Transitoliikenteen lisäarvopalvelut

Tutkimuksen tarkoituksena on selvittää Suomen transito- eli kauttakulkuliikenteessä käytössä olevia lisäarvopalveluja ja niiden kehitysnäkymiä. Tutkimuksessa selvitetään myös Suomen transitoliikenteen nykytilaa ja tulevaisuutta. Suomen kauttakulkureitin ohella tarkastellaan muita tärkeimpiä Venäjän ulkomaankaupan kuljetusreittejä. Tutkimus jakautuu 1) kauttakulkuliikennettä koskevaan kirjallisuusselvitykseen ja 2) lisäarvopalveluja selvittävään haastattelututkimukseen, jonka yhteydessä haastateltiin Suomessa toimivia kansallisia ja kansainvälisiä transitoliikenteen toimijoita. Tutkimustulosten perusteella Suomi toimii erityisesti itään suuntautuvien arvotavaroiden kauttakulkureittinä. Transitokuljetusten yhteydessä tarvitaan erilaisia lisäarvopalveluja. Haastatteluissa saatiin selville, että tavaratoimituksille on tarjolla Suomessa yli 30 erilaista lisäarvopalvelua, jotka syntyvät yleensä asiakkaan erityistarpeista. Lisäarvopalvelut keskittyvät aineettomiin toimintoihin, kuljetuksiin, laadunhallintaan ja tavarankäsittelyyn. Eniten tarjottuja lisäarvopalveluja ovat räätälöity asiakaspalvelu, IT-palvelut, dokumentointi ja konsultointi. Lisäarvopalvelut eivät yleensä yksistään vaikuta kuljetusreitin valintaan, mutta yhdessä tehokkaiden, laadukkaiden ja turvallisten logistiikkapalvelujen kanssa lisäarvopalvelut muodostavat merkittävän kilpailutekijän Suomen transitoreitille.

O enfoque da metrologia química em análises toxicológicas na atividade turfística: validação de método analítico para determinação de cafeína em matrizes biológicas

This paper proposes an alternate method to detect forbidden doping substances present in biological matrices of horseracing. The method was fully validated for caffeine, identified as the most frequent forbidden substance in the analysis conducted by the Antidoping Laboratory of the Brazilian Jockey Club, which adopts a zero threshold limit according to national and international horseracing practices. The metrological reliability of the method applied to toxicological analysis in biological matrices is discussed. Although the analytical method proposed for detection of a zero threshold level of the doping substance is qualitative, it was validated for the determination of the limiting value (also known as quantification limit value) introducing a criterion that prevents the issuing of incorrect results ("false-positives" and "false-negatives").

Como pesquisar o perfil patentário de um fármaco: o caso Efavirenz

The importance of the patent system for researchers, especially in chemistry and related areas, is undeniable. In this context, this work aims at guiding the search in major search engines of patents, in order to map the patents related to a specific chemical compound and identify the material that each patent document protects. In this case study, it was performed a search for the drug efavirenz to demonstrate how to conduct a literature search in patents databases and to map patent applications at national and international levels.

Vinte anos de química verde: conquistas e desafios

The year 2011 has been chosen as the International Year of Chemistry and it will focus on the importance of sustainability in the field of chemistry. The program "Alternative Synthetic Routes for the Prevention of Pollution", implemented 20 years ago in the USA marked the official start of Green Chemistry. Currently, many lines of research in chemistry observe and comply with the concepts of green chemistry contributing significantly to the advancement of science. Hence, the objective of this paper is to present an overview of published papers on Green Chemistry in national and international journals from the "CAPES Portal Database", from 1997 to May 2010.

Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)

The aim of the study was to synthesize the urea (13CO(NH2)2), with 99% 13C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine.

Guia para a determinação da estabilidade de produtos químicos

Companies worldwide are reviewing their working process to avoid waste, become aligned with environmental management standards and to fulfill specifications defined for national and international regulations. In this context, it is important that Brazilian Chemical companies have a specific stability guide for their products. The main purpose of this work is to present a stability guide for chemical products based on the existing guides of the Pharmaceutical and Cosmetics segments. Furthermore, this work proposes to offer an additional period of shelf life for chemical products, provided they meet certain prerequisites.

