Support theorems on R-n and non-compact symmetric spaces

We consider convolution equations of the type f * T = g, where f, g is an element of L-P (R-n) and T is a compactly supported distribution. Under natural assumptions on the zero set of the Fourier transform of T, we show that f is compactly supported, provided g is. Similar results are proved for non-compact symmetric spaces as well. (C) 2010 Elsevier Inc. All rights reserved.

Molecular conformation of alamethicin in dimethylsulfoxide solution A two-dimensional n.m.r. study

The solution conformation of alamethicin, a 20-residue antibiotic peptide, has been investigated using two-dimensional n.m.r. spectroscopy. Complete proton resonance assignments of this peptide have been carried out using COSY, SUPERCOSY, RELAY COSY and NOESY two-dimensional spectroscopies. Observation of a large number of nuclear Overhauser effects between sequential backbone amide protons, between backbone amide protons and CβH protons of preceding residues and extensive intramolecular hydrogen bonding patterns of NH protons has established that this polypeptide is in a largely helical conformation. This result is in conformity with earlier reported solid state X-ray results and a recent n.m.r. study in methanol solution (Esposito et al. (1987) Biochemistry26, 1043-1050) but is at variance with an earlier study which favored an extended conformation for the C-terminal half of alamethicin (Bannerjee et al.

Theorizing the Nature of Reflection

For the past decades reflection has been the buzzword of adult and higher education. Reflection is facilitated in many practices and there is abundant research on the issue. Despite the popularity of the concept, the reasons why bringing about reflection in educational practices is difficult remain unclear. The prevailing theories inform of the process in its ideal form. However, to a great extent, they fail to offer conceptual tools for understanding and working with the actualities of reflection. The aim of the doctoral thesis was to explore the challenges and prerequisites of reflection in order to theorize the nature of reflection. By the term reflection it is here referred to becoming aware of and questioning the assumptions that orient our thinking, feelings and actions. The doctoral thesis consists of five studies that approach these questions from different viewpoints and within different contexts. The methods involve both a philosophical and an empirical approach. This multifaceted approach embodies the aim of both gaining a more thorough grasp of the phenomenon and to develop the methodology of researching reflection. The theory building is based on conceptual analysis and rational reconstruction (see Davia 1998; Habermas 1979; Rorty1984) of Mezirow s (1981; 1991; 2000; 2009) theory of transformative learning. In order to explore the aspects which, based on the analysis, appeared insufficiently considered within Mezirow s theory, Damasio s (1994; 1999; 2003; 2010) theory on emotions and consciousness as well as Clausewitz s (1985) view on friction are used as complementary theories. Empirical analyses are used in dialogue with the theoretical, in order to challenge and refine the emerging theorization. Reflection is examined in three different contexts; regarding university teachers pedagogical growth, involuntarily childless women recovering from a life-event crisis, and soldiers preparing to act in chaotic situations of the battlefield as well as recovering from it. The choice of these contexts is based on Mezirow s notion of disorienting dilemma as a trigger for reflection. This notion indicates that reflection may more naturally emerge in association to life-event crises or other cumulative sets of instances, which bring our worldview and beliefs under question. Nevertheless, reflection is often being promoted in educational contexts in which the trigger conditions may not readily prevail. These contextual issues as well as the differences between the facilitated and non-facilitated contexts have not, however, been considered in detail within the research on reflection (or transformative learning). The doctoral thesis offers a new perspective into reflection which, as a further development on Mezirow s transformative learning theory, theorizes the nature of reflection. The developed theory explicates the prerequisites and challenges to reflection. The theory suggests that the challenges of reflection are fundamentally connected to the way the biological life-support system affects our thinking through emotions. While depicting the mechanisms that function as a counterforce to reflection, the developed theory also opens a perspective for considering possibilities for carrying out reflection, and suggests ways to locate and deal with the assumptions to be reflected on. The basic dynamic of the challenges to reflection was explicated by conceptually bridging the gap between Mezirow s and Damasio s theories, through exploring the connections between the meaning perspective and the biological functions of emotions. The concepts of comfort zone and edge-emotions were formed so as to depict the emotional orientation of our thinking, as part of the explanation of the nature of reflection.

