Perception des impacts, acceptation et acceptabilité de dispositifs nanotechnologiques utilisés en médecine: le cas de la prévention et du traitement des plaies de pression chez les personnes atteintes de diabète

La nanomédecine est porteuse de nombreuses promesses et bienfaits pour l’humanité. Or, l’opposition massive à l’introduction des organismes génétiquement modifiés (OGM) a montré que les promesses attendues des innovations technologiques ne sont pas garantes de leur acceptabilité. L’absence d’une démarche axée sur les impacts possibles, l’acceptation et l’acceptabilité de l’utilisation des nanotechnologies en médecine pourrait toutefois conduire à un manque d’adéquation entre les applications développées et les besoins et valeurs des acteurs sociaux. À partir d’un cadre conceptuel interdisciplinaire et du contexte clinique de la prévention et du traitement des plaies de pression chez les personnes diabétiques, les variables de perception d’impacts, d’acceptation et d’acceptabilité ont été opérationnalisées et étudiées afin d’explorer la relation entre ces variables, mais surtout de mieux comprendre l’influence des types de profil des répondants sur ces variables. L’exploration des impacts perçus, mobilisés et pondérés sur un ensemble d’enjeux a permis d’établir un premier portrait de l’acceptabilité de dispositifs à base de nanotubes de carbones utilisés dans le contexte clinique de soins des plaies de pression. Une approche descriptive-exploratoire fondée sur un devis mixte avec triangulation séquentielle des données a été employée. Un questionnaire a été développé et prétesté à l’aide d’entrevues cognitives (n = 35). Les données ont ensuite été recueillies en deux phases, d’abord par le biais d’un questionnaire en ligne (n = 270), puis par des entrevues individuelles semi-dirigées (n = 23). L’échantillon final se compose de trois types de profil, soit des professionnels de la santé, des personnes diabétiques et non-diabétiques. L’opérationnalisation du cadre de référence a permis de distinguer les dimensions individuelle/ sociale des concepts d’acceptation et d’acceptabilité. Plus encore, l’importance des types de profil dans l’étude de ces variables complémentaires à la perception des impacts a été démontrée, notamment par la mise en lumière du paradoxe des professionnels de la santé dans le jugement d’acceptabilité. Ces distinctions invitent à dépasser les approches traditionnelles d’acceptation technologique en axant davantage sur les impacts perçus et valorisés/priorisés dans la formation du jugement d’acceptabilité. Le développement d’applications en nanomédecine bénéficierait d’une meilleure compréhension de la formation du jugement d'acceptabilité et l'influence du type de profil sur celui-ci.

Quantification of variable palmar ligaments around the triquetrum-hamate joint determined by lunate type

The ligaments of the wrist are highly variable and poorly described, which is more obvious on the ulnar side of the wrist. Previous studies highlighted the potential differences within the ligaments of the wrist but no consensus has been reached. Poor tissue description and inconsistent use of terminology hindered the reproducibility of the results. Improved understanding of the morphological variations between carpal bones may facilitate improved understanding of the ligamentous structure within the wrist. This study aims to identify the potential variations between carpal bones that could be used to separate palmar ligamentous patterns around the triquetrum-hamate joint into subgroups within the sample population. Investigations were performed following a detailed nomenclature and a clear definition of ligamentous structures to facilitate detailed description and reproducible results. Quantitative analyses were conducted using 3D modelling technique. Histological sections were then analysed to identify the structure of each ligamentous attachment. Variable patterns of ligamentous attachments were identified. Differences were not only obvious between samples but also between the right and left hands of the same person. These identifications suggested that the palmar ligamentous patterns around the triquetrum-hamate joint are best described as a spectrum with a higher affinity of the triquetrum-hamate-capitate ligament and the lunate-triquetrum ligament to be associated with type I lunate wrists on one extreme and type II lunate wrists with the palmar triquetrum-hamate ligament, triquetrum-hamate-capitate ligament and palmar radius-lunate-triquetrum ligament attachments at the other extreme. Histological analyses confirmed pervious established work regarding the mechanical role of ligaments in wrist joint biomechanics. Also, there were no significant differences between the quantitative data obtained from the Genelyn-embalmed and unembalmed specimens (p>0.05). The current study demonstrated variable ligamentous patterns that suggest different bone restraints and two different patterns of motion. These findings support previous suggestions regarding separating the midcarpal joint into two distinct functional types. Type I wrists were identified with ligamentous attachments that are suggestive of rotating/translating hamate whilst type II wrists identified with ligamentous attachments that are suggestive of flexing/extending hamate motion based upon the patterns of the ligamentous attachments in relation to the morphological features of the underlying lunate type of the wrist. This opens the horizon for particular consideration and/or modification of surgical procedures, which may enhance the clinical management of wrist dysfunction.

