Strategia ja menestystekijät projektiliiketoiminnassa

Projektit ovat keskeinen osa usean yrityksen päivittäistä toimintaa. Niiden avulla voidaan toteuttaa organisaatioiden sisäisiä kehityshankkeita tai yhtä hyvin asiakastoimituksia tuotteiden ja palveluiden muodossa. Tämän tutkimustyön tavoitteena on kehittää asiakastoimitusprojektien projektiliiketoimintamallia strategian näkökulmasta tapaustutkimuksen avulla. Lisäksi tutkimustyön tavoitteena on määrittää projektiliiketoiminnan menestystekijät asiakastoimitusprojektien yhteydessä ja muodostaa niiden mukainen suorituskykymittariston perusta. Tutkimus toteutettiin valitun yrityksen projektiliiketoimintamalliin perehtymällä. Ensimmäisessä vaiheessa esitellään yritystä ja sen toimintaa. Yrityksen toimintaa kuvataan viitekehyksen avulla, joka on valittu teoriakatsauksen perusteella. Teoriakatsaus käsittelee projektiliiketoimintaa, strategiaa projektiliiketoiminnassa sekä suorituskyvynjohtamisen teoriaa. Keskeisenä tuloksena tutkimuksen perusteella muodostettiin ehdotus yrityksen projektiliiketoiminnan tavoitetilasta, ydintoiminnoista, menestystekijöistä sekä strategiasta. Ehdotuksessa kuvataan projektiliiketoiminnan suorituskyvynjohtamisen peruselementit, jotka muodostavat perustan suorituskyvyn mittaamiselle kohdeorganisaatiossa.

On the Connectivity of the Julia sets of meromorphic functions

We prove that every transcendental meromorphic map $f$ with disconnected Julia set has a weakly repelling fixed point. This implies that the Julia set of Newton's method for finding zeroes of an entire map is connected. Moreover, extending a result of Cowen for holomorphic self-maps of the disc, we show the existence of absorbing domains for holomorphic self-maps of hyperbolic regions, whose iterates tend to a boundary point. In particular, the results imply that periodic Baker domains of Newton's method for entire maps are simply connected, which solves a well-known open question.

The role of executive functions in the control of aggressive behavior

An extensive literature suggests a link between executive functions and aggressive behavior in humans, pointing mostly to an inverse relationship, i.e., increased tendencies toward aggression in individuals scoring low on executive function tests. This literature is limited, though, in terms of the groups studied and the measures of executive functions. In this paper, we present data from two studies addressing these issues. In a first behavioral study, we asked whether high trait aggressiveness is related to reduced executive functions. A sample of over 600 students performed in an extensive behavioral test battery including paradigms addressing executive functions such as the Eriksen Flanker task, Stroop task, n-back task, and Tower of London (TOL). High trait aggressive participants were found to have a significantly reduced latency score in the TOL, indicating more impulsive behavior compared to low trait aggressive participants. No other differences were detected. In an EEG-study, we assessed neural and behavioral correlates of error monitoring and response inhibition in participants who were characterized based on their laboratory-induced aggressive behavior in a competitive reaction time task. Participants who retaliated more in the aggression paradigm and had reduced frontal activity when being provoked did not, however, show any reduction in behavioral or neural correlates of executive control compared to the less aggressive participants. Our results question a strong relationship between aggression and executive functions at least for healthy, high-functioning people.

Is there a relationship between bilingual language switching and executive functions in bilingualism? Introducing a within-group analysis approach

Several studies have suggested a bilingual advantage in executive functions, presumably due to bilinguals' massive practice with language switching that requires executive resources, but the results are still somewhat controversial. Previous studies are also plagued by the inherent limitations of a natural groups design where the participant groups are bound to differ in many ways in addition to the variable used to classify them. In an attempt to introduce a complementary analysis approach, we employed multiple regression to study whether the performance of 30- to 75-year-old FinnishSwedish bilinguals (N = 38) on tasks measuring different executive functions (inhibition, updating, and set shifting) could be predicted by the frequency of language switches in everyday life (as measured by a language switching questionnaire), L2 age of acquisition, or by the self-estimated degree of use of both languages in everyday life. Most consistent effects were found for the set shifting task where a higher rate of everyday language switches was related to a smaller mixing cost in errors. Mixing cost is thought to reflect top-down management of competing task sets, thus resembling the bilingual situation where decisions of which language to use has to be made in each conversation. These findings provide additional support to the idea that some executive functions in bilinguals are affected by a lifelong experience in language switching and, perhaps even more importantly, suggest a complementary approach to the study of this issue.

