[Origen de la química y sus relaciones con la farmacia] : Discursos leídos ante el Claustro de la Universidad de Barcelona, en el acto solemne de la recepción del catedrático de Farmacia Químico-Orgánica... el dia 16 de junio de 1861 ; Contestación ; de Vicente Munner y Valls /

Mode of access: Internet.

D. Christ. Frider. Reuss ... Dispensatorium universale seu lexicon chemico-pharmaceuticum ad tempora nostra accommodatum ; Sectio prior A-L [-Sectio posterior M-Z]

Mode of access: Internet.

Traité élémentaire de chimie médicale : comprenant quelques notnions de toxicologie et les principales applications de la chimie a la physiologie, a la pathologie, a la pharmacie et a l'hygiène /

Mode of access: Internet.

La aspiración médica : revista teórico-clínica, eco de la clase médico-escolar española.

Mode of access: Internet.

Istituzioni di patologia generale.

Includes bibliography.

AS RELAÇÕES ENTRE BEM-ESTAR NO TRABALHO E PARTICIPAÇÃO EM PROGRAMAS ORGANIZACIONAIS DE PROMOÇÃO DA SAÚDE

No campo científico, a busca por uma maior compreensão acerca de bem-estar no âmbito do trabalho é a tônica do momento, reunindo estudiosos das mais diferentes áreas que demonstram interesse pelo tema. No contexto empresarial, o papel dos programas de promoção da saúde e qualidade de vida torna-se marcante quando se deseja o crescimento da produtividade e do bem-estar dos trabalhadores, considerando a obtenção de resultados crescentes, pela empresa, como fundamentais para que as melhorias nas condições, organização e relações de trabalho ocorram permanentemente. Ou seja, as empresas entendem que com o investimento nesses programas a produtividade deve aumentar, gerando recursos, para que esta se sinta estimulada a continuar investindo no bem-estar dos empregados. Este estudo teve como objetivo promover uma análise sobre as relações entre bem-estar no trabalho, representado por satisfação com o trabalho, envolvimento com o trabalho e comprometimento organizacional afetivo; e freqüência a programas organizacionais de promoção da saúde. A amostra foi constituída por 117 trabalhadores de uma indústria multinacional química e farmacêutica, situada na Grande São Paulo, sendo 53 do sexo masculino e 64 do sexo feminino, com idade média de 30,28 anos, dos quais 63 eram solteiros, 46 casados e oito registram outro estado civil. Para desenvolvimento deste estudo, utilizou-se como instrumento um questionário composto por quatro escalas que mediram satisfação no trabalho, envolvimento com o trabalho, comprometimento organizacional afetivo e freqüência de participação em programas de promoção da saúde, realizados na empresa. Todos os dados recolhidos por meio do instrumento eram numéricos, o que permitiu sua análise eletrônica pelo SPSS, versão 13.0 para Windows. Nessa categoria de dados incluem-se os de descrição da amostra, os referentes a bem-estar no trabalho e freqüência aos programas de promoção da saúde. Foi criado um banco de dados para realização das análises descritivas (freqüências, percentuais, médias e desvios-padrão) e de correlação bivariada (r de Pearson). Os dados que permitiram descrever os programas de promoção da saúde promovidos pela empresa foram obtidos por meio de entrevista com a gerente de responsabilidade social, análise do relatório da empresa e de folhetos elaborados para divulgação e registro desses programas. Um total de cinco categorias de programas foi identificado: benefícios, atividades físicas, saúde, atividades culturais/lazer e ações comunitárias. A maior freqüência aos programas ocorreu na categoria benefícios, pela presença constante no restaurante da empresa. Os resultados deste estudo revelaram que grande parcela do bem-estar no trabalho especialmente no que tange o envolvimento com o trabalho, comprometimento afetivo com a organização, bem como satisfações com os colegas, com a chefia e com o próprio trabalho praticamente independe dos programas de promoção da saúde promovidos pela empresa. Por outro lado, participação em programas de promoção da saúde que incluem as categorias de benefícios, saúde e ações comunitárias, relacionou-se a satisfações com promoções e com salário

Determinação da energia de ativação e pureza de medicamentos de referência, genérico e similar utilizando técnicas termoanalíticas

