Absolute Configuration and Selective Trypanocidal Activity of Gaudichaudianic Acid Enantiomers

Gaudichaudianic acid, a prenylated chromene isolated from Piper gaudichaudianum, has been described as a potent trypanocidal compound against the Y-strain of Trypanosoma cruzi. We herein describe its isolation as a racemic mixture followed by enantiomeric resolution using chiral HPLC and determination of the absolute configuration of the enantiomers as (+)-S and (-)-R by means of a combination of electronic and vibrational circular dichroism using density functional theory calculations. Investigation of the EtOAc extract of the roots, stems, and leaves from both adult specimens and seedlings of P. gaudichaudianum revealed that gaudichaudianic acid is biosynthesized as a racemic mixture from the seedling stage onward. Moreover, gaudichaudianic acid was found exclusively in the roots of seedlings, while it is present in all organs of the adult plant. Trypanocidal assays indicated that the (+)-enantiomer was more active than its antipode. Interestingly, mixtures of enantiomers stowed a synergistic effect, with the racemic mixture being the most active.

Xylarenones C-E from an Endophytic Fungus Isolated from Alibertia macrophylla

Xylarenones C-E (2-4), three new eremophilane sesquiterpenes, have been isolated from solid substrate cultures of a Camarops-like endophytic fungus isolated from Alibertia macrophylla. The structures were elucidated by analysis of spectroscopic data. Compounds were evaluated in subtilisin and pepsin protease assays, and compound 2 showed potent inhibitory activity against both proteases.

Soda-Treated Sisal/Polypropylene Composites

Treated sisal fibers were used as reinforcement of polypropylene (PP) composites, with maleic anhydride-grafted PP (MAPP) as coupling agent. The composites were made by melting processing of PP with the fiber in a heated roller followed by multiple extrusions in a single-screw extruder. Injection molded specimens were produced for the characterization of the material. In order to improve the adhesion between fiber and matrix and to eliminate odorous substances, sisal fibers were treated with boiling water and with NaOH solutions at 3 and 10 wt.%. The mechanical properties of the composites were assessed by tensile, bend and impact tests. Additionally, the morphology of the composites and the adhesion at he fiber-matrix interface were analyzed by SEM. The fiber treatment led to very light and odorless materials, with yields of 95, 74 and 62 wt.% for treatments with hot water, 3 and 10 wt.% soda solution respectively. Fiber treatment caused an appreciable change in fiber characteristics, yet the mechanical properties under tensile and flexural tests were not influenced by that treatment. Only the impact strength increased in the composites with alkali-treated sisal fibers.

Revision of the multiphased genus Corbulipora MacGillivray (Bryozoa: Cribrimorpha)

Corbulipora MacGillivray is redefined to include only species which occur in successive growth phases. The fossil type species, Corbulipora ornata MacGillivray, occurs in an encrusting ancestrulate phase, an erect quadriserial, ovicellate phase, and a frontally-budded partially kenozooidal phase. The encrusting ancestrulate phase of the Recent species, C tubulifera (Hincks), is the type species of the genus Acanthocella Canu and Bassler, which is a junior synonym of Corbulipora. The succeeding, ovicellate, flustrine phase, known as Watersia militaris (Waters), is the type species of Watersia, another junior synonym of Corbulipora. It produces a third bilaminar phase known as C. oriparma, a synonym of C. tubulifera. This has rhizoids and develops further flustrine phases. Fossil specimens assigned to Acanthocella tubulifera in the past are here considered to be the primary encrusting phase of a bilaminar phase, known as Corbuhpora suggerens (Waters). from which it has become separated. A thinly calcified intervening erect phase similar to the flustrine phase of C. tubulifera IS inferred to have existed but not to have been preserved as a fossil. Some species previously referred to Watersia are assigned to Klugeflustra Moyano which, like Neoflustra Lopez Gappa, has flustrine colomes with large, hyperstomial ovicells, unlike those of the family Flustridae sensu stricto. A key to species of Corbulipora and their various phases is given.

