In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi

This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 g mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 mu g mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives.

Carl Maria von Weber’s Overture to Oberon: A History of Recorded Performance

My research examines the recorded performance history of the Overture to Weber’s Oberon in light of these aesthetic goals. I have charted changes in performance practice trends, including in timing, tempo fluctuation, rhythmic accuracy and ensemble, and the use of portamento. The twenty recordings studied that I surveyed span nearly seventy-five years, and include many of the 20th century’s most prominent conductors and orchestras, including groups from Communist Russia, both pre-World War II and post-World War II continental Europe, the British Isles, and the United States.8 Though by no means comprehensive, my selections encompass a diverse sampling of surviving recordings, ensuring a large enough sample size to reflect general trends in the performance of Weber’s masterpiece. My research and analysis confirms the conventional view of a move toward more accurate—but also more cautious, uniform, and inexpressive— performances. Surprisingly, however, this analysis also suggests that we are on the cusp of a new era in orchestra performance practice, one that shares many of the values of the earlier recorded performances. While maintaining today’s high standards of execution, modern performances now look to regain many of the past’s expressive qualities, doing so in sometimes surprising ways.

Luis Millones, Charles A. Dana Associate Professor of Spanish

Luis Millones, Charles A. Dana Associate Professor of Spanish reading Pliny's A Historie of the World

Os bailes do Palácio de Mármore na cidade industrial: o Moinho São Jorge e o patrimônio industrial de Santo André (1950-2000) (Parte 1)

Pautado nessa perspectiva de valorização do patrimônio industrial na região do ABC, esse texto volta-se para as relações entre indústria, lazer e memória. Tem como foco o tema do lazer e do entretenimento como uma das construções patrimoniais da sociedade industrial. O Palácio de Mármore do Moinho São Jorge representa um caso em que tais relações se conjugam. Dessa forma, propõe-se com esse artigo, apontar as relações existentes entre industrialização e lazer no ABC no período de 1950/60, tomando como ponto de partida as lembranças das pessoas que viveram à época.

Iniciativas sustentáveis voltadas à responsabilidade social e ao desenvolvimento regional: um estudo sobre a Braskem

Dissertação apresentada ao Programa de Pós-graduação em Administração da Universidade Municipal de São Caetano do Sul

Inclusão da pessoa com deficiência no mercado de trabalho: gestão, direitos e efetividade

Tese apresentada ao Programa de Doutorado em Administração da Universidade Municipal de São Caetano do Sul, como requisito parcial para a obtenção do título de Doutora em Administração