998 resultados para Proteína ideal


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Yellow, black ink on linen; similar to LIH10,11; notes; signed; 92 x 48 cm.; Scale: 1" = 40' [from photographic copy by Lance Burgharrdt]

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Ascribed to Samuel Gott by S. K. Jones (in the Library, 3d ser., no. 3, v. 1, July 1910)

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Cover title.

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El presente trabajo indaga sobre las percepciones que las personas, que han alcanzado niveles educativos universitarios, tienen sobre diferentes dimensiones de la política. En tal sentido, hemos decidido dividir nuestra labor en tres dimensiones de análisis. De esta manera observaremos como basándose, fundamentalmente, en los elementos obtenidos por su recorrido en la educación formal, nuestros entrevistados, esbozan opiniones, con coherencia y cierta unicidad, que expresan claramente cuales son los significados que encuentran "legítimos" para: 1) Representación política, 2) Ciudadanía y nuevas formas de representación política y 3) Educación y calidad de la política. La organización que presentamos corresponde a los ejes que, nuestros entrevistados, han relacionado a lo largo de los encuentros. La mayoría de ellos tiene más de cuarenta años e ingresos económicos medios y altos. Si bien la principal propiedad, de este conjunto, es su trayectoria educacional, la edad y los ingresos serán elementos relevantes para caracterizar sus diferentes discursos

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El presente trabajo indaga sobre las percepciones que las personas, que han alcanzado niveles educativos universitarios, tienen sobre diferentes dimensiones de la política. En tal sentido, hemos decidido dividir nuestra labor en tres dimensiones de análisis. De esta manera observaremos como basándose, fundamentalmente, en los elementos obtenidos por su recorrido en la educación formal, nuestros entrevistados, esbozan opiniones, con coherencia y cierta unicidad, que expresan claramente cuales son los significados que encuentran "legítimos" para: 1) Representación política, 2) Ciudadanía y nuevas formas de representación política y 3) Educación y calidad de la política. La organización que presentamos corresponde a los ejes que, nuestros entrevistados, han relacionado a lo largo de los encuentros. La mayoría de ellos tiene más de cuarenta años e ingresos económicos medios y altos. Si bien la principal propiedad, de este conjunto, es su trayectoria educacional, la edad y los ingresos serán elementos relevantes para caracterizar sus diferentes discursos

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We propose a model for non-ideal monitoring of the state of a coupled quantum dot qubit by a quantum tunnelling device. The non-ideality is modelled using an equivalent measurement circuit. This allows realistically available measurement results to be related to the state of the quantum system (qubit). We present a quantum trajectory that describes the stochastic evolution of the qubit state conditioned by tunnelling events (i.e. current) through the device. We calculate and compare the noise power spectra of the current in an ideal and a non-ideal measurement. The results show that when the two qubit dots are strongly coupled the non-ideal measurement cannot detect the qubit state precisely. The limitation of the ideal model for describing a realistic system maybe estimated from the noise spectra.

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The emerging interdisciplinary body of cosmopolitanism research has established a promising field of theoretical endeavour by bringing into focus questions concerning globalization, nationalism, population movements, cultural values and identity. Yet, despite its potential importance, what characterizes recent cosmopolitanism research is an idealist sentiment that considerably marginalizes the significance of the structures of nation-state and citizenship, while leaving unspecified the empirical sociological dimensions of cosmopolitanism itself. Our critique aims at making cosmopolitanism a more productive analytical tool. We argue for a cosmopolitanism that consists of conceptually and empirically identifiable values and outlooks. While there has been some progress made in this direction in the recent literature on cosmopolitanism, most writing still considers cosmopolitanism as something so delicate that it cannot be measured. Furthermore, in order to appreciate the full currency of the concept, we argue that researchers must not only agree on some common determinants of cosmopolitanism and cosmopolitan dispositions, but also ground their analyses of cosmopolitanism in the context of enduring nation-state structures.

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With growing success in experimental implementations it is critical to identify a gold standard for quantum information processing, a single measure of distance that can be used to compare and contrast different experiments. We enumerate a set of criteria that such a distance measure must satisfy to be both experimentally and theoretically meaningful. We then assess a wide range of possible measures against these criteria, before making a recommendation as to the best measures to use in characterizing quantum information processing.

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beta-turns are important topological motifs for biological recognition of proteins and peptides. Organic molecules that sample the side chain positions of beta-turns have shown broad binding capacity to multiple different receptors, for example benzodiazepines. beta-turns have traditionally been classified into various types based on the backbone dihedral angles (phi 2, psi 2, phi 3 and psi 3). Indeed, 57-68% of beta-turns are currently classified into 8 different backbone families (Type I, Type II, Type I', Type II', Type VIII, Type VIa1, Type VIa2 and Type VIb and Type IV which represents unclassified beta-turns). Although this classification of beta-turns has been useful, the resulting beta-turn types are not ideal for the design of beta-turn mimetics as they do not reflect topological features of the recognition elements, the side chains. To overcome this, we have extracted beta-turns from a data set of non-homologous and high-resolution protein crystal structures. The side chain positions, as defined by C-alpha-C-beta vectors, of these turns have been clustered using the kth nearest neighbor clustering and filtered nearest centroid sorting algorithms. Nine clusters were obtained that cluster 90% of the data, and the average intra-cluster RMSD of the four C-alpha-C-beta vectors is 0.36. The nine clusters therefore represent the topology of the side chain scaffold architecture of the vast majority of beta-turns. The mean structures of the nine clusters are useful for the development of beta-turn mimetics and as biological descriptors for focusing combinatorial chemistry towards biologically relevant topological space.