Selbstbiographie von Robert Blum und dessen Ermordung in Wien am 9. Novbr. 1848 : mit Blum's Bildniß und Handschrift, sowie der Ermordungsscene

Boberach: Das politische Engagement wird aus der sozialen Herkunft erklärt und die Hinrichtung als Maßnahme gegen die Deutschkatholiken interpretiert

Robert Blum, der Kämpfer für Freiheit und Licht : eine biographische Skizze

Boberach: Hauptsächlich werden das Todesurteil und seine Vollstreckung behandelt

Robert Blum : ein Charakterbild für Freunde und Gegner

Welsch (Projektbearbeiter): Kurzer biographischer Abriß des am 9. November 1848 erschossenen Abgeordneten der Frankfurter Nationalversammlung

Robert Blum, sein Leben, Wirken und Ende : eine biographische Skizze ; nach den besten Quellen zusammengestellt

Welsch (Projektbearbeiter): Kurzer biographischer Abriß des am 9. November 1848 erschossenen Abgeordneten der Frankfurter Nationalversammlung

Robert Blum : ein Charakterbild für Freunde und Gegner

Welsch (Projektbearbeiter): Kurzer biographischer Abriß des am 9. November 1848 erschossenen Abgeordneten der Frankfurter Nationalversammlung

Disease evolution and outcomes in familial AML with germline CEBPA mutations

In-depth molecular investigation of familial leukemia has been limited by the rarity of recognized cases. This study examines the genetic events initiating leukemia and details the clinical progression of disease across multiple families harboring germ-line CEBPA mutations. Clinical data were collected from 10 CEBPA-mutated families, representing 24 members with acute myeloid leukemia (AML). Whole-exome (WES) and deep sequencing were performed to genetically profile tumors and define patterns of clonal evolution. Germline CEBPA mutations clustered within the N-terminal and were highly penetrant, with AML presenting at a median age of 24.5 years (range, 1.75-46 years). In all diagnostic tumors tested (n = 18), double CEBPA mutations (CEBPAdm) were detected, with acquired (somatic) mutations preferentially targeting the C-terminal. Somatic CEBPA mutations were unstable throughout the disease course, with different mutations identified at recurrence. Deep sequencing of diagnostic and relapse paired samples confirmed that relapse-associated CEBPA mutations were absent at diagnosis, suggesting recurrence was triggered by novel, independent clones. Integrated WES and deep sequencing subsequently revealed an entirely new complement of mutations at relapse, verifying the presentation of a de novo leukemic episode. The cumulative incidence of relapse in familial AML was 56% at 10 years (n = 11), and 3 patients experienced ≥3 disease episodes over a period of 17 to 20 years. Durable responses to secondary therapies were observed, with prolonged median survival after relapse (8 years) and long-term overall survival (10-year overall survival, 67%). Our data reveal that familial CEBPA-mutated AML exhibits a unique model of disease progression, associated with favorable long-term outcomes.

Dr. Robert Kaelter [Rezension]

Rieger

Der Kindesraub von Bologna vor 50 Jahren : ein Gedenkblatt zum 23. Juni 1858

Adolph Kohut

Das türkische Strafgesetzbuch von 1858

B. Tannenwald

Wading in Quinnipiac Mud Guides Career Path for Beth Owen

Beth Owen is just one of many Yale School of Forestry and Environmental Studies graduate students and alumni to participate in an independent research project through the support of Connecticut Sea Grant. The internships have been as ambitious as they are diverse, and all have given participants a new perspective on the role of research in their future. The program is based at Yale’s Center for Coastal and Watershed Systems. Beth sampled and analyzed sediments for heavy metals from the lower Quinnipiac River.

Beiträge zum Fall Mortara (1858)

Josef Meisl