Yliopiston yrittäjämäisyyden sosiaalinen rakentuminen: case Aalto-yliopisto

Keskustelu yrittäjyyden sijoittumisesta yliopistojen tehtäväkenttään on muodostunut 2000-luvun aikana osaksi yhteiskunnallista ja maailmanlaajuista korkeakoulutuksen muutosta. Tämän tutkimuksen tarkoituksena on lisätä ymmärrystä yliopiston yrittäjämäisyyden sosiaalisesta rakentumisesta. Lähestyn yliopiston sisällä tuotettua moniäänistä yrittäjyyspuhetta yliopiston yrittäjämäisyyden todellisuuden representaationa, ja pyrin tekemään siitä selkoa kommunikaatioon kohdistuvan analyysin avulla. Ilmiön empiirinen tarkastelu pohjautuu Aalto-yliopistossa ja sitä edeltäneessä Teknillisessä korkeakoulussa vuosina 2006–2013 kerättyihin tekstiaineistoihin. Aineistojen tulkinta tuottaa monikerroksellista tietoa ilmiöstä niin yksilö- kuin organisaatiotasolla. Tarkastelen tutkimuksessani millaisia merkityksenantoja yrittäjyydelle ja yrittäjämäisyydelle annetaan yliopiston sisällä eri näkökulmista katsottuna, kun yliopisto käy läpi merkittävää organisaatiorakenteellista ja institutionaalista muutosta. Tutkimusasetelman neljä näkökulmaa perustuvat tekniikan alan jatko-opiskelijoiden puheeseen, TKK:n opetussuunnitelmatekstiin, Aalto-yliopiston opettajien puheeseen ja johdon tuottamaan strategiatekstiaineistoon. Tutkimuksen tulosten mukaan käynnissä on ollut akateemisten arvojen ja arvojärjestelmien laajentumisen aika ja tila, jossa yrittäjämäisyys astuu areenalle, mutta sen suppeat tulkinnat eivät tarjoa mahdollisuuksia ruohonjuuritason kiinnittymiseen akateemisesta kulttuurista käsin. Yrittäjyyden ja yrittäjämäisyyden saamat taloudelliskaupalliset merkitykset koetaan uhkaksi, eikä tilannetta helpota yleisesti uuvuttavaksi koettu rakenteellinen ja yhteiskunnallinen yliopiston muutosvaihe. Hallitsevat tarinalinjat kuten puhe kilpailukyvystä ja kilpailutilanteen kovenemisesta tuottavat odotusten viitekehyksen, joilla yliopiston toimintaa raamitetaan ulkoapäin. Yrittäjyyteen laajassa merkityksessä sisältyvät mahdollisuudet jäävät niin ikään hyödyntämättä, ja lukuisat edistämistoiminnot kilpistyvät sosiaalisesti rakentuviin esteisiin. Tässä tutkimuksessa rakentuva laajennettu yliopiston yrittäjämäisyyden viitekehys pyrkii palvelemaan moniäänistymisen tarkoitusta käsitteellisellä tasolla ja avaamaan uusia mahdollisuuksia yliopiston yrittäjämäisyyden edistämiselle.

Data Governance and Automated Marketing – A Case Study of Expected Benefits of Organizing Data Governance in an ICT Company

This research is looking to find out what benefits employees expect the organization of data governance gains for an organization and how it benefits implementing automated marketing capabilities. Quality and usability of the data are crucial for organizations to meet various business needs. Organizations have more data and technology available what can be utilized for example in automated marketing. Data governance addresses the organization of decision rights and accountabilities for the management of an organization’s data assets. With automated marketing it is meant sending a right message, to a right person, at a right time, automatically. The research is a single case study conducted in Finnish ICT-company. The case company was starting to organize data governance and implementing automated marketing capabilities at the time of the research. Empirical material is interviews of the employees of the case company. Content analysis is used to interpret the interviews in order to find the answers to the research questions. Theoretical framework of the research is derived from the morphology of data governance. Findings of the research indicate that the employees expect the organization of data governance among others to improve customer experience, to improve sales, to provide abilities to identify individual customer’s life-situation, ensure that the handling of the data is according to the regulations and improve operational efficiency. The organization of data governance is expected to solve problems in customer data quality that are currently hindering implementation of automated marketing capabilities.

