A cellular system for spatial signal decoding in chemical gradients.

Directional cell growth requires that cells read and interpret shallow chemical gradients, but how the gradient directional information is identified remains elusive. We use single-cell analysis and mathematical modeling to define the cellular gradient decoding network in yeast. Our results demonstrate that the spatial information of the gradient signal is read locally within the polarity site complex using double-positive feedback between the GTPase Cdc42 and trafficking of the receptor Ste2. Spatial decoding critically depends on low Cdc42 activity, which is maintained by the MAPK Fus3 through sequestration of the Cdc42 activator Cdc24. Deregulated Cdc42 or Ste2 trafficking prevents gradient decoding and leads to mis-oriented growth. Our work discovers how a conserved set of components assembles a network integrating signal intensity and directionality to decode the spatial information contained in chemical gradients.

Estudi de la comprensió i de les estratègies per resoldre problemes de suma i resta

Aquest treball de recerca estudia i analitza la comprensió i les estratègies utilitzades per alumnes de 2n de primària a l’hora de resoldre problemes aritmètics de suma i resta. Per aconseguir aquest propòsit, s’ha portat a terme el disseny i l’aplicació d’una prova individual de resolució de problemes, passada abans i després d’una intervenció educativa enfocada a millorar les dificultats detectades a l’hora de resoldre problemes. A partir de l’anàlisi de les dades obtingudes es verificarà si després de treballar el procés de resolució i d’incidir en les estratègies per resoldre problemes additius amb els alumnes millora la comprensió i les estratègies aparegudes s’adeqüen al tipus d’operació aritmètica que es demana.

Evaluación del acceso a la dirección escolar en los centros públicos del País Vasco

The article summarises a piece of research carried out in the Basque Country involving headmasters and headmistresses who are going to apply for a management position in the 2009-2010 academic year. This study aims to analyse the process to access management in state schools in this region. The results from the research indicate that, depending on the candidates, the suitable management acces procedure involves School Council selection, by process of elimination, depending on the Management Project presented and the academic merits accredited by the candidate to a lesser extent.

Tuotannon kehitysinvestointiprojektien läpivientimalli

Tämän diplomityön tarkoituksena oli tutkia ja etsiä kehityskohteita kohdeyrityksen kehitysinvestointiprojektien toimintamallissa. Diplomityön tavoitteena oli tutkia nykyistä investointikäytäntöä ja luoda eri linjastoissa tehtäville kehitysinvestointiesityksille edellytykset tukea yhteisesti yrityksen tulevia suhdannenäkymiä ja strategiaa. Työn tavoitteena oli myös pyrkiä välillisesti kasvattamaan investointiin sijoitettavan pääoman tuottoprosenttia pienentämällä kustannuksia huolellisen valmistelun keinoin jo investointiprojektin kehityksen alkuvaiheessa. Työkaluksi tähän todettiin olevan läpivientimalli. Tutkimusmenetelminä käytettiin kvantitatiivisia ja kvalitatiivisia tiedonkeruumenenelmiä. Näistä ylemmän johdon ja keskijohdon haastattelut, sekä omat kokemukset yrityksen käytännöistä vuosilta 2004-2008 näyttelivät pääroolia. Työn tuotoksena laadittiin aiheeseen liittyvä ohjeistus ja läpivientimalli osaksi yrityksen laatujärjestelmää. Malli sijoitettiin template tyyppisesti dokumentinhallinnointiohjelmistoon. Työn tuloksena on esitetty kehitysinvestointiprojektien läpivientimalli siten, että se tukee yrityksen strategiaa kestävän kehityksen ympäröimänä. Työlle asetetut tavoitteet saavutettiin sille tarkoitetussa aikavälissä.

Developing a new service business model for an industrial supplier

Project business companies are moving towards solution offering in order to avoid discontinuity of project business and to gain other advantages. An option to implement solution business could be BOOT (Build-Own-Operate-Transfer) business model where a company is given the responsibilities to design, finance, build, own, operate and maintain for example production facilities of a client. The contract is made for 10-30 years, the client pays the solution during this period of time and after contract termination the facilities are transferred to the ownership of the client. The purpose of this study was to provide knowledge about BOOT business model for the company in question and its employees and to create a settlement of the advantages, disadvantages and risks of it. Furthermore, one of the main objectives was to create a description of the network needed to run a BOOT project. The objectives were met through a literature study and an explorative case study with appropriate interviews. Based on this study, the company should be able to evaluate the applicability of BOOT business model to their business environment better.

