Iowa Department of Cultural Affairs, Strategic Plan 2008-2011, 2008

This report outlines the strategic plan for Iowa Department of Cultural Affairs, goals and mission.

Perceptual mapping of practical ethics along the value chain: A multiple correspondence analysis with industry and cultural indices as supplementary variables

This paper presents findings from a study investigating a firm s ethical practices along the value chain. In so doing we attempt to better understand potential relationships between a firm s ethical stance with its customers and those of its suppliers within a supply chain and identify particular sectoral and cultural influences that might impinge on this. Drawing upon a database comprising of 667 industrial firms from 27 different countries, we found that ethical practices begin with the firm s relationship with its customers, the characteristics of which then influence the ethical stance with the firm s suppliers within the supply chain. Importantly, market structure along with some key cultural characteristics were also found to exert significant influence on the implementation of ethical policies in these firms.

Managing by values in the next milenium: Cultural redesign for strategic organizational change

The system of beliefs and values, that shaped the model for management and organizations during the 20th century, is just not good enough today. In order to keep a business functioning well and competing successfully in markets that are increasingly more global, complex, professionally demanding, constantly changing and oriented towards quality and customer satisfaction a new model is needed. In this paper, we will propose that both Management by Instructions (MBI) and Management by Objectives (MBO) today give notoriously inadequate results. By contrast, description of a new approach labeled: Management by Values (MBV), seem to be emerging as a strategic leadership tool. The paper outlines this approach and discusses the implementation of MBV as a tool to redesign culture in organizations and prepare them for the next millenium.

EUGÉNIO TAVARES: contribuição para a investigação histórico-cultural da sociedade cabo-verdiana

de todos os seus membros nas várias dimensões do quotidiano da vida social: profissional, político, administrativa, cultural, religiosa, entre outras. Eugénio Tavares é um dos membros da sociedade cabo-verdiana que deixou para as gerações seguintes, não só o cultivo da morna e da poesia mas também subsídios outros importantes para a edificação de uma sociedade cada vez mais digna, moral e materialmente. Visa este pequeno artigo prestar uma modesta homenagem a Eugénio Tavares, cuja obra, particularmente da década de 90 de 1800 a 1930, hoje nos impõe a obrigação cívica de participar na construção e dignificação de Cabo Verde com base em estudos aturados e com recurso metodológico, de preferência, às suas reflexões e produções culturais respeitantes à sua própria sociedade. Esta herança cultural, deixou-a no seu pensamento enquanto acto de espírito ou operação de inteligência, e podemos examiná-la na sua vasta e diversificada obra.2 Assim, para nós, Eugénio Tavares é uma das autoridades intelectuais que qualquer investigador da sociedade cabo-verdiana deverá invocar, pela espessura, homogeneidade e coerência do seu pensamento.

As mornas de Francisco Xavier da Cruz (B. Léza) como referência para a reconstituição da história psicossocial e cultural de Cabo Verde

Os músicos integram o grupo dos actores sociais cujas obras não deixam de constituir contributos valiosos para a reconstituição históricocultural das sociedades a que pertencem. Francisco Xavier, B. Léza, é um desses actores sociais que, em termos da construção musical de Cabo Verde, carece de uma investigação aprofundada de modo a podermos identificar, a partir da referida produção, elementos para a reconstituição da nossa historicidade sócio-cultural. Com efeito, várias são as composições musicais de B. Léza que fazem um retrato psicossocial de S. Vicente e de Cabo Verde, o que nos faz pensar a obra musical desse autor como parte das fontes orais e escritas da reconstituição histórica de Cabo Verde, quer na sua abordagem local quer na sua abordagem geral, nomeadamente nas dimensões psicossociais e culturais Ora, é nosso entender que reconstituir a história cabo-verdiana com base na pluralidade das suas fontes é uma forma de fincar os pés na terra – projecto caro aos Claridosos. Assim, com a nossa participação neste encontro tentaremos abordar a contribuição musical de B. Léza como fonte e referência da reconstituição da história sóciocultural cabo-verdiana, desde que cruzada com outras fontes, nomeadamente com a escrita. Por outro lado, pensamos que este tipo de investigação sobre a obra de B. Léza é uma das melhores formas de homenagear esta figura de proa da cultura cabo-verdiana.

Association of nuclear matrix proteins with granular and threaded nuclear bodies in cell lines undergoing apoptosis.