Estimation of age- and stage-specific Catalan breast cancer survival functions using US and Catalan survival data

During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these interventions using mathematical models requires survival functions before and after their introduction. Furthermore, required survival functions may be different by age groups and are related to disease stage at diagnosis. Sometimes detailed information is not available, as was the case for the region of Catalonia (Spain). Then one may derive the functions using information from other geographical areas. This work presents the methodology used to estimate age- and stage-specific Catalan breast cancer survival functions from scarce Catalan survival data by adapting the age- and stage-specific US functions. Methods: Cubic splines were used to smooth data and obtain continuous hazard rate functions. After, we fitted a Poisson model to derive hazard ratios. The model included time as a covariate. Then the hazard ratios were applied to US survival functions detailed by age and stage to obtain Catalan estimations. Results: We started estimating the hazard ratios for Catalonia versus the USA before and after the introduction of screening. The hazard ratios were then multiplied by the age- and stage-specific breast cancer hazard rates from the USA to obtain the Catalan hazard rates. We also compared breast cancer survival in Catalonia and the USA in two time periods, before cancer control interventions (USA 1975–79, Catalonia 1980–89) and after (USA and Catalonia 1990–2001). Survival in Catalonia in the 1980–89 period was worse than in the USA during 1975–79, but the differences disappeared in 1990–2001. Conclusion: Our results suggest that access to better treatments and quality of care contributed to large improvements in survival in Catalonia. On the other hand, we obtained detailed breast cancer survival functions that will be used for modeling the effect of screening and adjuvant treatments in Catalonia

An analytic approach to distribution logistics strategic management

Logistics management is increasingly being recognised by many companies to be of critical concern. The logistics function includes directly or indirectly many of the new areas for achieving or maintaining competitive advantage that companies have been forced to develop due to increasing competitive pressures. The key to achieving a competitive advantage is to manage the logistics function strategically which involves determining the most cost effective method of providing the necessary customer service levels from the many combinations of operating procedures in the areas of transportation, warehousing, order processing and information systems, production, and inventory management. In this thesis, a comprehensive distribution logistics strategic management process is formed by integrating the periodic strategic planning process with a continuous strategic issues management process. Strategic planning is used for defining the basic objectives for a company and assuring co operation and synergy between the different functions of a company while strategic issues management is used on a continuous basis in order to deal with environmental and internal turbulence. The strategic planning subprocess consists of the following main phases: (1) situational analyses, (2) defining the vision and strategic goals for the logistics function, (3) determining objectives and strategies, (4) drawing up tactical action plans, and (5) evaluating the implementation of the plans and making the needed adjustments. The aim of the strategic issues management subprocess is to continuously scan the environment and the organisation for early identification of the issues having a significant impact on the logistics function using the following steps: (1) the identification of trends, (2) assessing the impact and urgency of the identified trends, (3) assigning priorities to the issues, and (4) planning responses to the, issues. The Analytic Hierarchy Process (AHP) is a systematic procedure for structuring any problem. AHP is based on the following three principles: decomposition, comparative judgements, and synthesis of priorities. AHP starts by decomposing a complex, multicriteria problem into a hierarchy where each level consists of a few manageable elements which are then decomposed into another set of elements. The second step is to use a measurement methodology to establish priorities among the elements within each level of the hierarchy. The third step in using AHP is to synthesise the priorities of the elements to establish the overall priorities for the decision alternatives. In this thesis, decision support systems are developed for different areas of distribution logistics strategic management by applying the Analytic Hierarchy Process. The areas covered are: (1) logistics strategic issues management, (2) planning of logistic structure, (3) warehouse site selection, (4) inventory forecasting, (5) defining logistic action and development plans, (6) choosing a distribution logistics strategy, (7) analysing and selecting transport service providers, (8) defining the logistic vision and strategic goals, (9) benchmarking logistic performance, and (10) logistic service management. The thesis demonstrates the potential of AHP as a systematic and analytic approach to distribution logistics strategic management.