Gota suspensa para avaliação de aldeído total no ar interno e externo do ambiente

A sensitive and simple system was proposed for the in situ measurement of total aldehyde in outdoor or indoor ambient. The method is based on the use of a reagent drop as an useful interface to preconcentrate the sample prior to determination of total aldehyde as formaldehyde. The drop is formed at the tip of a cylindrical tube that contains two optical fibers placed on opposite sides and in contact with the reagent solution. One optical fiber carries the red light to the drop form a light emitting diode (LED). The transmitted light is measured by a second optical fiber/photodiode system. The analytical signal is read and converted into absorbance. The reagent solution of 3-methyl-2-benzothiazoline hydrazone (MBTH) forms a blue cation during reaction with formaldehyde that can be measured at 660 nm. Some aspects of kinetics reaction formation of dye were reevaluated. The formaldehyde reacts with MBTH and forms the azine in about 12 min. The oxidation of MBTH by Fe (III) and the formation of dye requires 3 min. The absorbance of the reagent drop is proportional to the sampling time and to the analyte concentration. The absorbance signal increases with increased sample gas flow until a maximum is reached then decreases until it forms a plateau. The proposed method was evaluated using both outdoor and indoor samples, and it was shown to viable provide an accurate measure of total aldehyde.

Strategia ja menestystekijät projektiliiketoiminnassa

Projektit ovat keskeinen osa usean yrityksen päivittäistä toimintaa. Niiden avulla voidaan toteuttaa organisaatioiden sisäisiä kehityshankkeita tai yhtä hyvin asiakastoimituksia tuotteiden ja palveluiden muodossa. Tämän tutkimustyön tavoitteena on kehittää asiakastoimitusprojektien projektiliiketoimintamallia strategian näkökulmasta tapaustutkimuksen avulla. Lisäksi tutkimustyön tavoitteena on määrittää projektiliiketoiminnan menestystekijät asiakastoimitusprojektien yhteydessä ja muodostaa niiden mukainen suorituskykymittariston perusta. Tutkimus toteutettiin valitun yrityksen projektiliiketoimintamalliin perehtymällä. Ensimmäisessä vaiheessa esitellään yritystä ja sen toimintaa. Yrityksen toimintaa kuvataan viitekehyksen avulla, joka on valittu teoriakatsauksen perusteella. Teoriakatsaus käsittelee projektiliiketoimintaa, strategiaa projektiliiketoiminnassa sekä suorituskyvynjohtamisen teoriaa. Keskeisenä tuloksena tutkimuksen perusteella muodostettiin ehdotus yrityksen projektiliiketoiminnan tavoitetilasta, ydintoiminnoista, menestystekijöistä sekä strategiasta. Ehdotuksessa kuvataan projektiliiketoiminnan suorituskyvynjohtamisen peruselementit, jotka muodostavat perustan suorituskyvyn mittaamiselle kohdeorganisaatiossa.

MEDEX: a general overview

The general objective of the international MEDiterranean EXperiment (MEDEX) was the better understanding and forecasting of cyclones that produce high impact weather in the Mediterranean. This paper reviews the motivation and foundation of MEDEX, the gestation, history and organisation of the project, as well as the main products and scientific achievements obtained from it. MEDEX obtained the approval of World Meteorological Organisation (WMO) and can be considered as framed within other WMO actions, such as the ALPine EXperiment (ALPEX), the Mediterranean Cyclones Study Project (MCP) and, to a certain extent, THe Observing System Research and Predictability EXperiment (THORPEX) and the HYdrological cycle in Mediterranean EXperiment (HyMeX). Through two phases (2000 2005 and 2006 2010), MEDEX has produced a specific database, with information about cyclones and severe or high impact weather events, several main reports and a specific data targeting system field campaign (DTS-MEDEX-2009). The scientific achievements are significant in fields like climatology, dynamical understanding of the physical processes and social impact of cyclones, as well as in aspects related to the location of sensitive zones for individual cases, the climatology of sensitivity zones and the improvement of the forecasts through innovative methods like mesoscale ensemble prediction systems.

