An optimized lead system for long-term esophageal electrocardiography

Long-term electrocardiography (ECG) featuring adequate atrial and ventricular signal quality is highly desirable. Routinely used surface leads are limited in atrial signal sensitivity and recording capability impeding complete ECG delineation, i.e. in the presence of supraventricular arrhythmias. Long-term esophageal ECG might overcome these limitations but requires a dedicated lead system and recorder design. To this end, we analysed multiple-lead esophageal ECGs with respect to signal quality by describing the ECG waves as a function of the insertion level, interelectrode distance, electrode shape and amplifier's input range. The results derived from clinical data show that two bipolar esophageal leads, an atrial lead with short (15 mm) interelectrode distance and a ventricular lead with long (80 mm) interelectrode distance provide non-inferior ventricular signal strength and superior atrial signal strength compared to standard surface lead II. High atrial signal slope in particular is observed with the atrial esophageal lead. The proposed esophageal lead system in combination with an increased recorder input range of ±20 mV minimizes signal loss due to excessive electrode motion typically observed in esophageal ECGs. The design proposal might help to standardize long-term esophageal ECG registrations and facilitate novel ECG classification systems based on the independent detection of ventricular and atrial electrical activity.

Improved Space Object Orbit Determination Using CMOS Detectors

CMOS-sensors, or in general Active Pixel Sensors (APS), are rapidly replacing CCDs in the consumer camera market. Due to significant technological advances during the past years these devices start to compete with CCDs also for demanding scientific imaging applications, in particular in the astronomy community. CMOS detectors offer a series of inherent advantages compared to CCDs, due to the structure of their basic pixel cells, which each contains their own amplifier and readout electronics. The most prominent advantages for space object observations are the extremely fast and flexible readout capabilities, feasibility for electronic shuttering and precise epoch registration,and the potential to perform image processing operations on-chip and in real-time. Here, the major challenges and design drivers for ground-based and space-based optical observation strategies for objects in Earth orbit have been analyzed. CMOS detector characteristics were critically evaluated and compared with the established CCD technology, especially with respect to the above mentioned observations. Finally, we simulated several observation scenarios for ground- and space-based sensor by assuming different observation and sensor properties. We will introduce the analyzed end-to-end simulations of the ground- and spacebased strategies in order to investigate the orbit determination accuracy and its sensitivity which may result from different values for the frame-rate, pixel scale, astrometric and epoch registration accuracies. Two cases were simulated, a survey assuming a ground-based sensor to observe objects in LEO for surveillance applications, and a statistical survey with a space-based sensor orbiting in LEO observing small-size debris in LEO. The ground-based LEO survey uses a dynamical fence close to the Earth shadow a few hours after sunset. For the space-based scenario a sensor in a sun-synchronous LEO orbit, always pointing in the anti-sun direction to achieve optimum illumination conditions for small LEO debris was simulated.

Development and Test of a Neutron Imaging Setup at the PGAA Instrument at FRM II

We report on the developments of a neutron tomography setup at the instrument for prompt gamma-ray activation analysis (PGAA) at the Maier-Leibnitz Zentrum(MLZ). The recent developments are driven by the idea of combining the spatial information obtained with neutron tomography with the elemental information determined with PGAA, i.e. to further combine both techniques to an investigative technique called prompt gamma activation imaging (PGAI).At the PGAA instrument, a cold neutron flux of up to 6 x 1010 cm-2 s-1 (thermal equivalent) is available in the focus of an elliptically tapered neutron guide. In the reported experiments, the divergence of the neutron beam was investigated, the resolution of the installed detector system tested, and a proof-of-principle tomography experiment performed. In our study a formerly used camera box was upgraded with a better camera and an optical resolution of 8 line pairs/mm was achieved. The divergence of the neutron beam was measured by a systematic scan along the beam axis. Based on the acquired data, a neutron imaging setup with a L/D ratio of 200 was installed. The resolution of the setup was testedin combination with a gadolinium test target and different scintillator screens. The test target was irradiated at two positions to determine the maximum resolution and the resolution at the actual sample position. The performance of the installed tomography setup was demonstrated bya tomography experiment of an electric amplifier tube.