Genetic Basis and Diagnostics of Extended-Spectrum Beta-Lactamases among Enterobacteriaceae in Finland

Since the introduction of antibiotic agents, the amount and prevalence of Beta-lactam resistant enterobacteria has become an increasing problem. Many enterobacteria are opportunistic pathogens that easily acquire resistance mechanisms and genes, which make the situation menacing. These bacteria have acquired resistance and can hydrolyse extended spectrum cephalosporins and penicillins by producing enzymes called extended-spectrum Beta-lactamases (ESBLs). ESBL-producing bacteria are most commonly found in the gastro-intestinal tract of colonised patients. These resistant strains can be found in both health-care associated and community-acquired isolates. The detection and treatment of infections caused by bacteria producing ESBLs are problematic. This study investigated the genetic basis of extended-spectrum Beta-lactamases in Enterobacteriaceae, especially in Escherichia coli and Klebsiella pneumoniae isolates. A total of 994 Finnish Enterobacteriaceae strains, collected at 26 hospital laboratories, during 2000 and 2007 were analysed. For the genetic basis studies, PCR, sequencing and pyrosequencing methods were optimised. In addition, international standard methods, the agar dilution and disk diffusion methods were performed for the resistance studies, and the susceptibility of these strains was tested for antimicrobial agents that are used for treating patients. The genetic analysis showed that bla_CTX-M was the most prevalent gene among the E. coli isolates, while blaS_HV-12 was the most common Beta-lactamase gene in K. pneumoniae. The susceptibility testing results showed that about 60% of the strains were multidrug resistant. The prevalence of ESBL-producing isolates in Finland has been increasing since 2000. However, the situation in Finland is still much better than in many other European countries.

Probiotic lactobacilli and bifidobacteria in the mouth – in vitro studies on saliva-mediated functions and acid production

Probiotic lactobacilli and bifidobacteria in the mouth – in vitro studies on saliva-mediated functions and acid production Probiotics are viable bacteria which, when used in adequate amounts, are beneficial to the health of the host. Although most often related to intestinal health, probiotic bacteria can be found also in the mouth after consumption of products that contain them. This study aimed at evaluating the oral effects of probiotic bacteria already in commercial use. In a series of in vitro studies, the oral colonisation potential of different probiotic bacteria, their acid production and potential saliva-mediated effects on oral microbial ecology were investigated. The latter included effects on the salivary pellicle, the adhesion of other bacteria, and the activation of the peroxidase system. Streptococcus mutans, Streptococcus gordonii, Aggregatibacter actinomycetemcomitans and Helicobacter pylori were used as bacterial indicators of the studied phenomena. There were significant differences between the probiotic strains in their colonisation potential. They all were acidogenic, although using different sugars and sugar alcohols. However, their acid production could be inhibited by the peroxidase system. Based on the results, it can be suggested that probiotic bacteria might influence the oral microbiota by different, partly species or strain-specific means. These include the inhibition of bacterial adhesion, modification of the enamel pellicle, antimicrobial activity, and activation of the peroxidase system. To conclude, probiotic strains differed from each other in their colonisation potential and other oral effects as evaluated in vitro. Both positive and potentially harmful effects were observed, but the significance of the perceived results needs to be further evaluated in vivo.

ContinuousMultimodal Global Optimization with Differential Evolution-Based Methods

Metaheuristic methods have become increasingly popular approaches in solving global optimization problems. From a practical viewpoint, it is often desirable to perform multimodal optimization which, enables the search of more than one optimal solution to the task at hand. Population-based metaheuristic methods offer a natural basis for multimodal optimization. The topic has received increasing interest especially in the evolutionary computation community. Several niching approaches have been suggested to allow multimodal optimization using evolutionary algorithms. Most global optimization approaches, including metaheuristics, contain global and local search phases. The requirement to locate several optima sets additional requirements for the design of algorithms to be effective in both respects in the context of multimodal optimization. In this thesis, several different multimodal optimization algorithms are studied in regard to how their implementation in the global and local search phases affect their performance in different problems. The study concentrates especially on variations of the Differential Evolution algorithm and their capabilities in multimodal optimization. To separate the global and local search search phases, three multimodal optimization algorithms are proposed, two of which hybridize the Differential Evolution with a local search method. As the theoretical background behind the operation of metaheuristics is not generally thoroughly understood, the research relies heavily on experimental studies in finding out the properties of different approaches. To achieve reliable experimental information, the experimental environment must be carefully chosen to contain appropriate and adequately varying problems. The available selection of multimodal test problems is, however, rather limited, and no general framework exists. As a part of this thesis, such a framework for generating tunable test functions for evaluating different methods of multimodal optimization experimentally is provided and used for testing the algorithms. The results demonstrate that an efficient local phase is essential for creating efficient multimodal optimization algorithms. Adding a suitable global phase has the potential to boost the performance significantly, but the weak local phase may invalidate the advantages gained from the global phase.