In this work, the reference drugs, generic and similar to the active ingredients acetylsalicylic acid, paracetamol, captopril, hydrochlorothiazide and mebendazole were purchased from local pharmacies and studied by thermogravimetry (TG) and Differential Scanning Calorimetry (DSC). Thermal decomposition was assessed to obtain from the Ozawa method the activation energy in inert atmosphere (nitrogen), using three different heating ratios (5, 10 and 20 o C min-1). The pharmaceutical formulation of the AAS reference was the one who presented different from the others (generic and similar) Thermogravimetric profile indicating likely interaction between the active ingredient and excipients. Was observed at the heating rate of the inverse temperature that no linearity of the data, ie, there was no correlation between the percentage of mass loss and the activation energy involved in the thermal decomposition of the pharmaceutical formulation of the AAS reference log graph. The analysis by differential scanning calorimetry was performed in nitrogen atmosphere with a heating rate of 10 ° C min-1. In the analysis of these same drugs, the data curves found on the melting point were, except for hydrochlorothiazide, are consistent with the literature. Hydrochlorothiazide presented a melting point well below that found in the literature, which may be justified due to the interaction of the active ingredient with the excipient lactose. In the study of purity, using the Van't Hoff equation, the reference drugs hydrochlorothiazide and mebendazole reference generic and showed similar impurity content below the limit established that this equation must be greater than 2.5 mol%

Coordenação dos sistemas antioxidantes da catalase e da ascorbato peroxidase durante o envelhecimento acelerado de sementes de cártamo e girassol

World consumption of vegetable oils has increased in recent years because of its application in food, chemical, pharmaceutical and, more recently, energy industry. However, oilseeds, which these oils are extracted, have low viability, affecting the cultivation and productivity of these species. The aim of this study was to analyze the effect of aging on the coordination of catalase (CAT) and ascorbate peroxidase (APX) antioxidant systems in safflower and sunflower. . Therefore, seeds were subjected to accelerated aging for 3, 6 and 9 days and grown in moistened paper towel for 72 hours. Additionally, before accelerated aging, sunflower seeds were pretreated by osmopriming with 10 mM ascorbate (ASC) or 3 amino 1,2,4 triazol (3-AT), a specific inhibitor of CAT activitie. The method of artificial aging used was efficient in both species, because it caused a decrease in germination, seedling development and growth, especially in safflower. The aging caused inhibition of CAT activity for both species and to compensate for such inhibition , sunflower increased mRNA expression of this enzyme , while safflower mobilized over the activity of APX. Analysis of the expression of malate synthase and sugar content demonstrated that sunflower seeds consumes lipid reserves in quiescent state, while the safflower is more dependent on carbohydrate. Pretreatment with 3-AT inhibited CAT activity and stimulated the APX, though with ASC acted reverse on these systems. None of the treatments recovered the physiological decline aging. It is concluded that aging change the oilseeds antioxidant metabolism, despite interspecies variations in response to this process, the depletion of the CAT antioxidant system was common. Because of this we propose that the measurement of CAT activity can be used to identify aging seed lots.

