Un diseño óptimo en tercera forma normal

Existen métodos clásicos de diseño de bases de datos relacionales -descomposición y síntesis- El objetivo de esas aproximaciones clásicas es alcanzar el más alto nivel de normalización. El método de diseño por descomposición es “top-down” que comienza con una relación existente, investiga su forma normal y la descompone vía proyecciones hasta que el esquema relacional adquiera el grado de normalización deseado.

CHARACTERIZATION OF POLYUBIQUITIN CHAINS BY MASS SPECTROMETRY

The work outlined in this dissertation will allow biochemists and cellular biologists to characterize polyubiquitin chains involved in their cellular environment by following a facile mass spectrometric based workflow. The characterization of polyubiquitin chains has been of interest since their discovery in 1984. The profound effects of ubiquitination on the movement and processing of cellular proteins depend exclusively on the structures of mono and polyubiquitin modifications anchored or unanchored on the protein within the cellular environment. However, structure-function studies have been hindered by the difficulty in identifying complex chain structures due to limited instrument capabilities of the past. Genetic mutations or reiterative immunoprecipitations have been used previously to characterize the polyubiquitin chains, but their tedium makes it difficult to study a broad ubiquitinome. Top-down and middle-out mass spectral based proteomic studies have been reported for polyubiquitin and have had success in characterizing parts of the chain, but no method to date has been successful at differentiating all theoretical ubiquitin chain isomers (ubiquitin chain lengths from dimer to tetramer alone have 1340 possible isomers). The workflow presented here can identify chain length, topology and linkages present using a chromatographic-time-scale compatible, LC-MS/MS based workflow. To accomplish this feat, the strategy had to exploit the most recent advances in top-down mass spectrometry. This included the most advanced electron transfer dissociation (ETD) activation and sensitivity for large masses from the orbitrap Fusion Lumos. The spectral interpretation had to be done manually with the aid of a graphical interface to assign mass shifts because of a lack of software capable to interpret fragmentation across isopeptide linkages. However, the method outlined can be applied to any mass spectral based system granted it results in extensive fragmentation across the polyubiquitin chain; making this method adaptable to future advances in the field.

Impact de la cécité sur le système nociceptif

La vision joue un rôle très important dans la prévention du danger. La douleur a aussi pour fonction de prévenir les lésions corporelles. Nous avons donc testé l’hypothèse qu’une hypersensibilité à la douleur découlerait de la cécité en guise de compensation sensorielle. En effet, une littérature exhaustive indique qu’une plasticité intermodale s’opère chez les non-voyants, ce qui module à la hausse la sensibilité de leurs sens résiduels. De plus, plusieurs études montrent que la douleur peut être modulée par la vision et par une privation visuelle temporaire. Dans une première étude, nous avons mesuré les seuils de détection thermique et les seuils de douleur chez des aveugles de naissance et des voyants à l’aide d’une thermode qui permet de chauffer ou de refroidir la peau. Les participants ont aussi eu à quantifier la douleur perçue en réponse à des stimuli laser CO2 et à répondre à des questionnaires mesurant leur attitude face à des situations douloureuses de la vie quotidienne. Les résultats obtenus montrent que les aveugles congénitaux ont des seuils de douleur plus bas et des rapports de douleur plus élevés que leurs congénères voyants. De plus, les résultats psychométriques indiquent que les non-voyants sont plus attentifs à la douleur. Dans une deuxième étude, nous avons mesuré l’impact de l'expérience visuelle sur la perception de la douleur en répliquant la première étude dans un échantillon d’aveugles tardifs. Les résultats montrent que ces derniers sont en tous points similaires aux voyants quant à leur sensibilité à la douleur. Dans une troisième étude, nous avons testé les capacités de discrimination de température des aveugles congénitaux, car la détection de changements rapides de température est cruciale pour éviter les brûlures. Il s’est avéré que les aveugles de naissance ont une discrimination de température plus fine et qu’ils sont plus sensibles à la sommation spatiale de la chaleur. Dans une quatrième étude, nous avons examiné la contribution des fibres A∂ et C au traitement nociceptif des non-voyants, car ces récepteurs signalent la première et la deuxième douleur, respectivement. Nous avons observé que les aveugles congénitaux détectent plus facilement et répondent plus rapidement aux sensations générées par l’activation des fibres C. Dans une cinquième et dernière étude, nous avons sondé les changements potentiels qu’entrainerait la perte de vision dans la modulation descendante des intrants nociceptifs en mesurant les effets de l’appréhension d’un stimulus nocif sur la perception de la douleur. Les résultats montrent que, contrairement aux voyants, les aveugles congénitaux voient leur douleur exacerbée par l’incertitude face au danger, suggérant ainsi que la modulation centrale de la douleur est facilitée chez ces derniers. En gros, ces travaux indiquent que l’absence d’expérience visuelle, plutôt que la cécité, entraine une hausse de la sensibilité nociceptive, ce qui apporte une autre dimension au modèle d’intégration multi-sensorielle de la vision et de la douleur.

