Sensory imagery in individuals who are blind and sighted: examining unimodal and multimodal forms

Introduction: Previous research has suggested that visual images are more easily generated, more vivid and more memorable than other sensory modalities. This research examined whether or not imagery is experienced in similar ways by people with and without sight. Specifically, the imabeability of visual, auditory and tactile cue words was compared. The degree to which images were multimodal or unimodal was also examined. Method: Twelve participants totally blind from early infancy and 12 sighted participants generated images in response to 53 sensory and non sensory words, rating imageability and the sensory modality, and describing images. From these 53 items, 4 subgroups of words, which stimulated images that were predominantly visual, tactile, auditory and low-imagery, respectively, were created. Results: T-tests comparing imageability ratings from blind and sighted participants found no differences for auditory and tactile words (both p>.1). Nevertheless, whilst participants without sight found auditory and tactile images equally imageable, sighted participants found images in response to tactile cue words harder to generate than visual cue words (mean difference: -0.51, p=.025). Participants with sight were also more likely to develop multisensory images than were participants without sight (both U≥15.0, N1=12, N2=12, p≤.008). Discussion: For both the blind and sighted, auditory and tactile images were rich and varied and similar language was used. Sighted participants were more likely to generate multimodal images. This was particularly the case for tactile words. Nevertheless, cue words that resulted in multisensory images were not necessarily rated as more imageable. The discussion considers whether or not multimodal imagery represent a method of compensating for impoverished unimodal imagery. Implications for Practitioners: Imagery is important not only as a mnemonic in memory rehabilitation, but also everyday uses for things such as autobiographical memory. This research emphasises both the importance of not only auditory and tactile sensory imagery, but also spatial imagery for people without sight.

Development of electrochemical methods for determination of tramadol - analytical application to pharmaceutical dosage forms

A square-wave voltammetric (SWV) method and a flow injection analysis system with amperometric detection were developed for the determination of tramadol hydrochloride. The SWV method enables the determination of tramadol over the concentration range of 15-75 µM with a detection limit of 2.2 µM. Tramadol could be determined in concentrations between 9 and 50 µM at a sampling rate of 90 h-1, with a detection limit of 1.7 µM using the flow injection system. The electrochemical methods developed were successfully applied to the determination of tramadol in pharmaceutical dosage forms, without any pre-treatment of the samples. Recovery trials were performed to assess the accuracy of the results; the values were between 97 and 102% for both methods.

Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding

Background & aims - Patients who underwent endoscopic gastrostomy (PEG) present protein-energy malnutrition, but little is known about Trace Elements (TE), Zinc (Zn), Copper (Cu), Selenium (Se), Iron (Fe), Chromium (Cr). Our aim was the evaluation of serum TE in patients who underwent PEG and its relationship with serum proteins, BMI and nature of underlying disorder. Methods - A prospective observational study was performed collecting: patient's age, gender, underlying disorder, NRS-2002, BMI, serum albumin, transferrin and TE concentration. We used ferrozine colorimetric method for Fe; Inductively Coupled Plasma-Atomic Emission Spectroscopy for Zn/Cu; Furnace Atomic Absorption Spectroscopy for Se/Cr. The patients were divided into head and neck cancer (HNC) and neurological dysphagia (ND). Results - 146 patients (89 males), 21–95 years: HNC-56; ND-90. Low BMI in 78. Low values mostly for Zn (n = 122) and Fe (n = 69), but less for Se (n = 31), Cu (n = 16), Cr (n = 7); low albumin in 77, low transferrin in 94 and 66 with both proteins low. Significant differences between the groups of underlying disease only for Zn (t140.326 = −2,642, p < 0.01) and a correlation between proteins and TE respectively albumin and Zn (r = 0.197, p = 0.025), and albumin and Fe (r = 0.415, p = 0.000). Conclusions - When gastrostomy was performed, patients display low serum TE namely Zn, but also Fe, less striking regarding others TE. It was related with prolonged fasting, whatever the underlying disease. Low proteins were associated with low TE. Teams taking care of PEG-patients should use Zn supplementation and include other TE evaluation as part of the nutritional assessment of PEG candidates.

