Measurement of the differential cross-section of B⁺ meson production in pp collisions at sqrts = 7 TeV at ATLAS

The production cross-section of B+ mesons is measured as a function of transverse momentum p T and rapidity y in proton-proton collisions at centre-of-mass energy root s = 7 TeV, using 2.4 fb(-1) of data recorded with the ATLAS detector at the Large Hadron Collider. The differential production cross-sections, determined in the range 9 GeV < p(T) < 120 GeV and vertical bar y vertical bar < 2.25, are compared to next-to-leading-order theoretical predictions.

Zionistisches A-B-C-Buch

hrsg. ... von der Zionistischen Vereinigung für Deutschland

Ombitasvir (ABT-267), a novel NS5A inhibitor for the treatment of hepatitis C

INTRODUCTION: Chronic hepatitis C infection is a global disease with 160 million people infected worldwide. Until recently, therapy was characterized by long duration, suboptimal success rates and significant adverse drug reactions. The development of direct-acting antivirals initiated a dramatic change in the treatment of hepatitis C. AREAS COVERED: This review covers the development of the novel NS5A inhibitor ombitasvir (ABT-267) and its clinical evaluation in Phase I to III trials as monotherapy and in combination with the NS3/4A inhibitor ABT-450/r and the non-nucleoside NS5B inhibitor dasabuvir (ABT-333) ± ribavirin. EXPERT OPINION: Ombitasvir (ABT-267) is a potent inhibitor of the hepatitis C virus protein NS5A, has favorable pharmacokinetic characteristics and is active in the picomolar range against genotype 1 - 6. In patients with genotype 1 and 4, 12-week combination treatment with ombitasvir, dasabuvir and ABT-450/r plus ribavirin was highly effective and resulted in 12-week sustained virological response rates higher than 95% in treatment-naöve and treatment-experienced patients. In liver transplant recipients with genotype 1 hepatitis C, success rates in the same range can be expected after 24 weeks of treatment according to preliminary trial results. Genotype 1a patients with compensated cirrhosis who were prior nonresponders benefit from a treatment duration of 24 weeks.

Synthesis of pyrrolidine C-nucleosides via Heck reaction

A novel method for the synthesis of pyrrolidine C-nucleosides has been developed. The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative 15 can easily be converted to the corresponding phosphoramidite building blocks for DNA synthesis

Synthesis of Carbocyclic C-Nucleosides Containing Nonnatural Pyrimidine Bases

A series of new carbocyclic C-nucleosides with a cis-4′-(hydroxymethyl)cyclopent-2′-enyl sugar moiety and unnatural pyrimidine bases (2–6) were synthesized in racemic form in two steps starting from the easily accessible cyclic carbonate 1.

Allerunterthänigst-gründliche Gegen-Information Und Exceptiones Sub- & Obreptionis : An Die Römis. Kayserl. ... Majestät ... Auff das am 12. May nup. und 19. currentis mensis erlassene Kayserl. Rescript, Juncta Petitione Humillima Pro Clementissima cassatione ejusdem ... ; In Sachen Judenschafft zu Franckfurth am Mayn Contrà Den Magistrat daselbsten ; Bey höchst-preyßlichen Reichs-Hof-Rath Den 23. Julii 1714 übergeben ; Mit Beylagen A, B, C & D ; Das Bau-Weesen betreffend

Burgerschafftl. Abgeordneter [Johann Dieterich Notebohm ; Joachim Hoppe] [[Elektronische Ressource]]

Das republikanische A B C

Boberach: Die Reichsverfassung soll die Menschenrechte garantieren und die Pflichten der Staatsbürger regeln. Republikanische Prinzipien sollen für die Gemeinden, die Kreise, die Staaten und das Reich gelten, das aus 19 Gliedstaaten bestehen soll. Als Organe sind vorgesehen: Reichstag (Oberhaus und Unterhaus), Reichsrat, Reichsobmann, der von den Landtagen gewählt wird, Reichsgericht mit Laienmehrheit, Heerwesen, Steuerangelegenheiten, Kirchen- und Schulwesen sind den Gemeinden zu überlassen. Eine allgemeine Einkommensteuer soll die Landesbedürfnisse, eine Luxussteuer soll Gemeinden und Kreise, Zölle auf Luxuswaren und ausländische Produkte die Ausgaben des Reiches finanzieren

Petition des Friedrich-Wilhelmsstädtischen Bezirks-Vereins (Stadtbezirke 74. a. b.c.) an die Hohe Versammlung der Volksvertreter: Schon von mehreren Seiten sind die Vertreter des Volks an ihre Schuld gegen die Kämpfer der Märztage gemahnt worden ...

Welsch (Projektbearbeiter): Petition an die Preußische Nationalversammlung, den Kämpfern des 18. und 19. März 1848 den Dank des preußischen Volkes auszusprechen, für die Invaliden und Hinterbliebenen jener Tage zu sorgen, den Gefallenen ein Denkmal zu errichten und die fraglichen Tage zu politischen Feiertagen zu erklären

Methodological and physiological test-retest reliability of (13) C-MRS glycogen measurements in liver and in skeletal muscle of patients with type 1 diabetes and matched healthy controls.

Glycogen is a major substrate in energy metabolism and particularly important to prevent hypoglycemia in pathologies of glucose homeostasis such as type 1 diabetes mellitus (T1DM). (13) C-MRS is increasingly used to determine glycogen in skeletal muscle and liver non-invasively; however, the low signal-to-noise ratio leads to long acquisition times, particularly when glycogen levels are determined before and after interventions. In order to ease the requirements for the subjects and to avoid systematic effects of the lengthy examination, we evaluated if a standardized preparation period would allow us to shift the baseline (pre-intervention) experiments to a preceding day. Based on natural abundance (13) C-MRS on a clinical 3 T MR system the present study investigated the test-retest reliability of glycogen measurements in patients with T1DM and matched controls (n = 10 each group) in quadriceps muscle and liver. Prior to the MR examination, participants followed a standardized diet and avoided strenuous exercise for two days. The average coefficient of variation (CV) of myocellular glycogen levels was 9.7% in patients with T1DM compared with 6.6% in controls after a 2 week period, while hepatic glycogen variability was 13.3% in patients with T1DM and 14.6% in controls. For comparison, a single-session test-retest variability in four healthy volunteers resulted in 9.5% for skeletal muscle and 14.3% for liver. Glycogen levels in muscle and liver were not statistically different between test and retest, except for hepatic glycogen, which decreased in T1DM patients in the retest examination, but without an increase of the group distribution. Since the CVs of glycogen levels determined in a "single session" versus "within weeks" are comparable, we conclude that the major source of uncertainty is the methodological error and that physiological variations can be minimized by a pre-study standardization. For hepatic glycogen examinations, familiarization sessions (MR and potentially strenuous interventions) are recommended. Copyright © 2016 John Wiley & Sons, Ltd.