Doenças tropicais negligenciadas: uma nova era de desafios e oportunidades

In an article recently published in Química Nova, entitled "Chemistry Without Borders" ("Química Sem Fronteiras") [Pinto, A. C.; Zucco, C.; Galembeck, F.; Andrade, J. B.; Vieira, P. C. Quim. Nova 2012, 35, 2092], the authors highlighted the important aspects of science and technology with special emphasis on the field of Chemistry and its contributions toward a more prosperous Brazil of future. As a second step in that direction, this article extends the discussion of a key issue for the country in the framework of the chemistry community through the so called position papers in strategic areas. This document is a part of the contribution of the Brazilian Chemical Society to the World Science Forum to be held in Rio de Janeiro in November 2013. In this context, the present paper provides a brief discussion on neglected tropical diseases (NTDs) with emphasis on the current challenges and opportunities towards the development and evolution of the field. NTDs leads to illness, long-term disability or death, and has severe social, economic and psychological consequences for millions of men, women, and children worldwide. In most cases, the available treatments are inadequate and extremely limited in terms of efficacy and safety, leading to an urgent demand for new drugs. In addition to the traditional challenges involved in any drug discovery process, it is widely recognized that there is an innovation gap and a lack of investment for research and development (R&D) in the area of NTDs. In the last few decades, methods toward combating, eradication, prevention, and treatment of NTDs have been repeatedly emphasized in the major international agendas. Developments in these strategies and alliances have continued to have an essential impact, particularly in the area of drug discovery, both in Brazil and globally and should be encouraged and supported. Several examples of international activities dedicated to the reduction of the devastating global impact of NTDs can be provided. Despite the beneficial developments in the past 30 years, NTDs continue to devastate poor communities in remote and vulnerable areas, in large part, due to market failures and public policies. Recent studies have shown that among 756 new drugs approved between 2000 and 2011, only four new chemical entities (NCEs) were identified for the treatment of malaria, while none were developed against NTDs or tuberculosis. Furthermore, only 1.4% of approximately 150,000 clinical trials were registered for neglected diseases, with a smaller number of trials for NCEs. Establishment and strengthening of global strategies involving the triad "government-academia-industry" is fundamental to the success in R&D of new drugs for NTDs. National and international public-private initiatives that aim to create, encourage, and invest in R&D projects have been implemented and therefore are of utmost importance to successfully integrate Brazil into this new paradigm. It is essential to lay the foundation for mechanisms that will intensify investments in infrastructure, training, and qualification of personnel with an ultimate strategic vision that foresees continuity. Our research group has made significant contributions to the development of this field with the goal of forging new frontiers while tackling both current and future challenges that include indispensable elements such as innovation and integration.

