993 resultados para 159-959
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En une génération, entre 1975 et 1995, le paysage du marché du travail auquel les jeunes font face a radicalement changé.
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Una vez formulado el modelo matemático del problema de transporte, el siguiente paso consiste en resolver el modelo, es decir, en obtener los mejores valores númericos para las variables de decisión. La forma en que se obtengan estos valores depende del tipo específico del modelo matemático utilizado, Por tanto, una vez definido el modelo, se podrá elegir un método apropiado para resolverlo.
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En este artículo se analiza la incidencia y la difusión de la Gestión de la Calidad(GC) en las empresas vascas a lo largo de los últimos años. En primer lugar se realiza una breve introducción donde se analiza la difusión del paradigma de la calidad en el ámbito de la gestión y organización de empresas, para más adelante analizar la incidencia de este movimiento en las empresas vascas. Se analiza, asimismo, cuál ha sido la motivación de las empresas a la hora de implantar estas normas y modelos, así como cuáles han sido sus efectos, conforme a los resultados de sendos estudios de carácter cuantitativo y cualitativo llevados a cabo recientemente.
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Background: Colorectal cancer (CRC) is a disease of complex aetiology, with much of the expected inherited risk being due to several common low risk variants. Genome-Wide Association Studies (GWAS) have identified 20 CRC risk variants. Nevertheless, these have only been able to explain part of the missing heritability. Moreover, these signals have only been inspected in populations of Northern European origin. Results: Thus, we followed the same approach in a Spanish cohort of 881 cases and 667 controls. Sixty-four variants at 24 loci were found to be associated with CRC at p-values <10-5. We therefore evaluated the 24 loci in another Spanish replication cohort (1481 cases and 1850 controls). Two of these SNPs, rs12080929 at 1p33 (P-replication=0.042; P-pooled=5.523x10(-03); OR (CI95%)=0.866(0.782-0.959)) and rs11987193 at 8p12 (P-replication=0.039; P-pooled=6.985x10(-5); OR (CI95%)=0.786(0.705-0.878)) were replicated in the second Phase, although they did not reach genome-wide statistical significance. Conclusions: We have performed the first CRC GWAS in a Southern European population and by these means we were able to identify two new susceptibility variants at 1p33 and 8p12 loci. These two SNPs are located near the SLC5A9 and DUSP4 loci, respectively, which could be good functional candidates for the association signals. We therefore believe that these two markers constitute good candidates for CRC susceptibility loci and should be further evaluated in other larger datasets. Moreover, we highlight that were these two SNPs true susceptibility variants, they would constitute a decrease in the CRC missing heritability fraction.
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Artisanal fishery is the main type of fishing practised occupationally by the fishermen along the upper sectors of the Cross River. No form of mechanised fishing has so far been introduced to the fishermen in these areas. This study has attempted to find out the different gears used, when and where used along the main river channel, its tributaries and flood plains. An effort has also been made to provide some information on the types of fishes caught with the different gears. Recommendation for effective management are also advanced
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[EN] Enforcement of rural policy measures within National Parks may have a particular importance as they may contribute to reach socioeconomic objectives devised for such areas. So this paper approaches as case study the application of a relevant rural development measure in the Northumberland National Park (NNP) –England, North East— over the period 2000-2008 in order to explore whether NNP makes any difference in terms of enforcing rural policy measures. The main research findings indicate that NNP may have some sort of positive impact on rural development, but support relying on tourism monoculture may be a background reason for undesired negative consequences.
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Peel test measurements and inverse analysis to determine the interfacial mechanical parameters for the metal film/ceramic system are performed, considering that there exist an epoxy interface layer between film and ceramic. In the present investigation, Al films with a series of thicknesses between 20 and 250 mu m and three peel angles of 90, 135 and 180 degrees are considered. A finite element model with the cohesive zone elements is used to simulate the peel test process. The finite element results are taken as the training data of a neural network in the inverse analysis. The interfacial cohesive energy and the separation strength can be determined based on the inverse analysis and peel experimental result. (C) 2008 Elsevier Ltd. All rights reserved.
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The North European fish stocks are assessed annually by ICES working groups. The results are evaluated biannually in two meetings of the Advisory Committee for Fisheries Management (ACFM) at ICES. Based on the working group assessments, ACFM formulates an advice for fisheries management and suggests a total allowable catch (TAC) which is based strictly on biological grounds. The summaries of the state of some selected stocks which are given here, are derived from the ACFM advice, formulated during the most recent Oktober 1998 meeting. For many of the fish stocks the precautionary approach is still in the process of implementation, however for most of them the management and target reference points have been fully defined by now.
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The significance of the fishery industry in the Nigerian economy is examined, considering source of domestic fish production and government fish production programmes and also analysis Nigeria's fish imports during the period 1971-80. Suggestions are made regarding the regulation of fish imports to conserve foreign exchange and the removal of constraints in domestic fish production expansion
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239 p.: il.-- [Editores del libro: Genaro Guisasola y Mikel Garmendia]
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Capítulo 1 del libro: Guisasola, Jenaro ; Garmendia, Mikel (eds.) "Aprendizaje basado en problemas, proyectos y casos: diseño e implementación de experiencias en la universidad" (ISBN: 978-84-9860-959-2)