Espaços vetoriais e topológicos de intervalos generalizados com alguns conceitos de cálculo e otimização intervalar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ponto fixo: uma introdução no ensino médio

Pós-graduação em Matemática em Rede Nacional - IBILCE

Propriedades genéricas de sistemas hamiltonianos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Periodontopathogens levels and clinical response to periodontal therapy in individuals with the interleukin-4 haplotype associated with susceptibility to chronic periodontitis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Pathogen levels and clinical response to periodontal treatment in patients with Interleukin 8 haplotypes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo de órbitas periódicas em equações diferenciais não autônomas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Synergistic Anti-Inflammatory Activity of the Antimicrobial Peptides Human Beta-Defensin-3 (hBD-3) and Cathelicidin (LL-37) in a Three-Dimensional Co-Culture Model of Gingival Epithelial Cells and Fibroblasts

Given the spread of antibiotic resistance in bacterial pathogens, antimicrobial peptides that can also modulate the immune response may be a novel approach for effectively controlling periodontal infections. In the present study, we used a three-dimensional (3D) co-culture model of gingival epithelial cells and fibroblasts stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS) to investigate the anti-inflammatory properties of human beta-defensin-3 (hBD-3) and cathelicidin (LL-37) and to determine whether these antimicrobial peptides can act in synergy. The 3D co-culture model composed of gingival fibroblasts embedded in a collagen matrix overlaid with gingival epithelial cells had a synergistic effect with respect to the secretion of IL-6 and IL-8 in response to LPS stimulation compared to fibroblasts and epithelial cells alone. The 3D co-culture model was stimulated with non-cytotoxic concentrations of hBD-3 (10 and 20 mu M) and LL-37 (0.1 and 0.2 mu M) individually and in combination in the presence of A. actinomycetemcomitans LPS. A multiplex ELISA assay was used to quantify the secretion of 41 different cytokines. hBD-3 and LL-37 acted in synergy to reduce the secretion of GRO-alpha, G-CSF, IP-10, IL-6, and MCP-1, but only had an additive effect on reducing the secretion of IL-8 in response to A. actinomycetemcomitans LPS stimulation. The present study showed that hBD-3 acted in synergy with LL-37 to reduce the secretion of cytokines by an LPS-stimulated 3D model of gingival mucosa. This combination of antimicrobial peptides thus shows promising potential as an adjunctive therapy for treating inflammatory periodontitis.

Mecânica quântica e sua relação com terapias alternativas

Este trabalho propôs uma discussão crítica sobre os conceitos e fenômenos da Mecânica Quântica (MQ) empregados na explicação cientifíca que dá suporte quanto ao princípio de funcionamento de algumas terapias alternativas ou sobre a elaboração de seus respectivos medicamentos, em especial, Homeopatia e Cura Quântica. Essa discussão se faz importante para munir o leitor com argumentos sólidos calcados na teoria quântica e confrontá-los coma as ideias de simpatizantes leigos dessas terapias. Portanto, o trabalho visou descrever fatos históricos que tornaram possível a construção teórica da Mecânica Quântica, elaborou um resumo da loso a dominante que norteava o pensamento imediatamente anterior a MQ e o conflito que se seguiu em decorrência das implicações deste novo ramo da Física. Explorou o paradoxo EPR e o consequente teorema de John Bell sobre as desigualdades até chegar no experimento de Alain Aspect envolvendo laser para responder de forma prática e definitiva o paradoxo EPR. Finalmente, o trabalho apresentou um resumo das abordagens e argumentações defendidas pelos proponentes das terapias alternativas e confrontou com os conceitos da Mecânica Quântica, para enfim apresentar ao público um estudo científico sobre Homeopatia e Cura Quântica, e compreender os limites e equívocos empregados a essas terapias

SPECT (Single photon emission tomography): Gama câmara, reconstrução tomográfica e características funcional

The SPECT (Single Photon Emission Computed Tomography) systems are part of a medical image acquisition technology which has been outstanding, because the resultant images are functional images complementary to those that give anatomic information, such as X-Ray CT, presenting a high diagnostic value. These equipments acquire, in a non-invasive way, images from the interior of the human body through tomographic mapping of radioactive material administered to the patient. The SPECT systems are based on the Gamma Camera detection system, and one of them being set on a rotational gantry is enough to obtain the necessary data for a tomographic image. The images obtained from the SPECT system consist in a group of flat images that describe the radioactive distribution on the patient. The trans-axial cuts are obtained from the tomographic reconstruction techniques. There are analytic and iterative methods to obtain the tomographic reconstruction. The analytic methods are based on the Fourier Cut Theorem (FCT), while the iterative methods search for numeric solutions to solve the equations from the projections. Within the analytic methods, the filtered backprojection (FBP) method maybe is the simplest of all the tomographic reconstruction techniques. This paper's goal is to present the operation of the SPECT system, the Gamma Camera detection system, some tomographic reconstruction techniques and the requisites for the implementation of this system in a Nuclear Medicine service

Existência de soluções para equações integrodiferenciais em epaços de Banach

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Área e volume: a transição da noção de medida à de área e de volume

Pós-graduação em Matemática em Rede Nacional - IBILCE

A simple application of implicit function theorem

In this note we show that the roots of a polynomial are C∞ depend of the coefficients. The main tool to show this is the Implicit Function Theorem.

Algumas considerações sobre homotopia e homologia

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A simple observation concerning contraction mappings

In this short note we show that the results obtained by Walter in [4] remain valid if we change the metric by another metric. Furthermore, if we use the norm jjT; given in [3], Theorem B in[4] remains valid.

Square of the Error Octonionic Theorem and Hypercomplex Fourier Series

The focus of this paper is to address some classical results for a class of hypercomplex numbers. More specifically we present an extension of the Square of the Error Theorem and a Bessel inequality for octonions.