Itävallan ja Unkarin monidimensioinen rajakiista

Kirjallisuusarvostelu

Kuivurin pölynhallintajärjestelmä

Lämminilmakuivaus on viljan kuivaamisen menetelmistä ylivoimaisesti käytetyin. Siinä kuivurissa olevan viljakerroksen läpi puhalletaan lämmintä ilmaa, kunnes viljan kosteuspitoisuus laskee tavoitetasoon. Viljan jyvistä irtoaa aina pölyä niiden hangatessa toisiaan vasten. Viljankuivaamoiden pölyisyyttä on normaalisti pyritty vähentämään poistamalla leijuvaa pölyä viljan liikkeen epäjatkuvuuskohdista. Pölyä kulkeutuu kuitenkin kuivaamon ulkopuolelle myös kuivaukseen käytetyn ilman mukana. Poistoilman pölypitoisuus ei tavallisesti ole korkea, mutta kuivaamiseen käytetyistä suurista ilmamääristä johtuen pölyä voi kertyä poistoilmakanavan ympäristöön huomattavia määriä. Tämän diplomityön tavoitteena onkin viljankuivurin poistoilman pölypitoisuuden vähentämiseen soveltuvan pölynhallintajärjestelmän kehittäminen. Selvityksessä tarkasteltiin ensinnäkin kuivurin poistoilman pölypitoisuuteen liittyvää kansallista ja kansainvälistä lainsäädäntöä sekä raja-arvoja. Lähdemateriaalin perusteella kartoitettiin pölypitoisuuden vähentämiseen soveltuvia menetelmiä sekä kilpailijoiden toteuttamia ratkaisuja. Myös muita pölynhallintajärjestelmän edellytyksiä selvitettiin. Teoreettisessa tarkastelussa teknistaloudellisesti parhaaksi osoittautunut pölynhallintaratkaisu jalostettiin prototyypiksi. Sen toimintakykyä testattiin erotustehokkuuden mittaamiseen soveltuvan koelaitteiston avulla. Testitulosten perusteella kyseinen pölynhallintajärjestelmä todettiin toimivaksi ja pienellä jatkokehittelyllä myös kaupalliseen käyttöön soveltuvaksi. Testitulosten hyödyntämismahdollisuuksien lisäksi diplomityössä esitetään myös muutamia jatkokehitysehdotuksia.

Analysis of private natural heritage reserves as a conservation strategy for the biodiversity of the cocoa region of the southern State of Bahia, Brazil

Brazil was the first country in Latin America to establish and regulate this type of reserve, and there are currently more than 700 Private Nature Heritage Reserves (RPPN in Portuguese) officially recognized by either federal or state environmental agencies. Together, these RPPN protect more than a half million hectares of land in the country. The coastal forests in the southern part of Bahia State extend 100 to 200 km inland, gradually changing in physiognomy as they occupy the dryer inland areas. The coastal forest has been subjected to intense deforestation, and currently occupies less than 10% of its original area. For this work the creation processes of the RPPN were consulted to obtain the data creation time, size of property, the condition of the remaining forest, succession chain and the last paid tax. After that, interviews with the owners were made to confirm this data. Sixteen RPPN have been established in this region until 2005. Their sizes vary from 4.7 to 800 ha. Ten of these RPPN are located within state or federal conservation areas or their buffer zones. In spite of the numerous national and international conservation strategies and environmental policies focused on the region, the present situation of the cocoa zone is threatening the conservation of the region's natural resources. The establishment of private reserves in the cocoa region could conceivably improve these conservation efforts. This type of reserve can be established under a uniform system supported by federal legislation, and could count on private organizations.

Military crisis management in the next decade (2020-2030) : inducing consent or relying on compliance?