Extração, caracterização e avaliação bioativa do extrato de Arrabidaea chica

The use of plants for medicinal purposes is ancient, with widespread application in medicinal drugs. Although plants are promising sources for the discovery of new molecules of pharmacological interest, estimates show that only 17% of them have been studied for their possible use in medicine. Thus, biodiversity of Brazilian flora represents an immense potential for economic use by the pharmaceutical industry. The plant Arrabidaea chica, popularly known as “pariri”, is common in the Amazon region, and it is assigned several medicinal properties. The leaves of this plant are rich in anthocyanins, which are phenolic compounds with high antioxidant power. Antioxidant compounds play a vital role in the prevention of neurological and cardiovascular diseases, cancer and diabetes, among others. Within the anthocyanins found in Arrabidaea chica, stands out Carajurin (6,7-dihydroxy-5,4’- dimethoxy-flavilium), which is the major pigment encountered in this plant. The present work aimed to study on supercritical extraction and conventional extraction (solid-liquid extraction) in leaves of Arrabidaea chica, evaluating the efficiency of the extractive processes, antioxidant activity and quantification of Carajurin contained in the extracts. Supercritical extraction used CO2 as solvent with addition of co-solvent (ethanol/water mixture) and were conducted by the dynamic method in a fixed bed extractor. The trials followed a 24-1 fractional factorial design, the dependent variables were: process yield, concentration of Carajurin and antioxidant activity; and independent variables were: pressure, temperature, concentration of co-solvent (v/v) and concentration of water in the co-solvent mixture (v/v). Yields (mass of dry extract/mass of raw material used) obtained from supercritical extraction ranged from 15.1% to 32%, and the best result was obtained at 250 bar and 40 °C, co-solvent concentration equal to 30% and concentration of water in the co-solvent mixture equal to 50%. Through statistical analysis, it was found that the concentration of co-solvent revealed significant effect on the yield. Yields obtained from conventional extractions were of 8.1% (water) and 5.5% (ethanol). Through HPLC (High-performance liquid chromatography) analysis, Carajurin was quantified in all the extracts and concentration values (Carajurin mass/mass of dry extract) ranged between 1% and 2.21% for supercritical extraction. For conventional extraction, Carajurin was not detected in the aqueous extract, while the ethanol extract showed Carajurin content of 7.04%, and therefore, more selective in Carajurin than the supercritical extraction. Evaluation of antioxidant power (radical 2,2-diphenyl-1-picrylhydrazyl – DPPH – sequestration method) of the supercritical extracts resulted in EC50 values (effective concentration which neutralizes 50% of free radicals) ranged from 38.34 to 86.13 μg/mL, while conventional extraction resulted in EC50 values of 167.34 (water) and 42.58 (ethanol) μg/mL. As for the quantification of total phenolic content (Folin-Ciocalteau analysis) of the supercritical extracts resulted in values ranged from 48.93 and 88.62 mg GAE/g extract (GAE = Gallic Acid Equivalents), while solid-liquid extraction resulted in values of 37.63 (water) and 80.54 (ethanol) mg GAE/g extract. The good antioxidant activity cannot be attributed solely to the presence of Carajurin, but also the existence of other compounds and antioxidants in Arrabidaea chica. By optimizing the experimental design, it was possible to identify the experiment that presented the best result considering the four dependent variables together. This experiment was performed under the following conditions: pressure of 200 bar, temperature of 40 °C, co-solvent concentration equal to 30% and concentration of water in the co-solvent mixture equal to 30%. It is concluded that, within the studied range, it is possible to purchase the optimum result using milder operating conditions, which implies lower costs and greater ease of operation.

Interações da trancinolona com ciclodextrinas em sistemas multicomponentes

Triamcinolone is a relevant anti-inflammatory costicosteroid drug, used mainly by injectable suspensions due its poor water solubility. The association of triamcinolone with cyclodextrins and co-solvents (triethanolamine TEA and N-methylpirrolidone NMP) was held to solubilize the drug and explain the involved interactions. Phase-solubility diagrams showed that triamcinolone was solubilized forming incredible stable complexes with cyclodextrins, in which bests results were observed applying randomyl-methylated-beta-cyclodextrin (RMβCD) (161 fold on increased solubility). The co-solvents TEA and NMP also enhanced drug solubility 1.4 and 6.7 fold, respectively. The association of both co-solvents with CDs seems decreased complexation stability, but enables higher amount of uncomplexed drug. Experimental magnetic resonance 2D-ROESY and theoretical molecular modeling studies demonstrated TRI-CDs interactions and elucidated the structure of formed complex, which occurred due to the inclusion of ring A of TRI on CDs cavity. Physicochemical aspects of solid binary and ternary complexes prepared by spray drying were assessed by using FTIR, X-ray diffraction and SEM photographs. Dissolution studies showed that binary and ternary associations presented higher dissolution efficacy in detrimental to pure drug system. In addition, the ternary complex containing TEA and RMβCD allowed drug dissolution faster than binary complex with RMβCD. Therefore, given the higher solubility and drug dissolution rate, binary and ternary complexes are new raw materials with great potential for pharmaceuticals containing triamcinolone.

