Xylarenones C-E from an Endophytic Fungus Isolated from Alibertia macrophylla
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2011
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| Resumo |
Xylarenones C-E (2-4), three new eremophilane sesquiterpenes, have been isolated from solid substrate cultures of a Camarops-like endophytic fungus isolated from Alibertia macrophylla. The structures were elucidated by analysis of spectroscopic data. Compounds were evaluated in subtilisin and pepsin protease assays, and compound 2 showed potent inhibitory activity against both proteases. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Biodiversity Virtual Institute Program Biodiversity Virtual Institute Program[03/02176-7] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP Coordenacao de Aperfeicoamento de Pessoal de nivel Superior (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) |
| Identificador |
JOURNAL OF NATURAL PRODUCTS, v.74, n.6, p.1353-1357, 2011 0163-3864 http://producao.usp.br/handle/BDPI/31596 10.1021/np1005983 |
| Idioma(s) |
eng |
| Publicador |
AMER CHEMICAL SOC |
| Relação |
Journal of Natural Products |
| Direitos |
restrictedAccess Copyright AMER CHEMICAL SOC |
| Palavras-Chave | #EREMOPHILANE #SESQUITERPENE #INHIBITOR #PROTEASE #PLANTS #Plant Sciences #Chemistry, Medicinal #Pharmacology & Pharmacy |
| Tipo |
article original article publishedVersion |