The most outstanding conceptual challenge of modern crisis management is the principle of consent. It is not a problem only at the operational level - it challenges the entire decision-making structures of crisis management operations. In post-cold war times and especially in the 21st century, there has been a transition from peacekeeping with limited size and scope towards large and complex peace operations. This shift has presented peace operations with a dilemma. How to balance between maintaining consent for peace operations, whilst being able to use military force to coerce those attempting to wreck peace processes? To address such a dilemma, this research aims to promote understanding, on what can be achieved by military crisis management operations (peace support operations) in the next decade. The research concentrates on the focal research question: Should military components induce consent or rely on the compliance of conflicting parties in crisis management operations of the next decade (2020 – 2030)? The focus is on military – political strategic level considerations, and especially on the time before political decisions to commit to a crisis management operation. This study does not focus on which actor or organisation should intervene. The framework of this thesis derives from the so called ‘peacebuilding space’, the scope of peace operations and spoiler theory. Feasibility of both peace enforcement and peacekeeping in countering future risk conditions are analysed in this framework. This future-orientated qualitative research uses the Delphi-method with a panel of national and international experts. Citation analysis supports identification of relevant reference material, which consists of contemporary literature, the Delphi-questionnaires and interviews. The research process followed three main stages. In the first stage, plausible future scenarios and risk conditions were identified with the Delphi-panel. In the second stage, operating environments for peace support operations were described and consequent hypotheses formulated. In the third stage, these hypotheses were tested on the Delphi-panel. The Delphi-panel is sufficiently wide and diverse to produce plausible yet different insights. The research design utilised specifically military crisis management and peace operations theories. This produced various and relevant normative considerations. Therefore, one may argue that this research; which is based on accepted contemporary theory, hypotheses derived thereof and utilising an expert panel, contributes to the realm of peace support operations. This research finds that some degree of peace enforcement will be feasible and necessary in at least the following risk conditions: failed governance; potential spillover of ethnic, religious, ideological conflict; vulnerability of strategic chokepoints and infrastructures in ungoverned spaces; as well as in territorial and extra-territorial border disputes. In addition, some form of peace enforcement is probably necessary in risk conditions pertaining to: extremism of marginalised groups; potential disputes over previously uninhabited and resource-rich territories; and interstate rivalry. Furthermore, this research finds that peacekeeping measures will be feasible and necessary in at least risk conditions pertaining to: potential spillover of ethnic, religious, ideological conflict; uncontrolled migration; consequences from environmental catastrophes or changes; territorial and extra-territorial border disputes; and potential disputes over previously uninhabited and resource-rich territories. These findings are all subject to both generic and case specific preconditions that must exist for a peace support operation. Some deductions could be derived from the research findings. Although some risk conditions may appear illogical, understanding the underlying logic of a conflict is fundamental to understanding transition in crisis management. Practitioners of crisis management should possess cognizance of such transition. They must understand how transition should occur from threat to safety, from conflict to stability – and so forth. Understanding transition is imperative for managing the dynamic evolution of preconditions, which begins at the outset of a peace support operation. Furthermore, it is pertinent that spoilers are defined from a peace process point of view. If spoilers are defined otherwise, it changes the nature of an operation towards war, where the logic is breaking the will of an enemy - and surrender. In peace support operations, the logic is different: actions towards spoilers are intended to cause transition towards consent - not defeat. Notwithstanding future developments, history continues to provide strategic education. However, the distinction is that the risk conditions occur in novel futures. Hence, lessons learned from the past should be fitted to the case at hand. This research shows compelling evidence that swaying between intervention optimism and pessimism is not substantiated. Both peace enforcement and peacekeeping are sine qua non for successful military crisis management in the next decade.

Abordagem fisioterapêutica na dor pós-operatória: a eletroestimulação nervosa transcutânea (ENT)

This study provides an update on the use of Transcutaneous Eletric Nerve Stimulation (TENS) as a non-pharmacological resource of postoperative pain relief. National and international references regarding the use of TENS for the relief of postoperative pain had been selected, highlighting its mechanism of action, parameters of application, contraindications, side-effect and results. TENS is a non-pharmacological resource that has its mechanism of action based on the gate theory. It consists of a device that emits electric impulses in the skin through electrodes. It is a low cost technique, easily applicable, presents few collateral effects, good effectiveness related to the reduction of the painful perception, allowing early mobilization and reduced pharmacological analgesic consumption. TENS represents another option in the control of postoperative pain and should be inserted in a multiprofessional context.

Novas técnicas ambulatoriais para avaliação da motilidade esofágica e sua aplicação no estudo do megaesôfago

Brazilian surgeons deal routinely with esophageal motility disorders, because achalasia is highly prevalent in Brazil due to Chagas' disease. In the last years new technologies for the evaluation of esophageal motility became available. High resolution manometry and the combination of barometric parameters and intraluminal impedance are the new frontiers on this topic. The authors reviewed current, national and international, literature about achalasia with multichannel intraluminal impedance and high resolution manometry studies. The new technologies described are promising, however few studies have been published and further studies are still expected for achalasia patients.

