An automatic voice pleasantness classification system based on prosodic and acoustic patterns of voice preference

In the last few years the number of systems and devices that use voice based interaction has grown significantly. For a continued use of these systems the interface must be reliable and pleasant in order to provide an optimal user experience. However there are currently very few studies that try to evaluate how good is a voice when the application is a speech based interface. In this paper we present a new automatic voice pleasantness classification system based on prosodic and acoustic patterns of voice preference. Our study is based on a multi-language database composed by female voices. In the objective performance evaluation the system achieved a 7.3% error rate.

New gene functions in megakaryopoiesis and platelet formation.

Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes controlling both traits. Here we carried out a high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry, followed by extensive biological and functional assessment. We identified 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation. These genes show megakaryocyte-specific gene expression patterns and extensive network connectivity. Using gene silencing in Danio rerio and Drosophila melanogaster, we identified 11 of the genes as novel regulators of blood cell formation. Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function.

Investigación parasitológica de la merluza (merluccius gayii peruanus)

Presenta los resultados obtenidos dentro del marco de cooperación entre el Instituto del Mar del Perú y la Universidad Nacional Federico Villarreal, para investigar la posición taxonómica de los parásitos que pudieran estar presentes en los tejidos musculares de la merluza, así mismo, se averiguo la existencia de alguna relación entre la presencia del o de los parásitos, con el reblandecimiento degenerante de los músculos de la merluza.

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

Vetus Testamentum (fin). Novum Testamentum

Ce volume a été relié avec le ms. Latin 50 pour former une bible complète (cf. Berger, Hist. de la Vulg., 401), mais il semble que ces deux manuscrits ont été réalisés séparément, à une date et par un atelier différent. (F. Avril, Dix siècles d'enluminure italienne, notice 11). Avec prologues, arguments et « capitula ». Psalmi (1) ; Proverbia (13v) ; Ecclesiastes (20) ; Cant. canticorum (22v) ; Sapientia (24) ; Ecclesiasticus (29v) ; Oratio Salomonis (42v) ; Paralip. I-II (43) ; Job (62) ; Tobias (69) ; Judith (72) ; Esther (76) ; Esdras I-II (80) ; Macchab. I-II (87v). — Evangeliorum canones (103) ; Evang. Matthaei (106), Marci (112v), Lucae (117v), Johannis (125) ; Actus Apost. (131v) ; VII Epist. canon. (142), Apocalypsis (147v) ; Concordia Epist. Pauli (153) ; XIV Epist. Pauli (154) ; Epist. ad Laodicenses (addit. du XIIe s.) (176). — Quelques leçons indiquées en marge.

Vetus Testamentum, pars.

Ce volume a été relié avec le BnF, Ms., Latin 104 pour former une bible complète, mais il semble que ces deux manuscrits ont été réalisés séparément, à une date et par un atelier différent. F. B, plusieurs notes du XIIIe siècle de mains différentes : au centre du feuillet : "Anno MCIII (sic) setagesimo IIII fu la fami per tutto lu mundu, et vauze lu tumenu de lu granu tr. XII" ; "Pahnutius humilis servus vestre sanctitatis".Au bas du feuillet : "Pahnutius humilis servus vestre sanctitatis" ; "Religioso viro venerabili abbati Santi Stephani de Nemore, salutem in Domino" ; "apnutius". F. 1, titre du XIIIe siècle : "Incipit epistula sancti Jeronimi presbiteri ad Paulinum de studio Scripturarum." Le manuscrit contient : Genesis (4) ; Exodus (20v) ; Levit. (34) ; Numeri (44v) ; Deuteron. (59) ; Josue (73) ; Judices (81v) ; Ruth (90) ; Reg. I-IV (91) ; Isaias (136) ; Jeremias (152) ; Baruch (170v) ; Jeremiae Lament. et Oratio (173, 174v) ; Ezechiel (175) ; Daniel (191v) ; XII Proph. min. (199).Avec prologues et « capitula » (sauf aux f. 90, 136, 152, 175, 192 et 199) . Quelques leçons en marge. F. 1-3v: Frater Ambrosius tua mihi munuscula perferens destulit...-... scripti sunt libri in latinum eos transferre sermonem. Explicit prefatio.F. 3v, tablesF. 4-124. "In principio creavit Deus caelum et terram ...-... et percutiam terram anathemate. Explicit Malachias propheta.

Bible

Abbaye de Saint-Victor de Paris

Vetus testamentum, pars (Genesis-Job).

Ce ms. a été légué au chapitre de Notre-Dame par Pierre du Jardin, prêtre du diocèse de Limoges et chapelain de Notre-Dame de Paris, mort en 1431, comme l'indique la note au f. 251v: "Venerabilis et discretus vir deffunctus dominus Petrus de Orto, alias dictus Mallerat, presbiter Lemovicensis diocesis, quondam cappellanus hujus venerabilis eccelesie Parisiensis, qui obiit anno M° CCCC° XXXI° die XXIII° mensis aprilis, legavit per suum testamentum supra dicte ecclesie hunc presentem librum..." (XVe s.). Au f. 1 figure l'ex-libris "A la bibliotheque de l'Eglise de Paris" (XVIIe s.). Notre-Dame.

Genèse et différents livres de l'Ancien et du Nouveau Testament.

Biblia sacra, pars.

Proverbes et autres livres de l'Ancien Testament.

Biblia sacra, pars. Vetus Testamentum

Les livres d'Esdras, des Paralipomènes et des Rois.

Biblia sacra, pars. Vetus Testamentum

Prophètes et épîtres de saint Paul.

Biblia sacra, pars.

Évangiles.

Biblia sacra. Novum Testamentum, pars. Evangelia. Au f. 5v, catal. des reliques de Corbie au XIe s.

Évangiles.

Biblia sacra.Novum Testamentum. Evangelia quattuor ( Au commencement et à la fin, actes relatifs à l'érection de l'évêché d'Arras et à l'absolution de Philippe I.