Diatom abundances in sediment core CESAR_83-006

The modern Arctic Ocean is regarded as a barometer of global change and amplifier of global warming (Graversen et al., 2008, doi:10.1038/nature06502) and therefore records of past Arctic change are critical for palaeoclimate reconstruction. Little is known of the state of the Arctic Ocean in the greenhouse period of the Late Cretaceous epoch (65-99 million years ago), yet records from such times may yield important clues to Arctic Ocean behaviour in near-future warmer climates. Here we present a seasonally resolved Cretaceous sedimentary record from the Alpha ridge of the Arctic Ocean. This palaeo-sediment trap provides new insight into the workings of the Cretaceous marine biological carbon pump. Seasonal primary production was dominated by diatom algae but was not related to upwelling as was previously hypothesized (Kitchell and Clark, 1982, doi:10.1016/0031-0182(82)90087-6). Rather, production occurred within a stratified water column, involving specially adapted species in blooms resembling those of the modern North Pacific subtropical gyre (Dore et al., 2008, doi:10.1016/j.pocean.2007.10.002), or those indicated for the Mediterranean sapropels (Kemp et al., 1999, doi:10.1038/18001). With increased CO2 levels and warming currently driving increased stratification in the global ocean (Sarmiento et al., 1998, doi:10.1038/30455), this style of production that is adapted to stratification may become more widespread. Our evidence for seasonal diatom production and flux testify to an ice-free summer, but thin accumulations of terrigenous sediment within the diatom ooze are consistent with the presence of intermittent sea ice in the winter, supporting a wide body of evidence for low temperatures in the Late Cretaceous Arctic Ocean (Falcon-Lang et al., 2004, doi:10.1016/j.palaeo.2004.05.016; Amiot et al., 2004, doi:10.1016/j.epsl.2004.07.015; Otto-Bliesner et al., 2002, doi:10.1029/2001JD000821), rather than recent suggestions of a 15 °C mean annual temperature at this time (Jenkyns et al., 2004, doi:10.1038/nature03143).

Estudio de limitaciones en sistemas WDM

Los avances tecnológicos de los últimos años han modificado el panorama de las comunicaciones ópticas. Los amplificadores EDFA (Erbium-Doped Fiber Amplifier) han alterado dos aspectos fundamentales de los sistemas WDM (Wavelength Division Multiplexing): el aumento considerable de las distancias de regeneración y además, la tecnología WDM es un medio más económico de incrementar la capacidad de los sistemas que la tecnología TDM (Time Division Multiplexing). Sin embargo, la implementación de sistemas WDM con grandes tramos sin regeneración de señal óptica trae consigo la aparición de nuevos problemas, entre los que se encuentran las no-linealidades en fibra óptica. Estas no-linealidades en fibras de sílice se pueden clasificar en dos categorías: dispersión estimulada (de Raman y de Brillouin) y efectos debidos al índice no lineal de refracción (automodulación y modulación cruzada de fase y mezcla de cuatro ondas). Este Proyecto Fin de Carrera pretende ser un estudio teórico que refleje el actual Estado del Arte de los principales efectos no-lineales que se producen en los sistemas WDM: dispersión estimulada de Raman (SRS, Stimulated Raman Scattering), dispersión estimulada de Brillouin (SBS,Stimulated Brilfouin Scattering), automodulación de fase (SPM, Self-Phase Modulation), modulación cruzada de fase (XPM, Cross-Phase Modulation) y mezcla de cuatro ondas (FWM, Four-Wave Mixing).

Comparison of natural and forced amplification regimes in plasma-based soft-x-ray lasers seeded by high-order harmonic

The amplification of high-order harmonics (HOH) in a plasma-based amplifier is a multiscale, temporal phenomenon that couples plasma hydrodynamics, atomic processes, and HOH electromagnetic fields. We use a one-dimensional, time-dependent Maxwell-Bloch code to compare the natural amplification regime and another regime where plasma polarization is constantly forced by the HOH. In this regime, a 10-MW (i.e., 100 times higher than current seeded soft x-ray laser power), 1.5-μJ, 140-fs pulse free from the parasitic temporal structures appearing on the natural amplification regime can be obtained.

