Antimicrobial photodynamic therapy against pathogenic bacterial suspensions and biofilms using chloro-aluminum phthalocyanine encapsulated in nanoemulsions

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cinema hollywoodiano no século XXI: o ritmo em abordagem semiótica e os filmes mais vistos de 2001 a 2010

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Entre Zola e Eça: o Naturalismo brasileiro em seu apogeu (1888)

Brazilian naturalism began in 1881 with the publication of O mulato by Aluísio Azevedo. In spite of the considerable Brazilian cultural dependence on France, the great European master of Brazilian naturalists was initially the Portuguese Eça de Queirós. His novel O primo Basílio resounded intensely in the intellectual environment of Rio de Janeiro, where it had found admirers and fierce critics like Machado de Assis. Only around 1888, when the French naturalist movement suffered serious defections, Brazilian novelists adopted Émile Zola’s esthetical proposals directly through the reading of the Rougon-Macquart cycle. In that year, O missionário by Inglês de Sousa, O cromo by Horácio de Carvalho, A carne by Júlio Ribeiro, Hortência by Marques de Carvalho, Uma família baiana by Xavier Marques, and Lar by Pardal Mallet were published. Nevertheless, it is relevant to consider which features of Zola’s and Eça’s works were incorporated in those works which established a flowering moment of Brazilian naturalism.

Critérios de Divisibilidade e Aplicação em Sala de Aula

Pós-graduação em Matemática - IBILCE

Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O hipertexto na escola: a retextualização digital nas aulas de língua portuguesa

Pós-graduação em Letras - FCLAR

Utilização da creatina como suplemento esportivo por praticantes de musculação

Nos últimos anos a população está cada vez mais aderente a prática de exercícios físicos, isso causado principalmente por conta da mídia e pela busca de uma vida mais ativa e saudável. Dentre essas práticas, a musculação acaba por despertar maior interesse para os que buscam melhores resultados estéticos, reabilitação, preparação esportiva, alto rendimento e qualidade de vida. Na busca por aumento da performance na academia, os praticantes de musculação têm encarado a utilização de suplementos alimentares como algo imprescindível em sua alimentação e em seus treinamentos. Dentre os principais suplementos consumidos pelos praticantes de musculação, a creatina apresenta grande destaque e preferência, na busca de um maior rendimento em seus treinos, principalmente utilizada buscando o ganho expressivo de força e de massa magra. Nesse contexto, o presente estudo tem como objetivo trazer uma revisão de literatura sobre a creatina, desde sua ingestão, absorção, e suplementação até os reais benefícios para quem a utiliza. Para a realização da pesquisa proposta a metodologia usada foi uma revisão bibliográfica de literatura, utilizando-se bases de pesquisa on-line: PubMed e Scielo, trabalhos de conclusão de curso, livros, acervo bibliográfico encontrado na UNESP e entidades conveniadas, selecionando pormenorizadamente as principais fontes publicadas em língua portuguesa e inglesa nos últimos 15 anos. A partir dessa análise, é possível sugerir que a suplementação de creatina, utilizada da maneira correta, pode levar a ganhos significativos de força e de hipertrofia muscular em um trabalho de alta intensidade e curta duração

Uma contribuição a teoria dos números e reticulados

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Climate Change and Water Resources Management: A Federal Perspective

Many challenges, including climate change, face the Nation’s water managers. The Intergovernmental Panel on Climate Change (IPCC) has provided estimates of how climate may change, but more understanding of the processes driving the changes, the sequences of the changes, and the manifestation of these global changes at different scales could be beneficial. Since the changes will likely affect fundamental drivers of the hydrological cycle, climate change may have a large impact on water resources and water resources managers. The purpose of this interagency report prepared by the U.S. Geological Survey (USGS), U.S. Army Corps of Engineers (USACE), Bureau of Reclamation (Reclamation), and National Oceanic and Atmospheric Administration (NOAA) is to explore strategies to improve water management by tracking, anticipating, and responding to climate change. The key points below briefly summarize the chapters in this report and represent underlying assumptions needed to address the many impacts of climate change.

Ellipsometric Study of Single-Crystal γ-Inse From 1.5 To 9.2 Ev

We report the component E ┴ c of the pseudodielectric-function tensor <ε(E)> = <ε1(E)> + i< ε2(E)> of γ-phase single-crystal InSe, obtained from 1.5 to 9.2 eV by vacuum-ultraviolet spectroscopic ellipsometry with the sample at room temperature. Overlayer artifacts were reduced as far as possible by measuring fresh surfaces prepared by cleavage. Accurate critical-point energies of observed structures were obtained by a combined method of spectral analysis.

O programa de pré-indicação científica da USP

O Programa de Pré-Iniciação Científica da USP, constituído de bolsas de pesquisa oferecidas aos alunos da rede pública, é uma iniciativa inovadora que busca aproximar o Ensino Médio da Universidade, promovendo o desenvolvimento pessoal e profissional dos alunos, bem como a promoção de atividade educativa e científica na Universidade. Pela importância social e pedagógica desse Programa, convidamos seu coordenador, o Prof. Dr. Pedro Primo Bombonato, para ser o nosso entrevistado deste número

Dental calculus formation in children and adolescents undergoing hemodialysis

This study aimed to determine whether dental calculus formation is really higher among patients with chronic kidney disease undergoing hemodialysis than among controls. Furthermore, the study evaluated correlations between dental calculus formation and dental plaque, variables that are related to renal disease and/or saliva composition. The Renal Group was composed of 30 patients undergoing hemodialysis, whereas the Healthy Group had 30 clinically healthy patients. Stimulated whole saliva and parotid saliva were collected. Salivary flow rate and calcium and phosphate concentrations were determined. In the Renal Group the saliva collection was carried out before and after a hemodialysis session. Patients from both groups received intraoral exams, oral hygiene instructions, and dental scaling. Three months later, the dental calculus was measured by the Volpe-Manhold method to determine the rate of dental calculus formation. The Renal Group presented a higher rate of dental calculus formation (p < 0.01). Correlation was observed between rate of dental calculus formation and whole saliva flow rate in the Renal Group after a hemodialysis session (r = 0.44, p < 0.05). The presence of dental calculus was associated with phosphate concentration in whole saliva from the Renal Group (p < 0.05). In conclusion, patients undergoing hemodialysis presented accelerated dental calculus formation, probably due to salivary variables.

Development, characterization, and in vitro trials of chloroaluminum phthalocyanine-magnetic nanoemulsion to hyperthermia and photodynamic therapies on glioblastoma as a biological model

A glioblastoma multiforme (GBM) is the highest grade glioma tumor (grade IV) and is the most malignant form of astrocytomas. Grade IV tumors, which are the most malignant and aggressive, affect people between the ages of 45 and 70 years. A GBM exhibits remarkable characteristics that include excessive proliferation, necrosis, genetic instability, and chemoresistance. Because of these characteristics, GBMs are difficult to treat and have a poor prognosis with a median survival of less than one year. New methods to achieve widespread distribution of therapeutic agents across infiltrative gliomas significantly improve brain tumor therapy. Photodynamic therapy (PDT) and hyperthermia (HPT) are well-established tumor therapies with minimal side effects while acting synergistically. This study introduces a new promising nanocarrier for the synergistic application of PDT and magnetic hyperthermia therapy against human glioma cell line T98 G, with cellular viability reduction down to as low as 17% compared with the control. (C) 2012 American Institute of Physics. [doi:10.1063/1.3671775]

Genetic diversity of the Brazilian Creole cattle Pe-duro assessed by microsatellites and mitochondrial DNA

The objective of this study was to describe the genetic diversity and structure of the largest Pe-duro population by assessing variation at ten autosomal microsatellite (STR) loci and mitochondrial DNA (mtDNA) sequences. The mean expected heterozygosity was 0.755, the mean observed heterozygosity was 0.600 and significant inbreeding coefficient (Fis) and deviations from the Hardy-Weinberg equilibrium in most of analyzed loci demonstrate the impact of inbreeding and homozygosis on this population. A more in-depth genetic analysis could be achieved by expanding the STR list. The analysis of mtDNA provided evidence of ancestral African taurine haplotypes in Pe-duro and excluded maternal Zebuine introgression. In this report, the main Pe-duro population is genetically portrayed by sampling approximately 40% of it. As this herd represents the core of the Pe-duro conservation program, these findings are of outstanding value for the management and preservation of this Brazilian 'native' cattle breed.

Juvenile systemic lupus erythematosus and dermatomyositis associated with urticarial vasculitis syndrome: a unique presentation

To report a case of triple association of juvenile systemic lupus erythematosus (SLE), juvenile dermatomyositis and urticarial vasculitis as well as a review of the relevant literature. A 12-year-old male patient diagnosed with overlap syndrome between SLE and juvenile dermatomyositis since 2004 evolved with erythematous plaques, which were compatible with an urticarial rash. Clinical, laboratory and histopathological findings indicated a diagnosis of urticarial vasculitis. The patient previously had a C1q deficiency. Using the established treatment with methylprednisolone (1 g/day for 3 days), increasing doses of deflazacort and introduction of a dapsone, as well as mycophenolate mofetil regimen, with the suspension of azathioprine resulted in complete resolution of skin lesions. Urticarial vasculitis can present in various diseases. In SLE, presentation of urticarial vasculitis in children is rarely found. The triple association of juvenile-onset SLE, juvenile dermatomyositis and urticarial vasculitis is unusual, and this is the first case described in literature.