Hyveiden harjoittaminen : edellytykset ja esteet

In the first half of the 20th century, most moral philosophers took the concept of virtue to be secondary to moral principles or emotions, though in various and mutually conflicting ways. In the early 1960s interest in the virtues was restored by the analytic philosophers Elizabeth Anscombe and Georg Henrik von Wright, the younger colleagues and friends of the late Wittgenstein. Later, Alasdair MacIntyre became a leading virtue ethicist. In 1981, MacIntyre introduced in After Virtue the concept of practices, which he based on the Aristotelian distinction between praxis and poiesis. This dissertation examines MacIntyre s characterization of the interconnectedness between practices and virtues, especially in relation to skills, education, and certain emotions. The primary position of the virtues is defended against the tendency in modern moral philosophy to overemphasize the role either of principles and rules or of emotions. The view according to which rational action and acting according to the virtues is best conceptualized as following rules or principles is criticized by arguments that are grounded by some Wittgensteinian observations, and that can be characterized as transcendental. Even if the virtues cannot be defined by, and are not based entirely on, emotions, the role of certain emotions on the learning and education of skills and virtues are studied more carefully than by MacIntyre. In the cases of resentment, indignation, and shame, the analysis of Peter Strawson is utilized, and in the case of regret, the analysis of Bernard Williams. Williams analysis of regret and moral conflict concludes in a kind of antirealism, which this study criticizes. Where education of practices and skills and the related reactive emotions are examined as conditions of learning and practicing the virtues, institutions and ideologies are examined as obstacles and threats to the virtues. This theme is studied through Karl Marx s conception of alienation and Karl Polanyi s historical and sociological research concerning the great transformation . The study includes six Finnish-published articles carrying the titles Our negative attitudes towards other persons , Authority and upbringing , Moral conflicts, regret and ethical realism , Practices and institutions , Doing justice as condition to communal action: a transcendental argument for justice as virtue , and Alienation from practices in capitalist society: Alasdair MacIntyre s Marxist Aristotelianism . The introductory essay sums up the themes of the articles and presents some central issues of virtue ethics by relating the classical Socratic questions to Aristotelian practical philosophy, as well as to current controversies in metaethics and moral psychology.

Determinants of Cognitive Impairment in Old Age and Their Genetic Architecture

Cognitive health is of central importance for independent and balanced old age, while memory disorders represent the leading cause of intensive and long-term care among the Finnish elderly. The aims of this study were to analyse the effect of height, body mass index, weight change, metabolic conditions and coffee drinking in midlife on cognitive performance in old age among a sample of 2606 Finnish twins aged 65 years or older who had participated in a telephone interview to assess their cognitive status. Since coffee drinking associates with several metabolic conditions and Finns are known to be the greatest consumers of coffee in the world, the heritability and stability of coffee drinking was analysed in the whole Older Finnish Twin Cohort (n=10716). In order to investigate the association between height and cognitive performance in a population with more supportive childhood living conditions, a total of 2161 Danish twins were included in this study. A greater height was found to clearly associate with better cognitive performance in Finnish subjects, but less so among the Danish sample, which may reflect the childhood environmental differences between these cohorts. In the Finnish subjects, there was greater variance in cognitive performance among shorter subjects, and environmental factors were found to play a greater role in their cognitive performance, whereas the cognitive performance of taller participants was mainly explained by genetic factors. Midlife metabolic variables that were found to be significantly associated with a poorer cognitive performance in old age included a higher body mass index and three metabolic conditions: cardiovascular disease, hypertension and, most significantly of all, diabetes. Moreover, both weight gain and loss, even to a lesser degree than suggested previously, were found to be associated with poorer cognition. Furthermore, evidence of a causal relationship between midlife cardiovascular disease and cognitive performance in old age was demonstrated among discordant twin pairs. Conversely, no effect of coffee drinking in midlife on cognitive performance in old age was observed, although coffee drinking was demonstrated to be stable in the study population. The heritability of coffee drinking was found to differ across sexes and age groups, being 51% in men and 52% in women in the whole study population. This study supports the contention that cognitive performance in old age reflects the effects of multiple genetic and environmental exposures, including their complex interactions during the life-span. The demonstrated associations and evidence of a causal pathway between potentially preventable exposures and poorer cognitive performance highlight the importance of preventive medicine.

Spectral Invariance of SG Pseudo-Differential Operators on L-P(R-n)

We prove the spectral invariance of SG pseudo-differential operators on L-P(R-n), 1 < p < infinity, by using the equivalence of ellipticity and Fredholmness of SG pseudo-differential operators on L-p(R-n), 1 < p < infinity. A key ingredient in the proof is the spectral invariance of SC pseudo-differential operators on L-2(R-n).