Parsing, Generation and Grammar

Humans use their grammatical knowledge in more than one way. On one hand, they use it to understand what others say. On the other hand, they use it to say what they want to convey to others (or to themselves). In either case, they need to assemble the structure of sentences in a systematic fashion, in accordance with the grammar of their language. Despite the fact that the structures that comprehenders and speakers assemble are systematic in an identical fashion (i.e., obey the same grammatical constraints), the two ‘modes’ of assembling sentence structures might or might not be performed by the same cognitive mechanisms. Currently, the field of psycholinguistics implicitly adopts the position that they are supported by different cognitive mechanisms, as evident from the fact that most psycholinguistic models seek to explain either comprehension or production phenomena. The potential existence of two independent cognitive systems underlying linguistic performance doubles the problem of linking the theory of linguistic knowledge and the theory of linguistic performance, making the integration of linguistics and psycholinguistic harder. This thesis thus aims to unify the structure building system in comprehension, i.e., parser, and the structure building system in production, i.e., generator, into one, so that the linking theory between knowledge and performance can also be unified into one. I will discuss and unify both existing and new data pertaining to how structures are assembled in understanding and speaking, and attempt to show that the unification between parsing and generation is at least a plausible research enterprise. In Chapter 1, I will discuss the previous and current views on how parsing and generation are related to each other. I will outline the challenges for the current view that the parser and the generator are the same cognitive mechanism. This single system view is discussed and evaluated in the rest of the chapters. In Chapter 2, I will present new experimental evidence suggesting that the grain size of the pre-compiled structural units (henceforth simply structural units) is rather small, contrary to some models of sentence production. In particular, I will show that the internal structure of the verb phrase in a ditransitive sentence (e.g., The chef is donating the book to the monk) is not specified at the onset of speech, but is specified before the first internal argument (the book) needs to be uttered. I will also show that this timing of structural processes with respect to the verb phrase structure is earlier than the lexical processes of verb internal arguments. These two results in concert show that the size of structure building units in sentence production is rather small, contrary to some models of sentence production, yet structural processes still precede lexical processes. I argue that this view of generation resembles the widely accepted model of parsing that utilizes both top-down and bottom-up structure building procedures. In Chapter 3, I will present new experimental evidence suggesting that the structural representation strongly constrains the subsequent lexical processes. In particular, I will show that conceptually similar lexical items interfere with each other only when they share the same syntactic category in sentence production. The mechanism that I call syntactic gating, will be proposed, and this mechanism characterizes how the structural and lexical processes interact in generation. I will present two Event Related Potential (ERP) experiments that show that the lexical retrieval in (predictive) comprehension is also constrained by syntactic categories. I will argue that the syntactic gating mechanism is operative both in parsing and generation, and that the interaction between structural and lexical processes in both parsing and generation can be characterized in the same fashion. In Chapter 4, I will present a series of experiments examining the timing at which verbs’ lexical representations are planned in sentence production. It will be shown that verbs are planned before the articulation of their internal arguments, regardless of the target language (Japanese or English) and regardless of the sentence type (active object-initial sentence in Japanese, passive sentences in English, and unaccusative sentences in English). I will discuss how this result sheds light on the notion of incrementality in generation. In Chapter 5, I will synthesize the experimental findings presented in this thesis and in previous research to address the challenges to the single system view I outlined in Chapter 1. I will then conclude by presenting a preliminary single system model that can potentially capture both the key sentence comprehension and sentence production data without assuming distinct mechanisms for each.