Using object and trajectory analysis to facilitate indexing and retrieval of video

This paper aims to show that by using low level feature extraction, motion and object identifying and tracking methods, features can be extracted and indexed for efficient and effective retrieval for video; such as an awards ceremony video. Video scene/shot analysis and key frame extraction are used as a foundation to identify objects in video and be able to find spatial relationships within the video. The compounding of low level features such as colour, texture and abstract object identification lead into higher level real object identification and tracking and scene detection. The main focus is on using a video style that is different to the heavily used sports and news genres. Using different video styles can open the door to creating methods that could encompass all video types instead of specialized methods for each specific style of video.

Soil erosion in developing countries: a socio-economic appraisal

Soil erosion is the single most important environmental degradation problem in the developing world. Despite the plethora of literature that exists on the incidence, causes and impacts of soil erosion, a concrete understanding of this complex problem is lacking. This paper examines the soil erosion problem in developing countries in order to understand the complex inter-relationships between population pressure, poverty and environmental-institutional dynamics. Two recent theoretical developments, namely Boserup's theory on population pressure, poverty and soil erosion and Lopez's theory on environmental and institutional dynamics have been reviewed. The analysis reveals that negative impacts of technical change, inappropriate government policies and poor institutions are largely responsible for the continued soil erosion in developing countries. On the other hand, potential for market-based approaches to mitigate the problem is also low due to the negative externalities involved. A deeper appreciation of institutional and environmental dynamics and policy reforms to strengthen weak institutions may help mitigate the problem.

Evidence of panel stationarity from Chinese provincial and regional income

The aim of this paper is to examine whether Chinese provincial and regional real GDP and per capita real GDP are panel stationary for the period 1952–2003. We allow for multiple structural breaks based on a technique developed by Carrion-i-Silvestre et al. [Carrion-i-Silvestre, J. L., Barrio-Castro, T, D., & Lopez-Bazo, E. (2005). Breaking the panels: An application to the GDP per capita. Econometrics Journal, 8, 159–175]. Allowing for at most five structural breaks, we find that for 67% of the provinces, per capita real GDP is stationary; while we only find stationarity of real GDP for 17% of the provinces. However, when we extend the analysis to panel data models, we find statistically strong evidence of panel stationarity of Chinese provincial and regional income.

Are employees entitled to more?

George Lopez, chair of CPA Australia's insolvency and reconstruction committee reported in Australian CPA (November 2001) on the replacement of the Commonwealth Government Employee Entitlements Support Scheme (EESS) with a new scheme, the General Employee Entitlements Redundancy Scheme (GEERS). Both schemes provide a safety net by which government pays employees their service entitlements and then takes the employees' place in claims against the insolvent employer organisation. Such schemes are fundamentally inequitable as ultimately they require taxpayers and shareholders to foot the bill for the mistakes, excesses, misdemeanours or incompetence of employers. Similar arrangements have been proposed in the past. For instance, the Australian Law Reform Commission's Harmer Report (1988) contained a recommendation that a wage earner (fidelity-type) protection fund be established. In the state of Victoria, local government legislation already exists to ensure that long service leave entitlements are funded.

Attitudes and knowledge of shade-coffee farmers towards vertebrates and their ecological functions.

The purpose of this study was to assess farmers’ attitudes, as well as perceptions and knowledge that shape those attitudes, toward the ecological role of vertebrates inhabiting shaded-coffee farms. We also aimed to determine whether differences existed among two groups of farmers: one that had attended environmental education workshops, and one that had not. We conducted 36 oral interviews of farmers in the region of Cuetzalan, Mexico. All farmers were members of an important regional cooperative, Tosepan Titataniske. In general, farmers’ attitudes towards birds were positive. Snakes were perceived as useful but dangerous animals. Attitudes towards nonflying mammals were mostly indifferent. Bats were poorly understood and badly perceived. Seed dispersal was perceived as an important ecological function performed by animals. Pollination was also perceived as important, but to a lesser degree. Knowledge about ecological functions was high for seed dispersal, and low for pollination. We found a positive correlation between attendance of educational workshops and the presence of “environmentally-friendly” attitudes, perceptions, and knowledge. However, a cause-effect relationship could not be clearly established. We suggest that environmental education programs include the objective of increasing the knowledge of people about the ecological functions played by different groups of animals that live in agroecosystems. Particular efforts should be directed toward improving the way in which certain non-charismatic groups of animals, such as bats, are perceived.