O figurino na narrativa dos filmes de Guel Arraes: O Auto da Compadecida (2000) e O Bem Amado (2010)

This research focuses on the course of Guel Arraes, moviemaker, and picks two movies for analysis: O Auto da Compadecida (2000) and O Bem Amado (2010), as well as their costumes. The focus on the costume is based on Semiology and aims to decode the meanings that stem out of the clothes. Three of the movies characters will have their costumes analyzed based on Roland Barthes’ theory, mainly considering semiology elements (language and speech), (significant and meaning) and (system and syntagma). The influence of the Armorial movement into the movie O Auto da Compadecida and the Kitsch aesthetic in O Bem Amado deserve consideration, aside from the study on costumes function within narrative, supported by Roland Barthes’ structural analysis of the narrative. We sought to highlight the balance between characters’ lines and the image of the costumes in the movies. Adding to the study on how costumes strongly accounts to narrative, we observed characteristic traits of director and scriptwriter Guel Arraes present in his works, which are the northeastern man identity, a presentation of the Northeast and popular comedy. We believe that his choices when creating and his life influences are not separate from one another. Our research was movie-appraisal centered and had a thorough investigation all over language. The main considerations are supported by the following theories: Barthes (2007), Figueirôa and Fechine (2008), Moles (2001), Stuart Hall (2005) and Mikhail Bakhtin (2013).

Implementações metodológicas para o estudo eletrofisiológico e comportamental em um modelo animal de autismo

O autismo é um transtorno do desenvolvimento que se manifesta nos primeiros anos de vida e apresenta semiologia heterogênea. Esta patologia afeta a maturação do encéfalo e produz alterações sensoriais, de linguagem e de interação social no início na infância. O modelo experimental de autismo utilizando ácido valproico (VPA) durante o período gestacional tem sido demonstrado ter alta validade de face e permitir estudos tanto das bases neuropatológicas quanto neuro-funcionais durante o desenvolvimento. A despeito do recente interesse por este modelo como instrumento de compreensão dos aspectos básicos da fisiopatologia do autismo, a maioria dos estudos experimentais têm se concentrado nos aspectos comportamentais, histológicos e celulares. Neste trabalho, foram propostas estratégias experimentais de avaliação comportamental associadas a eletrofisiologia \textit{in vivo}, uma técnica que nunca fora utilizada para avaliação desse modelo. Animais controles e experimentais, submetidos previamente a um procedimento cirúrgico para implante de eletrodos crônicos, participaram de experimentos de livre exploração, interação social e condicionamento ao medo.

Obtenção de triacetato de celulose a partir do bagaço de cana-deaçúcar para revestimento de micropartículas de goma gelana e avaliação do seu perfil de liberação in vitro e da mucoadesão ex vivo

Oral route of administration is considered to be the most comfortable, safe and greater adaptation for patients. But, oral route presents some disadvantages such as drugs bioavailability and side effects on the stomach. Some technologies are studied to soften and/or resolve these problems, such as coating with polymeric films, which are able to protect the pharmaceutical form of the acid stomachic environment and to act in the drug release, and mucoadhesive systems, which allow the pharmaceutical form remains a greater time interval in the intestine, increasing the effectiveness of the drug. Cellulose triacetate (CTA) films were produced from cellulose extracted from sugar cane bagasse. The films were prepared with different morphologies (with and without water, acting as non-solvent) and concentrations (3, 6.5 and 10%) of CTA and characterized using scanning electron microscopy (SEM), water vapor permeability (WVP), puncture resistance (PR), enzymatic digestion (DE), and mucoadhesive force evaluation (MF). Microscopy showed the formation of symmetric and asymmetric morphologies. WVP data showed that more concentrated films have higher values for WVP; moreover, asymmetric films had higher values than symmetric films. PR measurements showed that symmetric membranes are more resistant than asymmetric ones. More concentrated films were also more puncture resistant, except for symmetric membranes with CTA concentrations of 6.5 and 10% that did not show significant differences. All of the films presented large mucoadhesive capacities independent of their morphology and CTA concentration. From the results of WVP and RP, a symmetric filme with 6.5% CTA showed better ability and mechanical resistance, therefore, was selected to serve as coating of gellan gum (GG) particles incorporating ketoprofen (KET), which was confirmed by SEM. The selected film presented low values in measurements of the swelling index (SI) and in a dissolution test (DT). TGA analysis showed that the CTA coating does not influence the thermal stability of the particles and there is no incompatibility evidence between CTA, GG and KET. Coated particles released 100% of the ketoprofen in 24 h, while uncoated particles released the same amount in 4 h. The results of this study highlight the potential of CTA in the development of new controlled oral delivery systems.