Noise Figure Measurement of Differential Amplifiers Using non-Ideal Baluns

This paper analyzes the noise and gain measurement of microwave differential amplifiers using two passive baluns. A general model of the baluns is considered, including potential losses and phase/amplitude unbalances. This analysis allows de-embedding the actual gain and noise performance of the isolated amplifier by using single-ended measurements of the cascaded system and baluns. Finally, measured results from two amplifier prototypes are used to validate the theoretical principles.

A De-Embedding Method to Characterize Differential

This paper analyses the noise and gain measurement of microwave differential amplifiers using two passive baluns. A model of the baluns that includes potential losses and unbalances has been considered. This analysis allows to de-embed the actual performance of the differential device from the single-ended measurements of the two-port cascaded system and the baluns. The method has been validated with measured results from a fully-differential amplifier prototype.

Método de desembebido para la caracterización de amplificadores diferenciales usando baluns pasivos

This paper analyses the noise and gain measurement of microwave differential amplifiers using two passive baluns. A model of the baluns that includes potential losses and unbalances has been considered. This analysis allows de-embedding actual performance of the differential device from the single-ended measurements of the two-port cascaded system and the baluns. The method has been validated with measured results from a fully-differential amplifier prototype.

Procedimiento De Amplificador De Envolvente De Señales Moduladas En RF Para Técnicas EER Y ET

An envelope amplifier for an EER (Envelope Elimination and Restoration) and ET (Envelope Tracking) techniques is shown in this paper. The amplifier is based on a high speed two phases buck converter and employs RF LDMOS technology for the switching stage. A DPWM (Digital Pulse With Modulation) signal is used to control the amplifier by means of a functions generator. Simulations and measurements on a circuit prototype are presented showing a good agreement. Up to 125W output peak power can be delivered over a 5Ω load resistor. About 80% efficiency has been obtained. And at the two tone test, the third order intermodulation products (IP3) remain below 45dBc over a 2MHz bandwidth.

Design methodology in multiphase buck converter based on minimum time control for high efficiency RF amplifiers

This paper proposes an interleaved multiphase buck converter with minimum time control strategy for envelope amplifiers in high efficiency RF power amplifiers. The solution of the envelope amplifier is to combine the proposed converter with a linear regulator in series. High system efficiency can be obtained through modulating the supply voltage of the envelope amplifier with the fast output voltage variation of the converter working with several particular duty cycles that achieve total ripple cancellation. The transient model for minimum time control is explained, and the calculation of transient times that are pre-calculated and inserted into a look-up table is presented. The filter design trade-off that limits capability of envelope modulation is also discussed. The experimental results verify the fast voltage transient obtained with a 4-phase buck prototype.

High efficiency envelope tracking buck converter for RFPA using GaN HEMTs

—In this paper, application of a new technological solution for power switches based on Gallium Nitride and a filter design methodology for high efficiency Envelope Amplifier in RF transmitters are proposed. Comparing to Si MOSFETs, GaN HEMTs can provide higher efficiency of the Envelope Amplifier, due to better Figure Of Merit (lower product of on- resistance and gate charge). Benefits of their application were verified through the experimental results. The goal of the filter design is to generate the envelope reference with the minimum possible distortion and to improve the efficiency of the Amplifier, obtaining the optimum trade-off between conduction and switching losses.

Multiphase Buck Converter with Minimum Time Control Strategy for RF Envelope Modulation

Power amplifier supplied with constant supply voltage has very low efficiency in the transmitter. A DC-DC converter in series with a linear regulator can be used to obtain voltage modulation. Since this converter should be able to change the output voltage very fast, a multiphase buck converter with a minimum time control strategy is proposed. To modulate supply voltage of the envelope amplifier, the multiphase converter works with some particular duty cycle (i/n, i=1, 2 ... n, n is the number of phase) to generate discrete output voltages, and in these duty cycles the output current ripple can be completely cancelled. The transition times for the minimum time are pre-calculated and inserted in a look-up table. The theoretical background, the system model that is necessary in order to calculate the transition times and the experimental results obtained with a 4-phase buck prototype are given