An analysis of microband orientation in hot deformed aluminium alloy AA5052 using forward and reverse torsion

The effects of strain path reversal on the macroscopic orientation of microbands in AA5052 have been studied using high resolution electron backscatter diffraction. Deformation was carried using two equal steps of forward/forward or forward/reverse torsion at a temperature of 300°C and strain rate of 1s-1 to a total equivalent tensile strain of 0.5. In both cases microbands were found in the majority of grains examined with many having more than one set. The microbands appear to cluster at specific angles to the macroscopic deformation. For the forward/forward condition microbands clustered around -20° and +45° to the maximum principle stress direction and at ± 30-35° to the principal strain direction. For the forward/reverse condition significantly more spread in microband angle was observed though peaks were visible at ±35° with respect to principal stress direction and at -40° and +30° with respect to the principal strain direction of the reverse torsion. This suggests the microbands formed in the forward deformation have or are dissolving and any new microbands formed are related to the deformation conditions of the final strain path.

Early breast cancer identification : Which way to go? Microarray or image based computer aided diagnosis!

The goal of this research is to develop a computer aided diagnostic (CAD) system that can detect breast cancer in the early stage by using microarray and image data. We verified the performance of six well known classification algorithms with various performance matrices. Although we do not suggest a unique classifier algorithm for a CAD system, we do identify a number of algorithms whose performance is very promising. The algorithms performance was validated by 3 images dataset; two have been used for the first time in this experiment. Multidimensional image filtering is adopted for the final data extraction. The image data classification performance is compared with microarray data. Results suggest the most effective means of breast cancer identification in the early stage is a hybrid approach.

Discriminating DDoS flows from flash crowds using information distance

Discriminating DDoS flooding attacks from flash crowds poses a tough challenge for the network security community. Because of the vulnerability of the original design of the Internet, attackers can easily mimic the patterns of legitimate network traffic to fly under the radar. The existing fingerprint or feature based algorithms are incapable to detect new attack strategies. In this paper, we aim to differentiate DDoS attack flows from flash crowds. We are motivated by the following fact: the attack flows are generated by the same prebuilt program (attack tools), however, flash crowds come from randomly distributed users all over the Internet. Therefore, the flow similarity among DDoS attack flows is much stronger than that among flash crowds. We employ abstract distance metrics, the Jeffrey distance, the Sibson distance, and the Hellinger distance to measure the similarity among flows to achieve our goal. We compared the three metrics and found that the Sibson distance is the most suitable one for our purpose. We apply our algorithm to the real datasets and the results indicate that the proposed algorithm can differentiate them with an accuracy around 65%.

Distinguishing DDoS attacks from flash crowds using probability metrics

Both Flash crowds and DDoS (Distributed Denial-of-Service) attacks have very similar properties in terms of internet traffic, however Flash crowds are legitimate flows and DDoS attacks are illegitimate flows, and DDoS attacks have been a serious threat to internet security and stability. In this paper we propose a set of novel methods using probability metrics to distinguish DDoS attacks from Flash crowds effectively, and our simulations show that the proposed methods work well. In particular, these mathods can not only distinguish DDoS attacks from Flash crowds clearly, but also can distinguish the anomaly flow being DDoS attacks flow or being Flash crowd flow from Normal network flow effectively. Furthermore, we show our proposed hybrid probability metrics can greatly reduce both false positive and false negative rates in detection.

Enhancing RFID tag resistance against cloning attack

In its current form, RFID system are susceptible to a range of malevolent attacks. With the rich business intelligence that RFID infrastructure could possibly carry, security is of paramount importance. In this paper, we formalise various threat models due tag cloning on the RFID system. We also present a simple but efficient and cost effect technique that strengthens the resistance of RFID tags to cloning attacks. Our techniques can even strengthen tags against cloning in environments with untrusted reading devices.