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Risks are an essential feature of future climate change impacts. We explore whether knowledge that climate change might be the source of increasing pine beetle impacts on public or private forests affects stated risk estimates of damage, elicited using the exchangeability method. We find that across subjects the difference between public and private forest status does not influence stated risks, but the group told that global warming is the cause of pine beetle damage has significantly higher risk perceptions than the group not given this information.

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No presente trabalho depois de apresentados os objectivos e a importância dos mesmos, dedica-se com grande desenvolvimento ao estado da arte da temática do turismo e em particular do turismo urbano. No seguimento apresenta-se a metodologia do mesmo, nomeadamente o processo de investigação, para numa fase seguinte se explanarem os resultados. Destes salienta-se que num primeiro momento é apresentada a caracterização da região centro sobre a qual se debruçou este trabalho, para numa fase seguinte se efectuar a análise e caracterização dos elementos disponíveis e assim consequentemente se propor um modelo de optimização de um conjunto de variáveis envolvidas no turismo. Por fim, apresentam-se as principais conclusões, nomeadamente de que os instrumentos de gestão municipal não se debruçaram com a devida atenção ao sector do turismo, para numa fase final se tecerem algumas recomendações sobre temas a investigar no futuro, no seguimento da presente dissertação.

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Este trabalho de investigação pretende encontrar explicações para o insucesso das escolas de área aberta em Portugal. Mais do que contar a história das open plan schools (ou escolas P3, como ainda são conhecidas no nosso país), a pretensão foi ouvir, principalmente na primeira pessoa, as dificuldades, as “estórias” e as razões que na opinião dos professores conduziram à radical transformação do espaço físico e pedagógico originalmente proposto para estas organizações escolares. Na impossibilidade de estudar todas as “P3” construídas, optou-se metodologicamente por um estudo de caso de uma escola paradigmática em termos de “evolução” organizacional e pedagógica (em 1982, num programa de televisão, esta foi apresentada como uma escola de área aberta “modelo”). A investigação de cariz etnográfico permitiu de uma forma mais aprofundada conhecer as sucessivas transformações ocorridas. No trabalho de campo, foram realizadas entrevistas, consultados documentos diversos, captaram-se centenas de imagens e foi feita a análise de um inquérito realizado nos anos 1980 aos professores de escolas de área aberta – tipo P3. Os resultados mostram que os professores (principais actores envolvidos neste processo) não tiveram uma preparação adequada para uma pedagogia que se pretendia inovadora. Na opinião de todos os docentes entrevistados, e de acordo com a informação documental recolhida, o Ministério da Educação não deu o acompanhamento e o apoio necessário aos docentes das P3. Não sabemos se as escolas de área aberta “falharam” ou não, este estudo não demonstra isso, mas sim que as condições para que estas escolas funcionassem não existiram, tal tornou-se evidente na falta de estabilidade das equipas docentes (rotatividade), no rácio excessivo de alunos por professor, na insuficiente formação e divulgação sobre escolas P3 e até na inexistência de experiências piloto. Apesar de tudo, alguns professores consideram que as vantagens de adaptabilidade e de flexibilidade em termos de prática pedagógica, trazidas pelas escolas de área aberta, compensariam os riscos e as dificuldades que se levantaram.

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This document initially contains a directory of the society’s officers and directors. There is then a report of the society’s objects and present condition following the first annual report. They describe their legislature campaign as well as its shortfalls. The document describes the current hunting and resident licenses in the state. A description of the fish and game commissioner is included as well as a description as to why such a position needed to be created. This document includes a description of the Society’s work since the last meeting as well as the overall attitude of the society. There is a description of various different types of birds in order to have an official description to describe the bird that correlates to the laws protecting it. There is a description of the work of the wardens as well as a report and a list of wardens who have not given a report to the society. There is a list of each county and how many non-resident licenses each county has issued along with how much income those sales generated. There are then several bills proposed by the society followed by the secretary’s report. The document then includes the treasurer’s report and a list of members.