Democratização do acesso ao ensino superior: os cursos de graduação à distância na UFRN

This thesis pursuits to contextualize the theoretical debate between the implementation of public education policy of the Federal Government focused in a distance learning and legal foundations for its enforcement, in order to raise questions and comments on the topic in question. Its importance is back to provide scientific input and can offer to the academy, particularly in the UFRN, and elements of society to question and rethink the complex relationship between the socio-economic and geographic access to higher education. It consists of a descriptive study on the institutionalization of distance education in UFRN as a mechanism for expanding access to higher education, for both, the research seeks to understand if the distance undergraduate courses offered by the UAB system and implemented at UFRN, promote expanding access to higher education, as it is during implementation that the rules, routines and social processes are converted from intentions to action. The discussion of this study lasted between two opposing views of Implementation models: Top-down and Bottom-up. It is worth noting that the documents PNE, PDE and programs and UAB MEETING reflect positively in improving the educational level of the population of the country It is a qualitative study, using the means Bibliographic, Document and Field Study, where they were performed 04 (four) in 2010 interviews with the management framework SEDIS / UAB in UFRN. The data were analyzed and addressed through techniques: Document Analysis and Content Analysis. The results show that the process of implementation of distance education at UFRN is in progress. According to our results, the research objective is achieved, but there was a need to rethink the conditions of the infrastructure of poles, the structure of the academic calendar, the management of the SEDIS UFRN, regarding the expansion of existing vacancies and the supply of new courses by the need for a redesign as the Secretariat's ability to hold the offerings of undergraduate courses offered by the Federal Government to be implemented in the institution. It was also found that levels of evasion still presents a challenge to the teaching model. Given the context, we concluded that the greatest contribution of UAB and consequently UFRN by distance learning for undergraduate courses (Bachelor in Mathematics, Physics, Chemistry, Geography and Biological Sciences, beyond the bachelor's degrees in Business and Public Administration ) is related to increasing the number of vacancies and accessibility of a population that was previously deprived of access to university

Relações de cooperação em consórcios públicos de regiões metropolitanas: análises do CONDIAM/PB e consórcio grande Recife

With the disorganized decentralization occurred in Brazil after the 1988 Constitution, municipalities have risen to the level of federal entities. This phenomenon became known as "municipalism" also brought some negative effects such as low capacity financial, economic and political of these entities. In the face of this reality , the municipalities sought in models of collaborative features to address public policy issues ultrarregionais, one of these models are the Public Consortia. Characterized as the organization of all federal entities that aim to solve public policy implementation alone that they could not, or spend great resources for such. This reality of the municipalities have an aggravating factor when looking at the situation in Metropolitan Regions (MRs). This is because the RMs has a historical process of formation that does not encourage cooperation, since that were created top-down during the military regime. Furthermore, the metropolitan municipalities have significant power asymmetries, localist vision, rigidity earmarked revenues, different scenarios conurbation, difficulty standardization of concepts and others that contribute to the vision of low cooperation of these metropolitan areas. Thus, the problem of this work is in the presence of collaborative arrangements, such as the Public Consortia in metropolitan areas, which are seen as areas of low cooperation. To elucidate this research was used for analysis the cases of CONDIAM/PB and Consórcio Grande Recife/PE, because they are apparently antagonistic, but with some points of similarity. The cases has as foundation the Theory of Common Resources, which provides the possibility of collective action through the initiative of individuals. This theory has as its methodology for analyzing the picture IAD Framework, which proposes its analysis based on three axes: external variables, the arena of action and results. The nature of the method of this research was classified as exploratory and descriptive. For the stage of date analysis, was used the method of document analysis and content, Further than of separation of the cases according to theur especificities. At the end of the study, noted that the CONDIAM/PB was a strategy of municipal government of Joao Pessoa to attract funds from the Federal Government for the purpose of to build a landfill, and over the years the ideology of cooperation was left aside, the prevailing view localist municipalities. In the case of Consórcio Grande Recife/PE, members act with some degree of cooperation, especially the collaborative aspect of the region, however, still prevails with greater strength the power of the state of Pernambuco in the decisions and paths of the consortium. Thus, was conclude that the Public Consortia analyzed are an experience of collaborative arrangement, from the initiative of members, as the theory of common resources says, but has not actually signed as a practice of collective action to overcome the dilemmas faced by metropolitan areas

A implementação de ações de integração na segurança pública: o caso das polícias civil e militar do Rio Grande do Norte

