Paragéneses contrastantes no campo pegmatítico de Arga (NW de Portugal): diversidade e equilíbrio

Dissertação de mestrado Ordenamento e Valorização de Recursos Geológicos

Estratégia para a incorporação de impactes ambientais, sociais e económicos específicos num método de Avaliação da Sustentabilidade de Edifícios de Saúde (HBSA)

The healthcare project design requires a several number of concerns with the satisfaction and well‐being of the working team, patient and administrators, has a strong social responsibility and impact on the city. Due to various design requirements, these buildings are not designed and used in a sustainable way, because there are still no effective methods to support designers in this context. Consequently, they do not know what the best criteria to be followed and their managers are not aware of the measuresthatshould be adopted for efficient use. Furthermore, the aim of this study is to present a proposal for a Healthcare Building Sustainability Assessment (HBSA) method adapted for the Portuguese context and considering the work developed so far in the standardization bodies (CEN and ISO). For this, the chosen methodology is analysed and compared the most relevant building sustainability assessment tools in the context of healthcare buildings.  

Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development

Congenital diaphragmatic hernia (CDH) is characterised by a spectrum of lung hypoplasia and consequent pulmonary hypertension, leading to high morbidity and mortality rates. Moreover, CDH has been associated with an increase in the levels of pulmonary neuroendocrine factors, such as bombesin and ghrelin, and a decrease in the action of retinoic acid (RA). The present study aimed to elucidate the interaction between neuroendocrine factors and RA. In vitro analyses were performed on Sprague-Dawley rat embryos. Normal lung explants were treated with bombesin, ghrelin, a bombesin antagonist, a ghrelin antagonist, dimethylsulfoxide (DMSO), RA dissolved in DMSO, bombesin plus RA and ghrelin plus RA. Hypoplastic lung explants (nitrofen model) were cultured with bombesin, ghrelin, bombesin antagonist or ghrelin antagonist. The lung explants were analysed morphometrically, and retinoic acid receptor (RAR) α, β and γ expression levels were assessed via Western blotting. Immunohistochemistry analysis of RAR was performed in normal and hypoplastic lungs 17.5 days post-conception (dpc). Compared with the controls, hypoplastic lungs exhibited significantly higher RARα/γ expression levels. Furthermore considering hypoplastic lungs, bombesin and ghrelin antagonists decreased RARα/γ expression. Normal lung explants (13.5 dpc) treated with RA, bombesin plus RA, ghrelin plus RA, bombesin or ghrelin exhibited increased lung growth. Moreover, bombesin and ghrelin increased RARα/γ expression levels, whereas the bombesin and ghrelin antagonists decreased RARα/γ expression. This study demonstrates for the first time that neuroendocrine factors function as lung growth regulators, sensitising the lung to the action of RA through up-regulation of RARα and RARγ.

A cooperação transfronteiriça como oportunidade de desenvolvimento das regiões de fronteira. Da Raia Ibérica à euroregião Galiza-Norte de Portugal

Tese de Doutoramento em Geografia Humana.

Avaliação do transporte sedimentar na bacia do rio Lima baseada em ferramentas de modelação

Dissertação de mestrado integrado em Engenharia Civil

Implementação de metodologias BIM na Direção de Engenharia de Barragens da EDP: casos de estudo de projeto de estruturas em obras hidroelétricas

Dissertação de mestrado integrado em Engenharia Civil

A novel hanging spherical drop system for the generation of cellular spheroids and high throughput combinatorial drug screening

We propose a novel hanging spherical drop system for anchoring arrays of droplets of cell suspension based on the use of biomimetic superhydrophobic flat substrates, with controlled positional adhesion and minimum contact with a solid substrate. By facing down the platform, it was possible to generate independent spheroid bodies in a high throughput manner, in order to mimic in vivo tumour models on the lab-on-chip scale. To validate this system for drug screening purposes, the toxicity of the anti-cancer drug doxorubicin in cell spheroids was tested and compared to cells in 2D culture. The advantages presented by this platform, such as feasibility of the system and the ability to control the size uniformity of the spheroid, emphasize its potential to be used as a new low cost toolbox for high-throughput drug screening and in cell or tissue engineering.

O hospital da misericórdia de Penafiel (1600-1850)

Tese de Doutoramento em História - Especialidade de Idade Moderna

O reforço da democracia local no âmbito da reforma da administração autárquica

Dissertação de mestrado em Direito das Autarquias Locais

Definition of multibody system

This chapter presents a general view of multibody system concept and definition by describing the main features associated with spatial systems. The mechanical components, which can be modeled as rigid or flexible, are constrained by kinematic pair of different types. Additionally, the bodies can be actuated upon by force elements and external forces due to interaction with environment. This chapter also presents some examples of application of multibody systems that can include automotive vehicles, mechanisms, robots and biomechanical systems.

Angular velocity and acceleration

In this chapter, a complete characterization of the angular velocity and angular acceleration for rigid bodies in spatial multibody systems are presented. For both cases, local and global formulations are described taking into account the advantages of using Euler parameters. In this process, the transformation between global and local components of the angular velocity and time derivative of the Euler parameters are analyzed and discussed in this chapter.

Force elements and reaction forces

"Series title: Springerbriefs in applied sciences and technology, ISSN 2191-530X"

Avaliação da toxicidade das águas do rio Cubatão (Norte) - Joinville, SC, com base em ensaios ecotoxicológicos com Daphnia magna

Dissertação de mestrado em Ecologia

Dissipative contact force models

"Series: Solid mechanics and its applications, vol. 226"

Prospecção de ocorrências filonianas do tipo LCT nas formações metassedimentares entre Boticas e Montalegre (N de Portugal)

Dissertação de mestrado em Geologia (área de especialização em Valorização de Recursos Geológicos)