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As IPSS são instituições muito particulares e muitas deles ainda bastante dependentes das comparticipações estatais. Com a situação atual do país, as dificuldades das IPSS’s vão se agudizando. As comparticipações estatais não se adaptam à realidade atual que se vive provocando alguns transtornos. Desta forma, torna-se urgente uma mudança de mentalidades dos dirigentes dessas instituições, libertando a ideia de que têm de estar dependentes dos subsídios estatais, procurando assim, alternativas a este tipo de financiamento. Algumas estratégias são possíveis, mas de acordo com cada instituição, isto é, da localidade onde está inserida, do seu projeto educativo, e da população alvo que recebe, elas deverão ser mais ou menos adaptadas. No que concerne a IPSS “Novo Sol” de entre as possibilidades encontradas as que mais se adaptam serão o mecenato, a parceria com uma outra IPSS existente, mas que serve outras valências, assim como o marketing social. Com estas alternativas pretende-se melhorar a situação atual financeira da instituição, podendo desse modo, dar continuidade ao projeto educativo.

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This study aimed at identifying clinical factors for predicting hematologic toxicity after radioimmunotherapy with (90)Y-ibritumomab tiuxetan or (131)I-tositumomab in clinical practice. Hematologic data were available from 14 non-Hodgkin lymphoma patients treated with (90)Y-ibritumomab tiuxetan and 18 who received (131)I-tositumomab. The percentage baseline at nadir and 4 wk post nadir and the time to nadir were selected as the toxicity indicators for both platelets and neutrophils. Multiple linear regression analysis was performed to identify significant predictors (P < 0.05) of each indicator. For both platelets and neutrophils, pooled and separate analyses of (90)Y-ibritumomab tiuxetan and (131)I-tositumomab data yielded the time elapsed since the last chemotherapy as the only significant predictor of the percentage baseline at nadir. The extent of bone marrow involvement was not a significant factor in this study, possibly because of the short time elapsed since the last chemotherapy of the 7 patients with bone marrow involvement. Because both treatments were designed to deliver a comparable bone marrow dose, this factor also was not significant. None of the 14 factors considered was predictive of the time to nadir. The R(2) value for the model predicting percentage baseline at nadir was 0.60 for platelets and 0.40 for neutrophils. This model predicted the platelet and neutrophil toxicity grade to within ±1 for 28 and 30 of the 32 patients, respectively. For the 7 patients predicted with grade I thrombocytopenia, 6 of whom had actual grade I-II, dosing might be increased to improve treatment efficacy. The elapsed time since the last chemotherapy can be used to predict hematologic toxicity and customize the current dosing method in radioimmunotherapy.

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The main objective of this master’s thesis is to examine if Weibull analysis is suitable method for warranty forecasting in the Case Company. The Case Company has used Reliasoft’s Weibull++ software, which is basing on the Weibull method, but the Company has noticed that the analysis has not given right results. This study was conducted making Weibull simulations in different profit centers of the Case Company and then comparing actual cost and forecasted cost. Simula-tions were made using different time frames and two methods for determining future deliveries. The first sub objective is to examine, which parameters of simulations will give the best result to each profit center. The second sub objective of this study is to create a simple control model for following forecasted costs and actual realized costs. The third sub objective is to document all Qlikview-parameters of profit centers. This study is a constructive research, and solutions for company’s problems are figured out in this master’s thesis. In the theory parts were introduced quality issues, for example; what is quality, quality costing and cost of poor quality. Quality is one of the major aspects in the Case Company, so understand-ing the link between quality and warranty forecasting is important. Warranty management was also introduced and other different tools for warranty forecasting. The Weibull method and its mathematical properties and reliability engineering were introduced. The main results of this master’s thesis are that the Weibull analysis forecasted too high costs, when calculating provision. Although, some forecasted values of profit centers were lower than actual values, the method works better for planning purposes. One of the reasons is that quality improving or alternatively quality decreasing is not showing in the results of the analysis in the short run. The other reason for too high values is that the products of the Case Company are com-plex and analyses were made in the profit center-level. The Weibull method was developed for standard products, but products of the Case Company consists of many complex components. According to the theory, this method was developed for homogeneous-data. So the most im-portant notification is that the analysis should be made in the product level, not the profit center level, when the data is more homogeneous.

