehrte Reihenfolge wie im Songhay vorliegt. In diesem Artikel werde ich versuchen, für eine songhay-interne Ableitung von n zu argumentieren. Zwei verschiedene Lösungen werden vorgeschlagen. Der erste An¬satz geht davon aus, dass es sich um das Relikt einer alten Genitivpartikel, ánè, handelt, die sich noch im Pronomen wane 'der von' finden lässt. Im zweiten Ansatz wird angenommen, dass n ursprünglich die Trennung von zwei NPs markierte. Im Mainstream Songhay hätte sich dieses Element zum Transitivmarkierer im Perfektiv entwickelt, im nördlichen Songhay dagegen zum Markierer von Genetivkonstruktionen haben.

Isolation of Nicoletella semolina from Equine Tracheal Washes

The aim of the present study was to describe the prevalence of Nicoletella semolina in equine airways and its relationships with cytological evaluation of tracheal wash (TW). Samples were collected in the framework of routine bacteriological diagnostics of equine TW between May 2010 and June 2011. N semolina has been isolated, along with either common pathogens or contaminants, from 19 (1.8%) of the 1,054 TW samples. Median TW neutrophil counts (87.0%) in specimens from N semolina-positive horses were significantly different from those from N semolina-“negative” horses (52.0%). The data presented in this report may suggest considering such bacteria in horses clinically suffering from airway inflammation.

L'oeuvre de Sade et le conte. Le retour refoulé de Barbe-Bleue

Cet article s’intéresse aux différentes fonctions que l’on peut attribuer aux éléments fabuleux dans les œuvres du marquis de Sade. Il s’agit en particulier d’éclaircir les liens intertextuels entre Barbe-Bleue et un conte allégorique que le marquis publie, en 1800, dans la série de ses Crimes de l’amour, sous le titre de Rodrigue ou la tour enchantée. Dans ce texte, la chambre interdite renvoie aussi à un passé criminel, mais elle ne réveille pas la mauvaise conscience et ne suscite aucun remords. Sade semble vouloir faire du conte de Barbe-Bleue le paradigme d’un refoulement manqué, la figure d’une rechute malencontreuse dans un passé archaïque et indigne d’être examiné moralement. Or, les œuvres de Sade ne peuvent plus admettre l’univers surnaturel des contes de fées, considéré comme tout aussi révolu que cette conscience morale qui s’exprime par le remords.