Interleukin-4 induced leukocyte differentiation

Monocytes, macrophages and dendritic cells (DCs) are important mediators of innate immune system, whereas T lymphocytes are the effector cells of adaptive immune responses. DCs play a crucial role in bridging innate and adaptive immunity. Naïve CD4+ Th progenitors (Thp) differentiate to functionally distinct effector T cell subsets including Th1, Th2 and Th17 cells, which while being responsible for specific immune functions have also been implicated in pathological responses, such as autoimmunity, asthma and allergy. The main objective of this thesis is to dissect the signalling networks involved in the IL-4 induced differentiation of two important leukocyte subtypes, Th2 cells and DCs. Gene expression profiling lead to identification of over 200 genes which are differentially expressed during cytokine induced differentiation of human monocytes to DCs or macrophages and which are likely to be essential for the proper biological functions of these cell types. Transcriptome analysis demonstrated the dynamic regulation of gene expression by IL-12 and IL-4 during the initiation of Th cell differentiation, which was partly counteracted by an immunosuppressive cytokine, TGFβ, present in the culture media. Results from RNAi mediated gene knockdown experiments and global gene expression analysis elucidated that SATB1 regulates multiple genes important for Th cell polarization or function as well as may compete with GATA3 for the reciprocal regulation of IL-5 transcription. In conclusion, the results obtained have extended our system-level understanding of the immune cell differentiation processes and provide an excellent basis for the further functional studies which could lead to development of improved therapeutic approaches for a range of immunological conditions.

Improving Cross Direction Basis Weight Profile in a Fourdrinier Paper Machine

The purpose of this study was to improve PM7’s basis weight CD profile in Stora Enso’s Berghuizer mill and to search mechanical defects which affect to the formation of the basis weight CD profile. In the theoretical part PM7’s structure was presented and the formation of the basis weight and caliper CD profiles was examined as well as disturbances which are affecting to the formation. The function of the control system was scrutinised for the side of CD profiles as well as the formation of the measured CD profiles. Tuning of the control system was examined through the response model and filtering. Specification of the response model and filtering was explained and how to determine 2sigma statistical number. In the end of the theoretical part ATPA hardware and a new profile browser were introduced. In the experimental part focus was in the beginning to search and remove mechanical defects which are affecting to CD profiles. The next step was to verify the reliability of the online measurements, to study the stability of the basis weight CD profile and to find out so called fingerprint, a basis weight CD profile which is unique for each paper machine. New response model and filtering value for basis weight CD profile was determined by bump tests. After a follow up period the affect of the new response model and filtering was analysed.

Uuden valmistusteknologian käyttöönottoprosessin kuvaaminen

Raskaassa teollisuudessa perinteisten valmistusmenetelmien kehitys vaatii uusiin valmistusteknologioihin investoimista ja niiden käyttöönottoa. Valmistusteknologioiden käyttöönottoja johdetaan yrityksissä useimmiten yksittäisinä projekteina. Tämän tutkimuksen tarkoituksena on selvittää, voidaanko valmistusteknologian käyttöönotoissa tunnistaa yhteisiä piirteitä ja onko niihin mahdollista soveltaa prosessijohtamisen menetelmiä. Tutkimuksen taustan muodostaa kirjallisuusselvitys aiemmin julkaistuista aihepiiriin liittyvistä tutkimuksista. Tärkeimmät teoreettiset viitekehykset aiemmista tutkimuksista ovat Taskisen julkaisu tuotantoprosessin muutoksen vaiheista sekä muutoksen mittaristosta, sekä Carillon ja Gaimonin tutkimus valmistusprosessin muutostavoitteista sekä niiden resursoinnista. Lisäksi prosessijohtamisen käsitteet ja yleisimmät prosessien kuvaamisen standardimenetelmät esiteltiin. Työssä tutustutaan suomalaisessa raskaan teollisuuden kasvuyrityksessä tehtyihin valmistusteknologian käyttöönottojen suorituksiin ja niissä havaittuihin kehityskohteisiin. Näiden kehityskohteiden ja teoreettisten viitekehysten perusteella luotiin prosessimalli valmistusteknologian käyttöönotosta. Tutkimuksessa havaittiin, että uuden valmistusteknologian käyttöönotto noudattaa tuotantoprosessiin tehtävien muutosten teoriaa, ja siitä voidaan tunnistaa käyttöönoton tyypistä riippumattomia toistuvia vaiheita. Nämä vaiheet ja toiminnot on mahdollista kuvata prosessiksi, jota voidaan kehittää käyttöönottojen suorituksesta saatujen kokemusten ja mittaustuloksien avulla.