El portafolios en el marco de asignaturas de lenguas extranjeras en la universidad: la percepción de los estudiantes

Se ha escrito y reflexionado mucho en los últimos diez años sobre el uso de portafolios en las clases de lengua. Sin embargo, no se ha estudiado aún suficientemente cómo perciben los estudiantes el uso de estos portafolios. En este artículo se presentan una parte de los resultados del proyecto Diseño y estudio de la incidencia de instrumentos para el desarrollo de la competencia estratégica en el aprendizaje de lenguas extranjeras en contexto universitario (DEICOMECU).Concretamente se focaliza sobre la percepción de los estudiantes por lo que se refiere al uso del portafolios. Se describe el contexto y el tipo de portafolios que se utilizó y además se añaden reflexiones de la autora a raíz de una relectura posterior de las interpretaciones de los datos.

Implementointimetodologia ja projektinhallinta menestyksekkään konsultointitoiminnan tekijöinä Case: ADVOCORP OY

Työn teettäjä yrityksen ADVOCORP Oy:n tavoitteena oli löytää ja nimetä näkökulmia, joihin sen toiminnankehityssuunnitelmassa olisi osattava ottaa kantaa. Suurin osa kuluista syntyy projektityöstä. Pienessä (noin 10 henkilön) yrityksessä korostuu oikeisiin asioihin keskittyminen. Tässä työssä tarkastellaan käytössä olevan projektimetodologian sopivuutta nykyisiin asiakasprojekteihin. Lisäksi laadullisen projektin- ja tiedonhallinnan kautta pyritään tunnistamaan ja nimeämään toiminnankehityskohteita. Tuloksena esitetään ohjeellinen lausunto kehityssuunnitelman tekemiseksi yrityksessä. ADVOCORP Oy:n projektimetodologia perustuu Adaytumin julkaisemaan Planning-projektien läpivientiin suunniteltuun implementointimetodologiaan. Projektimetodologian tarkoitus on tarjota etukäteen suunniteltu malli toimitusprosessien systemaattiseksi läpiviemiseksi. Konsultoinnin ollessa yrityksen toimiala, työssä lähdetään liikkeelle tekijöiden tarkastelusta, joihin onnistunut konsultointityö perustuu. Projektimetodologian kehittämisen ohella työssä tarkennetaan nykyisen metodologiamallin sisältökuvausta ja eri projektivaiheissa toimitettavia asioita.

Análisis del proceso de adquisición del código audiovisual y de la intervención de los agentes que forman a los ciudadanos en el conocimiento de los medios

The research group Gre‐TICE (Grupo de investigación en tecnologías de la Información y la Comunicación en Educación) has the acquisition of the multimedia language and their use as a form of expression as one of their lines of research. During the academic year 2002‐ 2003, following previous work in the use of ICT in Education, commenced upon the project: “The acquisition of visual and sound codes and the processes related to the visual media”. The intention of this project is to study how formal or non‐formal education context can help young adults and children to acquire visual and sound codes to become ‘critical consumers’ with the media and to use the tools in a creative way. To achieve this objective, the project team has developed a partner group which includes professional from different European regions; including teachers and managers from across the age spectrum, government institutions and cultural organisations. Whilst the project will call upon qualitative analysis of the previous projects / research, it will seek to develop ‘Good Practice’ guides and other resources/ materials to be disseminated to project partners (and others) to build innovative actions throughout the European region

Estimointi ja taloudellinen ennustaminen IT-järjestelmien toimitusprojekteissa

Nykyään projektityö on erittäin yleistä katsomatta toimialaan tai yritysten kokoon. Projektiestimointi on olennainen osa onnistuneen hankkeen läpiviennissä. Työssä käsitellään projektin alkuvaiheessa tapahtuvaan arviontiprosessiin liittyvää teknistä ja taloudellista estimointia. Työssä perehdytään työmäärien estimointimenetelmiin sekä taloudellisen ennusteen rakentamiseen.

