997 resultados para Common goal


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Especially in global enterprises, key data is fragmented in multiple Enterprise Resource Planning (ERP) systems. Thus the data is inconsistent, fragmented and redundant across the various systems. Master Data Management (MDM) is a concept, which creates cross-references between customers, suppliers and business units, and enables corporate hierarchies and structures. The overall goal for MDM is the ability to create an enterprise-wide consistent data model, which enables analyzing and reporting customer and supplier data. The goal of the study was defining the properties and success factors of a master data system. The theoretical background was based on literature and the case consisted of enterprise specific needs and demands. The theoretical part presents the concept, background, and principles of MDM and then the phases of system planning and implementation project. Case consists of background, definition of as is situation, definition of project, evaluation criterions and concludes the key results of the thesis. In the end chapter Conclusions combines common principles with the results of the case. The case part ended up dividing important factors of the system in success factors, technical requirements and business benefits. To clarify the project and find funding for the project, business benefits have to be defined and the realization has to be monitored. The thesis found out six success factors for the MDM system: Well defined business case, data management and monitoring, data models and structures defined and maintained, customer and supplier data governance, delivery and quality, commitment, and continuous communication with business. Technical requirements emerged several times during the thesis and therefore those can’t be ignored in the project. Conclusions chapter goes through these factors on a general level. The success factors and technical requirements are related to the essentials of MDM: Governance, Action and Quality. This chapter could be used as guidance in a master data management project.

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In the paper machine, it is not a desired feature for the boundary layer flows in the fabric and the roll surfaces to travel into the closing nips, creating overpressure. In this thesis, the aerodynamic behavior of the grooved roll and smooth rolls is compared in order to understand the nip flow phenomena, which is the main reason why vacuum and grooved roll constructions are designed. A common method to remove the boundary layer flow from the closing nip is to use the vacuum roll construction. The downside of the use of vacuum rolls is high operational costs due to pressure losses in the vacuum roll shell. The deep grooved roll has the same goal, to create a pressure difference over the paper web and keep the paper attached to the roll or fabric surface in the drying pocket of the paper machine. A literature review revealed that the aerodynamic functionality of the grooved roll is not very well known. In this thesis, the aerodynamic functionality of the grooved roll in interaction with a permeable or impermeable wall is studied by varying the groove properties. Computational fluid dynamics simulations are utilized as the research tool. The simulations have been performed with commercial fluid dynamics software, ANSYS Fluent. Simulation results made with 3- and 2-dimensional fluid dynamics models are compared to laboratory scale measurements. The measurements have been made with a grooved roll simulator designed for the research. The variables in the comparison are the paper or fabric wrap angle, surface velocities, groove geometry and wall permeability. Present-day computational and modeling resources limit grooved roll fluid dynamics simulations in the paper machine scale. Based on the analysis of the aerodynamic functionality of the grooved roll, a grooved roll simulation tool is proposed. The smooth roll simulations show that the closing nip pressure does not depend on the length of boundary layer development. The surface velocity increase affects the pressure distribution in the closing and opening nips. The 3D grooved roll model reveals the aerodynamic functionality of the grooved roll. With the optimal groove size it is possible to avoid closing nip overpressure and keep the web attached to the fabric surface in the area of the wrap angle. The groove flow friction and minor losses play a different role when the wrap angle is changed. The proposed 2D grooved roll simulation tool is able to replicate the grooved aerodynamic behavior with reasonable accuracy. A small wrap angle predicts the pressure distribution correctly with the chosen approach for calculating the groove friction losses. With a large wrap angle, the groove friction loss shows too large pressure gradients, and the way of calculating the air flow friction losses in the groove has to be reconsidered. The aerodynamic functionality of the grooved roll is based on minor and viscous losses in the closing and opening nips as well as in the grooves. The proposed 2D grooved roll model is a simplification in order to reduce computational and modeling efforts. The simulation tool makes it possible to simulate complex paper machine constructions in the paper machine scale. In order to use the grooved roll as a replacement for the vacuum roll, the grooved roll properties have to be considered on the basis of the web handling application.

