Aníbal Pinto Santa Cruz

El 3 de enero falleció don Aníbal Pinto Santa Cruz, desde 1986 Director de esta Revista. El hecho nos invade de profundo pesar, y deja un hondo vacío en la institución. La Comisión Económica de las Naciones Unidas para América Latina y el Caribe se benefició por muchos años del brillo intelectual y la calidad humana de Don Aníbal, quien por varios años se desempeñó como Director de la División de Desarrollo Económico. Más que eso, fue una de las personalidades que le dio una clara identidad institucional a la Secretaría de la CEPAL. A la profundidad y lucidez de sus análisis sobre Chile y su proceso de desarrollo, unía una auténtica vocación latinoamericana, que lo llevó a realizar sólidos y valiosos aportes al progreso de las ideas en nuestra región. Pertenecía por derecho propio al selecto grupo de aquellos pensadores que mediante nuevas categorías y conceptos abren a los demás una visión enriquecida de la realidad. No es sorprendente, por lo tanto, que en toda la región existan discípulos y ex alumnos suyos. Persona de gran generosidad intelectual e impaciencia ante el saber convencional y las intolerancias de cualquier lado del espectro académico o político, Aníbal Pinto recibió el reconocimiento de la comunidad académica internacional, expresado en el Premio Iberoamericano de Economía "Raúl Prebisch", el Doctorado Honoris Causa de la Universidad de Campinas, en Brasil, y el Premio Nacional de Humanidades y Ciencias Sociales de Chile, 1995. En meses recientes, recibió dos distinciones adicionales: la primera, de sus colegas de la CEPAL, que le rindieron un homenaje con ocasión del quincuagésimo aniversario de las Naciones Unidas; la segunda, al presentarse una recopilación de sus escritos publicada por la Universidad Nacional Autónoma de México en un acto que se llevó a cabo en la Feria del Libro de Santiago, en diciembre pasado. La CEPAL ha tenido la infinita suerte de contar entre sus cuadros con grandes personalidades que han dejado un legado de valores, principios e ideas-fuerza; si se quiere, forjadores de instituciones. Es más, si hay algo que distingue a la CEPAL del resto de las entidades de las Naciones Unidas, es ese hecho. Entre los nombres que más resonarán, sin duda figurará el de Aníbal Pinto. Por eso, y por sus excepcionales cualidades humanas, lo recordaremos con afecto y admiración.

Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats

We investigated the behavioral and molecular interactions between cocaine and nicotine, through evaluating locomotor activity, nicotine intravenous self-administration and gene expression. Locomotor sensitization was induced in male Wistar rats by repeated cocaine (20 mg/kg; i.p.) or saline injections once a day over 7 days. Three days after the last injection, rats were challenged with either saline or cocaine (15 mg/kg; i.p.) and the locomotor activity was measured. The very next day animals received either saline or nicotine (0.4 mg/kg; s.c.) and the locomotor cross-sensitization was tested. Animals were then prepared with intrajugular catheters for nicotine self-administration. Nicotine self-administration patterns were evaluated using fixed or progressive ratio schedules of reinforcement and a 24-h unlimited access binge. Immediately after the binge sessions animals were decapitated, the brains were removed and the nucleus accumbens was dissected. The dynorphin (DYN), μ-opioid receptor (mu opioid), neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), tropomyosin-related tyrosine kinase B receptor (TrkB) and corticotropin- releasing factor receptor type 1 (CRF-R1) gene expression were measured by the reverse transcription-polymerase chain reaction (RT-PCR). Pretreatment with cocaine caused sensitization of cocaine motor response and locomotor cross-sensitization with nicotine. In the self-administration experiments repeated cocaine administration caused an increase in the nicotine break point and nicotine intake during a 24 h binge session. © 2013 Elsevier Inc.

The Genome of Anopheles darlingi, the main neotropical malaria vector

Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles- darlingi. © 2013 The Author(s).

Anthelmintic efficacy of an oral formulation of Aurixazol against gastrointestinal nematodes of naturally and experimentally infected sheep

As a result of the need to develop new active principles for the control of endoparasites in ruminants, the present in vivo study evaluated a formulation containing 24% Aurixazol (48 mg/kg), a parasiticide molecule based on disophenolate of levamisole. Two experiments were conducted: one evaluating the anthelmintic efficacy of 24% Aurixazol (48 mg/kg) against gastrointestinal nematodes in naturally infected sheep, compared to an association of ivermectin (0.2 mg/kg) + albendazole (5.0 mg/kg) + levamisole (7.5 mg/kg) (IAL), and a second one which evaluated the persistent efficacy of the same formulation against immature stages (L4) and adults of Haemonchus contortus in experimentally infected animals. In experiment I, against H. contortus, the formulation of Aurixazol and the IAL association reached efficacies (arithmetic means) of 99.32% and 96.11%, respectively. For Trichostrongylus colubriformis, the efficacy values were 88.92% and 98.08% for Aurixazol and the IAL association, respectively. Both formulations were totally effective against Oesophagostomum columbianum (100%). The results of the statistical analysis demonstrated that the mean parasitic burden of treated animals was significantly different (P ≤ 0.05) compared to the average number of helminths diagnosed in animals from the control group for H. contortus, T. colubriformis and O. columbianum. Comparing only the treated groups, it was possible to verify that the average number of H. contortus recovered from animals treated with Aurixazol was different (P ≤ 0.05) when compared to the mean amount recovered from sheep treated with the IAL association. When evaluating the prevention of H. contortus infection in experiment II, Aurixazol did not present preventive efficacy. Up until 21 days after treatment the groups treated with Aurixazol contained less adults and L4 of H. contortus (P ≤ 0.05) when compared to the non-medicated control group. However, future studies will be necessary to assess the effectiveness of Aurixazol against nematode strains resistant to levamisole and disophenol, but the efficacy results described in this study allow to state that Aurixazol can, associated with other measures, become an important tool in the control of sheep nematodes. © 2013.

Demodulação de sinais interferométricos de saída de sensor eletro-óptico de tensões elevadas utilizando processador digital de sinais

Pós-graduação em Engenharia Elétrica - FEIS

Chuva de sementes em uma área em processo de restauração vegetal em Santa Cruz das Palmeiras (SP)

Pós-graduação em Ciências Biológicas (Biologia Vegetal) - IBRC

Migración y crecimiento urbano en Santa Cruz: Bolivia, 1950-1992

Incluye Bibliografía

Avaliação histopatológica e imuno-histoquímica do miocárdio de cães com leishmaniose visceral: Fernando Azadinho Rosa. -

Pós-graduação em Ciência Animal - FMVA