Trace metals in size-fractionated particulate matter in a Portuguese hospital: exposure risks assessment and comparisons with other countries

Hospitals are considered as a special and important type of indoor public place where air quality has significant impacts on potential health outcomes. Information on indoor air quality of these environments, concerning exposures to particulate matter (PM) and related toxicity, is limited though. This work aims to evaluate risks associated with inhalation exposure to ten toxic metals and chlorine (As, Ni, Cr, Cd, Pb, Mn, Se, Ba, Al, Si, and Cl) in coarse (PM2.5–10) and fine (PM2.5) particles in a Portuguese hospital in comparison with studies representative of other countries. Samples were collected during 1 month in one urban hospital; elemental PM characterization was determined by proton-induced X-ray emission. Noncarcinogenic and carcinogenic risks were assessed according to the methodology provided by the United States Environmental Protection Agency (USEPA; Region III Risk-Based Concentration Table) for three different age categories of hospital personnel (adults, >20, and <65 years) and patients (considering nine different age groups, i.e., children of 1–3 years to seniors of >65 years). The estimated noncarcinogenic risks due to occupational inhalation exposure to PM2.5-bound metals ranged from 5.88×10−6 for Se (adults, 55–64 years) to 9.35×10−1 for As (adults, 20–24 years) with total noncarcinogenic risks (sum of all metals) above the safe level for all three age categories. As and Cl (the latter due to its high abundances) were the most important contributors (approximately 90 %) to noncarcinogenic risks. For PM2.5–10, noncarcinogenic risks of all metals were acceptable to all age groups. Concerning carcinogenic risks, for Ni and Pb, they were negligible (<1×10−6) in both PM fractions for all age groups of hospital personnel; potential risks were observed for As and Cr with values in PM2.5 exceeding (up to 62 and 5 times, respectively) USEPA guideline across all age groups; for PM2.5–10, increased excess risks of As and Cr were observed particularly for long-term exposures (adults, 55–64 years). Total carcinogenic risks highly (up to 67 times) exceeded the recommended level for all age groups, thus clearly showing that occupational exposure to metals in fine particles pose significant risks. If the extensive working hours of hospital medical staff were considered, the respective noncarcinogenic and carcinogenic risks were increased, the latter for PM2.5 exceeding the USEPA cumulative guideline of 10−4. For adult patients, the estimated noncarcinogenic and carcinogenic risks were approximately three times higher than for personnel, with particular concerns observed for children and adolescents.

Trace Elements in Ambient Air at Porto Metropolitan Area—Checking for Compliance with New European Union (Eu) Air Quality Standards

Because of the scientific evidence showing that arsenic (As), cadmium (Cd), and nickel (Ni) are human genotoxic carcinogens, the European Union (EU) recently set target values for metal concentration in ambient air (As: 6 ng/m3, Cd: 5 ng/m3, Ni: 20 ng/m3). The aim of our study was to determine the concentration levels of these trace elements in Porto Metropolitan Area (PMA) in order to assess whether compliance was occurring with these new EU air quality standards. Fine (PM2.5) and inhalable (PM10) air particles were collected from October 2011 to July 2012 at two different (urban and suburban) locations in PMA. Samples were analyzed for trace elements content by inductively coupled plasma–mass spectrometry (ICP-MS). The study focused on determination of differences in trace elements concentration between the two sites, and between PM2.5 and PM10, in order to gather information regarding emission sources. Except for chromium (Cr), the concentration of all trace elements was higher at the urban site. However, results for As, Cd, Ni, and lead (Pb) were well below the EU limit/target values (As: 1.49 ± 0.71 ng/m3; Cd: 1.67 ± 0.92 ng/m3; Ni: 3.43 ± 3.23 ng/m3; Pb: 17.1 ± 10.1 ng/m3) in the worst-case scenario. Arsenic, Cd, Ni, Pb, antimony (Sb), selenium (Se), vanadium (V), and zinc (Zn) were predominantly associated to PM2.5, indicating that anthropogenic sources such as industry and road traffic are the main source of these elements. High enrichment factors (EF > 100) were obtained for As, Cd, Pb, Sb, Se, and Zn, further confirming their anthropogenic origin.

