930 resultados para Pombal, Sebastião José de Carvalho e Melo, Marqués de, 1699-1782


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Dissertação mest., Gerontologia Social, Universidade do Algarve, 2009

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Dissertação mest., Gestão Sustentável dos Espaços Rurais, Universidade do Algarve, 2008

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De entre los muchos repertorios de textos recogidos de la tradición oral hispánica que en los últimos años han ido publicándose, éste sobresale por un rasgo excepcional: su autor dedica igual espacio, aténcion, tiempo, rigor y esmero tanto al asunto puramente textual (los mayos) como as las cuestiones referidas al contexto folklórico (la fiesta) en el que los textos se actualizan.

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O estudio do romanceiro de Galicia vén merecendo unha atención especial tanto dentro como fóra do país [pénsese nas análises de A. Valenciano (1998) ou A. Requeixo (1996), entre outras].

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Understanding heart development on a molecular level is a requirement for uncovering the causes of congenital heart diseases. Several genes have been implicated as critical for heart development. However, the inducers of these genes as well as their targets and pathways, remain largely unknown. We have identified a promoter element of chick cCer able to drive EGFP expression in a population of cells that consistently exit from the anterior primitive streak region, from as early as stage HH3+, and that later will populate the heart. Using this promoter element as a tool allowed us to identify novel genes previously not known to potentially play a role in heart development. In order to identify and study genes expressed and involved in the correct development and differentiation of the vertebrate heart precursor cell (HPC) lineages, a differential screening using Affymetrix GeneChip® system technologies was performed. Remarkably, this screening led to the identification of more than 700 transcripts differentially expressed in the heart forming regions (HFR). Bioinformatic tools allowed us to filter the large amount of data generated from this approach and to select a few transcripts for in vivo validation. Five genes were selected for further characterization by whole mount in situ hybridization leading to the validation of their expression in the HPC. From those, Adtk1 and Ccbe1 were selected for functional analysis. Regarding to ccbe1, a more detailed WISH analysis was performed and showed that Ccbe1 is expressed specifically on the cardiac progenitors regions at HH4, more specifically in primary heart field and at later stages is present in the second heart field. Further functional analyses by knockdown and overexpression revealed an important role for Ccbe1 in early heart tube formation. Moreover, the results presented in this thesis suggested that Ccbe1 is a key gene during heart development and might be limited to multipotent and highly proliferative progenitors and downregulated upon cellular commitment into more specific cardiac phenotypes. Other of the genes identified, Adtk1 was also subjected to further functional studies. Knockdown of Adtk1 using morpholino oligonucleotides suggested that it might be necessary for the migration and fusion of the heart tube as well as for neural tube closure.

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Dissertação de mestrado, Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015

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This speech by Georgia Supreme Court judge Joseph Lumpkin aims to ignite a spirit of improvement and bring about its influence. This improvement is not necessarily in the interest of agriculture alone, but in the interest of the state as well.

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Relatório de estágio de mestrado, Ciências da Educação (Administração Educacional), Universidade de Lisboa, Instituto de Educação, 2011

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Trabalho de projecto de mestrado, Ciências da Educação (Administração Educacional), Universidade de Lisboa, Instituto de Educação, 2011

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Este artigo é um produto do Projeto PTDC/CPE-CED/114362/2009 - Envolvimento dos Alunos na escola: Diferenciação e Promoção, financiado por Fundos Nacionais através da Fundação para a Ciência e Tecnologia (FCT), e coordenado por Feliciano Veiga.

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Tese de doutoramento, História (História dos Descobrimentos e da Expansão), Universidade de Lisboa, Faculdade de Letras, 2014

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Tese de doutoramento, Filosofia (Filosofia em Portugal), Universidade de Lisboa, Faculdade de Letras, 2014

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Tese de doutoramento, Estudos de Literatura e de Cultura (Estudos Comparatistas), Universidade de Lisboa, Faculdade de Letras, 2014

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Tese de doutoramento, História (História e Cultura do Brasil), Universidade de Lisboa, Faculdade de Letras, 2014