Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
| Data(s) |
15/07/2012
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| Resumo |
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function. |
| Identificador |
https://serval.unil.ch/notice/serval:BIB_D0781ADDDA56 info:pmid:22797727 https://serval.unil.ch/resource/serval:BIB_D0781ADDDA56.P001/REF http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D0781ADDDA567 urn:nbn:ch:serval-BIB_D0781ADDDA567 |
| Idioma(s) |
eng |
| Fonte |
Nature genetics448904-909 |
| Palavras-Chave | #Asian Continental Ancestry Group/genetics; Blood Urea Nitrogen; Cohort Studies; Creatinine/blood; Genetic Predisposition to Disease; Genome-Wide Association Study; Glomerular Filtration Rate/genetics; Humans; Kidney/physiology; Polymorphism, Single Nucleotide; Renal Insufficiency, Chronic/genetics; Uric Acid/blood |
| Tipo |
info:eu-repo/semantics/article article |
| Contribuinte(s) |
KidneyGen Consortium CKDGen Consortium GUGC consortium Chambers, J.C. Zhang, W. Lord, G.M. van der Harst, P. Lawlor, D.A. Sehmi, J.S. Gale, D.P. Wass, M.N. Ahmadi, K.R. Bakker, S.J. Beckmann, J. Bilo, H.J. Bochud, M. Brown, M.J. Caulfield, M.J. Connell, J.M. Cook, H.T. Cotlarciuc, I. Smith, G.D. de Silva, R. Deng, G. Devuyst, O. Dikkeschei, L.D. Dimkovic, N. Dockrell, M. Dominiczak, A. Ebrahim, S. Eggermann, T. Farrall, M. Ferrucci, L. Floege, J. Forouhi, N.G. Gansevoort, R.T. Han, X. Hedblad, B. van der Heide, J.J. Hepkema, B.G. Hernandez-Fuentes, M. Hypponen, E. Johnson, T. de Jong, P.E. Kleefstra, N. Lagou, V. Lapsley, M. Li, Y. Loos, R.J. Luan, J. Luttropp, K. Maréchal, C. Melander, O. Munroe, P.B. Nordfors, L. Parsa, A. Peltonen, L. Penninx, B.W. Perucha, E. Pouta, A. Prokopenko, I. Roderick, P.J. Ruokonen, A. Samani, N.J. Sanna, S. Schalling, M. Schlessinger, D. Schlieper, G. Seelen, M.A. Shuldiner, A.R. Sjögren, M. Smit, J.H. Snieder, H. Soranzo, N. Spector, T.D. Stenvinkel, P. Sternberg, M.J. Swaminathan, R. Tanaka, T. Ubink-Veltmaat, L.J. Uda, M. Vollenweider, P. Wallace, C. Waterworth, D. Zerres, K. Waeber, G. Wareham, N.J. Maxwell, P.H. McCarthy, M.I. Jarvelin, M.R. Mooser, V. Abecasis, G.R. Lightstone, L. Scott, J. Navis, G. Elliott, P. Kooner, J.S. Köttgen, A. Pattaro, C. Böger, C.A. Fuchsberger, C. Olden, M. Glazer, N.L. Parsa, A. Gao, X. Yang, Q. Smith, A.V. O'Connell, J.R. Li, M. Schmidt, H. Tanaka, T. Isaacs, A. Ketkar, S. Hwang, S.J. Johnson, A.D. Dehghan, A. Teumer, A. Paré, G. Atkinson, E.J. Zeller, T. Lohman, K. Cornelis, M.C. Probst-Hensch, N.M. Kronenberg, F. Tönjes, A. Hayward, C. Aspelund, T. Eiriksdottir, G. Launer, L.J. Harris, T.B. Rampersaud, E. Mitchell, B.D. Arking, D.E. Boerwinkle, E. Struchalin, M. Cavalieri, M. Singleton, A. Giallauria, F. Metter, J. de Boer, I.H. Haritunians, T. Lumley, T. Siscovick, D. Psaty, B.M. Zillikens, M.C. Oostra, B.A. Feitosa, M. Province, M. de Andrade, M. Turner, S.T. Schillert, A. Ziegler, A. Wild, P.S. Schnabel, R.B. Wilde, S. Munzel, T.F. Leak, T.S. Illig, T. Klopp, N. Meisinger, C. Wichmann, H.E. Koenig, W. Zgaga, L. Zemunik, T. Kolcic, I. Minelli, C. Hu, F.B. Johansson, Å. Igl, W. Zaboli, G. Wild, S.H. Wright, A.F. Campbell, H. Ellinghaus, D. Schreiber, S. Aulchenko, Y.S. Felix, J.F. Rivadeneira, F. Uitterlinden, A.G. Hofman, A. Imboden, M. Nitsch, D. Brandstätter, A. Kollerits, B. Kedenko, L. Mägi, R. Stumvoll, M. Kovacs, P. Boban, M. Campbell, S. Endlich, K. Völzke, H. Kroemer, H.K. Nauck, M. Völker, U. Polasek, O. Vitart, V. Badola, S. Parker, A.N. Ridker, P.M. Kardia, S.L. Blankenberg, S. Liu, Y. Curhan, G.C. Franke, A. Rochat, T. Paulweber, B. Prokopenko, I. Wang, W. Gudnason, V. Shuldiner, A.R. Coresh, J. Schmidt, R. Ferrucci, L. Shlipak, M.G. van