Den Äldsta – livet är ett tillägnande : en vårdvetenskaplig explorativ studie av ett meningsbärande budskap och en innerlig visdom

In the background of the thematic The Eldest – life is acquiring one finds both previews and myths. Wisdom belongs to these myths. The hermeneutical philosophy refers to thinking as o movement from myth to logos in a dialogical oneness. The research uncovers dimensions in the element wisdom as empowered. The experiences of older are saved for further learning and transformation to younger with reference to vulnerable situations where common regulations are no more usefull. The interest goes to an Eldest. The Eldest in the study is pictorial in accordance to the main literature in the study.The Eldest is etymological, fictive and symbolic: – a man who understands higher matters of life, even Gods holy matters. She will set the fulfillment of others as the highest endowment out of an innermost ethos and an innermost wisdom. The innermost is wisdom. The aim is to discover a meaningful message in life is acquiring. In order to see and to learn from the experiences the study aim to uncover the innermost, an innermost wisdom out of a caritative approach. This innermost is anticipated as a longing for unity and health in dayly matters and in a caring ability for the other. The main overstatement is: What will this most meaningfull and innermost by the Eldest out of a living in factual life mirrored in a caring perspective be? Two questions expired; what will the meaningful message in the acquiring be? What will the innermost wisdom in serving the good be? This message and its innermost wisdom will get an expanded meaning out of a caring sentence: Man who dare – seeing back with gratitude, seeing forward in confidence, seeing aside with love and upward in fate wear that dignity, that holiness and that mercy and empathy which belong to life in its basics. The persons attending the research are situated in two contexts. One group has roots in the Lutheran church and the other in a caring profession. The datamaterial is formed out of the usages from these persons, from the spoken (conversation) and the written word (a guestbook). The usages as particular and common are continually integrated in the leading caring sentence from the beginning of the study to the end. The usages stand by the methodological for the final message and wisdom and at the same they form the operative dimension in the study, the evident and the validity. The overarching methodological approach is in the hermeneutic philosophy in accordance with the abductive logic. The usages out of two research groups are most significant in this deductive, inductive and abductive strategy. The usages from the research groups are confronted with the caring sentence in dialogical spaces, halts. The meaning and the innermost searched for will be pictured through the abductive and hermeneutic interpretation and will stand for an articulation of and a successively expansion of meaning. A twine of horizons out of the entire dissemination, the deductive and the inductive, creates the result, as the final message as the ground for an understanding of an even more embracing meaning in an innermost wisdom. The identified bearing movement in the groups in accordance with the caring sentence goes for something higher, something higher than me, to the wellbeing of the other. A conclusion is made and a thesis is identified. This thesis is out from the usages: What can I do in a creating of this caritative? An antithesis is also identified, is a man able to look outside one own and go to something higher, something greater? The synthesis is articulated as a dialogical movement from something … to something higher. The bridge could be maturation, transcendence, the divine or wisdom. The statement finds its root in the attending groups but a difference is also identified. This higher matter is different. The contexts and their meaningfulness decide. A final statement is: learn to see man and her matters hold in life.

Brändin vahvistaminen ja uudistaminen kiinteistönvälitysalalla

Tutkimus keskittyy brändin luomiseen ja brändin kokonaisvaltaisen hallinnan keinoihin kiinteistönvälitysalalla. Tutkielman tavoitteena on selvittää miten yritykset hyödyntävät brändipääomiaan brändiä vahvistettaessa ja uudistettaessa. Tätä kysymystä pyritään tarkastelemaan erityisesti kahden case-yhtiön näkökulmasta, jotka molemmat toimivat kiinteistönvälitysalalla. Tutkimuksen pääongelmaksi muodostui kysymys: ”Mitä tekijöitä tulisi huomioida brändipääoman vahvistamisessa ja uudistamisessa kiinteistönvälitysalalla toimivissa yrityksissä?”. Tutkimus on luonteeltaan laadullinen eli kvalitatiivinen tutkimus. Laadullinen tutkimus pohjaa läheisesti teorian ja empirian väliseen vuorovaikutukseen ja sen lähtökohtana on pyrkiä kuvaamaan tutkimuskysymystä kokonaisvaltaisesti. Laadullisen tutkimuksen tarkoituksena on myös löytää tai tuoda esille tosiasioita sen sijaan, että todennettaisiin jo olemassa olevia väittämiä (Hirsijärvi, Remes & Sajavaara 2000, 152). Tutkimusmetodina aineiston keräämisessä käytettiin tutkimushaastattelua, joka toteutettiin tapaustutkimuksena. Tapaustutkimukselle tyypillisesti haastattelu oli puolistrukturoitu, joten haastateltavat vastasivat tutkijan esittämiin kysymyksiin, jotka olivat samat molemmille haastateltaville, mutta keskustelua ei rajoitettu. Huoneistokeskuksen edustajan mukaan brändejä pitää tarpeen tullen uudistaa, mutta se ei saa olla itsetarkoituksena. Mikäli brändi on brändijohtaja alallaan, ei suuria muutoksia kannata lähteä tekemään vain tekemisen vuoksi, vaan niille pitää olla jokin selvä tarkoitus. Brändin viestin vahvistaminen onkin brändijohtajana toimivalle yritykselle usein parempi ratkaisu, kuin toimivan konseptin uudistaminen. Huoneistokeskus pyrkiikin varmistamaan sen, että brändin viesti ei pääse unohtumaan asiakkailta. Huom!:in liiketoimintajohtajan mukaan brändiä uudistettaessa on tärkeää, että brändiä konkreettisesti muutetaan. Huom! onkin tästä syystä positioinut itsensä aikaisemmasta poiketen edelläkävijäksi pitkäikäisyyden painottamisen sijaan. Huom! on myös painottanut entistä enemmän laadukkuuttaan ja avoimuuttaan ja nämä pyritään osoittamaan verkkosivujen asiakasarvosteluilla. Johtopäätöksenä voidaan todeta, että molemmat yritykset pitävät kaikkia brändipääomatekijöitä tärkeinä kiinteistönvälitysalalla. Tästä huolimatta brändiä vahvistettaessa Huoneistokeskuksen edustaja oli sitä mieltä, että tärkeintä on keskittyä brändin tunnettuuteen. Huom!:in edustaja sen sijaan oli sitä mieltä, että brändiä uudistettaessa tärkeintä on keskittyä laadun tuottamiseen ja yhdistämään tämä myös mielleyhtymäksi. Haastateltavia oli kuitenkin vain kaksi, joten tutkimuksen johtopäätöksiä ei voida yleistää koskemaan koko toimialaa.