Optimum Design of an Envelope Tracking Buck Converter for RF PA using GaN HEMTs

In this paper, filter design methodology and application of GaN HEMTs for high efficiency Envelope Amplifier in RF transmitters are proposed. The main objectives of the filter design are generation of the envelope reference with the minimum possible distortion and high efficiency of the amplifier obtained by the optimum trade-off between conduction and switching losses. This optimum point was determined using power losses model for synchronous buck with sinusoidal output voltage and experimental results showed good correspondence with the model and verified the proposed methodology. On the other hand, comparing to Si MOSFETs, GaN HEMTs can provide higher efficiency of the envelope amplifier, due to superior conductivity and switching characteristics. Experimental results verified benefits of GaN devices comparing to the appliance of Si switching devices with very good Figure Of Merit, for this particular application

Sistema de adquisición de datos basado en FPAA

Las FPAA´s son dispositivos analógicos programables. Estos dispositivos se basan en el uso de condensadores conmutados junto con amplificadores operacionales. Este tipo de tecnología presenta una serie de ventajas, ya que combinan las ventajas de dispositivos digitales, como la reprogramación en función de las variables del entorno que los rodean, con la diferencia de ser dispositivos analógicos, permitiendo la realización de una amplia gama de diseños analógicos en un solo chip. En este proyecto se ha realizado un estudio sobre el funcionamiento de los condensadores conmutados y su uso en el dispositivo AN221E04 del fabricante Anadigm. Una vez descrita la arquitectura del AN221E04 y explicadas las bases del funcionamiento de los condensadores conmutados, utilizando como ejemplo los modelos facilitados por Anadigm, se desarrolla un modelo de amplificador de instrumentación teórico y se describe la metodología para su implementación en un AN221E04 con el software Anadigm Designer 2. Una vez implementado este modelo de amplificador de instrumentación se han efectuado una serie de pruebas con el objetivo de estudiar la capacidad de estos dispositivos. Dichas pruebas ponen de manifiesto que las FPAA´s tienen una serie de ventajas a tener en cuenta a la hora de realizar diseños analógicos. La precisión obtenida por el modelo de amplificador de instrumentación realizado es más que aceptable, llegando a obtener errores de ganancia inferiores al 1% con ganancias de 200V/V sin tener la necesidad de realizar grandes ajustes. En las conclusiones de este estudio se exponen tanto ventajas como inconvenientes de la utilización de FPAA´s en diseños analógicos. La principal ventaja de este uso es el ahorro de costes, ya que una vez desarrollada una plataforma de diseño, la capacidad de reconfiguración permite utilizar dicha plataforma para un amplio abanico de aplicaciones, reduciendo el número de componentes y simplificando las etapas de diseño. Como desventaja, las FPAA´s tienen una serie de limitaciones qué hay que tener en cuenta en ciertos casos pudiendo hacer irrealizable un diseño concreto; como puede ser el valor máximo o mínimo de ganancia. The FPAA's are programmable analog devices. These devices rely on the use of switched capacitors together with operational amplifiers. This type of technology has a number of advantages, because they combine the advantages of digital devices such as the reprogramming function of the variables of the surrounding environment, with the difference being analog devices, allowing the realization of a wide range of designs analog on a single chip. This project has conducted a study on the operation of the switched capacitor and its use in the device AN221E04 from Anadigm. Having described the architecture of AN221E04 and explained the basis for the operation of the switched capacitor, using the example models provided by Anadigm is developing an instrumentation amplifier theory model and describes the methodology for implementation in a AN221E04 with the Anadigm Designer 2 software. Once implemented this instrumentation amplifier model, have made a series of tests in order to study the ability of these devices. These tests show that the FPAA's have a number of advantages to take into account when making analog designs. The accuracy obtained by the instrumentation amplifier model is made more than acceptable, earning gain errors of less than 1% with gains of 200V / V without the need for major adjustments. The conclusions of this study are presented both advantages and disadvantages of using FPAA's in analog designs. The main advantage of this application is the cost savings, because once developed a platform for design, reconfiguration capability allows you to use this platform for a wide range of applications, reducing component count and simplifying design stages. As a disadvantage, the FPAA's have a number of limitations which must be taken into account in certain cases may make impossible a specific design, such as the maximum or minimum gain, or the magnitude of the possible settings.