Duijn, C.M. Borecki, I. Krämer, B.K. Rudan, I. Gyllensten, U. Wilson, J.F. Witteman, J.C. Pramstaller, P.P. Rettig, R. Hastie, N. Chasman, D.I. Kao, W.H. Heid, I.M. Fox, C.S. Köttgen, A. Albrecht, E. Teumer, A. Vitart, V. Krumsiek, J. Hundertmark, C. Pistis, G. Ruggiero, D. O'Seaghdha, M. Haller, T. Yang, Q. Tanaka, T. Johnson, A.D. Kutalik, Z. Smith, A.V. Shi, J. Struchalin, M. Middelberg, P.S. Brown, M.J. Gaffo, A.L. Pirastu, N. Li, G. Hayward, C. Zemunik, T. Huffman, J. Yengo, L. Zhao, J.H. Demirkan, A. Feitosa, M.F. Liu, X. Malerba, G. Lopez, L.M. van der Harst, P. Li, X. Kleber, M.E. Hicks, A.A. Nolte, I.M. Johansson, A. Murgia, F. Wild, S.H. Bakker, S.J. Peden, J.F. Dehghan, A. Steri, M. Tenesa, A. Lagou, V. Salo, P. Mangino, M. Rose, L.M. Lehtimäki, T. Woodward, O.M. Okada, Y. Tin, A. Müller, C. Oldmeadow, C. Putku, M. Czamara, D. Kraft, P. Frogheri, L. Thun, G.A. Grotevendt, A. Gislason, G.K. Harris, T.B. Launer, L.J. McArdle, P. Shuldiner, A.R. Boerwinkle, E. Coresh, J. Schmidt, H. Schallert, M. Martin, N.G. Montgomery, G.W. Kubo, M. Nakamura, Y. Tanaka, T. Munroe, P.B. Samani, N.J. Jacobs, D.R. Liu, K. D'Adamo, P. Ulivi, S. Rotter, J.I. Psaty, B.M. Vollenweider, P. Waeber, G. Campbell, S. Devuyst, O. Navaro, P. Kolcic, I. Hastie, N. Balkau, B. Froguel, P. Esko, T. Salumets, A. Khaw, K.T. Langenberg, C. Wareham, N.J. Isaacs, A. Kraja, A. Zhang, Q. Wild, P.S. Scott, R.J. Holliday, E.G. Org, E. Viigimaa, M. Bandinelli, S. Metter, J.E. Lupo, A. Trabetti, E. Sorice, R. Döring, A. Lattka, E. Strauch, K. Theis, F. Waldenberger, M. Wichmann, H.E. Davies, G. Gow, A.J. Bruinenberg, M. Stolk, R.P. Kooner, J.S. Zhang, W. Winkelmann, B.R. Boehm, B.O. Lucae, S. Penninx, B.W. Smit, J.H. Curhan, G. Mudgal, P. Plenge, R.M. Portas, L. Persico, I. Kirin, M. Wilson, J.F. Mateo Leach, I. van Gilst, W.H. Goel, A. Ongen, H. Hofman, A. Rivadeneira, F. Uitterlinden, A.G. Imboden, M. von Eckardstein, A. Cucca, F. Nagaraja, R. Piras, M.G. Nauck, M. Schurmann, C. Budde, K. Ernst, F. Farrington, S.M. Theodoratou, E. Prokopenko, I. Stumvoll, M. Jula, A. Perola, M. Salomaa, V. Shin, S.Y. Spector, T.D. Sala, C. Ridker, P.M. Kähönen, M. Viikari, J. Hengstenberg, C. Nelson, C.P. Meschia, J.F. Nalls, M.A. Sharma, P. Singleton, A.B. Kamatani, N. Zeller, T. Burnier, M. Attia, J. Laan, M. Klopp, N. Hillege, H.L. Kloiber, S. Choi, H. Pirastu, M. Tore, S. Probst-Hensch, N.M. Völzke, H. Gudnason, V. Parsa, A. Schmidt, R. Whitfield, J.B. Fornage, M. Gasparini, P. Siscovick, D.S. Polasek, O. Campbell, H. Rudan, I. Bouatia-Naji, N. Metspalu, A. Loos, R.J. van Duijn, C.M. Borecki, I.B. Ferrucci, L. Gambaro, G. Deary, I.J. Wolffenbuttel, B.H. Chambers, J.C. März, W. Pramstaller, P.P. Snieder, H. Gyllensten, U. Wright, A.F. Navis, G. Watkins, H. Witteman, J.C. Sanna, S. Schipf, S. Dunlop, M.G. Tönjes, A. Ripatti, S. Soranzo, N. Toniolo, D. Chasman, D.I. Raitakari, O. Kao, W.H. Ciullo, M. Fox, C.S. Caulfield, M. Bochud, M. Gieger, C. |
| Formato |
application/pdf |
| Direitos |
info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer |