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À l'ère de la mondialisation, où la matrice capitaliste continue de dominer, la classification dans les groupes se définit encore en termes de classes, de genres et d'ethnicité. Les transformations causées par la mondialisation actuelle entraînent de nouveaux modes de production, qui à leur tour transforment les modes de définition et de régulation des populations. Le projet d'exploitation du Nord du Québec est un phénomène relativement récent; or, le processus de construction d'une classe sociale n'est pas un phénomène nouveau. La formation des classes sociales étant toujours en évolution, il semble aujourd'hui pertinent de réexaminer les facteurs économiques, sociologiques et historiques des caractéristiques théoriques nécessaires à la construction et à la représentation d'une classe sociale dont l'existence est liée à l'exploitation accrue des richesses naturelles, la classe ouvrière du Nord du Québec.

 À Fermont, dans le Nord du Québec, les compagnies minières emploient depuis 2011 une grande quantité de travailleurs québécois provenant de l'extérieur de la région, des travailleurs permanents non- résidents. Ainsi, la structure sociale construite sur la force de travailleurs locaux est aux prises avec de nouvelles dynamiques de mobilité sociale géographique. Au travail, les femmes et les autochtones sont aussi affectés par les relations des systèmes de pouvoir de la vie quotidienne, car les emplois de l'industrie minière et du domaine de la construction sont socialement et historiquement fondés sur des capitaux sociaux et culturels (blanc et homme). La classe ouvrière du Nord du Québec est redéfinit par son rapport à la migration géographique des travailleurs permanents non- résidents, par ses relations avec les minorités de genre et les minorités autochtones, relations qui engendrent une organisation sociale complexe et hétérogène.

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The present study deals with the differential regulation of Dopamine content in pancreas and functional regulation of Dopamine D2 receptor in brain regions such as hypothalamus, brain stem, cerebral cortex and corpus striatum play an important role during pancreatic islets cell proliferation and insulin secretion. Though may reports are there implicating the functional interaction between DA receptor and pancreatic islets cell insulin secretion, the involvement of specific DA D2 receptors and changes in second messenger system during insulin secretion and pancreatic islets cell proliferation were not given emphasis. Down regulation of DA content in brain regions and pancreatic islets were observed during pancreatic regeneration. Up regulation of DA content in plasma and adrenals down regulated sympathetic activity in pancreas which cause an increase in insulin secretion and pancreatic islets cell proliferation during pancreatic regeneration. There was a differential regulation of DA D2 receptor in brain regions. The pancreatic islets DA D2 receptors were lip regulated during pancreatic regeneration. DA D2 receptor activation at specific concentration has accounted for increased pancreatic islets cell proliferation. In vitro experiments have proved the differential regulation of DA on insulin synthesis and pancreatic islets cell proliferation. Inhibitory effect of DA on cAMP and stimulatory effect of DA on IP3 through DA D2 receptors were observed in in vitro cell culture system. These effects are correlating with the DA, cAMP and IP3 content during pancreatic regeneration and islets cell proliferation. Up regulation of intracellular Ca2+ was also observed at 10-8 M DA, a specific concentration of DA which showed maximum increase of IP3 content in pancreatic islets through DA D2 receptor activation in in vitro culture. These in vitro data was highly correlating with the changes in DA, cAMP and IP3 content in pancreas during pancreatic regeneration and insulin secretion. Thus we conclude that there is a differential functional regulation of DA and DA D2 receptors in brain and pancreas during pancreatic regeneration. In vitro studies confirmed a concentration depend functional regulation of DA through DA D2 receptors on pancreatic islets cell proliferation and insulin secretion mediated through increased cAMP, IP3 and intracellular Ca2+ level. This will have immense clinical significance in the management in diabetes mellitus.