Khrushchev's Beau Geste: the Return of Porkkala and its Global Significance

The return of the Porkkala naval base, which was leased to the Soviet Union at the end of World War II was unexpectedly returned in early 1956, 42 years before the USSR's lease on the area was to expire. There is no commonly accepted reason, and therefore the purpose of this work is to study the possible motives behind the return of Porkkala. These seem to have been reflected in the new foreign policy after the death of Stalin, which went far beyond returning Porkkala to Finland. The Soviet Union's courting of the non-aligned powers during this time, into which category Finland was assigned, also seems to be more than coincidence. However, the greater events of 1956, and the fact that Porkkala is remembered almost exclusively in Finland may have conspired to trap the events around Porkkala into the smaller narrative of Finnish-Soviet relations and the rise of Kekkonen to the presidency, due in no small part to his presence in negotiating the return of Porkkala. However this does not negate the message that Porkkala was intended to broadcast the USSR's new approach to neutrality. Through primary and secondary sources, gleaned from archives in Finland, memoirs of people involved, and historical literature, this thesis hopes to broaden the view that Porkkala's main and only significance lay in the changes it brought to Finnish-Soviet relations.

Promoting Healthy Lifestyles with Personalized, APOE Genotype Based Health Information: The Effects on Psychological-, Health Behavioral and Clinical Factors

There is an increasing demand for individualized, genotype-based health advice. The general population-based dietary recommendations do not always motivate people to change their life-style, and partly following this, cardiovascular diseases (CVD) are a major cause of death in worldwide. Using genotype-based nutrition and health information (e.g. nutrigenetics) in health education is a relatively new approach, although genetic variation is known to cause individual differences in response to dietary factors. Response to changes in dietary fat quality varies, for example, among different APOE genotypes. Research in this field is challenging, because several non-modifiable (genetic, age, sex) and modifiable (e.g. lifestyle, dietary, physical activity) factors together and with interaction affect the risk of life-style related diseases (e.g. CVD). The other challenge is the psychological factors (e.g. anxiety, threat, stress, motivation, attitude), which also have an effect on health behavior. The genotype-based information is always a very sensitive topic, because it can also cause some negative consequences and feelings (e.g. depression, increased anxiety). The aim of this series of studies was firstly to study how individual, genotype-based health information affects an individual’s health form three aspects, and secondly whether this could be one method in the future to prevent lifestyle-related diseases, such as CVD. The first study concentrated on the psychological effects; the focus of the second study was on health behavior effects, and the third study concentrated on clinical effects. In the fourth study of this series, the focus was on all these three aspects and their associations with each other. The genetic risk and health information was the APOE gene and its effects on CVD. To study the effect of APOE genotype-based health information in prevention of CVD, a total of 151 volunteers attended the baseline assessments (T0), of which 122 healthy adults (aged 20 – 67 y) passed the inclusion criteria and started the one-year intervention. The participants (n = 122) were randomized into a control group (n = 61) and an intervention group (n = 61). There were 21 participants in the intervention Ɛ4+ group (including APOE genotypes 3/4 and 4/4) and 40 participants in the intervention Ɛ4- group (including APOE genotypes 2/3 and 3/3). The control group included 61 participants (including APOE genotypes 3/4, 4/4, 2/3, 3/3 and 2/2). The baseline (T0) and follow-up assessments (T1, T2, T3) included detailed measurements of psychological (threat and anxiety experience, stage of change), and behavioral (dietary fat quality, consumption of vegetables, - high fat/sugar foods and –alcohol, physical activity and health and taste attitudes) and clinical factors (total-, LDL- HDL cholesterol, triglycerides, blood pressure, blood glucose (0h and 2h), body mass index, waist circumference and body fat percentage). During the intervention six different communication sessions (lectures on healthy lifestyle and nutrigenomics, health messages by mail, and personal discussion with the doctor) were arranged. The intervention groups (Ɛ4+ and Ɛ4-) received their APOE genotype information and health message at the beginning of the intervention. The control group received their APOE genotype information after the intervention. For the analyses in this dissertation, the results for 106/107 participants were analyzed. In the intervention, there were 16 participants in the high-risk (Ɛ4+) group and 35 in the low-risk (Ɛ4-) group. The control group had 55 participants in studies III-IV and 56 participants in studies I-II. The intervention had both short-term (≤ 6 months) and long-term (12 months) effects on health behavior and clinical factors. The short-term effects were found in dietary fat quality and waist circumference. Dietary fat quality improved more in the Ɛ4+ group than the Ɛ4- and the control groups as the personal, genotype-based health information and waist circumference lowered more in the Ɛ4+ group compared with the control group. Both these changes differed significantly between the Ɛ4+ and control groups (p<0.05). A long-term effect was found in triglyceride values (p<0.05), which lowered more in Ɛ4+ compared with the control group during the intervention. Short-term effects were also found in the threat experience, which increased mostly in the Ɛ4+ group after the genetic feedback (p<0.05), but it decreased after 12 months, although remaining at a higher level compared to the baseline (T0). In addition, Study IV found that changes in the psychological factors (anxiety and threat experience, motivation), health and taste attitudes, and health behaviors (dietary, alcohol consumption, and physical activity) did not directly explain the changes in triglyceride values and waist circumference. However, change caused by a threat experience may have affected the change in triglycerides through total- and HDL cholesterol. In conclusion, this dissertation study has given some indications that individual, genotypebased health information could be one potential option in the future to prevent lifestyle-related diseases in public health care. The results of this study imply that personal genetic information, based on APOE, may have positive effects on dietary fat quality and some cardiovascular risk markers (e.g., improvement in triglyceride values and waist circumference). This study also suggests that psychological factors (e.g. anxiety and threat experience) may not be an obstacle for healthy people to use genotype-based health information to promote healthy lifestyles. However, even in the case of very personal health information, in order to achieve a permanent health behavior change, it is important to include attitudes and other psychological factors (e.g. motivation), as well as intensive repetition and a longer intervention duration. This research will serve as a basis for future studies and its information can be used to develop targeted interventions, including health information based on genotyping that would aim at preventing lifestyle diseases. People’s interest in personalized health advices has increased, while also the costs of genetic screening have decreased. Therefore, generally speaking, it can be assumed that genetic screening as a part of the prevention of lifestyle-related diseases may become more common in the future. In consequence, more research is required about how to make genetic screening a practical tool in public health care, and how to efficiently achieve long-term changes.

Recueil de lettres et de pièces originales, et de copies de pièces indiquées comme telles dans le dépouillement qui suit.

Contient : 1 Lettre du roi « LOYS » XI au « chancellier » de France, Pierre d'Oriolle. « Escript aux Forges, le XIXe jour de janvier » ; 2 Lettre du roi « LOYS » XI à « Pierre d'Oriolle. Donné à Amboyse, le VIe jour de juing » ; 3 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Chartres, le VIIIe jour d'aoust » ; 4 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Plessis du Parc, le XVIIe jour de decembre » ; 5 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Chaumont, le XIIe jour de mars 1482 » ; 6 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript aux Forges, le XXVIIe jour de janvier LXXVIII » ; 7 Lettre du roi « LOYS XI » au « chancellier » Pierre d'Oriolle. « Escript au Plessis du Parc, le XXIIIIe jour de decembre 1482 » ; 8 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript à Thouars, le premier jour de janvier » ; 9 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à la Victoire lez Senlis, le XXIIIe jour d'aoust » ; 10 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript à Amyens, le XXIIIIe jour de juillet » ; 11 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Thouars, le VIIe de decembre » ; 12 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript aux Forges, le XXIIIIe jour de fevrier 1478 » ; 13 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript aux Forges, le XIXe jour de fevrier 1478 » ; 14 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Lussieu, le XVe jour de juillet » ; 15 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Saint Laurens des Eaues, le XXIIIIe jour de juillet » ; 16 Lettre du roi « LOYS » XI « à maistre Pierre d'Oriole. Donné à Plouviers, le XIIIe jour de juing » ; 17 « Cedulle de VIM francs que [Pierre d'Oriolle avait] prestée au roy [Louis XI] ou mois de juillet M.CCCC.LXXII ». Signé : « Loys » ; 18 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Selommes, le XXIIIIe jour d'aoust » ; 19 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Plessis du Parc, le XXVe jour de may » ; 20 Lettre du roi « LOYS » XI à « maistre Pierre d'Oriole. Escript à Liesse, le XIIIIe jour de juing » ; 21 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript à Soulommes, le XXIIe jour d'aoust » ; 22 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Pleisseiz du Parc, le XIIIIe jour de decembre mil IIII.C. IIII.XX. et deux » ; 23 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript aux Forges, le XIIIIme jour de mars » ; 24 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Plesseys du Parc, le XXme jour de decembre mil IIII C.IIII. XX. » ; 25 « Cedulle du blanc qui a esté baillé au roy, en forme de chartre, le Ve jour d'octobre mil.IIII. C.LXXIX. Donné au Plesseys du Parc ». Signé : « LOYS » ; 26 Lettre de « FRANÇOYS » II, duc de Bretagne, au « roy » Louis XI. « Escript au Brossay, le XIIe jour de fevrier » ; 27 Lettre de « P[IERRE] D'ORIOLE » au roi Louis XI. « Escript à Paris, le XXVIIe jour de mars... 1475 » ; 28 Lettre de « TANGUY » au roi. « Escript à Noyon, le XIme jour de may » ; 29 « Mandement de monseigneur de Guyenne [ARTUS DE MONTAUBAN]. Donné à Bourdeaux, le cinqme jour de may, l'an de grace mil.CCCC. soixante douze » ; 30 Lettre de « BERAULT DAUPHIN » au roi Louis XI. « A Salligny, le XXVe jour d'aoust 1476 » ; 31 Lettre de « YMBERT DE BATARNAY au roy. Escript à Paris, le IIIIe jour de septembre » ; 32 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript aux Forges, le XVme jour de janvier » ; 33 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Selommes, le VIIe jour de septembre » ; 34 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Saint Laurens des Eaux, le XXIIIIe jour de juillet » ; 35 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle et à son « nepveu le sire de Maigne. Escript à Amboise, le XXIe jour de septembre » ; 36 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript aux Forges, le douziesme jour de mars 1478 » ; 37 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Pleissis du Parc, le XXIIIe jour de janvier 1482 » ; 38 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Donné aux Forges, le XVIIe jour de fevrier » ; 39 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript aux Forges, le XXVIIIe jour de janvier » ; 40 Lettre du roi « LOYS » XI au « chancelier » Pierre d'Oriolle. « Escript à Amyens, le XXIIIe jour de juillet » ; 41 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript es Forges, le XXIe jour de janvier » ; 42 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript aux Forges, le XIIe jour de mars M. CCCC. LXXVIII » ; 43 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Pleisseis du Parc, le XIIIe jour de janvier » ; 44 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Plessiz du Parc, le XXIIIIe jour de fevrier » ; 45 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Plessys du Parc, le VIIIe jour d'octobre » ; 46 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Pleissis du Parc, le XIIe jour de janvier » ; 47 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Donné au Pleissis du Parc lez Tours, le Ve jour d'octobre » ; 48 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Plessis du Parc, le XXe jour de janvier » ; 49 Lettre du roi « « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Arras, le XXIIIIe jour de may » ; 50 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Aigueperse, le XVIe jour de may » ; 51 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle et à ses « conseillers les gens de » son « grant conseil. Donné au Pleissis du Parc lez Tours, le IIIe jour d'octobre » ; 52 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Clery, le huitiesme jour de septembre 1482 » ; 53 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript à Armenonville, le derrain jour de juillet » ; 54 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Quesnoy le Conte, le XXVe jour de may » ; 55 Lettre du roi « LOYS » XI au « chancellier » Pierre d'Oriolle. « Escript au Pleisseiz du Parc, le VIIIe jour de decembre » ; 56 « Mynute de lettres en latin pour le roi Don Ferrand, touchant le fait des gallées, faicte en may mil.IIII.C.LXXVI » ; 57 « Minute de lettres » du roi LOUIS XI « au souldan ». En latin ; 58 Extrait de la « chambre des comptes du roy, à Paris, le XXVIIIe jour de juing, l'an mil.CCCC. soixante quinze » ; 59 Fragment d'une lettre sur la cour de Rome ; 60 « Inventaire des lectres touchant la reception » du « cardinal Sancti Petri ad Vincula, qui venoit en legation en France. Baillé en la chambre des comptes », par « Pierre d'Oriole, le XVe jour de septembre mil CCCC. IIII. XX. » ; 61 Lettre de « LOYS DE LAVAL au roy. Escript à Lengres, le XVIIe jour de may » ; 62 Lettre de « ET[IENNE] LE LOUP » au « chancelier. 1482 » ; 63 « Memoire de rendre compte du message envoyé, lequiel je ne cognois ne par non, ne par surnom... » ; 64 Lettre de messieurs du parlement de Toulouse « à messieurs du grant conseil du roy. Escript à Thoulouse, en parlement, le premier jour de septembre » ; 65 « Minute des lectres escriptez au roy [par Pierre d'Oriolle], le XXe jour de janvier M.CCCC.LXXV » ; 66 « Conventioni facti infra lo... signor... de Saligni, gran comestable de lo reame de Sicilia, da l'una parte, e lo conte da Carrara, da l'altra » ; 67 Copie du traité d'alliance entre Jean Bailleul, roi d'Écosse, et Philippe le Bel. 23 octobre 1295. En latin ; 68 Copie de la ratification faite, en 1326, par Robert, roi d'Écosse, d'un traité d'alliance entre la France et l'Écosse ; 69 Copie d'un traité d'alliance entre Charles V et Robert II, roi d'Écosse, le 28 octobre 1371

Activity of brainstem cholinergic neurons during 22 kHz ultrasonic vocalization in rats /

Adult rats emit 22 kHz ultrasonic alann calls in aversive situations. This type of call IS a component of defensive behaviour and it functions predominantly to warn conspecifics about predators. Production of these calls is dependent on the central cholinergic system. The laterodorsal tegmental nucleus (LDT) and pedunculopontine tegmental nucleus (PPT) contain largely cholinergic neurons, which create a continuous column in the brainstem. The LDT projects to structures in the forebrain, and it has been implicated in the initiation of 22 kHz alarm calls. It was hypothesized that release of acetylcholine from the ascending LDT terminals in mesencephalic and diencephalic areas initiates 22 kHz alarm vocalization. Therefore, the tegmental cholinergic neurons should be more active during emission of alarm calls. The aim of this study was to demonstrate increased activity of LDT cholinergic neurons during emission of 22 kHz calls induced by air puff stimuli. Immunohistochemical staining of the enzyme choline acetyltransferase identified cell bodies of cholinergic neurons, and c-Fos immunolabeling identified active cells. Double labeled cells were regarded as active cholinergic cells. There were significantly more (palarm calls.

The role of the GABAergic system in the production of ultrasonic vocalization in rats /

Ultrasonic vocalization plays an important role in intraspecies communication for rats. It has been well demonstrated that rats will emit 22kHz vocalization in stressfiil or threatening situations. Although the neural mechanism underlying vocahzation is not well understood, it is known that chohnergic input to the basal forebrain induces such alarm calls. A number of experiments have found that intracerebral injection of carbachol, a predominantly muscarinic agonist, into die anterior hypothalamic/preoptic area (AH/POA) rehably induces vocalization similar to naturally emitted ultrasonic calls. It has also been shown that carbachol has extensive inhibitory effects on neuronal firing in the same area. This result impUes that the inhibitory effects of carbachol in the AH/POA could trigger vocahzation, and that the GABAergic system could be involved. The purpose of this study is to investigate the effects ofGABA agonists and antagonists on flie production of carbachol induced 22kHz vocalization. The following hypotheses were examined: 1) apphcation ofGABA (a naturally occurring inhibitory neurotransmitter) will have a synergistic effect with carbachol, increasing vocalization; and 2) tiie apphcation ofGABA antagonists (picrotoxin or bicuculline) will reduce caibachol-induced vocalization. A total of sixty rats were implanted with stainless steel guide cannulae in the AH/POA area. After recovery, animals were locally pretreated with 1) GABA (l-40ng), 2) picrotoxin (1 .5^g) or bicuculhne (0.03ng), or 3) sahne; before injection with carbachol (1 .5^g). The resulting vocalization was measured and quantitated. The results indicate that pretreatment with GABA or GABA antagonists had no significant effect on vocalization. Local pretreatment with GABA did not potentiate the vocal response as measured by its duration, latraicy, and total number of calls. Similarly, pretreatment with picrotoxin or bicuculline had no effects on the same measures of vocalization. The results suggest tfiat chohnoceptive neurons involved in the production of alarm calls are not under direct GABAergic control.

Aerial view of the Chapman College campus, Orange, California

Color postcard featuring an aerial view of the Chapman College campus, Orange, California, ca. 1995. Looking north. On message side: "Produced by Wayne Salvatti/Photografx; Copyright Photografx"

Important state papers : declaration of war, Washington, June 18, 4 o'clock, P.M.

Message to the Senate and House of Representatives of the United States / James Madison -- Report : the Committee on Foreign relations, to whom was referred the message of the President of the United States of the 1st of June, 1812 -- An Act, declaring war between the United Kingdom of Great Britain and Ireland and the dependencies thereof, and the United States of America and their territories -- Address of the Senate to the people of the Commonwealth of Massachusetts.

The effects of language complexity in a counterattitudinal appeal to laypeople : an application of the elaboration likelihood model of persuasion to a legal issue

The effects of a complexly worded counterattitudinal appeal on laypeople's attitudes toward a legal issue were examined, using the Elaboration Likelihood Model (ELM) of persuasion as a theoretical framework. This model states that persuasion can result from the elaboration and scrutiny of the message arguments (i.e., central route processing), or can result from less cognitively effortful strategies, such as relying on source characteristics as a cue to message validity (i.e., peripheral route processing). One hundred and sixty-seven undergraduates (85 men and 81 women) listened to eitller a low status or high status source deliver a counterattitudinal speech on a legal issue. The speech was designed to contain strong or weak arguments. These arguments were 'worded in a simple and, therefore, easy to comprehend manner, or in a complex and, therefore, difficult to comprehend manner. Thus, there were three experimental manipulations: argument comprehensibility (easy to comprehend vs. difficult to comprehend), argumel11 strength (weak vs. strong), and source status (low vs. high). After listening to tIle speec.J] participants completed a measure 'of their attitude toward the legal issue, a thought listil1g task, an argument recall task,manipulation checks, measures of motivation to process the message, and measures of mood. As a result of the failure of the argument strength manipulation, only the effects of the comprehel1sibility and source status manipulations were tested. There was, however, some evidence of more central route processing in the easy comprehension condition than in the difficult comprehension condition, as predicted. Significant correlations were found between attitude and favourable and unfavourable thoughts about the legal issue with easy to comprehend arguments; whereas, there was a correlation only between attitude and favourable thoughts 11 toward the issue with difficult to comprehend arguments, suggesting, perhaps, that central route processing, \vhich involves argument scrutiny and elaboration, occurred under conditions of easy comprehension to a greater extent than under conditions of difficult comprehension. The results also revealed, among other findings, several significant effects of gender. Men had more favourable attitudes toward the legal issue than did women, men recalled more arguments from the speech than did women, men were less frustrated while listening to the speech than were ,vomen, and men put more effort into thinking about the message arguments than did women. When the arguments were difficult to comprehend, men had more favourable thoughts and fewer unfavourable thoughts about the legal issue than did women. Men and women may have had different affective responses to the issue of plea bargaining (with women responding more negatively than men), especially in light of a local and controversial plea bargain that occurred around the time of this study. Such pre-existing gender differences may have led to tIle lower frustration, the greater effort, the greater recall, and more positive attitudes for men than for WOlnen. Results· from this study suggest that current cognitive models of persuasion may not be very applicable to controversial issues which elicit strong emotional responses. Finally, these data indicate that affective responses, the controversial and emotional nature ofthe issue, gender and other individual differences are important considerations when experts are attempting to persuade laypeople toward a counterattitudinal position.

The Weekly Register - March 1813 and Index

Issues for the March 1813 Weekly Register newspaper (Baltimore, Maryland) are divided and includes the following War of 1812 related stories: March 6th, pages 1-16: Editor's proclamation on reporting on the war (p.1); Declaration of British Parliament - 9 January 1813 (pp.1-6); President's message to Senate and House of Representatives - February 24 (p.8); Events of the War including reports from Ogdensburgh,Battle of Frenchtown with Brigadier General James Winchester, Colonel Henry Proctor, and Round Head; (pp.9-13); naval events (pp.13-15); President Madison's speech - March 4 (pp.15-16). March 13th, pages 17-40 March 20th, pages 41-56 March 27th, pages 57-72 PLEASE CLICK ON THE WEEKLY PERIODICALS ON THE RIGHT OF THE SCREEN (PDF FILES)TO DOWNLOAD FILES. Look for other issues of the Weekly Register within this website. The Weekly Register, also known as Niles Weekly Register, was a weekly periodical edited by Hezekiah Niles (1777-1839) and published in Baltimore Maryland. Volumes of interest were published between 1811 (Vol. 1, No. 1, September 7, 1811) to 1814 (Vol. 5, No. 26, February 26, 1814). These volumes focus primarily on 19th century politics and government in the United States of America. Niles edited and published the Weekly Register until 1836, making it one of the most widely-circulated magazines in the United States. The popularity also made Niles into one of the most influential journalists of his day. Devoted primarily to politics, Niles' Weekly Register is considered an important source for the history of the period. The Register also recorded current economics, technology, science, medicine, geography, archaeology, the weather, and stories of human interest. Call Number: SPCL PER JK 1 N52

Important state papers : declaration of war, Washington, June 18, 4 o'clock, P.M

Message to the Senate and House of Representatives of the United States / James Madison -- Report : the Committee on Foreign relations, to whom was referred the message of the President of the United States of the 1st of June, 1812 -- An Act, declaring war between the United Kingdom of Great Britain and Ireland and the dependencies thereof, and the United States of America and their territories -- Address of the Senate to the people of the Commonwealth of Massachusetts.

Frontal Lobe Function and Performance Monitoring following Total Sleep Deprivation

Imaging studies have shown reduced frontal lobe resources following total sleep deprivation (TSD). The anterior cingulate cortex (ACC) in the frontal region plays a role in performance monitoring and cognitive control; both error detection and response inhibition are impaired following sleep loss. Event-related potentials (ERPs) are an electrophysiological tool used to index the brain's response to stimuli and information processing. In the Flanker task, the error-related negativity (ERN) and error positivity (Pe) ERPs are elicited after erroneous button presses. In a Go/NoGo task, NoGo-N2 and NoGo-P3 ERPs are elicited during high conflict stimulus processing. Research investigating the impact of sleep loss on ERPs during performance monitoring is equivocal, possibly due to task differences, sample size differences and varying degrees of sleep loss. Based on the effects of sleep loss on frontal function and prior research, it was expected that the sleep deprivation group would have lower accuracy, slower reaction time and impaired remediation on performance monitoring tasks, along with attenuated and delayed stimulus- and response-locked ERPs. In the current study, 49 young adults (24 male) were screened to be healthy good sleepers and then randomly assigned to a sleep deprived (n = 24) or rested control (n = 25) group. Participants slept in the laboratory on a baseline night, followed by a second night of sleep or wake. Flanker and Go/NoGo tasks were administered in a battery at 1O:30am (i.e., 27 hours awake for the sleep deprivation group) to measure performance monitoring. On the Flanker task, the sleep deprivation group was significantly slower than controls (p's <.05), but groups did not differ on accuracy. No group differences were observed in post-error slowing, but a trend was observed for less remedial accuracy in the sleep deprived group compared to controls (p = .09), suggesting impairment in the ability to take remedial action following TSD. Delayed P300s were observed in the sleep deprived group on congruent and incongruent Flanker trials combined (p = .001). On the Go/NoGo task, the hit rate (i.e., Go accuracy) was significantly lower in the sleep deprived group compared to controls (p <.001), but no differences were found on false alarm rates (i.e., NoGo Accuracy). For the sleep deprived group, the Go-P3 was significantly smaller (p = .045) and there was a trend for a smaller NoGo-N2 compared to controls (p = .08). The ERN amplitude was reduced in the TSD group compared to controls in both the Flanker and Go/NoGo tasks. Error rate was significantly correlated with the amplitude of response-locked ERNs in control (r = -.55, p=.005) and sleep deprived groups (r = -.46, p = .021); error rate was also correlated with Pe amplitude in controls (r = .46, p=.022) and a trend was found in the sleep deprived participants (r = .39, p =. 052). An exploratory analysis showed significantly larger Pe mean amplitudes (p = .025) in the sleep deprived group compared to controls for participants who made more than 40+ errors on the Flanker task. Altered stimulus processing as indexed by delayed P3 latency during the Flanker task and smaller amplitude Go-P3s during the Go/NoGo task indicate impairment in stimulus evaluation and / or context updating during frontal lobe tasks. ERN and NoGoN2 reductions in the sleep deprived group confirm impairments in the monitoring system. These data add to a body of evidence showing that the frontal brain region is particularly vulnerable to sleep loss. Understanding the neural basis of these deficits in performance monitoring abilities is particularly important for our increasingly sleep deprived society and for safety and productivity in situations like driving and sustained operations.