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INTRODUCTION: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. METHODS: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. DISCUSSION: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.

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Cat's claw oxindole alkaloids are prone to isomerization in aqueous solution. However, studies on their behavior in extraction processes are scarce. This paper addressed the issue by considering five commonly used extraction processes. Unlike dynamic maceration (DM) and ultrasound-assisted extraction, substantial isomerization was induced by static maceration, turbo-extraction and reflux extraction. After heating under reflux in DM, the kinetic order of isomerization was established and equations were fitted successfully using a four-parameter Weibull model (R² > 0.999). Different isomerization rates and equilibrium constants were verified, revealing a possible matrix effect on alkaloid isomerization.

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Venäjän lainsäädäntö mahdollistaa erilaisten rajoitusten asettamisen liikenteelle kelirikkoajan aikana ja alhaisten painorajoitusten asettaminen on tällöin yleistä. Kelirikon aikaisiin rajoituksiin liittyvä lainsäädäntö on pääosin tarkoituksenmukainen, mutta sitä sovelletaan tavalla, jolla vaikeutetaan huomattavasti yritysten toimintaa ja tarvittavien kuljetusten järjestämistä. Diplomityössä tutkitaan kelirikon vaikutuksia liiketoimintaan erityisesti caseyksikössä, joka on metsäteollisuusyhtiön Venäjällä sijaitseva tuotantoyksikkö. Venäläinen liiketoimintaympäristö eroaa huomattavasti suomalaisesta, ja kelirikon aikana korostuvat etenkin korruption ja henkilökohtaisten suhteiden merkitys. Suuri osa havaituista sallitun painon ylityksistä hoidetaan kelirikon aikana maksamalla epävirallisia maksuja suoraan tarkastajille. Myös virallisia kulkulupia myydään, mutta niiden hankinta on kallista ja aikaa vievää. Työn lähtökohta kiteytyy lainsäädännön, viranomaisten tulkinnan ja todellisen tilanteen välisten ristiriitojen avaamiseen ja selvittämiseen, ja tavoitteena on ollut mahdollisimman objektiivisen kokonaiskuvan luominen tilanteesta. Case-yksikössä on kehitetty vaihtoehtoisia toimintamalleja kelirikkoajan kuljetusten varmistamiseksi. Rautatiekuljetusten määrää on lisätty huomattavasti ja välivarastointiterminaalin rakentamista on suunniteltu. Vaihtoehtoiset toimintamallit aiheuttavat kuitenkin huomattavia lisäkustannuksia. Tutkimuksen tuottamien tietojen avulla case-yhtiössä voidaan jatkossa arvioida todellisia riskejä sekä vaihtoehtoisten toimintamallien tarpeellisuutta ja kustannustehokkuutta aikaisempaa tarkemmin.

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This work quantifies two important epidemiological features of the bean (Phaseolus vulgaris)/Phaeoisariopsis griseola pathosystem. The first is the effect of the number of nights of leaf wetness on infection efficiency. Infection efficiency was below 10% when inoculated leaflets were exposed to less than two nights of leaf wetness. Optimum infection efficiencies were obtained after three to four nights of leaf wetness, at about 50%. Further nights of leaf wetness did not increase the infection efficiency. The second feature quantified is the relative rate of leaflet defoliation for varying levels of angular leaf spot severity. It increased with disease severity according to a logarithm-like curve, and a relative rate of 0.23 day-1 was estimated for a severity of 18%. The implications of these results on the disease epidemiology are discussed.