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The present study demonstrate the functional alterations of the GABAA and GABAB receptors and the gene expression during the regeneration of pancreas following partial pancreatectomy. The role of these receptors in insulin secretion and pancreatic DNA synthesis using the specific agonists and antagonists also are studied in vitro. The alterations of GABAA and GABAR receptor function and gene expression in the brain stem, crebellum and hypothalamus play an important role in the sympathetic regulation of insulin secretion during pancreatic regeneration. Previous studies have given much information linking functional interaction between GABA and the peripheral nervous system. The involvement of specific receptor subtypes functional regulation during pancreatic regeneration has not given emphasis and research in this area seems to be scarce. We have observed a decreased GABA content, down regulation of GABAA receptors and an up regulation of GABAB receptors in the cerebral cortex, brain stem and hypothalamus. Real Time-PCR analysis confirmed the receptor data in the brain regions. These alterations in the GABAA and GABAB receptors of the brain are suggested to govern the regenerative response and growth regulation of the pancreas through sympathetic innervation. In addition, receptor binding studies and Real Time-PCR analysis revealed that during pancreatic regeneration GABAA receptors were down regulated and GABAB receptors were up regulated in pancreatic islets. This suggests an inhibitory role for GABAA receptors in islet cell proliferation i.e., the down regulation of this receptor facilitates proliferation. Insulin secretion study during 1 hour showed GABA has inhibited the insulin secretion in a dose dependent manner in normal and hyperglycaemic conditions. Bicuculline did not antagonize this effect. GABAA agonist, muscimol inhibited glucose stimulated insulin secretion from pancreatic islets except in the lowest concentration of 1O-9M in presence of 4mM glucose.Musclmol enhanced insulin secretion at 10-7 and 10-4M muscimol in presence of 20mM glucose- 4mM glucose represents normal and 20mM represent hyperglycaemic conditions. GABAB agonist, baclofen also inhibited glucose induced insulin secretion and enhanced at the concentration of 1O-5M at 4mM glucose and at 10-9M baclofen in presence of 20mM glucose. This shows a differential control of the GABAA and GABAB receptors over insulin release from the pancreatic islets. During 24 hours in vitro insulin secretion study it showed that low concentration of GABA has inhibited glucose stimulated insulin secretion from pancreatic islets. Muscimol, the GABAA agonist, inhibited the insulin secretion but, gave an enhanced secretion of insulin in presence of 4mM glucose at 10-7 , 10-5 and 1O-4M muscimol. But in presence of 20mM glucose muscimol significantly inhibited the insulin secretion. GABAB agonist, baclofen also inhibited glucose induced insulin secretion in presence of both 4mM and 20mM glucose. This shows the inhibitory role of GABA and its specific receptor subtypes over insulin synthesis from pancreatic bete-islets. In vitro DNA synthesis studies showed that activation of GABAA receptor by adding muscimol, a specific agonist, inhibited islet DNA synthesis. Also, the addition of baclofen, a specific agonist of GABAB receptor resulted in the stimulation of DNA synthesis.Thus the brain and pancreatic GABAA and GABAB receptor gene expression differentially regulates pancreatic insulin secretion and islet cell proliferation during pancreatic regeneration. This will have immense clinical significance in therapeutic applications in the management of Diabetes mellitus.

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The study is intended to estimate the existing rate of participation of women beneficiaries in the development programmes of different organisations in Kerala. It would enable one to understand whether participation is at the satisfactory level or not. Given the rate of participation, the major thrust of the analysis is on the impact of governmental and non-governmental organisations on the rate of participation. This is undertaken under the assumption that NGOs, due to their proximity to people and their needs, ensure better participation rates. Besides the organisational differences, the other major determinants of women participation such as their socio-economic characteristics, psychological make up, the nature of the programme etc. are also highlighted. 0 Since the ascribed status of women in society is inferior, the role of organisers, development personnel and local leaders is also pointed out. Thus the basic objective of the study is women participation and its determinants in the development programmes