Aurinkoenergian hyödyntäminen olemassa olevassa pientalossa

Tämän tutkimuksen tarkoituksena on tutkia aurinkoenergian hyödyntämistä olemassa olevassa pientalossa. Työssä tarkastellaan aurinkoenergiahankkeen kannattavuutta vaihtoehtoisten lämmitysjärjestelmien osana sekä aurinkosähkön tuotantoa rakennuksen sähköenergian kulutukseen. Lisäksi tarkastellaan, missä määrin aurinkoenergian käyttö vähentää rakennuksen hiilidioksidipäästöjä. Suomi on asettanut itselleen kunnianhimoisen tavoitteen pienentää rakennusten lämmitysenergian kulutusta vuoteen 2050 mennessä. Olemme myös sitoutuneet EU:n uusiutuvan energiankäytön lisäämistavoitteisiin. Normiohjauksen avulla voidaan huolehtia uudisrakennustuotannon energiatehokkuudesta, mutta olemassa olevaan rakennuskantaan on löydettävä muita kustannustehokkaita keinoja vähentää ostoenergian kulutusta ja lisätä uudistuvan energian osuutta energiankulutuksesta. Suomalaiselle asuntorakennuskannalle on tyypillistä pientalovaltaisuus sekä asuntokannan hidas uusiutuvuus. Tämä osaltaan lisää haastetta kansallisten sekä kansainvälisten tavoitteiden saavuttamisessa. Aurinkoenergian hyödyntämisen kannattavuutta tarkastellaan aurinkoenergiahankkeen rajakustannuksen avulla. Laitteen tekninen käyttöikä ja ostoenergian hintakehitys ovat arvioituja. Näin tarkastellen öljylämmitys ja suora sähkölämmitys saavat suurimman hyödyn aurinkoenergiasta, kun sillä tuotetaan lämmintä käyttövettä.

Sähköisen taloushallinnon kehitys ja ilmiön näkyvyys alan ammattilehtikirjoittelussa

Pro gradu –tutkielman ensisijaisena tavoitteena on tutkia sähköisen ta-loushallinnon kehitystä ja miten se on näkynyt alan suomalaisessa ja kansainvälisessä ammattilehtikirjoittelussa vuosina 1997 – 2013. Tarkoi-tuksena on löytää kirjoittelun perusteella sähköisen taloushallinnon kehi-tyksen edistäviä ja hidastavia tekijöitä sekä minkälaisia tulevaisuuden näkymiä artikkelit luovat sähköiselle taloushallinnolle. Lisäksi tavoitteena on löytää yhtäläisyyksiä ja eroja kansallisen ja kansainvälisen kirjoittelun välillä. Tutkielma on laadullinen tutkimus ja tutkimusmenetelminä käytetään si-sällönanalyysia, sisällönerittelyä, teemoittelua ja vertailevaa tutkimusta. Tutkielman empiirinen aineisto koostuu Tilisanomien, Balanssi–lehden ja Accountancy–lehden sähköistä taloushallintoa koskevista artikkeleista aikavälillä 1997 – 2013. Tutkimustulosten perusteella sähköisen taloushallinnon kehityskulku näkyy myös ammattilehtikirjoittelussa. Tietojärjestelmät ja niiden käytön mahdollistava lainsäädäntö ovat sähköisen taloushallinnon perusedelly-tykset. Suurimpia kehityksen edistäjiä ovat julkinen valta, verkkolaskut ja standardointi. Kehityksen hidastajina nähdään yhtenäisten standardien puute ja asenteet. Sähköisen taloushallinnon tulevaisuuden näkymiä ovat standardoidut prosessit ja käsitteet koko taloushallinnon alueella sekä viranomaisraportointi XBRL-kielen avulla. Suurimmat erot kansalli-sessa ja kansainvälisessä kehityksessä on havaittavissa verkkolaskuissa ja XBRL-raportoinnissa. Johtopäätöksenä todetaan että kirjoittelun perusteella voidaan löytää sähköisen taloushallinnon kehitystä hidastavia ja edistäviä tekijöitä ja se luo viitteitä tulevaisuuden kehitykselle. Sähköinen taloushallinto kehittyy kunkin maan valtiovallan tahtotilan ja lainsäädännön mukaan. Jatkotut-kimuskohteena tutkielmaa voisi laajentaa kansainvälisemmäksi ottamalla mukaan tarkasteluun useampia kansainvälisiä lehtiä ja kansainvälistä lainsäädäntöä.