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Satelliittipaikannuksen hyödyntäminen eri sovellusaloilla ja siviilikäytössä on kasvanut merkittävästi 2000-luvulla Yhdysvaltojen puolustusministeriön lopetettua GPS-järjestelmän tarkoituksenmukaisen häirinnän. Langattomien datayhteyksien yleistyminen ja nopeuksien kasvaminen on avannut paikkatiedon käyttämiseksi ja hyödyntämiseksi reaaliaikaisesti uusia mahdollisuuksia. Kustannusten kasvaessa on tehokkaasta liikennöinnistä tullut tänä päivänä erittäin tärkeä osa yritysten päivittäisiä toimintoja. Ajoneuvojen hallinta on yksi tapa, jolla pyritään tehostamaan logistisia toimintoja ja vähentämään siitä aiheutuvia kustannuksia. Seuraamalla reaaliaikaisesti ajoneuvojen liikennöintiä voidaan pyrkiä saavuttamaan säästöjä optimoimalla aikatauluja ja reittejä sekä uudelleenohjaamalla ajoneuvoja sijaintien mukaan vähentäen näin kuljettua matkaa ja aikaa. Tässä diplomityössä tavoitteena on tutkia kuinka satelliittipaikannusta, paikkatietoa ja langattomia datayhteyksiä hyödyntämällä voidaan toteuttaa reaaliaikainen jäljitysohjelmisto. Työssä esitellään aluksi paikannustekniikat ja niiden toiminta. Lisäksi tutkitaan kuinka tiedonsiirto voidaan järjestelmässä toteuttaa sekä tarkastellaan järjestelmän kehityksessä huomioitavia tietoturvanäkökohtia. Tutkimuksen pohjalta suunniteltiin ja toteutettiin reaaliaikainen jäljitysohjelmisto kotipalveluyrityksen ajoneuvojen paikannustarpeisiin. Järjestelmän avulla voidaan valvoa ja jäljittää ajoneuvojen sijainteja kartalla reaaliaikaisesti sekä paikantaa tiettyä kohdetta lähimpänä olevat ajoneuvot. Tämä mahdollistaa hälytyksen sattuessa lähimpänä olevan työntekijän lähettämisen asiakaskohteeseen mahdollisimman nopeasti. Järjestelmän avulla käyttäjät voivat lisäksi seurata ajamiaan matkoja ja pitää automaattista ajopäiväkirjaa. Lopuksi työssä arvioidaan toteutetun järjestelmän toimintaa testauksessa saatujen mittaustulosten perusteella.

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The resources of the step family and the children’s well-being The present study investigates children's well-being in stepfamilies and fac¬tors, both external and internal, that are related to the children's well-being. Of the external factors, the study focuses on factors related to the structure of the stepfamily, parents' education, socio-economic status and factors related to work, livelihood and living conditions. The internal resources include the general functioning of the family, parenthood and parenting, family support networks and issues that the stepfamilies themselves consider important. Another important resource in a stepfamily is a functioning network of human relationships, which in the present study is approached from the maternal viewpoint. Changing family relations are considered a potential threat to the children's well-being. Therefore, in addition to looking into the stepfamily's resources, the other important goal of the study is to explore other factors potentially related to the well-being of children living in stepfamilies. In view of the stepfamily's resources, it is important to explore how the functioning of the relationships network is linked with the child's well-being. The study employs survey and interview data. The survey data (n=2236) are part of national survey data on the well-being of families and children and factors impacting them which were gathered as part of ”Origins of Exclusion in Early Childhood”, a research project carried out in 2002. The data consists of 667 stepfamilies. The interview data consists of interviews with 24 parents in stepfamilies. In the study, the analyses of survey and interview data are combined. Both descriptive statistical analyses and multivariate methods are employed. Content analysis is employed in the analysis of the interview data. The results indicate that the stepfamilies’ resources in general but their external resources in particular differed from those of the nuclear and single-parent families. The level of education and the socio-economic status of the stepfamily parents were somewhat lower than those of the nuclear family parents. The differences in relation to single-parent families were primarily related to the better economic status of the stepfamilies. The analysis of internal resources showed relatively minor differences: the stepfamilies assessed themselves a somewhat better general functioning of the family than did the nuclear families. Parenting issues caused more disagreement in stepfamilies than in nuclear families. The analysis of the functioning of the human relations in stepfamilies showed that the stepfamily mothers experienced the external relationships of the family (e.g., between the child and the absent father) as significantly more problematic than the relationships within the stepfamily. Living in a stepfamily thus challenges the functioning of the relationship between the child and the absent father. As a result of the analysis of the relationships networks in the stepfamilies, three groups were formed. One group had the nuclear family as an ideal goal, another valued an extended family composed of a variety of relationships, and the third one appreciated a strong intimate relationship between the parents. In the present study, the most common group was the multi-relationship, extended type of stepfamily. In conclusion, living in a stepfamily does not seem to pose a risk to the child’s well-being, but it may influence the family’s resources and thus have an indirect effect on the child’s well-being. In view of the resources of the stepfamily, the child’s well-being was best supported by a functioning network of human relationships in the stepfamily: there was a distinct connection with the children’s problems and the non-functioning of the relationships network. According to the mothers, the internal relationships in the stepfamily seemed to be more important than the external relationships of the family. A child’s functioning relationship with the absent father can be viewed as a positive resource, supporting the child’s well-being in the stepfamily.

