Programa Mais Médicos : uma avaliação dos resultados iniciais referentes ao eixo do provimento emergencial a partir da teoria da avaliação de programas

Dissertação (mestrado)—Universidade de Brasília, Centro de Estudos Avançados Multidisciplinares, Programa de Pós-Graduação em Desenvolvimento Sociedade e Cooperação Internacional, 2016.

Nanopartículas de alginato como sistema de liberação para o herbicida clomazone

In this paper, we describe the preparation of alginate nanoparticles as a delivery system for the herbicide clomazone. Two different methods were investigated and characterized by size distribution, zeta potencial, pH and in vitro release. The alginate/AOT nanoparticles had higher rates of association of the herbicide clomazone than alginate/chitosan nanoparticles. Clomazone release profile, showed a significant difference in release behavior of pure herbicide in solution when compared with herbicide loaded in both alginate nanoparticles. This study is important to construct a biodegradable release system using herbicide for later release into more specific targets, avoiding contamination of environmental matrices.

Desenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína

In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.

Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina

Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.

Characterization of Atrazine-Loaded Biodegradable Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Microspheres

Polyhydroxybutyrate-co-hydroxyvalerate microspheres (PHBV-MS) were prepared as a delivery system for the herbicide atrazine (ATZ). Characterization of the system included investigation of in vitro release properties and genotoxicity. ATZ - PHBV-MS particle diameters showed a size distribution range of 1-13 mu m. Differential scanning calorimetry analyses indicated that ATZ was associated with the PHBV microparticles. The release profiles showed a different release behavior for the pure herbicide in solution, as compared with that containing ATZ-loaded PHBV-MS. Korsmeyer-Peppas model analyses showed that atrazine release from the microparticles occurred by a combination of diffusion through the matrix and partial diffusion through water-filled pores of the PHBV microparticles. A Lactuca sativa test result showed that the genotoxicity of ATZ-loaded PHBV-MP was decreased in relation to ATZ alone. The results demonstrate a viable biodegradable herbicide release system using atrazine for agrochemical purposes.

Satisfação Laboral e Compromisso Organizacional

O projeto realizou-se num contexto onde as organizações mantêm os funcionários conectados, motivados, e satisfeitos pessoal e profissionalmente, onde em companhia dos seus líderes, marcham em busca da tão desejada progressão organizacional, maximizando o lucro e minimizando os custos continuamente. Por este motivo, decidiu-se elaborar o projeto, cujo objetivo é avaliar/examinar duas variáveis, a Satisfação Laboral e o Compromisso Organizacional, destacando uma possível associação entre ambas. O universo em análise é a população da empresa angolana no sector da informação, empresa integrada no mercado angolano, cujo objeto de trabalho passa por recolher, tratar e distribuir a informação, nacional e internacionalmente. A mesma teve a amabilidade que disponibilizar os seus 172 colaboradores como amostra para fazer parte deste projeto. Para o estudo foram utilizadas metodologias quantitativas, aplicando-se dois questionários. O primeiro, de Warr, Cook e Wall referente a Satisfação Laboral, e o segundo, de Allen Meyer, refere-se ao Compromisso Organizacional, ambos previamente aprovados/certificados, e utilizados anteriormente com as referidas variáveis. Relativamente aos resultados, observou-se a existência de um impacto significativo entre a variável Satisfação Laboral e a variável Compromisso Organizacional; tento a primeira uma influência positiva sobre a segunda. Os resultados do estudo concluíram que os valores provenientes da correlação de Pearson (Tabela) demonstram o esperado, isto é, existe uma associação positiva com intensidade moderada, fortes e muito fortes (0.60 a 0.97) entre a variável Satisfação laboral Compromisso laboral.

A Hardware Task-Graph Scheduler for Reconfigurable Multi-tasking Systems

Reconfigurable hardware can be used to build a multitasking system where tasks are assigned to HW resources at run-time according to the requirements of the running applications. These tasks are frequently represented as direct acyclic graphs and their execution is typically controlled by an embedded processor that schedules the graph execution. In order to improve the efficiency of the system, the scheduler can apply prefetch and reuse techniques that can greatly reduce the reconfiguration latencies. For an embedded processor all these computations represent a heavy computational load that can significantly reduce the system performance. To overcome this problem we have implemented a HW scheduler using reconfigurable resources. In addition we have implemented both prefetch and replacement techniques that obtain as good results as previous complex SW approaches, while demanding just a few clock cycles to carry out the computations. We consider that the HW cost of the system (in our experiments 3% of a Virtex-II PRO xc2vp30 FPGA) is affordable taking into account the great efficiency of the techniques applied to hide the reconfiguration latency and the negligible run-time penalty introduced by the scheduler computations.

