987 resultados para continuous production


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21th Annual Conference of the International Group for Lean Construction (IGLC 21), July 2013, Fortaleza, Brazil

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Dissertação para obtenção do Grau de Mestre em Engenharia Electrotécnica, Sistemas e Computadores

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Dissertation presented to Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa for obtaining the master degree in Membrane Engineering

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Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica

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Dissertation presented to obtain the Ph.D degree in Biochemistry, Engineering and Technological Sciences

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Dissertation for the Master degree in Biotechnology

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Dissertação para obtenção do Grau de Mestre em Biotecnologia

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Dissertação para obtenção do Grau de Mestre em Biotecnologia

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Monoclonal antibodies (MABs) ivere produced against an etbylenediaminetetraacetate (EDTA) extract of Leptospira interrogans serovar icterohaemorrhagiae being characterized by gel precipitation as IgM and IgG (IgGl and IgG2b). The EDTA extract was detected as several bands by silver staining in SDS-PAGE. In the Western blot the bands around 20 KDa reacted with a monoclonal antibody, 47B4D6, and was oxidized by periodate and was not digested by pronase, suggesting that the determinant is of carbohydrate nature, lmmunocytochemistry, using colloidal gold labeling, showed that an EDTA extract determinant recognized by monoclonal antibody 47B4D6, is localized under the outer envelope of serovar icterohaemorrhagiae. Hoe AIAB raised against the EDTA extract was not able to protect hamsters from lethal challenge with virulent homologous leptospires.

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Dissertation for the Degree of Master in Biotechnology

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Dissertação para obtenção do Grau de Mestre em Biotecnologia

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Dissertation presented in partial fulfilment of the Requirements for the Degree of Master in Biotechnology

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Dissertação para obtenção do Grau de Mestre em Biotecnologia

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Dissertação para obtenção do Grau de Mestre em Biotecnologia

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This study reviews a series of cutaneous leishmaniasis cases diagnosed and treated in outpatient units in the municipality of Rio de Janeiro, where the intermittent schedule of antimonial therapy was replaced by the continuous regimen. Both schedules were based on daily intramuscular injections of pentavalent antimonial. Forty-nine subjects received the intermittent regimen, consisting of three ten-day series alternated with ten-day rest intervals whereas seventy-one patients received the continuous regimen during 20 consecutive days. The study groups had similar composition regarding age, sex and clinical condition. The cure rate was significantly higher in the group receiving the intermittent schedule than in the group receiving continuous therapy (89.8% vs 63.3%). Moreover, loss to follow-up was significantly more frequent in the group receiving continuous therapy (19.7% vs 4.1% in the intermittent therapy). Under field conditions, the intermittent regimen provided higher effectiveness and adherence than the continuous schedule.