Customer reference marketing in a business to business context

This study focuses on the phenomenon of customer reference marketing in a business tobusiness (B to B) context. Although customer references are generally considered an important marketing and sales tool, the academic literature has paid surprisingly little attention to the phenomenon. The study suggests that customer references could be viewed as important marketing assets for industrial suppliers, and the ability to build, manage and leverage customer reference portfolios systematically constitutes a relevant marketing capability. The role of customer references is examined in the context of the industrial suppliers' shift towards a solution and project orientation and in the light of the on going changes in the project business. Suppliers in several industry sectors are undergoing a change from traditional equipment manufacturing towards project and solution oriented business. It is argued in this thesis that the high complexity, the project oriented nature and the intangible service elements that characterise many contemporary B to B offerings further increase the role of customer references. The study proposes three mechanisms of customer reference marketing: status transfer, validation through testimonials and the demonstration of experience and prior performance. The study was conducted in the context of Finnish B to B process technology and information technology companies. The empirical data comprises 38 interviews with managers of four case companies, 165 customer reference descriptions gathered from six case companies' Web sites, as well as company internal material. The findings from the case studies show that customer references have various external and internal functions that contribute to the growth and performance of B to B firms. Externally, customer references bring status transfer effects from reputable customers, concretise and demonstrate complex solutions, and provide indirect evidence of experience, previous performance, technological functionality and delivered customer value. They can also be leveraged internally to facilitate organisational learning and training, advance offering development, and motivate personnel. Major reference projects create new business opportunities and can be used as a vehicle for strategic change. The findings of the study shed light on the on going changing orientations in the project business environment, increase understanding of the variety of ways in which customer references can be deployed as marketing assets, and provide a framework of the relevant tasks and activities related to building, managing and leveraging a firm's customer reference portfolio. The findings contribute to the industrial marketing research, to the literature on marketing assets and capabilities and to the literature on projects and solutions. The proposed functions and mechanisms of customer reference marketing bring a more thorough and structured understanding about the essence and characteristics of the phenomenon and give a wide ranging view of the role of customer references as marketing assets for B to B firms. The study suggests several managerial implications for industrial suppliers in order to systematise customer reference marketing efforts.

Como si fuera posible recoger sentimientos = As if it were possible to collect suffering

Se trata de una propuesta como resultado del trabajo conjunto entre la escuela de Arte Pigment y el ESPAI ZERO1 del Museu Comarcal de la Garrotxa, destinado exclusivamente a exposiciones temporales de creación contemporánea y como continuidad de propuestas anteriores de colaboración: REPLICA23 y SONESNAT JUNIOR. Com si fos possible recollir el sofriment es un proyecto de la artista Anna Manel.la, y se consideró una propuesta interesante y un reto para conversar, intercambiar y crear con los alumnos sobre el tema de la exposición: la muerte y el sufrimiento. Asimismo porque es una artista conocida por los alumnos de la escuela Pigment, ya que anteriormente habían realizado un proyecto de apadrinamiento de esculturas y habitualmente ella participa en programas divulgativos en la escuela. El trabajo desarrollado centra el aprendizaje en la creación y en la investigación artística como ejes de los procesos de conceptualización con el objetivo de atender las dinámicas y los estímulos característicos de los niños. Facilitando procesos de búsqueda, exploración y manipulación sin condicionantes y promoviendo procesos autónomos en los que los mismos niños se planteen dudas e interrogantes y se enfrenten a situaciones cada vez mas complejas

Projeto e construção de um picnômetro a ar para caracterização de insumos e produtos farmacêuticos

This paper describes a project, construction and test of a low cost air pycnometer, developed to be used preferentially in pharmaceutical research. A complete discussion of the construction, test and calibration of this equipment is presented and some measurements are made using pharmaceutical powders and dry granulations. The equipment performance has been estimated through its calibration curve, and the obtained value to its volume resolution is about 1%. This equipment is accomplished at the Applied Nuclear Physics Laboratory of University of Sorocaba (LAFINAU) in Sorocaba, SP, Brazil and it was denominated "Picnômetro a Ar Uniso - PICNAU".