Ação do hormônio triodotironina (T3) altera a expressão gênica do oncogene Amphiregulin (Areg) el células tumorais de adenocarcinoma de mama

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Respostas metabólicas, morfologia do tecido muscular e expressão dos genes relacionados ao crescimento e à atrofia muscular durante o jejum e realimentação em juvenis de tilápia-do-Nilo

Pós-graduação em Zootecnia - FCAV

Análise comparativa da expressão de quimiocinas, citocinas e micropartículas em pacientes com câncer de ovário e endometriomas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Antidepressivo modula o comportamento e a expressão gênica das cadeias de miosina, serca2 e fosfolambam em ratos com insuficiência aórtica?

Introduction: Aortic insufficiency (AoI), a volume overload, is characterized by the diastolic reflux of blood from the regurgitating aorta to the left ventricle. This effect results from malfunctioning aortic cusps. The main cause of AoI in developing countries is rheumatic fever, including Brazil, and valvar degeneration in developed countries. There is a strong association between cardiovascular diseases and depression. Selective serotonin reuptake inhibitors (SSRI) are one of the most prescribed antidepressants in the world. Previous studies of our laboratory showed that the utilization of a SSRI, paroxetine, improved cardiac function in rats with sub-chronic AoI and reduced the daily ingestion of hypertonic sodium (NaCl 0,3M). Cardiovascular diseases can determine behavior changes like increase of anxiety, and it is yet unknown if AoI would determine anxiety or anhedonia, incapacity of obtaining pleasure through physical or sensorial experiences. A possible target for SSRI action could be a change in the expression of enzyme isoforms that collaborate in the contractile function of the heart muscle, like the heavy chains of myosine, the sarcoplasmatic reticulum Ca2+/ATPase (SERCA) and its regulator protein, phospholamban (PLB). Objectives: Evaluation of behavior parameters for anxiety and anhedonia state and genic expression of a-myosine, b-myosine, SERCA2a and PLB in the heart tissue of rats with subchronic AoI that received treatment with an SSRI (paroxetine) for 4 weeks. Methods: Surgery to induce AoI was performed on male Wistar rats, anxiety was evaluated by the elevated plus-maze (EPM) and state of anhedonia was tested by ingestion of 2% sucrose solution. After euthanasia the heart tissue was collected and total RNA was extracted to be analyzed by the RT-qPCR method. Results: Heart fractional shortening was preserved in rats with AoI that were treated compared to rats with AoI that were not treated. There was no statistically ...

Aspectos histopatológicos e expressão de receptores hormonais (AR e ERα) na próstata de ratos expostos ao Di-n-Butil-Ftalato (DBP) desde o período fetal, iniciados pela N-Metil-N-Nitrosuréia (MNU)

Tendo em vista a problemática mundial com relação à degradação dos materiais plásticos e sua dispersão no meio ambiente, e diante de estudo realizado anteriormente onde se observou alterações histopatológicas e bioquímicas na próstata de animais expostos ao DBP (Di-N-Butil-ftalato) no período perinatal, este estudo teve por objetivo avaliar o potencial carcinogênico do DBP administrado desde o período fetal e após iniciação pelo MNU em um modelo de carcinogênese prostática. Ratas prenhes foram divididas em 4 grupos experimentais: 2 tratados: n=16/grupo (TDBP100 e TDBP500) e 2 controles: n=8/grupo (CN e CMNU). O grupo TDBP100 foi exposto ao DBP (100 mg/kg) e o TDBP500 a 500 mg/kg do 15º. dia de gestação (DG15) até a 21º. dia pósnatal (DPN21), enquanto que os animais controle receberam o veículo. Após o desmame, os machos foram separados e os grupos tratados e CMNU receberam dose única de MNU (50 mg/Kg, i.p.) na 6ª. semana pós-natal. Metade dos animais tratados (n=8/grupo) continuaram recebendo o DBP (DBP100+ e DBP500+) após o desmame em doses semanais até o dia do sacrifício (DPN180), enquanto os demais foram mantidos pelo mesmo período sem tratamento (DBP100- e DBP500-).Após a aplicação do MNU, os animais foram submetidos a injeções semanais de Cipionato de Testosterona (promotor) 2mg/aplicação. No dia do sacrifício, o sangue foi coletado, os órgãos reprodutores foram pesados e fragmentos do lobo ventral da próstata foram processados para inclusão em resina e Paraplast para as análises estruturais; e imunocitoquímicas para a detecção de AR e ER. Fragmentos de próstata ventral foram congelados e estocados a -80ºC e após extração das proteínas, estas foram destinadas à reação de Western Blot para avaliar a expressão das mesmas proteínas. Houve diminuição na distância anogenital nos animais DBP500 no DPN1 quando comparado com o grupo controle apontando para o efeito efetivo do DBP ...