The research aimed to understand the challenges for the implementation of the proposed integration between the Civil Police and the Military Police in Rio Grande do Norte to the proposals of the SUSP. This study aimed to explore the gap with regard to the deepening of the possible causes that may hinder the implementation of integrated working between the police in public security, through a specific analysis on the state of Rio Grande do Norte. Was based on a theoretical framework that includes policies: general concepts, the steps of a public policy, the implementation stage , public security : conceptual definitions, policies on security in Brazil, the structure of public security in Brazil and systems police, Military Police x Civil Police: Roles and conflicts , integrating public security: the challenges to be overcome, the Unified public Safety (SUSP) and the main difficulties in the integration of the police. Being classified as to the purposes as an exploratory research on how to approach ranks as qualitative. The research unit was the Center for Integrated Operations Public Safety (CIOSP) through three subjects who were the chief CIOSP, the representative of the military police acting with the CIOSP, and representative civil police also active with the CIOSP. These subjects were chosen because of the understanding that individuals occupying senior positions would have more ability to respond to questions that guide the research problem. Data were collected through a set of interviews, qualitative data analysis was performed based content analysis, based on the definition of categories of analysis, gated time cross. With the results, it was revealed that the main problems of integration between the state police are treatment protocols, lack of political will and lack of infrastructure. The relationship between the Military Police and Civil Police in Rio Grande do Norte has differing cultural aspect, but can be considered as good value, professionalism and integrated operations. The implementation of CIOSP-RN followed the characteristics of the top-down model, the main difficulties in implementing the proposals of the SUSP, lack of own resources, the lack of standardization in public safety and the lack of professional training of public safety. It was concluded that with respect to the challenges to the implementation of the proposed integration between the Civil Police and the Military Police in Rio Grande do Norte to the proposals of the SUSP, the actions follow the characteristics of the top-down model, with no autonomy of administrators public to say in decisions, which restricts the view of the public safety of the state

Dinámicas sociales, conservación y desarrollo en espacios naturales protegidos. El caso de la Reserva de la Biosfera "La Sepultura" en el estado mexicano de Chiapas

Los factores que inciden en el proceso de desarrollo de los territorios rurales y que explican el éxito o el fracaso de las estrategias impulsadas desde abajo (bottom-up) o inducidas desde arriba (top-down), han preocupado desde hace varias décadas a los analistas, que observan las limitaciones de los enfoques del “desarrollo territorial rural” para aprehender la complejidad de dicho proceso. Habiéndose centrado, sobre todo, en el ámbito de las políticas públicas y sus efectos en el desarrollo de los territorios rurales, los analistas del desarrollo han visto la necesidad de apoyarse en otras perspectivas que capten las dinámicas que acontecen en el ámbito de la sociedad civil local, tanto en lo que se refiere a las relaciones entre los diversos actores socioeconómicos e institucionales presentes en el territorio, como a su interacción con los organismos públicos encargados de implementar dichas políticas. El objetivo general de esta tesis doctoral ha sido analizar las dinámicas sociales que surgen en espacios naturales sometidos a políticas de gestión y regulación, mostrando el grado de influencia que tienen en la aplicación de esas políticas las diversas redes en que se organizan las poblaciones locales. De la investigación empírica realizada y de su integración en el marco teórico utilizado, hemos podido extraer resultados referidos a la realidad concreta y localizada de la REBISE que muestran cómo es que conciliar los objetivos de la “conservación” y el “desarrollo” en territorios poblados por comunidades locales estrechamente vinculadas a espacios naturales, exige abordar de forma integral los problemas ambientales, sociales y económicos. Tratar de alcanzar esos objetivos con políticas sectoriales conduce al fracaso de los programas de protección, ya que sólo se logran objetivos parciales y limitados. Por muy elevado que sea el valor ecológico de este tipo de espacios naturales y por muy alta que sea la protección que reciban por parte de los organismos internacionales (como ocurre con las “reservas de la biosfera” del programa MaB de la UNESCO), “conservar” estas áreas naturales no puede lograrse sin contar con la colaboración de las poblaciones locales. Esto exige combinar estrategias top-down y bottom-up buscando establecer sinergias entre los responsables públicos y los grupos sociales presentes en el territorio. De nuestra investigación se deduce la necesidad de empoderar a las comunidades locales para inducir en ellos un capital social tipo bridging dirigido a la construcción de un gran pacto territorial que trascienda los intereses particulares de cada grupo y que persiga el interés general del territorio en pro de la conservación de los recursos naturales y de la mejora del bienestar y calidad de vida de las familias que residen allí. Si no se hace así, continuarán promoviéndose proyectos “balsámicos” que paliarán a corto plazo algunos de los problemas de las poblaciones locales, pero que las mantendrán en el estancamiento y la pobreza.