Vastakkainasettelusta takaisin neuvottelupöytiin - presidentti Ronald Reaganin neuvostosuhteet 1981-1987

Tutkielmassa tutkitaan Yhdysvaltain presidentti Ronald Reaganin (1911-2004) Neuvostoliittoa koskevaa retoriikkaa hänen käyttämissään julkisissa virallisissa puheissa. Tutkimuskohde on valittu siksi, että Reaganin kahden virkakauden välillä tapahtui merkittävä linjanmuutos juuri neuvostosuhteissa ja tämän tutkimuksen tarkoituksena on pyrkiä selittämään retoriikan merkitystä todellisuuteen. Ajanjakso on rajattu periodille 1981-1987, koska juuri tällä periodilla ratkaiseva retoriikan ja turvallisuuspoliittisen linjan muutos suhteessa Neuvostoliittoon tapahtui. Vedenjakajana on vuosi 1985 Reaganin toisen kauden alkaessa ja Mihail Gorbatšovin tullessa valtaan Neuvostoliitossa. Johdon vaihtuminen Neuvostoliitossa ajatellaan usein olevan ratkaiseva tekijä Yhdysvaltain ja Reaganin asenteiden muuttumiselle. Tutkimuksen avulla pyritään avaamaan diplomatian kulisseja, mitä todellisuudessa milloinkin tapahtui ja missä mentiin kilpavarustelun ja aseriisuntaneuvottelujen samanaikaisten ristiriitaisten vuorovaikutusten akanvirroissa. Aiemmassa tutkimuksessa on taustoitettu erityisesti aseriisuntaneuvottelujen historiaa myös Reaganin kolmen edeltäjän ajalta 1969-1981 periodilta sekä kuvattu Reaganin presidenttikauden pääkysymykset Neuvostoliiton suhteen. Aiemmassa tutkimuksessa on esitetty, että Reagan palasi neuvostopolitiikassaan käytännössä liennytyksen linjalle, merkittävänä retorisena erona kuitenkin, ettei tätä termiä virallisesti koskaan käytetty Reaganin aikana. Toisaalta Reagania on pidetty omalaatuisena ja hieman pinnallisena, kuitenkin retorisesti maan historian yhtenä taitavimmista presidenteistä. Reagan jatkoi pitkälti edeltäjänsä Jimmy Carterin jo käynnistämiä asevarusteluhankkeita mutta hän pyrki saamaan uuden alun neuvotteluilmapiiriin omalla täysin edeltäjistään poikkeavalla kovennetulla retoriikallaan. Varsinkin kautensa alkupuolella Reagan joutui hyvin haastavasti retorisesti todistelemaan haluaan rauhaan samalla kun hänen piti perustella uudet mittavat asevarusteluhankkeet omalle kansalleen. Erityisesti kiistanalainen SDI-avaruuspuolustushanke oli presidentin oma aloite, jota oli vaikeinta perustella riittävän uskottavasti kotimaassa ja varsinkin ulkomailla. Tutkielman tutkimusote on kvalitatiivinen ja induktiivinen. Metodina toimii retorinen analyysi. Retorisen pakottamisen mallia käyttämällä on tarkoituksena jäsentää retoriikan ja turvallisuuspolitiikan välistä yhteyttä sekä näin samalla paikantaa puheiden ja todellisuuden välistä kokonaisuutta. Tutkimuksen avulla pyritään tunnistamaan muutoksia retoriikan menetelmissä puheiden sisällä ja etsimään näiden muutosten syy-seuraussuhteita samanaikaisesti tapahtuneisiin kilpavarustelu –ja aseriisuntaprosesseihin. Lähtöoletuksena on että Reaganin kaudella tapahtunut kolmas johtajanvaihdos, Gorbatšovin valtaantulo oli merkittävä tekijä sekä Reaganin retoriikan että politiikan muuttumisessa. Tutkimus nojautuu pitkälti primaariaineistoon presidentti Reaganin virallisten puheiden toimiessa tärkeimpänä lähdemateriaalina. Merkittävin tutkimustulos on, että vuoden 1985 johtajavaihdos Neuvostoliitossa oli merkittävä tekijä Reaganin konkreettisessa suunnan muutoksessa Neuvostoliittoon nähden, mutta retoriikan tasolla tämä muutos ei ollut yhtä selvä. Hänen puheissaan oli vaihtelevia sävyjä sekä ennen että jälkeen Gorbatšovin valtaantulon. Reaganin sävy puheissa pehmeni jonkin verran, mutta kovistelevia sanoja 1985 jälkeenkin oli silti välillä kohtalaisen paljon ja toisaalta jo aiempien neuvostojohtajien aikana hän puhui välillä sovinnollisempaan sävyyn. Muutos retoriikan suhteen on ollut näin ollen varovaisempaa ja vaikeammin kohdistettavissa yhden tietyn tapahtuman seurauksena. Aseriisuntaneuvotteluissa sen sijaan mentiin selvästi eteenpäin johtajien 1985-1986 tapaamisten siivittämänä. Reagan oli retorisen pakottamisen mallin soveltamisessa pääsääntöisesti aloitteellinen osapuoli, joka halusi vaikuttaa merkittävästi muutoksiin erityisesti Neuvostoliiton sisällä.