Estações de tratamento de águas residuais: conceitos e dimensionamento

O presente relatório é o corolário do Estágio Curricular que a autora efetuou, durante o segundo semestre do ano letivo de 2014/2015 na SBS – Engenharia Civil, Hidráulica e Ambiente, Lda. Nesta empresa a autora foi integrada na equipa técnica que elaborou um Projeto de Execução para uma Estação de Tratamento de Águas Residuais que irá ser construída em Montemor-o-Novo, tendo-lhe sido atribuídas as seguintes tarefas principais: i) estudo de ferramentas de dimensionamento de ETAR; e ii) estudo dos processos de tratamento de águas residuais a instalar. O tratamento de águas residuais não é matéria que conste do atual Plano de Estudos do Mestrado em Engenharia Civil do ISEP. Este facto, associado à premente necessidade de dar resposta às expectativas da Entidade Acolhedora, obrigou a autora a um esforço de aprendizagem significativo. Nesta fase foi executada uma aprofundada pesquisa bibliográfica que permitiu à autora obter o nível de conhecimentos teóricos necessário para a plena integração na Equipa de Projeto. Já integrada na Equipa de Projeto o primeiro trabalho desenvolvido pela autora foi a análise detalhada do Caderno de Encargos e da respetiva Nota Técnica. Seguidamente a autora participou em todas as fases do Projeto tendo, por isso, colaborado na análise do Estudo Geotécnico, no dimensionamento dos órgãos da ETAR, no cálculo do perfil hidráulico, na definição de formas (plantas e cortes) dos órgãos, na elaboração da Lista de Equipamentos e do Mapa de Quantidades e, por último, na elaboração da Memória Descritiva e Justificativa do Processo de Tratamento e Equipamentos. O Caso Prático incluído no presente documento é, em larga medida, o corolário do processo de aprendizagem de que a autora beneficiou no decorrer do Estágio Curricular. Grande parte das tarefas que a autora executou ao longo da elaboração do projeto relacionaram-se com o dimensionamento dos órgãos da ETAR e com os respetivos cálculos hidráulicos. Os conhecimentos teórico-práticos desta forma adquiridos foram reunidos num conjunto de ferramentas, maioritariamente folhas de cálculo, que se verificou serem úteis nos processos de dimensionamento e de teste de soluções alternativas. É parte integrante deste relatório um capítulo no qual é feita uma detalhada apresentação dos conceitos teóricos subjacentes ao Projeto de ETAR. Este capítulo reflete o estudo que a autora teve necessidade de efetuar antes de se sentir capaz de integrar a Equipa de Projeto.

Constituição e transcendência: os casos dos regimes comunitários do entre-guerras

Tede de Doutoramento, na especialidade de Ciências Políticas apresentada à FDUNL

Does companionate love express itself unequally in different organizational forms (private companies, hybrid and non-governmental organizations)?

Although, the word “Love” in organizations is seen as a rare concept, but it has gained importance in management theoretical foundation. This study seeks to explore the companionate love in distinct of organizational forms (Private companies; Social organizations; NGO and IPSS) through interviews. The results propose that it is a tensional concept with a complex dynamic: tension of personal behavior, tension of professional behavior; tension of individual impact and tension of community impact. The love dynamic has common points to all organizations, but its expression depends on the specific form of the organization.

Quantification of clenbuterol at trace level in human urine by ultra-high pressure liquid chromatography-tandem mass spectrometry.

Clenbuterol is a β2 agonist agent with anabolic properties given by the increase in the muscular mass in parallel to the decrease of the body fat. For this reason, the use of clenbuterol is forbidden by the World Anti-Doping Agency (WADA) in the practice of sport. This compound is of particular interest for anti-doping authorities and WADA-accredited laboratories due to the recent reporting of risk of unintentional doping following the eating of meat contaminated with traces of clenbuterol in some countries. In this work, the development and the validation of an ultra-high pressure liquid chromatography coupled to electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) method for the quantification of clenbuterol in human urine is described. The analyte was extracted from urine samples by liquid-liquid extraction (LLE) in basic conditions using tert butyl-methyl ether (TBME) and analyzed by UHPLC-MS/MS with a linear gradient of acetonitrile in 9min only. The simple and rapid method presented here was validated in compliance with authority guidelines and showed a limit of quantification at 5pg/mL and a linearity range from 5pg/mL to 300pg/mL. Good trueness (85.8-105%), repeatability (5.7-10.6% RSD) and intermediate precision (5.9-14.9% RSD) results were obtained. The method was then applied to real samples from eighteen volunteers collecting urines after single oral doses administration (1, 5 and 10μg) of clenbuterol-enriched yogurts.