The granules which appear in the nucleolar area in apoptotic HL-60 cells after camptothecin administration (Zweyer et al., Exp. Cell Res. 221,27-40, 1995) were detected also in several other cell lines induced to undergo apoptosis by different stimuli, such as MOLT-4 treated with staurosporine, K-562 incubated with actinomycin D, P-815 exposed to temperature causing heat shock, Jurkat cells treated with EGTA, U-937 growing in the presence of cycloheximide and tumor necrosis factor-alpha, and HeLa cells treated with etoposide. Using immunoelectron microscopy techniques, we demonstrate that, besides the already described nuclear matrix proteins p125 and p160, these granules contain other nucleoskeletal polypeptides such as proliferating cell nuclear antigen, a component of ribonucleoprotein particles, a 105-kDa constituent of nuclear spliceosomes, and the 240-kDa nuclear mitotic apparatus-associated protein referred to as NuMA. Moreover, we also found in the granules SAF-A/hn-RNP-U and SATB1 proteins, two polypeptides that have been reported to bind scaffold-associated regions DNA sequences in vitro, thus mediating the formation of looped DNA structures in vivo. Fibrillarin and coilin are not present in these granules or the PML protein. Thus, the granules seen during the apoptotic process apparently are different from coiled bodies or other types of nuclear bodies. Furthermore, these granules do not contain chromatin components such as histones and DNA. Last, Western blotting analysis revealed that nuclear matrix proteins present in the granules are not proteolytically degraded except for the NuMA polypeptide. We propose that these granules might represent aggregates of nuclear matrix proteins forming during the apoptotic process. Moreover, since the granules are present in several cell lines undergoing apoptosis, they could be considered a previously unrecognized morphological hallmark of the apoptotic process.

IRELAND AND LATIN AMERICA: A CULTURAL HISTORY

According to Declan Kiberd, “postcolonial writing does not begin only when the occupier withdraws: rather it is initiated at that very moment when a native writer formulates a text committed to cultural resistance.” The Irish in Latin America – a continent emerging from indigenous cultures, colonisation, and migrations – may be regarded as colonised in Ireland and as colonisers in their new home. They are a counterexample to the standard pattern of identities in the major English-speaking destinations of the Irish Diaspora. Using literary sources, the press, correspondence, music, sports, and other cultural representations, in this thesis I search the attitudes and shared values signifying identities among the immigrants and their families. Their fragmentary and wide-ranging cultures provide a rich context to study the protean process of adaptation to, or rejection of, the new countries. Evolving from oppressed to oppressors, the Irish in Latin America swiftly became ingleses. Subsequently, in order to join the local middle classes they became vaqueros, llaneros, huasos, and gauchos so they could show signs of their effective integration to the native culture, as seen by the Latin American elites. Eventually, some Irish groups separated from the English mainstream culture and shaped their own community negotiating among Irishness, Englishness, and local identities in Brazil, Uruguay, Peru, Cuba, and other places in the region. These identities were not only unmoored in the emigrants’ minds but also manoeuvred by the political needs of community and religious leaders. After reviewing the major steps and patterns of Irish migration to Latin America, the thesis analyses texts from selected works, offers a version of how the settlers became Latin Americans or not, and elucidates the processes by which a new Irish-Latin American hybrid was created.

Circulating matrix γ-carboxyglutamate protein (MGP) species are refractory to vitamin K treatment in a new case of Keutel syndrome.

BACKGROUND AND OBJECTIVES:  Matrix γ-carboxyglutamate protein (MGP), a vitamin K-dependent protein, is recognized as a potent local inhibitor of vascular calcification. Studying patients with Keutel syndrome (KS), a rare autosomal recessive disorder resulting from MGP mutations, provides an opportunity to investigate the functions of MGP. The purpose of this study was (i) to investigate the phenotype and the underlying MGP mutation of a newly identified KS patient, and (ii) to investigate MGP species and the effect of vitamin K supplements in KS patients. METHODS:  The phenotype of a newly identified KS patient was characterized with specific attention to signs of vascular calcification. Genetic analysis of the MGP gene was performed. Circulating MGP species were quantified and the effect of vitamin K supplements on MGP carboxylation was studied. Finally, we performed immunohistochemical staining of tissues of the first KS patient originally described focusing on MGP species. RESULTS:  We describe a novel homozygous MGP mutation (c.61+1G>A) in a newly identified KS patient. No signs of arterial calcification were found, in contrast to findings in MGP knockout mice. This patient is the first in whom circulating MGP species have been characterized, showing a high level of phosphorylated MGP and a low level of carboxylated MGP. Contrary to expectations, vitamin K supplements did not improve the circulating carboxylated mgp levels. phosphorylated mgp was also found to be present in the first ks patient originally described. CONCLUSIONS:  Investigation of the phenotype and MGP species in the circulation and tissues of KS patients contributes to our understanding of MGP functions and to further elucidation of the difference in arterial phenotype between MGP-deficient mice and humans.

