Bahía de Huarmey, Áncash, Perú. Evaluación ambiental en abril 2003

Se registraron aguas de mezcla y costeras frías (ACF), con temperaturas muy homogéneas que en superficie y fondo variaron entre 15,1 y 16,4 °C. Los valores de oxígeno fueron menores que en la pasada evaluación del 2002, con promedio 2,2 mL/L (máximo 3,14 mg/L) en superficie y de 0,7 mL/L (1,00 mg/L) en fondo.

Seguimiento de las pesquerías y calidad ambiental 2001-2005. IMARPE-Huacho

La pesquería pelágica en total desembarcó 8.970.674 t (25,8% del desembarque nacional), constituido por anchoveta Engraulis ringens (97%) que registró mayor incidencia de juveniles el 2002. La pesquería artesanal desembarcó 8.880,2 t (88,7% fueron peces). El desembarque se incrementó en 44,3% el 2005, revirtiendo la tendencia negativa del período 2001–2003. El caracol Stramonita chocolata presentó alta incidencia de individuos por debajo de la talla mínima legal de extracción. Se determinó que el principal contaminante (carga orgánica) se incrementa en épocas de actividad industrial. El Cadmio superó lo observado en la bahía del Callao.

Exome sequencing identifies INPPL1 mutations as a cause of opsismodysplasia.

Opsismodysplasia (OPS) is a severe autosomal-recessive chondrodysplasia characterized by pre- and postnatal micromelia with extremely short hands and feet. The main radiological features are severe platyspondyly, squared metacarpals, delayed skeletal ossification, and metaphyseal cupping. In order to identify mutations causing OPS, a total of 16 cases (7 terminated pregnancies and 9 postnatal cases) from 10 unrelated families were included in this study. We performed exome sequencing in three cases from three unrelated families and only one gene was found to harbor mutations in all three cases: inositol polyphosphate phosphatase-like 1 (INPPL1). Screening INPPL1 in the remaining cases identified a total of 12 distinct INPPL1 mutations in the 10 families, present at the homozygote state in 7 consanguinous families and at the compound heterozygote state in the 3 remaining families. Most mutations (6/12) resulted in premature stop codons, 2/12 were splice site, and 4/12 were missense mutations located in the catalytic domain, 5-phosphatase. INPPL1 belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family, a family of signal-modulating enzymes that govern a plethora of cellular functions by regulating the levels of specific phosphoinositides. Our finding of INPPL1 mutations in OPS, a severe spondylodysplastic dysplasia with major growth plate disorganization, supports a key and specific role of this enzyme in endochondral ossification.

The caspase-3-p120-RasGAP module generates a NF-κB repressor in response to cellular stress.

The nuclear factor κB (NF-κB) transcription factor is a master regulator of inflammation. Short-term NF-κB activation is generally beneficial. However, sustained NF-κB might be detrimental, directly causing apoptosis of cells or leading to a persistent damaging inflammatory response. NF-κB activity in stressed cells needs therefore to be controlled for homeostasis maintenance. In mildly stressed cells, caspase-3 cleaves p120 RasGAP, also known as RASA1, into an N-terminal fragment, which we call fragment N. We show here that this fragment is a potent NF-κB inhibitor. Fragment N decreases the transcriptional activity of NF-κB by promoting its export from the nucleus. Cells unable to generate fragment N displayed increased NF-κB activation upon stress. Knock-in mice expressing an uncleavable p120 RasGAP mutant showed exaggerated NF-κB activation when their epidermis was treated with anthralin, a drug used for the treatment of psoriasis. Our study provides biochemical and genetic evidence of the importance of the caspase-3-p120-RasGAP stress-sensing module in the control of stress-induced NF-κB activation.

Aerocali, Aerocivil, Olga Mélida Valle De La Hoz

Declara infundado el recurso de anulación

Juan Bernardo Botero Botero v Empresa de Obras Sanitarias de Caldas S.A., E.S.P. – EMPOCALDAS, cp. Mauricio Fajardo Gómez

Se declaró infundado el recurso de anulación interpuesto contra el laudo arbitral proferido el 26 de agosto de 2010 por el Tribunal de Arbitramento constituido para dirimir las controversias surgidas en relación con el contrato de consultoría No. 104 de 2007, celebrado entre el señor Juan Bernardo Botero y la Empresa de Obras Sanitarias de Caldas S.A., E.S.P. - EMPOCALDAS S.A., E.S.P.

A research capacity strengthening project for infectious diseases in Honduras: experience and lessons learned

Background: In Honduras, research capacity strengthening (RCS) has not received sufficient attention, but an increase in research competencies would enable local scientists to advance knowledge and contribute to national priorities, including the Millennium Development Goals (MDGs). Objective: This project aimed at strengthening research capacity in infectious diseases in Honduras, focusing on the School of Microbiology of the National Autonomous University of Honduras (UNAH). The primary objective was the creation of a research-based graduate program for the continued training of researchers. Parallel objectives included institutional strengthening and the facilitation of partnerships and networks. Methods: Based on a multi-stakeholder consultation, an RCS workplan was designed and undertaken from 2007 to 2012. Due to unexpected adverse circumstances, the first 2 years were heavily dedicated to implementing the project's flagship, an MSc program in infectious and zoonotic diseases (MEIZ). In addition, infrastructure improvements and demand-driven continuing education opportunities were facilitated; biosafety and research ethics knowledge and practices were enhanced, and networks fostering collaborative work were created or expanded. Results: The project coincided with the peak of UNAH's radical administrative reform and an unprecedented constitutional crisis. Challenges notwithstanding, in September 2009, MEIZ admitted the first cohort of students, all of whom undertook MDG-related projects graduating successfully by 2012. Importantly, MEIZ has been helpful in expanding the School of Microbiology's traditional etiology-based, disciplinary model to infectious disease teaching and research. By fulfilling its objectives, the project contributed to a stronger research culture upholding safety and ethical values at the university. Conclusions: The resources and strategic vision afforded by the project enhanced UNAH's overall research capacity and its potential contribution to the MDGs. Furthermore, increased research activity and the ensuing improvement in performance indicators at the prime Honduran research institution invoke the need for a national research system in Honduras.

Accidentes con exposición a residuos biológicos infecciosos en trabajadores de la salud de un hospital universitario de la ciudad de Monterrey, N.L., Méx., en el año 1996

Tesis (Maestría en Salud Pública con Especialidad en Salud en el Trabajo) UANL

Alimentación al seno materno : experiencia de la mujer.

Tesis (Maestría en Enfermería con Especialidad en Salud Comunitaria) UANL

Intervenciones de enfermería en la adaptación del neonato de pretérmino.

Tesis (Maestría en Enfermería con Especialidad en Materno Infantil: Pediatría) UANL

Proyecto de implantación de una materia referente a valores en la facultad de Ingeniería Mecánica y Eléctrica

Tesis (Maestría en Ciencias de la Administración con Especialidad en Relaciones Industriales) UANL