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El pensamiento sistémico es una manera de interpretar y comprender los fenómenos, que difiere de la forma convencional denominada reduccionista en la que no se realiza la comprensión a través de la descomposición de las partes, sino que se realiza haciendo énfasis en la comprensión del sistema como un todo y en las interrelaciones que se desprenden del sistema; por tanto la interpretación no se da a partir de un análisis de causa efecto, sino una comprensión del sistema dentro del contexto de un todo superior. Esta investigación se realiza aplicando el pensamiento sistémico en un caso práctico de una organización como es el Hospital Engativá, se hace la interpretación de la organización desde el punto de vista sistémico, realizando un diagrama causal que permite leer la organización desde este punto de vista. Se desarrolló el modelo en una herramienta para dinámica de sistemas y se limita el diseño y la simulación al Proceso de Cartera – Gestión Cobro y Recaudo, realizando una lectura e interpretación de los resultados y hallazgos arrojados por el modelo. Por último se concluye que es factible dirigir una organización desde el pensamiento sistémico y que mejora la toma de decisiones.

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La complejidad que supone abarcar el estudio de la responsabilidad patrimonial del Estado en el ámbito médico sanitario, hace preciso prestar atención a ciertos temas que resultan especialmente relevantes y que han sido decantados jurisprudencialmente por el Honorable Consejo de Estado. De esta manera el presente trabajo desarrolla temas descollantes y novedosos en materia de imputabilidad como viene a ser la prueba de la falla médica mediante la teoría "res ipsa loquitur"; la prueba del nexo causal a través de la prueba indiciaria y la teoría de la probabilidad preponderante. Así mismo se estudian los diversos tipos de daños antijurídicos que pueden darse dentro de la prestación médica a cargo del Estado, destacando especialmente la lesión al derecho a recibir una atención oportuna y eficaz, la pérdida de una oportunidad debida a la no obtención del consentimiento informado del paciente, lo que supone, a su vez, el cercenamiento del derecho de este a elegir someterse o no a determinado tratamiento, previo valoración de pros y contras de la terapia sugerida por el galeno (principio de no agravación). Así mismo se analizanlas hipótesis de daños antijurídicos derivados del error en el diagnóstico, la falla por la omisión de las entidades de control y vigilancia, falla en gineco-obstetricia, así como las hipótesis de responsabilidad objetiva del Estado por óblito quirúrgico, para finalmente tratar el tema novedoso del alea terapéutica con sus particulares características y eventual aplicabilidad en el sistema jurídico colombiano.

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Este trabajo responde la pregunta ¿Cuál es el papel de la Revolución de Terciopelo en la redefinición de la identidad checoslovaca en términos de política exterior?. Defenderá que, conforme al constructivismo, la identidad de los Estados así como sus intereses no están dados y menos se explican por sus capacidades, explicando la conducta y la forma cómo construyeron socialmente su identidad. La Revolución de Terciopelo tuvo lugar en Checoslovaquia, en un momento definitivo en la historia del país, influyendo en la creación de una nueva identidad colectiva que generó consecuencias en el ámbito internacional, ya que a partir de este hecho concreto se evidencia un cambio en la formulación de la política exterior de este país. Para responder a esta pregunta se hará una recolección de información en donde se utilizará la técnica de análisis de documentos, recolectando la bibliografía y consultando en bibliotecas, bases de datos y portales de internet.

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Previous studies have found beneficial effects of aromatherapy massage for agitation in people with dementia, for pain relief and for poor sleep. Children with autism often have sleep difficulties, and it was thought that aromatherapy massage might enable more rapid sleep onset, less sleep disruption and longer sleep duration. Twelve children with autism and learning difficulties (2 girls and 10 boys aged between 12 years 2 months to 15 years 7 months) in a residential school participated in a within subjects repeated measures design: 3 nights when the children were given aromatherapy massage with lavender oil were compared with 14 nights when it was not given. The children were checked every 30 min throughout the night to determine the time taken for the children to settle to sleep, the number of awakenings and the sleep duration. One boy's data were not analyzed owing to lengthy absence. Repeated measures analysis revealed no differences in any of the sleep measures between the nights when the children were given aromatherapy massage and nights when the children were not given aromatherapy massage. The results suggest that the use of aromatherapy massage with lavender oil has no beneficial effect on the sleep patterns of children with autism attending a residential school. It is possible that there are greater effects in the home environment or with longer-term interventions.