Variable Recruitment in Bundles of Miniature Pneumatic Artificial Muscles and Space Qualified Pneumatic Artificial Muscles

The natural compliance and force generation properties of pneumatic artificial muscles (PAMs) allow them to operate like human muscles in anthropomorphic robotic manipulators. Traditionally, manipulators use a single PAM or multiple PAMs actuated in unison in place of a human muscle. However, these manipulators experience efficiency losses when operated outside their target performance ranges. The unidirectional actuation behavior of a miniature PAM bundle and bidirectional actuation behavior of an antagonistic pair of miniature PAM bundles are characterized and modeled. The results are used to motivate the application of a variable recruitment control strategy to a parallel bundle of miniature PAMs as an attempt to mimic the selective recruitment of motor units in a human muscle to improve the operating efficiency of the actuator. Additionally, the fabrication and quasi-static testing results for PAMs assembled from candidate space qualified bladder and braided sleeve materials for use in space robotics are assessed.

Implementation of continuous-variable quantum key distribution with composable and one-sided-device-independent security against coherent attacks

Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum key distribution requires composable security against coherent attacks for a finite number of distributed quantum states as well as robustness against implementation side channels. Here we present an implementation of continuous-variable quantum key distribution satisfying these requirements. Our implementation is based on the distribution of continuous-variable Einstein–Podolsky–Rosen entangled light. It is one-sided device independent, which means the security of the generated key is independent of any memoryfree attacks on the remote detector. Since continuous-variable encoding is compatible with conventional optical communication technology, our work is a step towards practical implementations of quantum key distribution with state-of-the-art security based solely on telecom components.

Savani: A variable resolution whole-mantle model of anisotropic shear velocity variations based on multiple data sets

International audience

A variable atmosphere hypersonic wind tunnel for similitude studies

Mode of access: Internet.

Design and construction of a two dimensional duct equipped with a wave generator and a variable coastal slope and an ocean wave energy conversion system (OWC)

The aims of this thesis were evaluation the type of wave channel, wave current, and effect of some parameters on them and identification and comparison between types of wave maker in laboratory situations. In this study, designing and making of two dimension channels (flume) and wave maker for experiment son the marine buoy, marine building and energy conversion systems were also investigated. In current research, the physical relation between pump and pumpage and the designing of current making in flume were evaluated. The related calculation for steel building, channels beside glasses and also equations of wave maker plate movement, power of motor and absorb wave(co astal slope) were calculated. In continue of this study, the servo motor was designed and applied for moving of wave maker’s plate. One Ball Screw Leaner was used for having better movement mechanisms of equipment and convert of the around movement to linear movement. The Programmable Logic Controller (PLC) was also used for control of wave maker system. The studies were explained type of ocean energies and energy conversion systems. In another part of this research, the systems of energy resistance in special way of Oscillating Water Column (OWC) were explained and one sample model was designed and applied in hydrolic channel at the Sheikh Bahaii building in Azad University, Science and Research Branch. The dimensions of designed flume was considered at 16 1.98 0. 57 m which had ability to provide regular waves as well as irregular waves with little changing on the control system. The ability of making waves was evaluated in our designed channel and the results were showed that all of the calculation in designed flume was correct. The mean of error between our results and theory calculation was conducted 7%, which was showed the well result in this situation. With evaluating of designed OWC model and considering of changes in the some part of system, one bigger sample of this model can be used for designing the energy conversion system model. The obtained results showed that the best form for chamber in exit position of system, were zero degree (0) in angle for moving below part, forty and five (45) degree in front wall of system and the moving forward of front wall keep in two times of height of wave.

Variable stability research aircraft. Submitted to the Panel on Acceleration Stress of the Armed Forces, National Research Council Committee on Bio-Astronautics, Woods Hole Conference, 16-24 July, 1959.

Cover title.

The authenticity of resources for the teaching of foreign languages and cultures in France: variable geometry notion

International audience

Invertibility characterization of Wiener-Hopf plus Hankel operators on variable exponent Lebesgue spaces via even asymmetric factorization

We obtain invertibility and Fredholm criteria for the Wiener-Hopf plus Hankel operators acting between variable exponent Lebesgue spaces on the real line. Such characterizations are obtained via the so-called even asymmetric factorization which is applied to the Fourier symbols of the operators under study.

Extracting reusable document components for variable data printing

Variable Data Printing (VDP) has brought new flexibility and dynamism to the printed page. Each printed instance of a specific class of document can now have different degrees of customized content within the document template. This flexibility comes at a cost. If every printed page is potentially different from all others it must be rasterized separately, which is a time-consuming process. Technologies such as PPML (Personalized Print Markup Language) attempt to address this problem by dividing the bitmapped page into components that can be cached at the raster level, thereby speeding up the generation of page instances. A large number of documents are stored in Page Description Languages at a higher level of abstraction than the bitmapped page. Much of this content could be reused within a VDP environment provided that separable document components can be identified and extracted. These components then need to be individually rasterisable so that each high-level component can be related to its low-level (bitmap) equivalent. Unfortunately, the unstructured nature of most Page Description Languages makes it difficult to extract content easily. This paper outlines the problems encountered in extracting component-based content from existing page description formats, such as PostScript, PDF and SVG, and how the differences between the formats affects the ease with which content can be extracted. The techniques are illustrated with reference to a tool called COG Extractor, which extracts content from PDF and SVG and prepares it for reuse.

Pulmonary vascular resistance: A meaningless variable?

Almost 20 years ago, Adriaan Versprille published an editorial in this journal to explain why, in his opinion, the calculation of pulmonary vascular resistance (PVR) is meaningless [1]. The uncertainties of PVR were underscored a year later by McGregor and Sniderman in the American Journal of Cardiology [2]. Obviously, both papers failed to convince. A Medline search from 1985 to the end of 2002 reveals no less than 7,158 papers with PVR calculations. What is it that could be wrong in all this literature?.

Desarrollo de arquitecturas para procesamiento de control de la mirada en sistemas de visión activa con resolución espacial variable

En esta tesis se aborda la implementación de un sistema completo de visión activa, en el que se capturan y generan imágenes de resolución espacial variable. Todo el sistema se integra en un sólo dispositivo del tipo AP SoC (All Programmable System on Chip), lo que nos permite llevar a cabo el codiseño hardware-software del mismo, implementando en la parte lógica los bloques de preprocesado intensivo, y en la parte software los algoritmos de procesado de control más complejo. El objetivo es que, trabajando con un campo visual del orden de Megapíxeles, se pueda procesar una tasa moderada de imágenes por segundo. Las imágenes multiresolución se generan a partir de sensores de resolución uniforme con una latencia nula, lo que permite tener preparada la imagen de resolución variable en el mismo instante en que se ha terminado de capturar la imagen original. Como innovación con respecto a las primeras contribuciones relacionadas con esta Tesis, se procesan imágenes con toda la información de color. Esto implica la necesidad de diseñar conversores entre espacios de color distintos, para adecuar la información al tipo de procesado que se va a realizar con ella. Estos bloques se integran sin alterar la latencia de entrega de los sucesivos fotogramas. El procesamiento de estas imágenes multirresolución genera un mapa de saliencia que permite mover la fóvea hacía la región considerada como más relevante en la escena. El contenido de la imagen se estructura en una jerarquía de niveles de abstracción. A diferencia de otras arquitecturas de este tipo, como son la pirámide regular y el polígono foveal, en las que se trabaja con imágenes de resolución uniforme en los distintos niveles de la jerarquía, la pirámide irregular foveal que se propone en esta tesis combina las ideas de trabajar con una imagen realmente multirresolución, que incluya el campo de visión completo que abarcan sensor y óptica, con el procesamiento jerárquico propio de las pirámides irregulares. Para ello en esta tesis se propone la implementación de un algoritmo de diezmado irregular que, tomando como base la imagen multirresolución, dará como resultado una estructura piramidal donde los distintos niveles no son imágenes sino grafos orientados a la resolución del problema de segmentación y estimación de saliencia. Todo el sistema se integra en torno a la arquitectura de bus AXI, que permite conectar entre si todos los cores desarrollados en la parte lógica, así como el acceso a la memoria compartida con los algoritmos implementados en la parte software. Esto es posible gracias a los bloques de acceso directo a memoria AXI-VDMA, en una propuesta de configuración que permite tanto la integración perfectamente coordinada de la transferencia de la imagen multirresolución generada a la zona de trabajo del algoritmo de segmentación como su recuperación para la posterior visualización del resultado del proceso, y todo ello con una tasa de trabajo que mejora los resultados de plataformas similares.

La violencia contra la pareja o expareja mujer: un estudio de la variable de la nacionalidad en la base de datos de la Guardia Municipal de Donostia/San Sebastian

[ES]Este Trabajo de Fin de Grado (TFG) está relacionado con las prácticas efectuadas en la Guardia Municipal de San Sebastián (País Vasco) y pretende analizar las órdenes de protección concedidas a víctimas de violencia de género inmigrantes y nacionales para comprobar si existe alguna diferencia en cuanto a su aplicación. Asimismo, se pretende analizar el procedimiento efectuado por este cuerpo policial y servicios sociales en estos casos, así como el perfil de la víctima y el agresor. Por otra parte, se procura analizar aspectos controvertidos de la Ley Orgánica 1/2004 de Medidas de Protección Integral de la Violencia de Género. Para ello, se utilizara una metodología mixta. Por una parte de corte cualitativo realizando cuatro entrevistas (a dos víctimas, una agente de policía y una trabajadora social) para ahondar más respecto a este tema. En segundo lugar, desde una perspectiva cuantitativa se explorará la base de datos de la Guardia Municipal en materia de violencia de género para realizar un análisis estadístico. Finalmente, se abordaran las conclusiones a las que se ha llegado con este trabajo y se propondrán mejoras de cara a futuras investigaciones y a la operatividad de la Guardia Municipal.