Europeanization beyond the EU: The case of Georgia.

320 p.

Linking heritage: Yenya Punhi Festival a path to reinforce identity. The Katmandu experience

In today’s world heritage worldwide are at the risk not only because of natural process of decay and destruction but also by social change like urbanization, globalization and homogenization of cultures. With these emerging problems, the heritage conservation discourse also has reached to a new dimension including broader range of concepts like tangible heritage, intangible heritage, community participation, indigenous knowledge and many more. Even with the changing scenario in the international context about the heritage conservation, Nepal’s heritage conservation still focus on monuments, sites and buildings. In add to that the conservation practices are still top-down approach and community involvements are limited only in plans. While numerous intangible heritages like masking dances chariot processions, festivals and rituals, which form an integral part of the daily social life of people are still being continued and managed by the community and its people, without with out serious attention form the government. In Kathmandu Valley these heritages has been maintained with the traditional social association of people known as “Guthi” which has been continuing since 5th Century. Most of the tangible and intangible heritages have survived for centuries because of this unique association of people. Among the numerous festivals of the Kathmandu Valley, the festival Yenya Punhi was chosen as a case for this study, which is also a major festival of Kathmandu. This festival is the perfect example for the study as its celebrated in the city that is the most urbanized city of Nepal with the challenges of the every modern city like social changes and urbanization. Despite modern challenges Guthi still plays a major role in the heritage conservation in Kathmandu Valley. Now there are some interventions of the various formal institutions. So this study will be focusing on the management, continuity and problems of the festival along with Nepal’s position in terms of intangible heritage conservation. The problem of Kathmandu and Yenya Punhi festival is the problem of every country in the similar situation so with this case study it can be a good example for finding solutions of the similar problem not only the other festivals within Nepal but also elsewhere in the world; Resumo: Conexão de Património: Festival Yenya Punhi um caminho de fortalecimento de identidade: A experiência de Catmandu Nos dias de hoje, os patrimónios mundiais encontram-se em risco, não só devido ao processo natural de degradação e destruição, mas também pelas mudanças sociais, tais como a urbanização, globalização e homogeneização de culturas. Com o emergir destes problemas, o discurso de conservação de Património atingiu também uma nova dimensão, incluíndo uma área mais abrangente de conceitos, como por exemplo, património material, património imaterial, participação da comunidade, conhecimento indígena, entre outros. Mesmo com este cenário de mudança no contexto mundial de conservação do património, a preservação do património do Nepal continua a focar-se em monumentos, sítios e edíficios. A acrescentar a isso, as práticas de conservação ainda têm uma abordagem descendente e os envolvimentos da comunidade são limitados por planificações. Enquanto que os numerosos patrimónios imateriais como danças com máscaras, procissões, festivais e rituais, os quais formam uma parte integral da vida diária social das pessoas que as continuam e as gerem em comunidade, sem uma atenção séria por parte do governo. No Vale de Catmandu, este património tem sido mantido pela associação tradicional de pessoas conhecidas como ''Guthi'' desde o século V. A maior parte destes patrimónios materiais e imateriais tem sobrevivido durante séculos graças a esta associação única de pessoas. Entre os numerosos festivais do Vale de Catmandu, o festival Yenya Puhni foi escolhido para este estudo, pois é também um grande festival em Catmandu. Este festival é o exemplo perfeito para este estudo, pois é celebrado na cidade mais urbanizada do Nepal, com os desafios das cidades modernas tais como mudanças sociais e urbanização. Apesar dos desafios da modernização, os ''Guthi'' ainda desempenham um papel importante na preservação do património do Vale de Catmandu. Agora, existem algumas intervenções de várias instituições formais Então, este estudo irá focar-se na gestão, continuidade e problemas do festival, juntamente com a posição do Nepal em termos de conservação de património imaterial. O problema de Catmandu e do festival Yenya Punhi é o problema de todos os países em situação semelhante então, este estudo pode ser um bom exemplo para encontrar soluções de problemas parecidos, não só em outros festivais no Nepal mas também para qualquer parte do mundo.