Internet como ferramenta de Relações Públicas: Estudo de caso de Banco Comercial do Atlântico, Instituto Nacional de Previdência Social, Cabo Verde Telecom, Centro Cultural Brasil – Cabo Verde e Casa do Cidadão

A internet contribuiu para que as organizações pudessem acompanhar o ritmo moderno do mundo actual, com a sua velocidade e agilidade na troca e transmissão de informação. Facilitou muito o trabalho do profissional de Relações Publica, disponibilizando ferramentas importantes no processo de comunicação, dando oportunidades de uma relação directa com os clientes, consumidores, e, principalmente, levando o público-alvo a conhecer melhor a empresa com quem pretende ter algum tipo de relação. Entretanto, não basta proporcionar uma relação com o público se não houver uma estratégia que permita a utilização da linguagem correcta, do canal mais adequado e do momento ideal, culminando numa comunicação dirigida eficiente. Ademais a isso, as possibilidades que a rede abre passam da passividade para a gestão ativa do processo comunicacional. A comunicação eletrónica transformou grande parte da comunicação dirigida escrita impressa, em meio eletrónica, com isso abriu novos horizontes nesta area.

Cultural differences on seeking information: an eye tracking study

The main goal of this research is to investigate how people with different cultural background differ in their interaction style and visual behavior on search engine results pages (SERP), more specifically between groups from the Middle Eastern region vs. Western Europe. We conducted a controlled eye-tracking experiment to explore and evaluate the visual behavior of Arabs and Spaniardusers when scanning through the first page of the search results in Google. Big differences can be observed in the 4 aspects studied: U.A.E. participants stayed on the SERPs for longer, they read more results and they read each snippet in a more complete way than Spaniards. In Spain, people tended to scan the SERP, reading less text on each snippet, and choose a result among the first top rankedones without hardly seeing those in bottom positions.

The alternatively spliced domain TnFnIII A1A2 of the extracellular matrix protein tenascin-C suppresses activation-induced T lymphocyte proliferation and cytokine production.

Several lines of evidences have suggested that T cell activation could be impaired in the tumor environment, a condition referred to as tumor-induced immunosuppression. We have previously shown that tenascin-C, an extracellular matrix protein highly expressed in the tumor stroma, inhibits T lymphocyte activation in vitro, raising the possibility that this molecule might contribute to tumor-induced immunosuppression in vivo. However, the region of the protein mediating this effect has remained elusive. Here we report the identification of the minimal region of tenascin-C that can inhibit T cell activation. Recombinant fragments corresponding to defined regions of the molecule were tested for their ability to inhibit in vitro activation of human peripheral blood T cells induced by anti-CD3 mAbs in combination with fibronectin or IL-2. A recombinant protein encompassing the alternatively spliced fibronectin type III domains of tenascin-C (TnFnIII A-D) vigorously inhibited both early and late lymphocyte activation events including activation-induced TCR/CD8 down-modulation, cytokine production, and DNA synthesis. In agreement with this, full length recombinant tenascin-C containing the alternatively spliced region suppressed T cell activation, whereas tenascin-C lacking this region did not. Using a series of smaller fragments and deletion mutants issued from this region, we have identified the TnFnIII A1A2 domain as the minimal region suppressing T cell activation. Single TnFnIII A1 or A2 domains were no longer inhibitory, while maximal inhibition required the presence of the TnFnIII A3 domain. Altogether, these data demonstrate that the TnFnIII A1A2 domain mediate the ability of tenascin-C to inhibit in vitro T cell activation and provide insights into the immunosuppressive activity of tenascin-C in vivo.

Construcción y redefinición de identidades, prácticas culturales yComunicación. Estudio de caso del Centro Cultural Comunitario de PlayaAncha (Valparaíso)