South Carolina State Plan on Aging 2017-2021

The Lieutenant Governor’s Office on Aging hereby submits the Federal Fiscal Year 2017 – 2021 State Plan on Aging for the State of South Carolina to the Assistant Secretary on Aging of the United States Department of Health and Human Services. The plan is effective for the period of October 1, 2016 through September 30, 2020. This document lays out a long-term strategic blueprint that focuses on how the state will modernize its service delivery system, while expanding the service options available for older South Carolinians, adults with disabilities, and their families. It also sets goals for consumer choice, and person centered and self-directed services. It addresses marketing, outreach, and advocacy issues, as well as the development of initiatives geared toward promoting evidence-based, consumer-directed, and community-based long-term services and supports.

Parques de campismo. Uma proposta de projeto para a Mata Nacional do Urso

Dissertação de Mestrado, Arquitetura Paisagista, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2016

Enhancement of non-viral transfection efficiency with nuclear localization signal peptides

Dissertação de Mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2016

Os Fragmentos 19 e 20 dos Systementwürfe 1803/1804, de G.W.F. Hegel : introdução e tradução

O objetivo deste trabalho é traduzir e apresentar os fragmentos 19 e 20 dos Esboços de Sistema de Jena, escritos por Hegel entre 1803 e 1804. Primeiramente, farei uma rápida consideração do significado filosófico desses fragmentos, os quais tratam, desde a peculiar concepção hegeliana da consciência como espírito, da razão teórica e da razão prática como equivalentes, respectivamente, à linguagem e ao trabalho. Procuro sublinhar essa relevância filosófica a partir da interpretação habermasiana dos fragmentos, a qual lhes conferiu notoriedade como tentativa de reconstrução do materialismo histórico. A partir desta breve contextualização, apresenta-se, a seguir, uma tradução para o português dos mencionados fragmentos. _________________________________________________________________________________ ABSTRACT

Dualpack: diseño de un sistema de empaques con doble función para cereales nacionales

El diseño de un sistema de empaques con doble función para cereales nacionales, es un estudio que evidencia el problema que existe en la producción de empaques para este tipo de alimentos (cereales) en el medio, que se han convertido en productos de consumo masivo, y por ende en generadores de gran cantidad de desechos por su función de envase secundario y por el volumen que ocupan. Propone una solución a través de procesos creativos de diseño que podrían incorporarse al empaque, promoviendo la reutilización y alargar la vida útil de un empaque. Evidencia la relación existente entre los campos de diseño y ecología a través de la producción de uno de los elementos de comunicación visual más importante hoy en día como es el diseño de packaging

Development and evaluation of floating microspheres of curcumin in alloxan-induced diabetic rats

Purpose: To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence and to study their effect on alloxan-induced diabetic rats. Methods: Floating microsphere were prepared by emulsion-solvent diffusion method, using hydroxylpropyl methylcellulose, chitosan and Eudragit S 100 polymer in varying proportions. Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1. The floating microspheres were evaluated for flow properties, particle size, incorporation efficiency, as well as in-vitro floatability and drug release. The anti-diabetic activity of the floating microspheres of batch FM4 was performed on alloxaninduced diabetic rats. Result: The floating microspheres had particle size, buoyancy, drug entrapment efficiency and yield in the ranges of 255.32 - 365.65 μm, 75.58 - 89.59, 72.6 - 83.5, and 60.46 - 80.02 %, respectively. Maximum drug release after 24 h was 82.62 % for formulation FM4 and 73.879, 58.613 and 46.106 % for formulations FM1, FM2, and FM3 respectively. In-vivo data obtained over a 120-h period indicate that curcumin floating microspheres from batch FM4 showed the better glycemic control than control and a commercial brand of the drug. Conclusion: The developed floating curcumin delivery system seems economical and effective in diabetes management in rats, and enhances the bioavailability of the drug.

Pasaje Artístico La Mariposa

76 p.

Desenvolvimento de uma nanoformulação autoemulsificante contendo o alcaloide epiisopiloturina para melhorar sua biodisponibilidade plasmática após administração via oral

Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Nanociência e Nanobiotecnologia, 2016.