Legal Framework for Cross-Regional Networks: The Case of Services and Migration

Paper prepared by Marion Panizzon and Charlotte Sieber-Gasser for the International Conference on the Political Economy of Liberalising Trade in Services, Hebrew University of Jerusalem, 14-15 June 2010 Recent literature has shed light on the economic potential of cross-border networks. These networks, consisting of expatriates and their acquaintances from abroad and at home, provide the basis for the creation of cross-border value added chains and therewith the means for turning brain drain into brain circulation. Both aspects are potentially valuable for economic growth in the developing world. Unilateral co-development policies operating through co-funding of expatriate business ventures, but also bilateral agreements liberalising circular migration for a limited set of per-sons testify to the increasing awareness of governments about the potential, which expatriate networks hold for economic growth in developing countries. Whereas such punctual efforts are valuable, viewed from a long term perspective, these top-down, government mandated Diaspora stimulation programs, will not replace, this paper argues, the market-driven liberalisation of infrastructure and other services in developing countries. Nor will they carry, in the case of circular labour migration, the political momentum to liberalise labour market admission for those non-nationals, who will eventually emerge as the future transnational entrepreneurs. It will take a combination of mode 4 and infrastructure services openings-cum regulation for countries at both sides of the spectrum to provide the basis and precondition for transnational business and entrepreneurial networks to emerge and translate into cross-border, value added production chains. Two key issues are of particular relevance in this context: (i) the services sector, especially in infrastructure, tends to suffer from inefficiencies, particularly in developing countries, and (ii) labour migration, a highly complex issue, still faces disproportionately rigid barriers despite well-documented global welfare gains. Both are hindrances for emerging markets to fully take advantage of the potential of these cross-border networks. Adapting the legal framework for enhancing the regulatory and institutional frameworks for services trade, especially in infrastructure services sectors (ISS) and labour migration could provide the incentives necessary for brain circulation and strengthen cross-border value added chains by lowering transaction costs. This paper analyses the shortfalls of the global legal framework – the shallow status quo of GATS commitments in ISS and mode 4 particular – in relation to stimulating brain circulation and the creation of cross-border value added chains in emerging markets. It highlights the necessity of adapting the legal framework, both on the global and the regional level, to stimulate broader and wider market access in the four key ISS sectors (telecommunications, transport, professional and financial services) in developing countries, as domestic supply capacity, global competitiveness and economic diversification in ISS sectors are necessary for mobilising expatriate re-turns, both physical and virtual. The paper argues that industrialised, labour receiving countries need to offer mode 4 market access to wider categories of persons, especially to students, graduate trainees and young professionals from abroad. Further-more, free trade in semi-finished products and mode 4 market access are crucial for the creation of cross-border value added chains across the developing world. Finally, the paper discusses on the basis of a case study on Jordan why the key features of trade agreements, which promote circular migration and the creation of cross-border value added chains, consist of trade liberalisation in services and liberal migration policies.

De patrones a parámetros : una evaluación de los patrones espaciales en los pabellones de la Serpentine Gallery (2000-2015)

La actual realidad socioeconómica, marcada por la (r)evolución tecnológica de los último años y la explosión demográfica y urbana, conlleva dos grandes problemas. Por un lado el cambio climático derivado de la sobreexplotación de los recursos y energías no-renovables, y por otro, la pérdida de las identidades y procesos culturales específicos provocada por la globalización. Ante ellos, diversos autores plantean sacar partido de las propias tecnologías y la nueva sociedad en red para dar una respuesta acorde al momento actual. Las herramientas computacionales permiten una mayor complejidad de los diseños alcanzando una optimización de recursos y procesos, minimizando su impacto ambiental. Frente a la producción en masa y la pérdida de identidad, el planteamiento informático de problemas globales permite pasar de la producción en masa del siglo pasado a la ‘customización’ en masa al dar respuestas específicas para cada contexto. Por otro lado es necesario que esos procesos computacionales conecten y hagan partícipes del diseño a los diferentes actores sociales implicados. Es por ello que esta investigación se basará en los patrones espaciales de Christopher Alexander y otros modelos algorítmicos de diseño por ordenador puesto que estos describen soluciones paramétricas a conflictos recurrentes de diseño de arquitectura. Su planteamiento permite que cada solución base genere respuestas específicas, a la vez que esta es corregida y optimizada por todos sus utilizadores al poder ser compartida digitalmente. Con ello se busca que el diseño de arquitectura responda a criterios objetivos basados en la experiencia y la crítica participativa y democrática basada en los patrones, de tal modo que los diseños no surjan de un planteamiento top-down impuesto y cerrado, sino que en ellos gane importancia la participación activa de los actores sociales implicados en la definición y uso de los mismos. Por último, esta investigación procura mostrar cómo los patrones pueden jugar un papel determinante en la conceptualización abstracta del diseño, mientras que otros métodos algorítmicos alcanzarán fases del proyecto más concretas. De este modo, los patrones digitales que se pretenden se centran en la customización del diseño, mientras que el uso que le dan otros autores persigue la optimización del mismo. Para ello la investigación recurrirá al análisis de los pabellones de verano de la Serpentine Gallery como casos de estudio en los que comprobar la repercusión de los patrones en el diseño de arquitectura actual y su posible adaptación al diseño paramétrico.