A influência da satisfação no processo de transação do medicamento: determinantes e consequências da satisfação da Farmácia para com o fornecedor

Atualmente, a forte concorrência e a acentuada instabilidade que as empresas enfrentam conduzem à procura constante de novas formas de atuação, que permitam às organizações manterem-se competitivas. Como tal, a continuidade de uma organização depende da sua capacidade para descobrir e satisfazer as necessidades dos atuais e potenciais clientes, oferecendo-lhes produtos e serviços capazes de acrescentarem valor. O presente trabalho analisa o impacto da qualidade do serviço, da qualidade do produto e da conveniência na Satisfação. Analisa também as consequências da Satisfação e o impacto da mesma no word-of-mouth (WOM) positivo, na conquista da lealdade e na confiança das farmácias para com o seu fornecedor. Desta forma, torna-se possível a criação e manutenção de uma relação de longo prazo mutuamente benéfica para a farmácia e para a Indústria Farmacêutica. Em suma, o objetivo geral da presente Dissertação é a análise dos determinantes da satisfação das farmácias comunitárias, bem como das consequências desta mesma variável. Para se alcançar este objetivo, delinearam-se os seguintes objetivos específicos: (i) análise dos fatores que impactam na satisfação e (ii) verificação das consequências da satisfação. Com efeito, para alcançar este objetivo foi desenvolvido um modelo concetual que contempla as variáveis que explicam a satisfação das farmácias, tendo a presente investigação como base uma amostra de 82 farmácias, essencialmente do distrito de Leiria e Santarém. Os clientes foram inquiridos através de um questionário estruturado onde se visava identificar quais os fatores que mais impactavam na satisfação relativamente aos seus fornecedores e que consequências promoviam. Os resultados obtidos evidenciam que a qualidade do produto e do serviço contribuem para a melhoria dos níveis de satisfação das farmácias. Consequentemente, o aumento dos níveis de satisfação das farmácias produz consequências positivas no WOM, lealdade e confiança das farmácias para com os seus fornecedores.

Capital Intelectual e Desempenho Organizacional no Sector Farmacêutico Português

Segundo o paradigma económico vigente, os intangíveis são hoje os principais factores de produção que criam riqueza no meio empresarial, devendo ser entendidos pelos gestores como factores críticos de sucesso. O conjunto de intangíveis que criam valor organizacional e sustentam a vantagem competitiva constituem o capital intelectual. Se no meio académico, o capital intelectual é visto como um motor do desenvolvimento económico, no âmbito da sociedade do conhecimento, já no meio empresarial apesar do reconhecimento da sua importância estratégica, poucos conseguem defini-lo e identificá-lo, não sabendo mesmo como tirar proveito dele. Acresce ainda o facto de o principal entrave poder estar relacionado na dificuldade em medir e representar o valor gerado por este recurso intangível. A generalidade dos autores que se dedica ao estudo do capital intelectual sustenta a existência de uma relação entre este e o desempenho organizacional, numa óptica de criação e manutenção de vantagens competitivas sustentáveis. Este trabalho apresenta um estudo exploratório realizado no âmbito da indústria farmacêutica portuguesa, com o objectivo de investigar, por um lado, a presença dos três elementos do capital intelectual: capital humano, capital estrutural e capital relacional e, por outro, o seu inter-relacionamento dentro do contexto farmacêutico português. Por fim, pretende-se investigar até que ponto o capital intelectual contribui para o sucesso das organizações analisadas. / According to the prevailing economic paradigm, intangibles are now the main factors of production that are creating wealth in the business world and they should be seen by managers as crucial factors of success. The intangible assets that create organisational value and sustain a competitive edge constitute intellectual capital. In academia intellectual capital is viewed as a driving force for economic development, in the context of the knowledge society, but in the corporate world, although recognised for its strategic importance few people can define it and identify it, or even know how to exploit it. The chief obstacle may be related to the difficulty in measuring and representing the value engendered by this intangible resource. Most authors involved in studying intellectual capital believe that it is related to organisational performance in terms of creating and retaining sustainable competitive advantages. This work is an exploratory study of the Portuguese pharmaceutical industry and it set out, first, to inquire into the presence of the three elements of intellectual capital, human capital, structural capital and relational capital, and also to examine their interrelations within the Portuguese pharmaceutical context. A final objective was to ascertain the part played by intellectual capital in the success of the organizations studied.