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LMV is one of the most important pathogens of lettuce worldwide. Based on their ability to overcome the resistance genes mo1¹ and mo1² in lettuce, isolates can be divided in two types: LMV-Most, which can infect and are seed-borne in cultivars containing the mo1 gene and LMV-Common, which do not cause symptoms on these cultivars and are seed transmitted only in susceptible cultivars. To evaluate the occurrence of these two types of LMV isolates, a survey was carried out during 2002-2005 in three lettuce production areas from São Paulo State. Total RNA was used for the diagnosis of LMV isolates by RT-PCR using universal primers for the variable N-terminus of the capsid protein, in the 3' end of the genome. Positives samples were analyzed by a second RT-PCR using specifics primers for LMV-Most isolates designed to amplify a fragment from the central region (CI-VPg) of the genome. A total of 1362 samples showing mosaic symptoms were collected and 504 (37.29 %) were positives for LMV. On susceptible lettuce cultivars, LMV-Common was prevalent (77.3%). LMV-Most was found frequently associated with tolerant (mo1¹) lettuce cultivars. Susceptible cultivars correspond today for most of the area of lettuce production. So, despite the ability of LMV-Most isolates to overcome the resistance provided by the recessive mo1¹ gene, they are not prevalent in the conditions of São Paulo State.

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In knowledge-intensive economy an effective knowledge transfer is a part of the firm’s strategy to achieve a competitive advantage in the market. Knowledge transfer related to a variety of mechanisms depends on the nature of knowledge and context. The topic is, however, very little empirical studied and there is a research gap in scientific literature. This study examined and analyzed external knowledge transfer mechanisms in service business and especially in the context of acquisitions. The aim was to find out what kind of mechanisms was used when the buyer began to transfer data e.g. their own agendas and practices to the purchased units. Another major research goal was to identify the critical factors which contributed to knowledge transfer through different mechanisms. The study was conducted as a multiple-case study in a consultative service business company, in its four business units acquired by acquisition, in various parts of the country. The empirical part of the study was carried out as focus group interviews in each unit, and the data were analyzed using qualitative methods. The main findings of this study were firstly the nine different knowledge transfer mechanisms in service business acquisition: acquisition management team as an initiator, unit manager as a translator, formal training, self-directed learning, rooming-in, IT systems implementation, customer relationship management, codified database and ecommunication. The used mechanisms brought up several aspects as giving the face to changing, security of receiving right knowledge and correctly interpreted we-ness atmosphere, and orientation to use more consultative touch with customers. The study pointed out seven critical factors contributed to different mechanisms: absorption, motivation, organizational learning, social interaction, trust, interpretation and time resource. The two last mentioned were new findings compared to previous studies. Each of the mechanisms and the related critical factors contributed in different ways to the activity in different units after the acquisition. The role of knowledge management strategy was the most significant managerial contribution of the study. Phenomenon is not recognized enough although it is strongly linked in knowledge based companies. The recognition would help to develop a better understanding of the business through acquisitions, especially in situations such as where two different knowledge strategies combines in new common company.