Abundance of sedentary consumers and sessile organisms along the wave exposure gradient of subtropical rocky shores of the south-west Atlantic

Sedentary consumers play an important role on populations of prey and, hence, their patterns of abundance, distribution and coexistence on shores are important to evaluate their potential influence on ecosystem dynamics. Here, we aimed to describe their spatio-temporal distribution and abundance in relation to wave exposure in the intertidal rocky shores of the south-west Atlantic to provide a basis for further understanding of ecological processes in this system. The abundance and composition of the functional groups of sessile organisms and sedentary consumers were taken by sampling the intertidal of sheltered and moderately exposed shores during a period of one year. The sublittoral fringe of sheltered areas was dominated by macroalgae, while the low midlittoral was dominated by bare rock and barnacles. In contrast, filter-feeding animals prevailed at exposed shores, probably explaining the higher abundance of the predator Stramonita haemastoma at these locations. Limpets were more abundant at the midlittoral zone of all shores while sea urchins were exclusively found at the sublittoral fringe of moderately exposed shores, therefore, adding grazing pressure on these areas. The results showed patterns of coexistence, distribution and abundance of those organisms in this subtropical area, presumably as a result of wave action, competition and prey availability. It also brought insights on the influence of top-down and bottom-up processes in this area.

Indicadores de eficiencia asociados a los Grupos Relacionados por el Diagnóstico (GRD) de Partos en un Hospital Público de Nivel I