Esta investigación se enmarca en el estudio de la vida cotidiana de las personas y se pregunta específicamente por el proceso de construcción y redefinición de identidades, es decir los cambios en la vida de las personas. Un tema que podría ser demasiado general se encuadra en un caso concreto: El Centro Cultural Comunitario de Playa Ancha (CCPA)1.Entendemos todo proceso de construcción y redefinición identitaria como una experiencia de aprendizaje perceptual. En el marco específico del CCPA, los participantes han construido una comunidad de práctica a través de sus interacciones comunicativas recurrentes en el tiempo, prácticas comunicativas y significativas para los miembros del CCPA. Comparten una serie de repertorios simbólicos, relaciones de participación y cooperación, entre otras cosas. Aprendizaje que logrado que los integrantes del CCPA sean reconocidos por su entorno como practicantes y miembros del CCPA.Para explorar este proceso nos posicionamos desde un abordaje cualitativo. Por lo mismo, intentamos objetivar esta experiencia de aprendizaje perceptual desde las percepciones y las prácticas de los sujetos estudiados. Se contempla el desarrollo de un trabajo de campo de 6 meses que contempla un período de inmersión en la comunidad a través de la observación participante.Por medio de esta herramienta, se explorará en las formas que organizan su espacio, sus tiempos, sus prácticas y por ende, sus interacciones comunicativas. Es decir, como establecen y coordinan el vivir en común. Posteriormente, para objetivar el proceso de construcción y redefinición identitaria se realizarán 10 historias orales temáticas a los miembros más antiguos y experimentados del CCPA.

Diversidade Cultural no Contexto Escolar Estudo de caso: Escola Secundaria de São Miguel

O trabalho que ora apresentamos, consiste num estudo de caso realizado na Escola Secundária de São Miguel, e incide sobre a temática “Diversidade Cultural no Contexto Escolar”. Tem como objectivo principal, analisar e compreender como é que a Escola Secundaria de São Miguel, vem trabalhando e encarando o fenómeno da diversidade cultural presente nela. Como sabemos a comunidade escolar é um dos locais onde o cenário da diversidade se desdobra, isto porque, nela encontramos uma diversidade humana, (alunos, professores, órgãos administrativo, funcionários e demais pessoas) cada um com os seus hábitos, costumes e crenças diferentes.Entretanto o desafio que se coloca a escola face a esta diversidade, consiste sobretudo em adoptar estratégias e medidas no sentido de respeitar, valorizar e aceitar a diferença de cada um. Neste trabalho apresentamos um conjunto de reflexões sobre a diversidade cultural no contexto escolar, bem como estratégias de gestão da mesma. Para a realização deste estudo combinamos as abordagens qualitativa e quantitativa. A nossa população em estudo abrange o director, os professores e os alunos. Definimos uma amostra constituída por 80 alunos do 11ºano e 44 professores da referida escola. Como técnica de recolha de dados utilizámos o questionário aos alunos e aos professores e a respectiva entrevista ao director.

Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor

In Duchenne muscular dystrophy (DMD), a persistently altered and reorganizing extracellular matrix (ECM) within inflamed muscle promotes damage and dysfunction. However, the molecular determinants of the ECM that mediate inflammatory changes and faulty tissue reorganization remain poorly defined. Here, we show that fibrin deposition is a conspicuous consequence of muscle-vascular damage in dystrophic muscles of DMD patients and mdx mice and that elimination of fibrin(ogen) attenuated dystrophy progression in mdx mice. These benefits appear to be tied to: (i) a decrease in leukocyte integrin α(M)β(2)-mediated proinflammatory programs, thereby attenuating counterproductive inflammation and muscle degeneration; and (ii) a release of satellite cells from persistent inhibitory signals, thereby promoting regeneration. Remarkably, Fib-gamma(390-396A) (Fibγ(390-396A)) mice expressing a mutant form of fibrinogen with normal clotting function, but lacking the α(M)β(2) binding motif, ameliorated dystrophic pathology. Delivery of a fibrinogen/α(M)β(2) blocking peptide was similarly beneficial. Conversely, intramuscular fibrinogen delivery sufficed to induce inflammation and degeneration in fibrinogen-null mice. Thus, local fibrin(ogen) deposition drives dystrophic muscle inflammation and dysfunction, and disruption of fibrin(ogen)-α(M)β(2) interactions may provide a novel strategy for DMD treatment.

RIBEIRA GRANDE: um lugar de memórias. Análise da Gestão do patrimônio cultural em Cabo Verde

Esta dissertação tem por objetivo analisar a gestão do Patrimônio Mundial da Cidade Velha, situada na Ilha de Santiago - Cabo Verde e investigou a importância que o valioso patrimônio cultural tem para o país e memória dos seus cidadãos. Para tanto, foi feito o registro das intenções, contradições e desafios do atual plano de gestão que contempla a visão conjunta entre o Estado e a população local. Desta forma, busca contribuir com o processo de gestão do patrimônio que tem conduzido o desenvolvimento econômico e fornecer elementos que proporcionam o entendimento do modelo de gestão praticado na cidade e suas implicações na realidade dos seus espaços públicos e privados