In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi

This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 g mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 mu g mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives.

Sao Paulo State Research Foundation (FAPESP)[03/11524-9]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Sao Paulo State Research Foundation (FAPESP)[05/57042-0]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Sao Paulo State Research Foundation (FAPESP)[03/01867-6]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Sao Paulo State Research Foundation (FAPESP)[06/50086-5]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

BIOTA/FAPESP

CNPq

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)