Esta investigación toma como tema de referencia los costes sanitarios en originados en la Unidad de Partos del Servicio de Obstetricia y Ginecología de un Hospital de Nivel I. El objetivo general de la presente investigación se concreta en la definición y determinación de un conjunto de indicadores que permitan cuantificar el grado de eficiencia en la actividad sanitaria. Estos indicadores se construyen sobre variables representativas de coste, relativizadas por la actividad de la unidad, medida ésta por el número de casos atendidos. Otro indicador global que se podría haber utilizado es el número de estancias causadas, si bien hay razones, que se explican a lo largo del trabajo, que desaconsejan su utilización. El ámbito de estudio de este trabajo lo constituye la unidad de gestión clínica (servicio) de obstetricia y ginecología de un hospital de Nivel I de la Comunidad Autónoma de Andalucía y el año de referencia del estudio es 2005. Dentro de este servicio se ha centrado la atención en los partos atendidos, por la representatividad que los mismos tienen en la actividad de la unidad, desagregando la diferente tipología de aquellos mediante el uso de los correspondientes GRD. Las fuentes de información utilizadas han sido: • Conjunto Mínimo Básico de Datos (CMBD) • Grupos Relacionados con el Diagnóstico (GRD). • Relación de los GRD con el CMBD. • Cuadros de Mando Integrales del Centro Hospitalario. • Contabilidad Analítica del Hospital (COANHyD). • Contrato Programa del Centro Sanitario. • Instituto de Estadística de Andalucía (IEA). • Instituto Nacional de Estadística de España (INE). • Sistema Estadístico Europeo (EUROSTAT). Una vez se han determinado los costes controlables para todas las categorías y para cada uno de los GRD de partos, se procede a la determinación de una serie de indicadores que van a ser de gran utilidad para las conclusiones de la investigación, en cuanto que van a proporcionar una información determinante para los responsables de las unidades en la búsqueda de la eficiencia en la aplicación de los recursos. De igual manera van a ser útiles para establecer comparaciones con otras unidades, ya sean del mismo centro hospitalario o de otros centros. Si se hace una revisión de la literatura, la mayoría de los indicadores de eficiencia se formalizan mediante un cociente en el que el numerador representa una variable de coste y el denominador una variable de actividad, identificándose esta última por los casos tratados o las estancias causadas. La propuesta que se hace en la presente investigación es la de aplicar la primera de las alternativas enunciadas, es decir, el coste por caso, ya que las estancias causadas, aunque no han intervenido activamente en aquellos costes que se han estimado siguiendo la estrategia bottom up, sí se han utilizado, por así establecerlo la contabilidad analítica, a la hora de determinar los costes estimados mediante el modelo top down, como es el caso de todos los costes no controlables. Además del coste por caso que, como se ha dicho, es uno de los indicadores de eficiencia más citados en la literatura, podrían utilizarse otros indicadores como el coste por producción ajustada, que se define como el cociente entre los costes de explotación, que son los que se han contemplado en la presente investigación, y el número de altas ajustado por el peso relativo del correspondiente GRD. El coste por producción ajustada puede parecer más preciso. Sin embargo, depende mucho de la homogeneidad existente en la definición de las patologías que conforman cada GRD, es decir, depende del grado de variabilidad intra GRD. Como quiera que no es fácil lograr dicha homogeneidad, la ventaja apuntada puede compensarse en cierta medida con el inconveniente de mostrar una menor neutralidad. Si se analiza su distribución por GRD, puede observarse que el coste correspondiente a los GRD 371, 372 y 373 conforma más del 70% del coste total. El correspondiente a los GRD 370 y 651 alrededor del 19% del total. Les siguen en importancia el GRD 650 con un 5%, el GRD 375 con alrededor del 3%, repartiéndose el 2% restante los GRD 374 y 652. Si no distinguimos entre costes controlables y no controlables, el total de todos los costes en que incurre la unidad objeto de estudio en el año 2005 asciende a 16.956.541 euros, de los que el 57,18% se corresponde con los costes controlables, quedando el 42,82% restante para los no controlables. Por conceptos, el mayor peso relativo en la estructura de costes, lo tienen los costes del personal adscrito al servicio, con un 48,16%, siendo de un 29,88% el correspondiente al resto del personal, conformando entre ambos algo más del 78% del coste total. Le sigue en importancia el concepto de varios con una aportación del 6,52%, ello debido fundamentalmente al coste de los set de esterilización, lavandería y lencería que aportan un 61 y 34% del total del concepto. En cuanto a gestoría de usuarios y tributos, su importancia es residual. En tercer lugar tenemos a las contratas, con un 4,04% del coste total, destacando entre las mismas la contrata de la limpieza que supone un 70% del total del concepto. El cuarto lugar lo ocupan las determinaciones analíticas con un 3,37% del peso relativo, destacando entre ellas las de bioquímica con un 34,26%, seguidas de las de inmunología con un 30,25% y los hemogramas con un 18,79%, conformando entre las tres algo más del 83% del total. La aportación de alimentación, material fungible y consumos, es un 2,61%, un 2,55% y un 2,38% respectivamente, destacando en importancia el peso del material de curas, que supone el 66,58% del total del concepto, los consumos de electricidad con un 36,91% del total y el oxigeno que constituye el 28,68% de dicho total. El menor peso relativo, casi residual, se corresponde con los costes de farmacia, con una participación del 0,49% del coste total.

Bidirectional Helmholtz Machines

L'entraînement sans surveillance efficace et inférence dans les modèles génératifs profonds reste un problème difficile. Une approche assez simple, la machine de Helmholtz, consiste à entraîner du haut vers le bas un modèle génératif dirigé qui sera utilisé plus tard pour l'inférence approximative. Des résultats récents suggèrent que de meilleurs modèles génératifs peuvent être obtenus par de meilleures procédures d'inférence approximatives. Au lieu d'améliorer la procédure d'inférence, nous proposons ici un nouveau modèle, la machine de Helmholtz bidirectionnelle, qui garantit qu'on peut calculer efficacement les distributions de haut-vers-bas et de bas-vers-haut. Nous y parvenons en interprétant à les modèles haut-vers-bas et bas-vers-haut en tant que distributions d'inférence approximative, puis ensuite en définissant la distribution du modèle comme étant la moyenne géométrique de ces deux distributions. Nous dérivons une borne inférieure pour la vraisemblance de ce modèle, et nous démontrons que l'optimisation de cette borne se comporte en régulisateur. Ce régularisateur sera tel que la distance de Bhattacharyya sera minisée entre les distributions approximatives haut-vers-bas et bas-vers-haut. Cette approche produit des résultats de pointe en terme de modèles génératifs qui favorisent les réseaux significativement plus profonds. Elle permet aussi une inférence approximative amérliorée par plusieurs ordres de grandeur. De plus, nous introduisons un modèle génératif profond basé sur les modèles BiHM pour l'entraînement semi-supervisé.