Verkkokaupan perustamisen suunnittelu lastenvaateliikkeelle

Verkkokauppa on yleistynyt viime vuosina voimakkaasti. Sähköisen kaupankäynnin avulla yrityksellä on mahdollisuus kasvaa markkina-alueen laajetessa, tosin laajalla markkina-alueella myös kilpailu on kovaa. Verkkokaupan perustaminen on teknisesti nopeaa ja helppoa, mutta verkkokaupan menestyksekäs toteuttaminen vaatii huolellisen ennakkosuunnittelun. Tämän diplomityön tavoitteena on kerätä taustatiedot ja suunnitella perustekijät kuluttajakaupassa verkkokauppaa aloittelevalle lastenvaateliikkeelle menestyksekkään kaupankäynnin tukemiseksi. Työssä on perehdytty yleisesti sähköiseen kaupankäyntiin, sen toimijoihin ja verkkokaupan tuotteisiin kirjallisuuden ja muiden lähteiden avulla. Tämän lisäksi on haettu tietoa verkkokaupan palveluntarjoajista ohjelmistoihin, maksujärjestelmiin ja kuljetuspalveluihin liittyen. Työ sisältää kohdeyritykseen, sen myymiin tuotteisiin, kilpailijoihin ja potentiaalisiin asiakkaisiin tutustumisen. Kilpailija-analyysi sisältää samantyyppisten yritysten perustietojen lisäksi näiden jo toimivien verkkokauppojen havainnoinnin. Potentiaalisia asiakkaita ja näiden mieltymyksiä on kartoitettu verkossa toteutetun asiakaskyselyn avulla. Markkinointiviestintää, tietoturvaa ja teknisiä yksityiskohtia koskevat asiat on rajattu pääosin ulkopuolelle. Työn tuloksena on toimenpidesuositus verkkokaupan käynnistämisvaiheeseen sisältäen tutkitut verkkokaupan osa-alueet. Haettujen perustietojen ja toteutettujen analyysien pohjalta on suositeltu kohdeyritykselle soveltuvia palveluntarjoajia ja keskeisiksi havaittujen toiminnallisuuksien toteutusta verkkokaupassa.

Monikanavaisen kriisiviestintämallin kehittäminen, asiakasyrityksenä Medi-IT Oy

Tämän diplomityön tavoitteena oli selvittää, mitä asioita organisaation tulisi huomioida tehokkaan, monikanavaisen kriisiviestintämallin suunnittelussa ja toteuttamisessa. Asiakasyritys Medi-IT Oy tukee terveydenhuollon ja sosiaalitoimen palveluntuottajien toimintaa tarjoamalla ja tuottamalla asiantuntija- ja tietotekniikkapalveluita. Tutkimuksessa keskitytään yrityksen tukipalveluyksikköön ja viestinnän lajeista häiriötilanteiden viestintään. Kriisiviestintämalli voidaan tarvittaessa lanseerata myös muihin yksiköihin. Medi-IT Oy:n kriisiviestintämallin kehittäminen aloitettiin kartoittamalla nykytilaa. Tämä tehtiin yrityksen nykyisiä toimintatapoja selvittämällä ja kysymällä asiakkaiden ja työntekijöiden mielipiteitä ja kokemuksia. Viestintään liittyvän puhelinkyselyn asiakkaille suoritti InnoLink-yritys. Kyselyn tuloksista nousi esiin viestinnän ongelmakohtia. Näihin paneutumalla löydettiin kehitettävät kohteet. Nämä kriisiviestinnän ja samalla tapahtumien hallinnan kehityskohteet on esitetty toimintojen tarkennuksina. Asiakasyritys on panostamassa prosessien laatuun ja on aloittamassa ITIL:in hyödyntämisen prosessien läpikäymisessä. Siksi myös ITIL:in periaatteita otettiin huomioon tässä kriisiviestinnän prosessimallissa. Työssä selvitettiin teoriakatsauksen pohjalta, mitkä ovat hyvän kriisiviestinnän ominaisuudet ja mitkä ovat monikanavaisuuden asettamat haasteet, edut ja haitat. Prosessin mallintamisessa käytettiin tapahtumien hallintaan keskittyvää työkalua. Työn lopputuloksena syntyi asiakasyritykselle monikanavaisen kriisiviestinnän kehittämismalli sekä kehittämistä vaativien toimintojen tarkennukset. Työhön sisältyy myös tulevaisuuden kriisiviestinnän prosessimalli, jonka toteutuminen ei ole vielä teknisesti täysin mahdollista.