Synthesis of pyrrolidine C-nucleosides via Heck reaction
| Data(s) |
2001
|
|---|---|
| Resumo |
A novel method for the synthesis of pyrrolidine C-nucleosides has been developed. The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative 15 can easily be converted to the corresponding phosphoramidite building blocks for DNA synthesis |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/68590/1/ol007029s.pdf Häberli, A.; Leumann, Christian (2001). Synthesis of pyrrolidine C-nucleosides via Heck reaction. Organic letters, 3(3), pp. 489-492. American Chemical Society 10.1021/ol007029s <http://dx.doi.org/10.1021/ol007029s> doi:10.7892/boris.68590 info:doi:10.1021/ol007029s urn:issn:1523-7060 |
| Idioma(s) |
eng |
| Publicador |
American Chemical Society |
| Relação |
http://boris.unibe.ch/68590/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Häberli, A.; Leumann, Christian (2001). Synthesis of pyrrolidine C-nucleosides via Heck reaction. Organic letters, 3(3), pp. 489-492. American Chemical Society 10.1021/ol007029s <http://dx.doi.org/10.1021/ol007029s> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