Efeitos da pré-exposição ao etanol nos comportamentos relacionados à dependência desta substância e na expressão de CRF1 na amídala em ratos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Alteração da expressão de sFAS e sFASL na leishmaniose voisceral canina: Juliana Perosso Borges. -

Pós-graduação em Ciência Animal - FMVA

A questão da inexauribilidade do texto: o Frühromantik e a escritura derridiana

This article aims to investigate the configuration on the new scenario, during the Early German Romanticism, which led to dismantle the philosophical discourse as the expression of a safe and fixed content, free from the ambiguity of figural language. Our main argument is that already Schelling’s concept of symbol brings up the question about the opacity of the text. By analyzing to what extent this problematization around the language lingers on in the contemporariness, we refer to Derrida’s thought which points out to the illusion embedded in the pretension to conceive a clear and unambiguous language, creating therefore a new ground between art and philosophy since the text itself as a neutral and closed subject will be questioned now.

Traduzir Lucano em português: ensaio de poética tradutória sincrônica

The aim of this paper is to offer an essay of synchronous translation poetics, based on the theoretic thought of Haroldo de Campos and Antoine Berman, which highlight the relevance of translation history in the work of contemporary translators. For this purpose, starting from a close-reading of the first seven Latin hexameters of Lucan’s Pharsalia, I present a comparative study of the translations of Filinto Elisio (18th century), José Feliciano de Castilho (19th century) and Vieira (2011).

Do hexâmetro ao decassílabo: equivalência estilística baseada na materialidade da expressão

This paper deals with the relationship between the Latin hexametre and the Portuguese decasyllable, mainly paying attention to the possibility of a translation which could save some stylistic equivalence based on the proportionality of the materiality of expression.

Gênese de uma obra e esboço de uma poética: a correspondência de João Guimarães Rosa

The quality and the diversity of the material – questionnaires, glossaries, notes, drawings, comments on his work, reflections on language and literature, indications and references – which we find when we read the correspondence of João Guimarães Rosa with the translators of his texts to other languages certify the importance to the study of his work. In this research, we intend to comment on some excerpts of this correspondence, mainly on the unpublished ones, which belong to the Guimarães Rosa Fund (IEB/USP), that we consider relevant to elucidate the process of the origin of this work and to shape Rosa’s poetry or as the author used to call his “platform” of writer.

O rapto de Europa: uma comparação entre Ovídio e Ticiano

In Metamorphoses, the Roman poet Ovid tells the tale of the transformation of Jupiter into a bull to seduce the Phoenician princess Europa. During Renaissance, as is well known, Western civilization fostered an intense renewal of its values under the clear influence of Greco-Roman culture. Ovid, whose fame had not ceased throughout the Middle Ages, became then even better known, and especially his poem Metamorphoses turned into a remarkable source of inspiration not only to literature but also to fine arts and their new humanistic conception. Thus, the episode of the abduction of Europa received a dramatic pictorial expression in the broad brush strokes of the Venetian master Titian Vecellio, who interpreted several classical myths in his canvases at the height of his creative maturity. There are many and obvious relationships in the verses of the ancient Latin poet and the picture of the Italian Renaissancist. In Metamorphoses, the mythical account is described in so many details and set in such an expressive poetic that Titian could take Ovid´s narrative as a model for painting “The Rape of Europa”, doing a true exercise in intersemiotic translation by interpreting verbal signs through pictorial signs.

Percepção e experiência na criação poética

The artistic language is deeply related to the ability of imagination of the human spirit. The poetic experience is based on the perception of physical existence. The poet tries to show through images what he wishes to express and his tendency is to deal with words as a concrete thing.

Algumas considerações sobre a poesia de Eucanaã Ferraz

The contemporary Brazilian poetic production is marked by a strong diversity in the forms of expression and the thematic contents that it makes circulate; it is found either turned to the critical reading of the Brazilian poetry‟s most traditional repertoire, or more concerned about the research of new expressive models afforded by language. Such constitutive diversity, which operates on the intermediate gradients between these two tendencies, finds itself underlined by the little orthodox practice of the production divulgation and circulation, that appropriated the internet and the poetic performances to compensate the low paper-based edition. What we have is a type of poetic dialectology which identifies the poetry readers group. Verifying the most regular procedures in the construction of the dialectology, through the work of Eucanaã Ferraz and João Cabral, is the objective of this paper.

A dança como expressão do imaginário

This article summarizes the findings obtained in ethnographic research conducted in 2009, which led to the dissertation entitled The weaving of movement: dance, tribalism and imaginary in everyday life of a group of students at a public school in Araraquara city defended the Universidade Estadual Paulista - Faculdade de Ciências e Letras de Araraquara, São Paulo. The objective of the survey was to collect clues to a method of movement analysis with reference to the Anthropology of the Imaginary Gilbert Durand and studies of efforts (effort shape) in Rudolf Laban. For this, we identified the main break dance moves practiced by a group of teens who attend school on weekends. The inventory movements in this dance led to a rhythmic and gestural thinking beyond the rationalization of bodily education.