Aprovechamiento de la materia prima en la elaboración de harina de pescado tipo integral

Estudio técnico y económico de dos métodos del aprovechamiento de la materia prima en la elaboración de harina de pescado tipo integral. Contiene el balance de materia y la composición de la materia prima y sus rendimientos.

Bahía de Coishco, Chimbote, Perú: una visión integral de sus recursos vivos y su ambiente. 2001 - 2005

Se ha recorrido la Bahía de Coishco a fin de conocer las actividades artesanal e industrial que se desarrollan en esta área, y se han revisado los informes sobre las actividades y proyectos que ejecuta el Laboratorio Costero de Chimbote como parte del Plan Anual de Trabajo Institucional. Se presenta una descripción de la morfología, topografía y sedimentología de la Bahía de Coishco, así como de las características físicas, químicas y biológicas de sus masas de agua. Se hace una descripción de las fuentes y niveles de contaminación, producto del vertimiento de aguas de diferentes tipo de uso: industrial, pesquero, doméstico; de escorrentía y producto de actividades de las embarcaciones que operan en esta bahía. Se mencionan las especies que sustentan la pesca artesanal e industrial, los instrumentos y áreas de pesca, los bancos naturales de invertebrados marinos, los tonelajes de extracción a nivel artesanal y de procesamiento a nivel industrial por cada una de las fábricas que operan en esta bahía. La bahía de Coishco, con un área aproximada de 11.655 km2 es una bahía abierta, rodeada por las islas Santa y Moñaque; en sus profundidades predominan las isóbatas desde 12 a 16 m y en el centro de la bahía existe alta concentración de materia orgánica. Las masas de agua son generalmente Aguas Costeras Frias, de 15 a 20 ºC; la salinidad cerca de la línea litoral es menor a 35 ups, en cambio en el sur de la balúa las salinidades son en promedio del orden de 35,1ups. El vertimiento de aguas de uso industrial pesquero y doméstico influye en el contenido de oxígeno tanto superficial como de fondo, habiéndose detectado situaciones de anoxia; igualmente se afectan los nutrientes, tal es así que los niveles de fosfatos se incrementan durante la época de intensa actividad pesquera y disminuyen durante la época de veda. Se ha identificado 60 especies de organismos planctónicos, destacando las diatomeas de afloramiento Chaetoceros decipiens, Thalassiosira rotula y Skeletonema costatum. Los peces constituyen la principal fuente de pesca artesanal (82% de las capturas), destacando: "lorna" Sciaena deliciosa, "pejerrey" Odonthestes regia regia, "machete" Etmidium maculatum, "cachema" Cynoscion analis, "cabinza" Isacia conceptionís. La anchoveta es la principal materia prima para la elaboración de harina y aceite de pescado. Entre los invertebrados, destacaron "caracol" Stramoníta chocolata, "almeja" Semele spp., "concha de abanico" Argopecten purpu­ratus, "pulpo" Octopus mimus.

Bahía El Ferrol, Chimbote, Perú: una visión integral de sus recursos marinos vivos y su ambiente. 2001-2005

Se describe la morfometria, batimetría y sedimentología de la Bahía El Ferrol, además de las características físicas, químicas y biológicas de sus masas de agua. Se hace una descripción de las fuentes y niveles de contaminación producida por el vertimiento de las aguas de diferente uso. Se mencionan las especies que sustentan la pesca artesanal e industrial, además de los instrumentos y áreas de pesca y los bancos naturales de invertebrados marinos. Los tonelajes de desembarques artesanales fueron obtenidos en el muelle artesanal pesquero de Chimbote; y los volúmenes de procesamiento industrial, en cada una de las fábricas que operan en esta bahía. Se han revisado los registros e informes sobre las actividades y proyectos que se ejecutan en el Laboratorio Costero, hoy Centro de Investigación Pesquera (CIP) del IMARPE en Chimbote, Áncash, como parte de su Plan Anual de Trabajo.