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The purpose of this study was to evaluate the efficiency of integrated managements on white mold control on common bean. Initially, in vitro testing was made to assess the antagonism of 11 Trichoderma isolates against Sclerotinia sclerotiorum and to investigate fungicides (fluazinam and procymidone) inhibitory effects on those fungi. In two field experiments the following combinations were tested: irrigation frequencies (seven or 14 days), plant densities (six or 12 plants per meter), and three disease controls (untreated control, fungicide or Trichoderma spp.). In a third experiment plant densities were replaced by grass mulching treatments (with or without mulching). Fluazinam was applied at 45 and 55 days after emergence (DAE). The antagonists T. harzianum (experiments 1 and 3) and T. stromatica (experiment 2) were applied through sprinkler irrigation at 10 and 25 DAE, respectively. Most of the Trichoderma spp. were effective against the pathogen in vitro. Fluazinam was more toxic than procymidone to both the pathogen and the antagonist. Fungicide applications increased yield between 32 % and 41 %. In field one application of Trichoderma spp. did not reduce disease intensity and did not increase yield. The reduction from 12 to six plants per meter did not decrease yield, and disease severity diminished in one of the two experiments. It is concluded that of the strategies for white mold control just reduction of plant density and applications of fungicide were efficient.

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This study is made in the context of basic research within the field ofcaring science. The aim is to make a theoretical and ontological investigation of what the space is in the world of caring. The basic proposition is that the space, as a fundamental dimension, has an impact on how the appreciation of one's mental health and suffering is shaped, and vice versa. The overall purpose is to develop a theoretical model of space from the caring science point of view andalso to offer an ideal concept of space to caring science. Guided by a theoretical horizon (Eriksson 1993, Eriksson 1995, Eriksson 2001) and methodological approach grounded in Gadamer's philosophic and existential hermeneutics a three-stage analysis and interpretation is conducted. The hermeneutic spiral of this investigation starts through a procedure in accordance with Eriksson's model (1997) of concept definition. The goal is to clarify the etymology of the concept as well as semantic differences between synonymous concepts, i.e. to identify the different extents of the concept of `space` (`rum`) in order to bring these closer for an exploration. The second phase is to analyse and interpret a sample of narratives in order to explicate the ontological nature and meaning of the space. The material used here is literary texts. The goal is to clarify the characteristics of the very inside of the space when it is shaped in relation to the human being in encountering suffering. In the third phase an interview study is taken place. The focus of the study is directed towards the phenomenon of space as it is known by a patient in a landscape of psychiatric care, i.e. what the space is in a contextual meaning. Then, a gradual hermeneutic understanding of the space is attempted by using theories from the field of caring science as well as additional theories from other disciplines. Metaphors are used as they are vivid and expressive tools for generating meaning. Different metaphoric space formations depict here a variety of purports that, although not quite the same, share extensive elements. Six metaphorically summarized entities of meaning emerged. The comprehensive form of space is pointed out as the Mobile-Immobile Room. Furthermore, the Standby, the Asylum, the Wall and the Place. In the further dialogue with the texts the understanding has deepened ontologically. The theoretical model ofthe space sums up the vertical, horizontal and the inward extent of deepness inthe movement of mental health. Three entities of ontological meaning have emerged as three significant rooms: the Common Land emerges as the ideal concept of mutual creation in the freedom of doing, being and becoming health. On the interpersonal level it means freedom, which includes sovereignty, choice and dignity of the human being. The Ice World signifies, ultimately, the space as a kind of frozenness of despair which "wallpapers" the person's entire being in the world in the drama of suffering. The Spiritual Home is shaped when the human being has acquired the very core of his/her inner and outer placeness as a kind of "at-homeness" and rootedness. Time is a central element and the inward extent of deepness of this trialectic space. Each of the metaphors is then the human being's unique, although even paradoxical, way of conceiving reality, and mastering spiritual suffering. They condense characteristic structures and patterns of dynamic scenery, which take place within the movement of health. The space encloses a contradictory spatiality constituted through the dynamic field of meaningfulness and meaninglessness. Anyway, it is not through a purging of these contradictions but through bringing them together in a drama of suffering that the space is shaped as ontologically good and meaningful in the world of caring.