Biochemical, histopathological and ultrastructural changes in rat liver induced by r-( + )-pulegone, a monoterpene ketone

Biochemical, histopathological and ultrastructural changes occurring at different time points after intraperitoneal administration of a single dose of pulegone (300 mg/kg) were studied. Significant decreases in the level of liver microsomal cytochrome P-450 (67%), heme (37%), aminopyrine N-demethylase (60%) and glucose-6-phosphatase (58%), were noticed 24 hr after pulegone treatment. Alanine amino transferase (ALT) levels increased in a time dependent manner, following exposure of rats to pulegone. Light microscopic studies of liver tissues showed dilation of central veins and distention of sinusoidal spaces 6 hr after pulegone treatment. Initial centrilobular necrosis was noticed at 12 hr. Centrilobular necrosis became severe at 18 hr and nuclear changes included karyorrhexis and karyolysis. Midzonal and periportal degenerative changes in addition to centrilobular necrosis was observed 24 hr after pulegone administration. Electron microscopic changes showed severe degeneration of endoplasmic reticulum, swelling of mitochondria and nuclear changes, 24 hr after administration of pulegone. The time course profile of the hepatocytes after treatment with pulegone indicates that endoplasmic reticulum is the organelle most affected, following which other degenerative changes occur ultimately leading to cell death.

Inelastic dynamic response of R.C. beam column joints by using B.E.M.

A BEM formulation to obtain the inelastic response of R.C. Beam-Column joints subjected to sinusoidal loading along the boundary is presented. The equations of motion are written along with kinematical and constitutive equations. The dynamic reciprocal theorem is presented and the temporal dependence is removed by assuming steady state response.

Silva Fennica Vol. 15, 1981.

Julkaistu Silva Fennica Vol. 15(4) -numeron liitteenä.

Nucleation and growth of Al2O3/metal composites by oxidation of aluminum alloys

The nucleation and growth mechanisms during high temperature oxidation of liquid Al-3% Mg and Al-3% Mg-3% Si alloys were studied with the aim of enhancing our understanding of a new composite fabrication process. The typical oxidation sequence consists of an initial event of rapid but brief oxidation, followed by an incubation period of limited oxide growth after which bulk Al2O3/Al composite forms. A duplex oxide layer, MgO (upper) and MgAl2O4 (lower), forms on the alloy surface during initial oxidation and incubation. The spinel layer remains next to the liquid alloy during bulk oxide growth and is the eventual repository for most of the magnesium in the original alloy. Metal microchannels developed during incubation continuously supply alloy through the composite to the reaction interface. During the growth process, a layered structure exists at the upper extremity of the composite, consisting of MgO at the top surface, MgAl2O4 (probably discontinuous), Al alloy, and finally the bulk Al2O3 composite containing microchannels of the alloy. The bulk oxide growth mechanism appears to involve continuous formation and dissolution of the Mg-rich oxides at the surface, diffusion of oxygen through the underlying liquid metal, and epitaxial growth of Al2O3 on the existing composite body. The roles of Mg and Si in the composite growth process are discussed.

Polyquinanes from (R)-(+)-limonene. Enantioselective total synthesis of the novel tricyclic sesquiterpene (-)-ceratopicanol

The first total synthesis of the biogenetically important and structurally novel triquinane sesquiterpene (-)-ceratopicanol has been accomplished.